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PubMed:20634289 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Requirement of calcium binding, myristoylation, and protein-protein interaction for the Copine BON1 function in Arabidopsis.
T2 125-232 Sentence denotes Copines are highly conserved proteins with lipid-binding activities found in animals, plants, and protists.
T3 233-364 Sentence denotes They contain two calcium-dependent phospholipid binding C2 domains at the amino terminus and a VWA domain at the carboxyl terminus.
T4 365-501 Sentence denotes The biological roles of most copines are not understood and the biochemical properties required for their functions are largely unknown.
T5 502-600 Sentence denotes The Arabidopsis copine gene BON1/CPN1 is a negative regulator of cell death and defense responses.
T6 601-687 Sentence denotes Here we probed the potential biochemical activities of BON1 through mutagenic studies.
T7 688-817 Sentence denotes We found that mutations of aspartates in the C2 domains did not alter plasma membrane localization but compromised BON1 activity.
T8 818-944 Sentence denotes Mutation at putative myristoylation residue glycine 2 altered plasma membrane localization of BON1 and rendered BON1 inactive.
T9 945-1036 Sentence denotes Mass spectrometry analysis of BON1 further suggests that the N-peptide of BON1 is modified.
T10 1037-1157 Sentence denotes Furthermore, mutations that affect the interaction between BON1 and its functional partner BAP1 abolished BON1 function.
T11 1158-1378 Sentence denotes This analysis reveals an unanticipated regulation of copine protein localization and function by calcium and lipid modification and suggests an important role in protein-protein interaction for the VWA domain of copines.

LocText

Id Subject Object Predicate Lexical cue
T1 95-99 uniprot:Q941L3 denotes BON1
T2 112-123 taxonomy:3702 denotes Arabidopsis
T3 506-517 taxonomy:3702 denotes Arabidopsis
T4 530-534 uniprot:Q941L3 denotes BON1
T5 535-539 uniprot:Q941L3 denotes CPN1
T6 656-660 uniprot:Q941L3 denotes BON1
T7 758-773 go:GO:0005886 denotes plasma membrane
T8 803-807 uniprot:Q941L3 denotes BON1
T9 880-895 go:GO:0005886 denotes plasma membrane
T10 912-916 uniprot:Q941L3 denotes BON1
T11 930-934 uniprot:Q941L3 denotes BON1
T12 975-979 uniprot:Q941L3 denotes BON1
T13 1019-1023 uniprot:Q941L3 denotes BON1
T14 1096-1100 uniprot:Q941L3 denotes BON1
T15 1128-1132 uniprot:Q941L2 denotes BAP1
T16 1143-1147 uniprot:Q941L3 denotes BON1
R1 T10 T9 localizeTo BON1,plasma membrane

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 112-123 OrganismTaxon denotes Arabidopsis 3701
T2 506-517 OrganismTaxon denotes Arabidopsis 3701
T3 862-869 OrganismTaxon denotes glycine 3846

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 758-773 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T2 880-895 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886