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PubMed:20709368 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease.
T2 95-216 Sentence denotes Conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in stabilization of the fibrin clot.
T3 217-391 Sentence denotes Fibrinogen consists of three pairs of non-identical polypeptide chains, encoded by different genes (fibrinogen alpha [FGA], fibrinogen beta [FGB] and fibrinogen gamma [FGG]).
T4 392-588 Sentence denotes A functional single nucleotide polymorphism (SNP) in the 3' untranslated region of the FGG gene (FGG 10034C>T, rs2066865) has been associated with deep venous thrombosis and myocardial infarction.
T5 589-696 Sentence denotes Aim of the present study was to analyze the role of this polymorphism in peripheral arterial disease (PAD).
T6 697-810 Sentence denotes The study was designed as case-control study including 891 patients with documented PAD and 777 control subjects.
T7 811-872 Sentence denotes FGG genotypes were determined by exonuclease (TaqMan) assays.
T8 873-956 Sentence denotes FGG genotype frequencies were not significantly different between PAD patients (CC:
T9 957-967 Sentence denotes 57.3%, CT:
T10 968-978 Sentence denotes 36.7%, TT:
T11 979-1010 Sentence denotes 5.8%) and control subjects (CC:
T12 1011-1021 Sentence denotes 60.9%, CT:
T13 1022-1046 Sentence denotes 33.5%, TT 5.6%; p=0.35).
T14 1047-1328 Sentence denotes In a multivariate logistic regression analysis including age, sex, smoking, diabetes, arterial hypertension and hypercholesterolemia, the FGG 10034 T variant was not significantly associated with the presence of PAD (Odds ratio 1.07, 95% confidence interval 0.84 - 1.37; p = 0.60).
T15 1329-1415 Sentence denotes The FGG 10034C>T polymorphism was furthermore not associated with age at onset of PAD.
T16 1416-1533 Sentence denotes We conclude that the thrombophilic FGG 10034 T gene variant does not contribute to the genetic susceptibility to PAD.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7894 4-20 GeneOrGeneProduct denotes fibrinogen gamma NCBIGene:2266
7895 21-29 SequenceVariant denotes 10034C>T DBSNP:rs2066865
7896 66-93 DiseaseOrPhenotypicFeature denotes Peripheral Arterial Disease MESH:D058729
7897 109-119 GeneOrGeneProduct denotes fibrinogen NCBIGene:2243|NCBIGene:2244|NCBIGene:2266
7898 123-129 GeneOrGeneProduct denotes fibrin NCBIGene:2243|NCBIGene:2244|NCBIGene:2266
7899 204-210 GeneOrGeneProduct denotes fibrin NCBIGene:2243|NCBIGene:2244|NCBIGene:2266
7900 217-227 GeneOrGeneProduct denotes Fibrinogen NCBIGene:2243|NCBIGene:2244|NCBIGene:2266
7901 317-333 GeneOrGeneProduct denotes fibrinogen alpha NCBIGene:2243
7902 335-338 GeneOrGeneProduct denotes FGA NCBIGene:2243
7903 341-356 GeneOrGeneProduct denotes fibrinogen beta NCBIGene:2244
7904 358-361 GeneOrGeneProduct denotes FGB NCBIGene:2244
7905 367-383 GeneOrGeneProduct denotes fibrinogen gamma NCBIGene:2266
7906 385-388 GeneOrGeneProduct denotes FGG NCBIGene:2266
7907 479-482 GeneOrGeneProduct denotes FGG NCBIGene:2266
7908 489-492 GeneOrGeneProduct denotes FGG NCBIGene:2266
7909 493-501 SequenceVariant denotes 10034C>T DBSNP:rs2066865
7910 503-512 SequenceVariant denotes rs2066865 DBSNP:rs2066865
7911 539-561 DiseaseOrPhenotypicFeature denotes deep venous thrombosis MESH:D020246
7912 566-587 DiseaseOrPhenotypicFeature denotes myocardial infarction MESH:D009203
7913 662-689 DiseaseOrPhenotypicFeature denotes peripheral arterial disease MESH:D058729
7914 691-694 DiseaseOrPhenotypicFeature denotes PAD MESH:D058729
7915 756-764 OrganismTaxon denotes patients NCBITaxon:9606
7916 781-784 DiseaseOrPhenotypicFeature denotes PAD MESH:D058729
7917 811-814 GeneOrGeneProduct denotes FGG NCBIGene:2266
7918 873-876 GeneOrGeneProduct denotes FGG NCBIGene:2266
7919 939-942 DiseaseOrPhenotypicFeature denotes PAD MESH:D058729
7920 943-951 OrganismTaxon denotes patients NCBITaxon:9606
7921 1123-1131 DiseaseOrPhenotypicFeature denotes diabetes MESH:D003920
7922 1142-1154 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
7923 1159-1179 DiseaseOrPhenotypicFeature denotes hypercholesterolemia MESH:D006937
7924 1185-1188 GeneOrGeneProduct denotes FGG NCBIGene:2266
7925 1189-1196 SequenceVariant denotes 10034 T DBSNP:rs2066865
7926 1259-1262 DiseaseOrPhenotypicFeature denotes PAD MESH:D058729
7927 1333-1336 GeneOrGeneProduct denotes FGG NCBIGene:2266
7928 1337-1345 SequenceVariant denotes 10034C>T DBSNP:rs2066865
7929 1411-1414 DiseaseOrPhenotypicFeature denotes PAD MESH:D058729
7930 1451-1454 GeneOrGeneProduct denotes FGG NCBIGene:2266
7931 1455-1462 SequenceVariant denotes 10034 T DBSNP:rs2066865
7932 1529-1532 DiseaseOrPhenotypicFeature denotes PAD MESH:D058729

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 66-93 DiseaseOrPhenotypicFeature denotes Peripheral Arterial Disease 0005386
T2 566-587 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T3 662-689 DiseaseOrPhenotypicFeature denotes peripheral arterial disease 0005386

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 21-27 SequenceVariant denotes 10034C
T2 493-499 SequenceVariant denotes 10034C
T3 503-512 SequenceVariant denotes rs2066865
T4 1337-1343 SequenceVariant denotes 10034C

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 4-14 GeneOrGeneProduct denotes fibrinogen
T2 15-20 GeneOrGeneProduct denotes gamma
T3 109-119 GeneOrGeneProduct denotes fibrinogen
T4 211-215 GeneOrGeneProduct denotes clot
T5 217-227 GeneOrGeneProduct denotes Fibrinogen
T6 246-251 GeneOrGeneProduct denotes pairs
T7 269-280 GeneOrGeneProduct denotes polypeptide
T8 281-287 GeneOrGeneProduct denotes chains
T9 317-327 GeneOrGeneProduct denotes fibrinogen
T10 328-333 GeneOrGeneProduct denotes alpha
T11 341-351 GeneOrGeneProduct denotes fibrinogen
T12 352-356 GeneOrGeneProduct denotes beta
T13 367-377 GeneOrGeneProduct denotes fibrinogen
T14 378-383 GeneOrGeneProduct denotes gamma
T15 436-450 GeneOrGeneProduct denotes (SNP) in the 3
T16 723-727 GeneOrGeneProduct denotes case
T17 830-840 GeneOrGeneProduct denotes determined
T18 844-855 GeneOrGeneProduct denotes exonuclease
T19 886-897 GeneOrGeneProduct denotes frequencies
T20 1123-1131 GeneOrGeneProduct denotes diabetes
T21 1142-1154 GeneOrGeneProduct denotes hypertension
T22 1159-1179 GeneOrGeneProduct denotes hypercholesterolemia

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 4-14 GeneOrGeneProduct denotes fibrinogen
T2 15-20 GeneOrGeneProduct denotes gamma
T3 109-119 GeneOrGeneProduct denotes fibrinogen
T4 211-215 GeneOrGeneProduct denotes clot
T5 217-227 GeneOrGeneProduct denotes Fibrinogen
T6 269-280 GeneOrGeneProduct denotes polypeptide
T7 317-327 GeneOrGeneProduct denotes fibrinogen
T8 328-333 GeneOrGeneProduct denotes alpha
T9 341-351 GeneOrGeneProduct denotes fibrinogen
T10 352-356 GeneOrGeneProduct denotes beta
T11 367-377 GeneOrGeneProduct denotes fibrinogen
T12 378-383 GeneOrGeneProduct denotes gamma
T13 844-855 GeneOrGeneProduct denotes exonuclease
T14 1123-1131 GeneOrGeneProduct denotes diabetes
T15 1142-1154 GeneOrGeneProduct denotes hypertension
T16 1159-1179 GeneOrGeneProduct denotes hypercholesterolemia

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 66-93 DiseaseOrPhenotypicFeature denotes Peripheral Arterial Disease D058729
T2 539-561 DiseaseOrPhenotypicFeature denotes deep venous thrombosis D020246
T3 566-587 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T4 662-689 DiseaseOrPhenotypicFeature denotes peripheral arterial disease D058729
T5 691-694 DiseaseOrPhenotypicFeature denotes PAD D058729
T6 781-784 DiseaseOrPhenotypicFeature denotes PAD D058729
T7 939-942 DiseaseOrPhenotypicFeature denotes PAD D058729
T8 1123-1131 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T9 1142-1154 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 1159-1179 DiseaseOrPhenotypicFeature denotes hypercholesterolemia D006937
T11 1259-1262 DiseaseOrPhenotypicFeature denotes PAD D058729
T12 1411-1414 DiseaseOrPhenotypicFeature denotes PAD D058729
T13 1503-1525 DiseaseOrPhenotypicFeature denotes genetic susceptibility D020022
T14 1529-1532 DiseaseOrPhenotypicFeature denotes PAD D058729

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 4-14 GeneOrGeneProduct denotes fibrinogen
T2 109-119 GeneOrGeneProduct denotes fibrinogen
T3 211-215 GeneOrGeneProduct denotes clot
T4 217-227 GeneOrGeneProduct denotes Fibrinogen
T5 269-280 GeneOrGeneProduct denotes polypeptide
T6 317-327 GeneOrGeneProduct denotes fibrinogen
T7 328-333 GeneOrGeneProduct denotes alpha
T8 341-351 GeneOrGeneProduct denotes fibrinogen
T9 367-377 GeneOrGeneProduct denotes fibrinogen
T10 844-855 GeneOrGeneProduct denotes exonuclease
T11 1159-1179 GeneOrGeneProduct denotes hypercholesterolemia

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 66-93 DiseaseOrPhenotypicFeature denotes Peripheral Arterial Disease 0005386
T2 544-561 DiseaseOrPhenotypicFeature denotes venous thrombosis 0008559
T3 566-587 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T4 662-689 DiseaseOrPhenotypicFeature denotes peripheral arterial disease 0005386
T5 691-694 DiseaseOrPhenotypicFeature denotes PAD 0005386
T6 781-784 DiseaseOrPhenotypicFeature denotes PAD 0005386
T7 939-942 DiseaseOrPhenotypicFeature denotes PAD 0005386
T8 953-955 DiseaseOrPhenotypicFeature denotes CC 0019087
T9 1007-1009 DiseaseOrPhenotypicFeature denotes CC 0019087
T10 1123-1131 DiseaseOrPhenotypicFeature denotes diabetes 0005015
T11 1142-1154 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T12 1259-1262 DiseaseOrPhenotypicFeature denotes PAD 0005386
T13 1411-1414 DiseaseOrPhenotypicFeature denotes PAD 0005386
T14 1529-1532 DiseaseOrPhenotypicFeature denotes PAD 0005386

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 66-93 DiseaseOrPhenotypicFeature denotes Peripheral Arterial Disease D058729
T2 539-561 DiseaseOrPhenotypicFeature denotes deep venous thrombosis D020246
T3 566-587 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T4 662-689 DiseaseOrPhenotypicFeature denotes peripheral arterial disease D058729
T5 691-694 DiseaseOrPhenotypicFeature denotes PAD D058729
T6 781-784 DiseaseOrPhenotypicFeature denotes PAD D058729
T7 939-942 DiseaseOrPhenotypicFeature denotes PAD D058729
T8 1123-1131 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T9 1142-1154 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 1159-1179 DiseaseOrPhenotypicFeature denotes hypercholesterolemia D006937
T11 1259-1262 DiseaseOrPhenotypicFeature denotes PAD D058729
T12 1411-1414 DiseaseOrPhenotypicFeature denotes PAD D058729
T13 1503-1525 DiseaseOrPhenotypicFeature denotes genetic susceptibility D020022
T14 1529-1532 DiseaseOrPhenotypicFeature denotes PAD D058729

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 66-93 DiseaseOrPhenotypicFeature denotes Peripheral Arterial Disease D058729
T2 539-561 DiseaseOrPhenotypicFeature denotes deep venous thrombosis D020246
T3 566-587 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T4 662-689 DiseaseOrPhenotypicFeature denotes peripheral arterial disease D058729
T5 691-694 DiseaseOrPhenotypicFeature denotes PAD D058729
T6 781-784 DiseaseOrPhenotypicFeature denotes PAD D058729
T7 939-942 DiseaseOrPhenotypicFeature denotes PAD D058729
T8 1123-1131 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T9 1142-1154 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 1159-1179 DiseaseOrPhenotypicFeature denotes hypercholesterolemia D006937
T11 1259-1262 DiseaseOrPhenotypicFeature denotes PAD D058729
T12 1411-1414 DiseaseOrPhenotypicFeature denotes PAD D058729
T13 1503-1525 DiseaseOrPhenotypicFeature denotes genetic susceptibility D020022
T14 1529-1532 DiseaseOrPhenotypicFeature denotes PAD D058729

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 756-764 OrganismTaxon denotes patients
T2 943-951 OrganismTaxon denotes patients

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 269-287 ChemicalEntity denotes polypeptide chains http://purl.obolibrary.org/obo/CHEBI_16541
T2 385-388 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T3 479-482 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T4 489-492 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T5 811-814 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T6 844-855 ChemicalEntity denotes exonuclease D005092
T7 873-876 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T8 1185-1188 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T9 1333-1336 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T10 1451-1454 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T10 1451-1454 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T9 1333-1336 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T8 1185-1188 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T7 873-876 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T6 844-855 ChemicalEntity denotes exonuclease D005092
T5 811-814 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T4 489-492 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T3 479-482 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T2 385-388 ChemicalEntity denotes FGG http://purl.obolibrary.org/obo/CHEBI_74714
T1 269-287 ChemicalEntity denotes polypeptide chains http://purl.obolibrary.org/obo/CHEBI_16541
T11 1159-1179 GeneOrGeneProduct denotes hypercholesterolemia
T13267 844-855 GeneOrGeneProduct denotes exonuclease
T10394 367-377 GeneOrGeneProduct denotes fibrinogen
T86575 341-351 GeneOrGeneProduct denotes fibrinogen
T11522 328-333 GeneOrGeneProduct denotes alpha
T48005 317-327 GeneOrGeneProduct denotes fibrinogen
T42834 269-280 GeneOrGeneProduct denotes polypeptide
T46293 217-227 GeneOrGeneProduct denotes Fibrinogen
T16772 211-215 GeneOrGeneProduct denotes clot
T16108 109-119 GeneOrGeneProduct denotes fibrinogen
T46481 4-14 GeneOrGeneProduct denotes fibrinogen
T14 1529-1532 DiseaseOrPhenotypicFeature denotes PAD D058729
T13 1503-1525 DiseaseOrPhenotypicFeature denotes genetic susceptibility D020022
T12 1411-1414 DiseaseOrPhenotypicFeature denotes PAD D058729
T39838 1259-1262 DiseaseOrPhenotypicFeature denotes PAD D058729
T80098 1159-1179 DiseaseOrPhenotypicFeature denotes hypercholesterolemia D006937
T62882 1142-1154 DiseaseOrPhenotypicFeature denotes hypertension D006973
T2817 1123-1131 DiseaseOrPhenotypicFeature denotes diabetes DISEASE
T87387 939-942 DiseaseOrPhenotypicFeature denotes PAD D058729
T17039 781-784 DiseaseOrPhenotypicFeature denotes PAD D058729
T84227 691-694 DiseaseOrPhenotypicFeature denotes PAD D058729
T50352 662-689 DiseaseOrPhenotypicFeature denotes peripheral arterial disease D058729
T27740 566-587 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T28155 539-561 DiseaseOrPhenotypicFeature denotes deep venous thrombosis D020246
T83855 66-93 DiseaseOrPhenotypicFeature denotes Peripheral Arterial Disease D058729
T6065 943-951 OrganismTaxon denotes patients
T65206 756-764 OrganismTaxon denotes patients
T50958 1337-1343 SequenceVariant denotes 10034C
T47771 503-512 SequenceVariant denotes rs2066865
T76310 493-499 SequenceVariant denotes 10034C
T74415 21-27 SequenceVariant denotes 10034C

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1451-1454 gene:2266 denotes FGG
T1 1529-1532 disease:C1704436 denotes PAD
R1 T0 T1 associated_with FGG,PAD

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 539-561 HP_0002625 denotes deep venous thrombosis
T2 544-561 HP_0004936 denotes venous thrombosis
T3 566-587 HP_0001658 denotes myocardial infarction
T4 662-689 HP_0004950 denotes peripheral arterial disease
T5 1142-1154 HP_0000822 denotes hypertension
T6 1159-1179 HP_0003124 denotes hypercholesterolemia

Allie

Id Subject Object Predicate Lexical cue
SS1_20709368_2_0 317-333 expanded denotes fibrinogen alpha
SS2_20709368_2_0 335-338 abbr denotes FGA
SS1_20709368_2_1 341-356 expanded denotes fibrinogen beta
SS2_20709368_2_1 358-361 abbr denotes FGB
SS1_20709368_2_2 367-383 expanded denotes fibrinogen gamma
SS2_20709368_2_2 385-388 abbr denotes FGG
SS1_20709368_3_0 405-435 expanded denotes single nucleotide polymorphism
SS2_20709368_3_0 437-440 abbr denotes SNP
SS1_20709368_4_0 662-689 expanded denotes peripheral arterial disease
SS2_20709368_4_0 691-694 abbr denotes PAD
SS1_20709368_7_0 989-1005 expanded denotes control subjects
SS2_20709368_7_0 1007-1009 abbr denotes CC
AE1_20709368_2_0 SS1_20709368_2_0 SS2_20709368_2_0 abbreviatedTo fibrinogen alpha,FGA
AE1_20709368_2_1 SS1_20709368_2_1 SS2_20709368_2_1 abbreviatedTo fibrinogen beta,FGB
AE1_20709368_2_2 SS1_20709368_2_2 SS2_20709368_2_2 abbreviatedTo fibrinogen gamma,FGG
AE1_20709368_3_0 SS1_20709368_3_0 SS2_20709368_3_0 abbreviatedTo single nucleotide polymorphism,SNP
AE1_20709368_4_0 SS1_20709368_4_0 SS2_20709368_4_0 abbreviatedTo peripheral arterial disease,PAD
AE1_20709368_7_0 SS1_20709368_7_0 SS2_20709368_7_0 abbreviatedTo control subjects,CC

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 21-29 DNAMutation:|SUB|C|10034|T denotes 10034C>T
T2 493-501 DNAMutation:|SUB|C|10034|T denotes 10034C>T
T3 503-512 SNP:rs2066865 denotes rs2066865
T4 1337-1345 DNAMutation:|SUB|C|10034|T denotes 10034C>T

PubTator4TogoVar

Id Subject Object Predicate Lexical cue resolved_to
43 503-512 SNP denotes rs2066865 tmVar:rs2066865;VariantGroup:0;CorrespondingGene:2266;RS#:2066865;CorrespondingSpecies:9606

PubTatorOnTogoVar

Id Subject Object Predicate Lexical cue resolved_to
43 503-512 SNP denotes rs2066865 tmVar:rs2066865;VariantGroup:0;CorrespondingGene:2266;RS#:2066865;CorrespondingSpecies:9606
T1 503-512 SNP denotes rs2066865 tmVar:rs2066865;VariantGroup:0;CorrespondingGene:2266;RS#:2066865;CorrespondingSpecies:9606