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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-183 Sentence denotes Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.
TextSentencer_T2 184-192 Sentence denotes PURPOSE:
TextSentencer_T3 193-384 Sentence denotes Bortezomib induces unfolded protein response (UPR) and endoplasmic reticulum stress, as well as exhibits clinical activity in patients with relapsed and refractory mantle cell lymphoma (MCL).
TextSentencer_T4 385-606 Sentence denotes Here, we determined the molecular basis of the improved in vitro and in vivo activity of the combination of the pan-histone deacetylase inhibitor panobinostat and bortezomib against human, cultured, and primary MCL cells.
TextSentencer_T5 607-627 Sentence denotes EXPERIMENTAL DESIGN:
TextSentencer_T6 628-861 Sentence denotes Immunoblot analyses, reverse transcription-PCR, and immunofluorescent and electron microscopy were used to determine the effects of panobinostat on bortezomib-induced aggresome formation and endoplasmic reticulum stress in MCL cells.
TextSentencer_T7 862-870 Sentence denotes RESULTS:
TextSentencer_T8 871-1113 Sentence denotes Treatment with panobinostat induced heat shock protein 90 acetylation; depleted the levels of heat shock protein 90 client proteins, cyclin-dependent kinase 4, c-RAF, and AKT; and abrogated bortezomib-induced aggresome formation in MCL cells.
TextSentencer_T9 1114-1237 Sentence denotes Panobinostat also induced lethal UPR, associated with induction of CAAT/enhancer binding protein homologous protein (CHOP).
TextSentencer_T10 1238-1324 Sentence denotes Conversely, knockdown of CHOP attenuated panobinostat-induced cell death of MCL cells.
TextSentencer_T11 1325-1537 Sentence denotes Compared with each agent alone, cotreatment with panobinostat increased bortezomib-induced expression of CHOP and NOXA, as well as increased bortezomib-induced UPR and apoptosis of cultured and primary MCL cells.
TextSentencer_T12 1538-1704 Sentence denotes Cotreatment with panobinostat also increased bortezomib-mediated in vivo tumor growth inhibition and improved survival of mice bearing human Z138C MCL cell xenograft.
TextSentencer_T13 1705-1716 Sentence denotes CONCLUSION:
TextSentencer_T14 1717-1874 Sentence denotes These findings suggest that increased UPR and induction of CHOP are involved in enhanced anti-MCL activity of the combination of panobinostat and bortezomib.
T1 0-183 Sentence denotes Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.
T2 184-192 Sentence denotes PURPOSE:
T3 193-384 Sentence denotes Bortezomib induces unfolded protein response (UPR) and endoplasmic reticulum stress, as well as exhibits clinical activity in patients with relapsed and refractory mantle cell lymphoma (MCL).
T4 385-606 Sentence denotes Here, we determined the molecular basis of the improved in vitro and in vivo activity of the combination of the pan-histone deacetylase inhibitor panobinostat and bortezomib against human, cultured, and primary MCL cells.
T5 607-627 Sentence denotes EXPERIMENTAL DESIGN:
T6 628-861 Sentence denotes Immunoblot analyses, reverse transcription-PCR, and immunofluorescent and electron microscopy were used to determine the effects of panobinostat on bortezomib-induced aggresome formation and endoplasmic reticulum stress in MCL cells.
T7 862-870 Sentence denotes RESULTS:
T8 871-1113 Sentence denotes Treatment with panobinostat induced heat shock protein 90 acetylation; depleted the levels of heat shock protein 90 client proteins, cyclin-dependent kinase 4, c-RAF, and AKT; and abrogated bortezomib-induced aggresome formation in MCL cells.
T9 1114-1237 Sentence denotes Panobinostat also induced lethal UPR, associated with induction of CAAT/enhancer binding protein homologous protein (CHOP).
T10 1238-1324 Sentence denotes Conversely, knockdown of CHOP attenuated panobinostat-induced cell death of MCL cells.
T11 1325-1537 Sentence denotes Compared with each agent alone, cotreatment with panobinostat increased bortezomib-induced expression of CHOP and NOXA, as well as increased bortezomib-induced UPR and apoptosis of cultured and primary MCL cells.
T12 1538-1704 Sentence denotes Cotreatment with panobinostat also increased bortezomib-mediated in vivo tumor growth inhibition and improved survival of mice bearing human Z138C MCL cell xenograft.
T13 1705-1716 Sentence denotes CONCLUSION:
T14 1717-1874 Sentence denotes These findings suggest that increased UPR and induction of CHOP are involved in enhanced anti-MCL activity of the combination of panobinostat and bortezomib.

Allie

Id Subject Object Predicate Lexical cue
SS1_20647473_2_0 212-237 expanded denotes unfolded protein response
SS2_20647473_2_0 239-242 abbr denotes UPR
SS1_20647473_2_1 357-377 expanded denotes mantle cell lymphoma
SS2_20647473_2_1 379-382 abbr denotes MCL
SS1_20647473_8_0 1181-1229 expanded denotes CAAT/enhancer binding protein homologous protein
SS2_20647473_8_0 1231-1235 abbr denotes CHOP
AE1_20647473_2_0 SS1_20647473_2_0 SS2_20647473_2_0 abbreviatedTo unfolded protein response,UPR
AE1_20647473_2_1 SS1_20647473_2_1 SS2_20647473_2_1 abbreviatedTo mantle cell lymphoma,MCL
AE1_20647473_8_0 SS1_20647473_8_0 SS2_20647473_8_0 abbreviatedTo CAAT/enhancer binding protein homologous protein,CHOP

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 369-377 HP_0002665 denotes lymphoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20647473-4#171#174#gene207 1042-1045 gene207 denotes AKT
20647473-4#232#235#diseaseC0334634 1103-1106 diseaseC0334634 denotes MCL
20647473-4#232#235#diseaseC1708350 1103-1106 diseaseC1708350 denotes MCL
171#174#gene207232#235#diseaseC0334634 20647473-4#171#174#gene207 20647473-4#232#235#diseaseC0334634 associated_with AKT,MCL
171#174#gene207232#235#diseaseC1708350 20647473-4#171#174#gene207 20647473-4#232#235#diseaseC1708350 associated_with AKT,MCL

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1685 1042-1045 gene:207 denotes AKT
T1686 1103-1106 disease:C0334634 denotes MCL
R1 T1685 T1686 associated_with AKT,MCL
R2 T1685 T1686 associated_with AKT,MCL

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 156-162 http://purl.obolibrary.org/obo/UBERON_0006575 denotes mantle
PD-UBERON-AE-B_T2 357-363 http://purl.obolibrary.org/obo/UBERON_0006575 denotes mantle

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 156-162 http://purl.obolibrary.org/obo/UBERON_0006575 denotes mantle
PD-UBERON-AE-B_T2 357-363 http://purl.obolibrary.org/obo/UBERON_0006575 denotes mantle