PubMed:20711231 / 856-1224 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/20711231","sourcedb":"PubMed","sourceid":"20711231","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/20711231","text":"We found a correlation between ErbB2 expression and activation of Pak in estrogen receptor-positive human breast tumor samples and observed that in 3D cultures, activation of Rac-Pak1 pathway by ErbB2 homodimers induced growth factor-independent proliferation and promoted disruption of 3D mammary acinar-like structures through activation of the Erk and Akt pathways.","tracks":[{"project":"PubMed_ArguminSci","denotations":[{"id":"T7","span":{"begin":0,"end":368},"obj":"DRI_Approach"}],"attributes":[{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"PubmedHPO","denotations":[{"id":"T8","span":{"begin":106,"end":118},"obj":"HP_0003002"},{"id":"T9","span":{"begin":106,"end":118},"obj":"HP_0100013"},{"id":"T10","span":{"begin":113,"end":118},"obj":"HP_0002664"}],"attributes":[{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"20711231-5#73#90#gene2099","span":{"begin":73,"end":90},"obj":"gene2099"},{"id":"20711231-5#106#118#diseaseC1458155","span":{"begin":106,"end":118},"obj":"diseaseC1458155"}],"relations":[{"id":"73#90#gene2099106#118#diseaseC1458155","pred":"associated_with","subj":"20711231-5#73#90#gene2099","obj":"20711231-5#106#118#diseaseC1458155"}],"attributes":[{"subj":"20711231-5#73#90#gene2099","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20711231-5#106#118#diseaseC1458155","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubMed_ArguminSci","color":"#c193ec","default":true},{"id":"PubmedHPO","color":"#93eca7"},{"id":"DisGeNET5_gene_disease","color":"#ec9398"}]}]}}