> top > docs > PubMed:20588063 > annotations

PubMed:20588063 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7623 109-134 ChemicalEntity denotes puromycin aminonucleoside MESH:D011692
7624 135-144 DiseaseOrPhenotypicFeature denotes nephrosis MESH:D009401
7625 219-230 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
7626 245-270 ChemicalEntity denotes puromycin aminonucleoside MESH:D011692
7627 271-280 DiseaseOrPhenotypicFeature denotes nephrosis MESH:D009401
7628 282-285 DiseaseOrPhenotypicFeature denotes PAN MESH:D009401
7629 287-291 OrganismTaxon denotes rats NCBITaxon:10116
7630 418-425 GeneOrGeneProduct denotes nephrin NCBIGene:64563
7631 427-436 GeneOrGeneProduct denotes α-actinin NCBIGene:81634
7632 438-445 GeneOrGeneProduct denotes dendrin NCBIGene:25113
7633 451-458 GeneOrGeneProduct denotes plekhh2 NCBIGene:313866
7634 725-728 GeneOrGeneProduct denotes ACE NCBIGene:24310
7635 816-827 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
7636 853-860 GeneOrGeneProduct denotes nephrin NCBIGene:64563
7637 1036-1047 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
7638 1104-1111 GeneOrGeneProduct denotes Nephrin NCBIGene:64563
7639 1137-1144 GeneOrGeneProduct denotes dendrin NCBIGene:25113
7640 1149-1156 GeneOrGeneProduct denotes plekhh2 NCBIGene:313866
7641 1176-1185 GeneOrGeneProduct denotes α-actinin NCBIGene:81634
7642 1206-1209 GeneOrGeneProduct denotes ACE NCBIGene:24310
7643 1272-1275 DiseaseOrPhenotypicFeature denotes PAN MESH:D009401
7644 1357-1368 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
7645 1399-1406 GeneOrGeneProduct denotes nephrin NCBIGene:64563
7646 1490-1497 GeneOrGeneProduct denotes dendrin NCBIGene:25113
7647 1502-1509 GeneOrGeneProduct denotes plekhh2 NCBIGene:313866
7648 1549-1552 DiseaseOrPhenotypicFeature denotes PAN MESH:D009401
7649 1562-1571 GeneOrGeneProduct denotes α-actinin NCBIGene:81634

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 287-291 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-145 Sentence denotes Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.
T2 146-162 Sentence denotes BACKGROUND/AIMS:
T3 163-238 Sentence denotes It is still unclear what happens in the glomerulus when proteinuria starts.
T4 239-525 Sentence denotes Using puromycin aminonucleoside nephrosis (PAN) rats, we studied early ultrastructural and permeability changes in relation to the expression of the podocyte-associated molecules nephrin, α-actinin, dendrin, and plekhh2, the last two of which were only recently discovered in podocytes.
T5 526-534 Sentence denotes METHODS:
T6 535-632 Sentence denotes Using immune stainings, semiquantitative measurement was performed under the electron microscope.
T7 633-704 Sentence denotes Permeability was assessed using isolated kidney perfusion with tracers.
T8 705-752 Sentence denotes Possible effects of ACE inhibition were tested.
T9 753-761 Sentence denotes RESULTS:
T10 762-838 Sentence denotes By day 2, some patchy foot process effacement, but no proteinuria, appeared.
T11 839-907 Sentence denotes The amount of nephrin was reduced in both diseased and normal areas.
T12 908-984 Sentence denotes The other proteins showed few changes, which were limited to diseased areas.
T13 985-1103 Sentence denotes By day 4, foot process effacement was complete and proteinuria appeared in parallel with signs of size barrier damage.
T14 1104-1205 Sentence denotes Nephrin decreased further, while dendrin and plekhh2 also decreased but α-actinin remained unchanged.
T15 1206-1258 Sentence denotes ACE inhibition had no significant protective effect.
T16 1259-1369 Sentence denotes CONCLUSIONS: PAN glomeruli already showed significant pathology by day 4, despite relatively mild proteinuria.
T17 1370-1470 Sentence denotes This was preceded by altered nephrin expression, supporting its pivotal role in podocyte morphology.
T18 1471-1586 Sentence denotes The novel proteins dendrin and plekhh2 were both reduced, suggesting roles in PAN, whereas α-actinin was unchanged.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 135-144 DiseaseOrPhenotypicFeature denotes nephrosis 0002331
T2 219-230 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T3 271-280 DiseaseOrPhenotypicFeature denotes nephrosis 0002331
T4 816-827 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T5 1023-1031 DiseaseOrPhenotypicFeature denotes complete 0700063
T6 1036-1047 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T7 1357-1368 DiseaseOrPhenotypicFeature denotes proteinuria 0003634

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 59-64 GeneOrGeneProduct denotes novel
T2 65-76 GeneOrGeneProduct denotes proteins in
T3 103-108 GeneOrGeneProduct denotes early
T4 175-182 GeneOrGeneProduct denotes unclear
T5 231-237 GeneOrGeneProduct denotes starts
T6 282-285 GeneOrGeneProduct denotes PAN
T7 304-309 GeneOrGeneProduct denotes early
T8 418-425 GeneOrGeneProduct denotes nephrin
T9 429-436 GeneOrGeneProduct denotes actinin
T10 438-445 GeneOrGeneProduct denotes dendrin
T11 451-458 GeneOrGeneProduct denotes plekhh2
T12 464-468 GeneOrGeneProduct denotes last
T13 526-533 GeneOrGeneProduct denotes METHODS
T14 541-547 GeneOrGeneProduct denotes immune
T15 674-680 GeneOrGeneProduct denotes kidney
T16 725-728 GeneOrGeneProduct denotes ACE
T17 745-751 GeneOrGeneProduct denotes tested
T18 789-796 GeneOrGeneProduct denotes process
T19 853-860 GeneOrGeneProduct denotes nephrin
T20 865-872 GeneOrGeneProduct denotes reduced
T21 901-906 GeneOrGeneProduct denotes areas
T22 912-917 GeneOrGeneProduct denotes other
T23 918-926 GeneOrGeneProduct denotes proteins
T24 958-965 GeneOrGeneProduct denotes limited
T25 978-983 GeneOrGeneProduct denotes areas
T26 1000-1007 GeneOrGeneProduct denotes process
T27 1083-1087 GeneOrGeneProduct denotes size
T28 1096-1102 GeneOrGeneProduct denotes damage
T29 1104-1111 GeneOrGeneProduct denotes Nephrin
T30 1137-1144 GeneOrGeneProduct denotes dendrin
T31 1149-1156 GeneOrGeneProduct denotes plekhh2
T32 1178-1185 GeneOrGeneProduct denotes actinin
T33 1206-1209 GeneOrGeneProduct denotes ACE
T34 1272-1275 GeneOrGeneProduct denotes PAN
T35 1399-1406 GeneOrGeneProduct denotes nephrin
T36 1434-1441 GeneOrGeneProduct denotes pivotal
T37 1475-1480 GeneOrGeneProduct denotes novel
T38 1481-1489 GeneOrGeneProduct denotes proteins
T39 1490-1497 GeneOrGeneProduct denotes dendrin
T40 1502-1509 GeneOrGeneProduct denotes plekhh2
T41 1520-1527 GeneOrGeneProduct denotes reduced
T42 1549-1552 GeneOrGeneProduct denotes PAN
T43 1564-1571 GeneOrGeneProduct denotes actinin

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 59-64 GeneOrGeneProduct denotes novel
T2 65-76 GeneOrGeneProduct denotes proteins in
T3 103-108 GeneOrGeneProduct denotes early
T4 175-182 GeneOrGeneProduct denotes unclear
T5 304-309 GeneOrGeneProduct denotes early
T6 418-425 GeneOrGeneProduct denotes nephrin
T7 429-436 GeneOrGeneProduct denotes actinin
T8 438-445 GeneOrGeneProduct denotes dendrin
T9 451-458 GeneOrGeneProduct denotes plekhh2
T10 674-680 GeneOrGeneProduct denotes kidney
T11 853-860 GeneOrGeneProduct denotes nephrin
T12 865-872 GeneOrGeneProduct denotes reduced
T13 912-917 GeneOrGeneProduct denotes other
T14 958-965 GeneOrGeneProduct denotes limited
T15 1104-1111 GeneOrGeneProduct denotes Nephrin
T16 1137-1144 GeneOrGeneProduct denotes dendrin
T17 1149-1156 GeneOrGeneProduct denotes plekhh2
T18 1178-1185 GeneOrGeneProduct denotes actinin
T19 1399-1406 GeneOrGeneProduct denotes nephrin
T20 1475-1480 GeneOrGeneProduct denotes novel
T21 1490-1497 GeneOrGeneProduct denotes dendrin
T22 1502-1509 GeneOrGeneProduct denotes plekhh2
T23 1520-1527 GeneOrGeneProduct denotes reduced
T24 1564-1571 GeneOrGeneProduct denotes actinin

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 109-134 ChemicalEntity denotes puromycin aminonucleoside http://purl.obolibrary.org/obo/CHEBI_42839
T2 245-270 ChemicalEntity denotes puromycin aminonucleoside http://purl.obolibrary.org/obo/CHEBI_42839
T3 282-285 ChemicalEntity denotes PAN http://purl.obolibrary.org/obo/CHEBI_61639|http://purl.obolibrary.org/obo/CHEBI_53571
T5 1272-1275 ChemicalEntity denotes PAN http://purl.obolibrary.org/obo/CHEBI_61639|http://purl.obolibrary.org/obo/CHEBI_53571
T7 1549-1552 ChemicalEntity denotes PAN http://purl.obolibrary.org/obo/CHEBI_61639|http://purl.obolibrary.org/obo/CHEBI_53571

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 135-144 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T2 219-230 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T3 271-280 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T4 816-827 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T5 881-889 DiseaseOrPhenotypicFeature denotes diseased D004194
T6 969-977 DiseaseOrPhenotypicFeature denotes diseased D004194
T7 1036-1047 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T8 1357-1368 DiseaseOrPhenotypicFeature denotes proteinuria D011507

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 59-76 GeneOrGeneProduct denotes novel proteins in
T2 418-425 GeneOrGeneProduct denotes nephrin
T3 429-436 GeneOrGeneProduct denotes actinin
T4 438-445 GeneOrGeneProduct denotes dendrin
T5 451-458 GeneOrGeneProduct denotes plekhh2
T6 853-860 GeneOrGeneProduct denotes nephrin
T7 1104-1111 GeneOrGeneProduct denotes Nephrin
T8 1137-1144 GeneOrGeneProduct denotes dendrin
T9 1149-1156 GeneOrGeneProduct denotes plekhh2
T10 1178-1185 GeneOrGeneProduct denotes actinin
T11 1399-1406 GeneOrGeneProduct denotes nephrin
T12 1475-1489 GeneOrGeneProduct denotes novel proteins
T13 1490-1497 GeneOrGeneProduct denotes dendrin
T14 1502-1509 GeneOrGeneProduct denotes plekhh2
T15 1564-1571 GeneOrGeneProduct denotes actinin

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 135-144 DiseaseOrPhenotypicFeature denotes nephrosis 0005377|0002331
T3 219-230 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T4 271-280 DiseaseOrPhenotypicFeature denotes nephrosis 0005377|0002331
T6 282-285 DiseaseOrPhenotypicFeature denotes PAN 0019170|0014306
T8 816-827 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T9 1036-1047 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T10 1272-1275 DiseaseOrPhenotypicFeature denotes PAN 0019170|0014306
T12 1357-1368 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T13 1549-1552 DiseaseOrPhenotypicFeature denotes PAN 0019170|0014306

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 135-144 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T2 219-230 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T3 271-280 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T4 282-285 DiseaseOrPhenotypicFeature denotes PAN DISEASE
T5 816-827 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T6 881-889 DiseaseOrPhenotypicFeature denotes diseased D004194
T7 969-977 DiseaseOrPhenotypicFeature denotes diseased D004194
T8 1036-1047 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T9 1272-1275 DiseaseOrPhenotypicFeature denotes PAN DISEASE
T10 1357-1368 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T11 1549-1552 DiseaseOrPhenotypicFeature denotes PAN DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 135-144 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T2 219-230 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T3 271-280 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T4 282-285 DiseaseOrPhenotypicFeature denotes PAN DISEASE
T5 816-827 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T6 1036-1047 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T7 1272-1275 DiseaseOrPhenotypicFeature denotes PAN DISEASE
T8 1357-1368 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T9 1549-1552 DiseaseOrPhenotypicFeature denotes PAN DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 282-285 OrganismTaxon denotes PAN
T2 287-291 OrganismTaxon denotes rats
T3 1272-1275 OrganismTaxon denotes PAN
T4 1549-1552 OrganismTaxon denotes PAN

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T7 1549-1552 ChemicalEntity denotes PAN http://purl.obolibrary.org/obo/CHEBI_53571|http://purl.obolibrary.org/obo/CHEBI_61639
T5 1272-1275 ChemicalEntity denotes PAN http://purl.obolibrary.org/obo/CHEBI_53571|http://purl.obolibrary.org/obo/CHEBI_61639
T3 282-285 ChemicalEntity denotes PAN http://purl.obolibrary.org/obo/CHEBI_53571|http://purl.obolibrary.org/obo/CHEBI_61639
T2 245-270 ChemicalEntity denotes puromycin aminonucleoside http://purl.obolibrary.org/obo/CHEBI_42839
T1 109-134 ChemicalEntity denotes puromycin aminonucleoside http://purl.obolibrary.org/obo/CHEBI_42839
T15 1564-1571 GeneOrGeneProduct denotes actinin
T14 1502-1509 GeneOrGeneProduct denotes plekhh2
T13 1490-1497 GeneOrGeneProduct denotes dendrin
T12 1475-1489 GeneOrGeneProduct denotes novel proteins
T11 1399-1406 GeneOrGeneProduct denotes nephrin
T10 1178-1185 GeneOrGeneProduct denotes actinin
T9 1149-1156 GeneOrGeneProduct denotes plekhh2
T8 1137-1144 GeneOrGeneProduct denotes dendrin
T85228 1104-1111 GeneOrGeneProduct denotes Nephrin
T6 853-860 GeneOrGeneProduct denotes nephrin
T15001 451-458 GeneOrGeneProduct denotes plekhh2
T4 438-445 GeneOrGeneProduct denotes dendrin
T43811 429-436 GeneOrGeneProduct denotes actinin
T65967 418-425 GeneOrGeneProduct denotes nephrin
T54950 59-76 GeneOrGeneProduct denotes novel proteins in
T73245 1549-1552 DiseaseOrPhenotypicFeature denotes PAN DISEASE
T41056 1357-1368 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T96869 1272-1275 DiseaseOrPhenotypicFeature denotes PAN DISEASE
T54494 1036-1047 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T66047 816-827 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T29541 282-285 DiseaseOrPhenotypicFeature denotes PAN DISEASE
T69067 271-280 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T17511 219-230 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T14274 135-144 DiseaseOrPhenotypicFeature denotes nephrosis D009401
T5536 1549-1552 OrganismTaxon denotes PAN
T93724 1272-1275 OrganismTaxon denotes PAN
T70440 287-291 OrganismTaxon denotes rats
T16025 282-285 OrganismTaxon denotes PAN

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 219-230 HP_0000093 denotes proteinuria
T2 271-280 HP_0000100 denotes nephrosis

Allie

Id Subject Object Predicate Lexical cue
SS1_20588063_3_0 245-280 expanded denotes puromycin aminonucleoside nephrosis
SS2_20588063_3_0 282-285 abbr denotes PAN
AE1_20588063_3_0 SS1_20588063_3_0 SS2_20588063_3_0 abbreviatedTo puromycin aminonucleoside nephrosis,PAN