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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-33 Sentence denotes Safety of capecitabine: a review.
T2 34-58 Sentence denotes IMPORTANCE OF THE FIELD:
T3 59-248 Sentence denotes Fluoropyrimidines, in particular 5-fluorouracil (5-FU), have been the mainstay of treatment for several solid tumors, including colorectal, breast and head and neck cancers, for > 40 years.
T4 249-278 Sentence denotes AREAS COVERED IN THIS REVIEW:
T5 279-384 Sentence denotes This article reviews the pharmacology and efficacy of capecitabine with a special emphasis on its safety.
T6 385-411 Sentence denotes WHAT THE READER WILL GAIN:
T7 412-564 Sentence denotes The reader will gain better insight into the safety of capecitabine in special populations such as patients with advanced age, renal and kidney disease.
T8 565-643 Sentence denotes We also explore different dosing and schedules of capecitabine administration.
T9 644-662 Sentence denotes TAKE HOME MESSAGE:
T10 663-819 Sentence denotes Capecitabine is an oral prodrug of 5-FU and was developed to fulfill the need for a more convenient therapy and provide an improved safety/efficacy profile.
T11 820-999 Sentence denotes It has shown promising results alone or in combination with other chemotherapeutic agents in colorectal, breast, pancreaticobiliary, gastric, renal cell and head and neck cancers.
T12 1000-1123 Sentence denotes The most commonly reported toxic effects of capecitabine are diarrhea, nausea, vomiting, stomatitis and hand-foot syndrome.
T13 1124-1261 Sentence denotes Capecitabine has a well-established safety profile and can be given safely to patients with advanced age, hepatic and renal dysfunctions.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7933 10-22 ChemicalEntity denotes capecitabine MESH:D000069287
7934 59-76 ChemicalEntity denotes Fluoropyrimidines
7935 92-106 ChemicalEntity denotes 5-fluorouracil MESH:D005472
7936 108-112 ChemicalEntity denotes 5-FU MESH:D005472
7937 169-175 DiseaseOrPhenotypicFeature denotes tumors MESH:D009369
7938 187-231 DiseaseOrPhenotypicFeature denotes colorectal, breast and head and neck cancers MESH:D001943|MESH:D006258|MESH:D015179
7939 333-345 ChemicalEntity denotes capecitabine MESH:D000069287
7940 467-479 ChemicalEntity denotes capecitabine MESH:D000069287
7941 511-519 OrganismTaxon denotes patients NCBITaxon:9606
7942 539-563 DiseaseOrPhenotypicFeature denotes renal and kidney disease MESH:D007674
7943 615-627 ChemicalEntity denotes capecitabine MESH:D000069287
7944 663-675 ChemicalEntity denotes Capecitabine MESH:D000069287
7945 698-702 ChemicalEntity denotes 5-FU MESH:D005472
7946 913-998 DiseaseOrPhenotypicFeature denotes colorectal, breast, pancreaticobiliary, gastric, renal cell and head and neck cancers MESH:D001943|MESH:D002292|MESH:D006258|MESH:D010190|MESH:D013274|MESH:D015179
7947 1044-1056 ChemicalEntity denotes capecitabine MESH:D000069287
7948 1061-1069 DiseaseOrPhenotypicFeature denotes diarrhea MESH:D003967
7949 1071-1077 DiseaseOrPhenotypicFeature denotes nausea MESH:D009325
7950 1079-1087 DiseaseOrPhenotypicFeature denotes vomiting MESH:D014839
7951 1089-1099 DiseaseOrPhenotypicFeature denotes stomatitis MESH:D013280
7952 1104-1122 DiseaseOrPhenotypicFeature denotes hand-foot syndrome MESH:D060831
7953 1124-1136 ChemicalEntity denotes Capecitabine MESH:D000069287
7954 1202-1210 OrganismTaxon denotes patients NCBITaxon:9606
7955 1230-1260 DiseaseOrPhenotypicFeature denotes hepatic and renal dysfunctions MESH:D007674|MESH:D008107

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 210-231 DiseaseOrPhenotypicFeature denotes head and neck cancers 0005627
T2 549-563 DiseaseOrPhenotypicFeature denotes kidney disease 0005240
T3 977-998 DiseaseOrPhenotypicFeature denotes head and neck cancers 0005627
T4 1089-1099 DiseaseOrPhenotypicFeature denotes stomatitis 0004842
T5 1230-1237 DiseaseOrPhenotypicFeature denotes hepatic 0002251

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 169-175 GeneOrGeneProduct denotes tumors
T2 233-241 GeneOrGeneProduct denotes for > 40
T3 242-247 GeneOrGeneProduct denotes years
T4 249-254 GeneOrGeneProduct denotes AREAS
T5 549-555 GeneOrGeneProduct denotes kidney
T6 880-885 GeneOrGeneProduct denotes other
T7 968-972 GeneOrGeneProduct denotes cell
T8 1104-1108 GeneOrGeneProduct denotes hand
T9 1114-1122 GeneOrGeneProduct denotes syndrome
T10 1137-1142 GeneOrGeneProduct denotes has a

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 549-555 GeneOrGeneProduct denotes kidney
T2 880-885 GeneOrGeneProduct denotes other
T3 968-972 GeneOrGeneProduct denotes cell
T4 1104-1108 GeneOrGeneProduct denotes hand
T5 1114-1122 GeneOrGeneProduct denotes syndrome

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 169-175 DiseaseOrPhenotypicFeature denotes tumors D009369
T2 219-231 DiseaseOrPhenotypicFeature denotes neck cancers D006258
T3 549-563 DiseaseOrPhenotypicFeature denotes kidney disease D007674
T4 986-998 DiseaseOrPhenotypicFeature denotes neck cancers D006258
T5 1061-1069 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T6 1071-1077 DiseaseOrPhenotypicFeature denotes nausea D009325
T7 1079-1087 DiseaseOrPhenotypicFeature denotes vomiting D014839
T8 1089-1099 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T9 1104-1122 DiseaseOrPhenotypicFeature denotes hand-foot syndrome D060831
T10 1242-1260 DiseaseOrPhenotypicFeature denotes renal dysfunctions DISEASE

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 210-231 DiseaseOrPhenotypicFeature denotes head and neck cancers 0005627|0002038
T3 549-563 DiseaseOrPhenotypicFeature denotes kidney disease 0005240|0001343
T5 977-998 DiseaseOrPhenotypicFeature denotes head and neck cancers 0005627|0002038
T7 1061-1069 DiseaseOrPhenotypicFeature denotes diarrhea 0001673
T8 1089-1099 DiseaseOrPhenotypicFeature denotes stomatitis 0004842
T9 1114-1122 DiseaseOrPhenotypicFeature denotes syndrome 0002254
T10 1179-1182 DiseaseOrPhenotypicFeature denotes can 0012833

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 169-175 DiseaseOrPhenotypicFeature denotes tumors DISEASE|D009369
T3 219-231 DiseaseOrPhenotypicFeature denotes neck cancers D006258
T4 549-563 DiseaseOrPhenotypicFeature denotes kidney disease D007674
T5 986-998 DiseaseOrPhenotypicFeature denotes neck cancers D006258
T6 1061-1069 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T7 1071-1077 DiseaseOrPhenotypicFeature denotes nausea D009325
T8 1079-1087 DiseaseOrPhenotypicFeature denotes vomiting D014839
T9 1089-1099 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T10 1104-1122 DiseaseOrPhenotypicFeature denotes hand-foot syndrome D060831
T11 1230-1260 DiseaseOrPhenotypicFeature denotes hepatic and renal dysfunctions DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 169-175 DiseaseOrPhenotypicFeature denotes tumors D009369
T2 210-231 DiseaseOrPhenotypicFeature denotes head and neck cancers D006258
T3 549-563 DiseaseOrPhenotypicFeature denotes kidney disease D007674
T4 977-998 DiseaseOrPhenotypicFeature denotes head and neck cancers D006258
T5 1061-1069 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T6 1071-1077 DiseaseOrPhenotypicFeature denotes nausea D009325
T7 1079-1087 DiseaseOrPhenotypicFeature denotes vomiting D014839
T8 1089-1099 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T9 1104-1122 DiseaseOrPhenotypicFeature denotes hand-foot syndrome D060831
T10 1230-1260 DiseaseOrPhenotypicFeature denotes hepatic and renal dysfunctions DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 10-22 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T2 59-76 ChemicalEntity denotes Fluoropyrimidines ChemicalEntity
T3 92-106 ChemicalEntity denotes 5-fluorouracil D005472|http://purl.obolibrary.org/obo/CHEBI_46345
T5 108-112 ChemicalEntity denotes 5-FU D005472|http://purl.obolibrary.org/obo/CHEBI_46345
T7 333-345 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T8 467-479 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T9 615-627 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T10 649-653 ChemicalEntity denotes HOME http://purl.obolibrary.org/obo/CHEBI_75830
T11 663-675 ChemicalEntity denotes Capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T12 698-702 ChemicalEntity denotes 5-FU D005472|http://purl.obolibrary.org/obo/CHEBI_46345
T14 1044-1056 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T15 1124-1136 ChemicalEntity denotes Capecitabine http://purl.obolibrary.org/obo/CHEBI_31348

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 511-519 OrganismTaxon denotes patients
T2 1202-1210 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T15 1124-1136 ChemicalEntity denotes Capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T14 1044-1056 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T12 698-702 ChemicalEntity denotes 5-FU http://purl.obolibrary.org/obo/CHEBI_46345|D005472
T11 663-675 ChemicalEntity denotes Capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T10 649-653 ChemicalEntity denotes HOME http://purl.obolibrary.org/obo/CHEBI_75830
T9 615-627 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T8 467-479 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T7 333-345 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T5 108-112 ChemicalEntity denotes 5-FU http://purl.obolibrary.org/obo/CHEBI_46345|D005472
T3 92-106 ChemicalEntity denotes 5-fluorouracil http://purl.obolibrary.org/obo/CHEBI_46345|D005472
T2 59-76 ChemicalEntity denotes Fluoropyrimidines ChemicalEntity
T1 10-22 ChemicalEntity denotes capecitabine http://purl.obolibrary.org/obo/CHEBI_31348
T1366 1230-1260 DiseaseOrPhenotypicFeature denotes hepatic and renal dysfunctions DISEASE
T87192 1104-1122 DiseaseOrPhenotypicFeature denotes hand-foot syndrome D060831
T77506 1089-1099 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T43521 1079-1087 DiseaseOrPhenotypicFeature denotes vomiting D014839
T6 1071-1077 DiseaseOrPhenotypicFeature denotes nausea D009325
T40453 1061-1069 DiseaseOrPhenotypicFeature denotes diarrhea D003967
T4 977-998 DiseaseOrPhenotypicFeature denotes head and neck cancers D006258
T15134 549-563 DiseaseOrPhenotypicFeature denotes kidney disease D007674
T70662 210-231 DiseaseOrPhenotypicFeature denotes head and neck cancers D006258
T65543 169-175 DiseaseOrPhenotypicFeature denotes tumors D009369
T48710 1202-1210 OrganismTaxon denotes patients
T4560 511-519 OrganismTaxon denotes patients

Allie

Id Subject Object Predicate Lexical cue
SS1_20722491_2_0 92-106 expanded denotes 5-fluorouracil
SS2_20722491_2_0 108-112 abbr denotes 5-FU
AE1_20722491_2_0 SS1_20722491_2_0 SS2_20722491_2_0 abbreviatedTo 5-fluorouracil,5-FU

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 169-175 HP_0002664 denotes tumors
T2 224-231 HP_0002664 denotes cancers