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PubMed:20711231 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 116-235 DRI_Outcome denotes The activation of receptor tyrosine kinases, particularly ErbB2, has an important role in the genesis of breast cancer.
T2 236-376 DRI_Background denotes ErbB2 kinase activity promotes Ras-mediated stimulation of downstream protein kinase cascades, including the Ras/Raf-1/MAPK/ERK kinase (Mek)
T3 408-473 DRI_Background denotes kinase (Erk) pathway, leading to tumor cell growth and migration.
T4 474-532 DRI_Approach denotes Signaling through the Ras-Erk pathway can be influenced by
T5 556-616 DRI_Approach denotes (Pak1), an effector of the Rho family GTPases Rac and Cdc42.
T6 617-855 DRI_Outcome denotes In this study, we asked if ErbB2 expression correlates with Pak1 and Erk activity in human breast cancer specimens, and if Pak1 signaling is required for ErbB2 transformation in a three-dimensional (3D) in vitro setting and in xenografts.
T7 856-1224 DRI_Approach denotes We found a correlation between ErbB2 expression and activation of Pak in estrogen receptor-positive human breast tumor samples and observed that in 3D cultures, activation of Rac-Pak1 pathway by ErbB2 homodimers induced growth factor-independent proliferation and promoted disruption of 3D mammary acinar-like structures through activation of the Erk and Akt pathways.
T8 1225-1421 DRI_Outcome denotes Further, we found that inhibition of Pak1 by small molecules compromised activation of Erk and Akt, resulting in reversion of the malignant phenotype and restoration of normal acinar architecture.
T9 1422-1586 DRI_Outcome denotes Finally, ErbB2-amplified breast cancer cells expressing a specific Pak inhibitor showed delayed tumor formation and downregulation of Erk and Akt signaling in vivo.
T10 1587-1784 DRI_Outcome denotes These data imply that the Rac-Pak pathway is vital to ErbB2-mediated transformation and that Pak inhibitors represent plausible drug targets in breast cancers in which ErbB2 signaling is activated.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 174-179 gene:2064 denotes ErbB2
T1 221-234 disease:C0006142 denotes breast cancer
T2 174-179 gene:2064 denotes ErbB2
T3 221-234 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with ErbB2,breast cancer
R2 T2 T3 associated_with ErbB2,breast cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 221-234 HP_0003002 denotes breast cancer
T2 221-234 HP_0100013 denotes breast cancer
T3 228-234 HP_0002664 denotes cancer
T4 441-446 HP_0002664 denotes tumor
T5 708-721 HP_0003002 denotes breast cancer
T6 708-721 HP_0100013 denotes breast cancer
T7 715-721 HP_0002664 denotes cancer
T8 962-974 HP_0003002 denotes breast tumor
T9 962-974 HP_0100013 denotes breast tumor
T10 969-974 HP_0002664 denotes tumor
T11 1447-1460 HP_0003002 denotes breast cancer
T12 1447-1460 HP_0100013 denotes breast cancer
T13 1454-1460 HP_0002664 denotes cancer
T14 1518-1523 HP_0002664 denotes tumor
T15 1731-1745 HP_0003002 denotes breast cancers
T16 1731-1745 HP_0100013 denotes breast cancers
T17 1738-1745 HP_0002664 denotes cancers

Allie

Id Subject Object Predicate Lexical cue
SS1_20711231_2_0 355-370 expanded denotes MAPK/ERK kinase
SS2_20711231_2_0 372-375 abbr denotes Mek
SS1_20711231_2_1 377-414 expanded denotes extracellular signal-regulated kinase
SS2_20711231_2_1 416-419 abbr denotes Erk
SS1_20711231_3_0 533-555 expanded denotes p21-activated kinase-1
SS2_20711231_3_0 557-561 abbr denotes Pak1
AE1_20711231_2_0 SS1_20711231_2_0 SS2_20711231_2_0 abbreviatedTo MAPK/ERK kinase,Mek
AE1_20711231_2_1 SS1_20711231_2_1 SS2_20711231_2_1 abbreviatedTo extracellular signal-regulated kinase,Erk
AE1_20711231_3_0 SS1_20711231_3_0 SS2_20711231_3_0 abbreviatedTo p21-activated kinase-1,Pak1

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20711231-4#60#64#gene5058 677-681 gene5058 denotes Pak1
20711231-4#91#104#diseaseC0006142 708-721 diseaseC0006142 denotes breast cancer
20711231-4#91#104#diseaseC0678222 708-721 diseaseC0678222 denotes breast cancer
20711231-5#73#90#gene2099 929-946 gene2099 denotes estrogen receptor
20711231-5#106#118#diseaseC1458155 962-974 diseaseC1458155 denotes breast tumor
20711231-7#9#14#gene2064 1431-1436 gene2064 denotes ErbB2
20711231-7#25#38#diseaseC0678222 1447-1460 diseaseC0678222 denotes breast cancer
20711231-8#54#59#gene2064 1641-1646 gene2064 denotes ErbB2
20711231-8#144#158#diseaseC0006142 1731-1745 diseaseC0006142 denotes breast cancers
60#64#gene505891#104#diseaseC0006142 20711231-4#60#64#gene5058 20711231-4#91#104#diseaseC0006142 associated_with Pak1,breast cancer
60#64#gene505891#104#diseaseC0678222 20711231-4#60#64#gene5058 20711231-4#91#104#diseaseC0678222 associated_with Pak1,breast cancer
73#90#gene2099106#118#diseaseC1458155 20711231-5#73#90#gene2099 20711231-5#106#118#diseaseC1458155 associated_with estrogen receptor,breast tumor
9#14#gene206425#38#diseaseC0678222 20711231-7#9#14#gene2064 20711231-7#25#38#diseaseC0678222 associated_with ErbB2,breast cancer
54#59#gene2064144#158#diseaseC0006142 20711231-8#54#59#gene2064 20711231-8#144#158#diseaseC0006142 associated_with ErbB2,breast cancers

CoMAGC

Id Subject Object Predicate Lexical cue
T1 1564-1567 Gene denotes Akt
E2 1538-1552 Negative_regulation denotes downregulation
T2 1447-1460 breast cancer denotes breast cancer
R1 T1 E2 themeOf Akt,downregulation
R3 T1 T2 CGE-decreased Akt,breast cancer
R4 T1 T2 CCS-cancerTOnormal Akt,breast cancer
R5 T1 T2 PT-observation Akt,breast cancer
R3 T1 T2 IGE-unidentifiable Akt,breast cancer