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PubMed:20558148 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7574 44-58 GeneOrGeneProduct denotes NMDA receptors NCBIGene:24408
7575 99-110 ChemicalEntity denotes haloperidol MESH:D006220
7576 119-128 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
7577 742-751 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
7578 767-784 GeneOrGeneProduct denotes dopamine receptor NCBIGene:24316
7579 793-804 ChemicalEntity denotes haloperidol MESH:D006220
7580 851-855 OrganismTaxon denotes rats NCBITaxon:10116
7581 857-868 ChemicalEntity denotes Haloperidol MESH:D006220
7582 877-886 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
7583 948-971 GeneOrGeneProduct denotes glutamate NMDA receptor NCBIGene:24408
7584 985-991 ChemicalEntity denotes MK-801 MESH:D016291
7585 1023-1026 ChemicalEntity denotes AP7 MESH:C031231
7586 1065-1078 GeneOrGeneProduct denotes NMDA receptor NCBIGene:24408
7587 1087-1107 ChemicalEntity denotes N-methyl-d-aspartate MESH:D016202
7588 1109-1113 ChemicalEntity denotes NMDA MESH:D016202
7589 1200-1206 ChemicalEntity denotes MK-801 MESH:D016291
7590 1211-1214 ChemicalEntity denotes AP7 MESH:C031231
7591 1250-1261 ChemicalEntity denotes haloperidol MESH:D006220
7592 1291-1300 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
7593 1419-1423 ChemicalEntity denotes NMDA MESH:D016202
7594 1496-1505 ChemicalEntity denotes glutamate MESH:D018698
7595 1575-1586 ChemicalEntity denotes haloperidol MESH:D006220
7596 1595-1604 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-129 Sentence denotes Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy.
T2 130-347 Sentence denotes The inferior colliculus (IC) is primarily involved in the processing of auditory information, but it is distinguished from other auditory nuclei in the brainstem by its connections with structures of the motor system.
T3 348-581 Sentence denotes Functional evidence relating the IC to motor behavior derives from experiments showing that activation of the IC by electrical stimulation or excitatory amino acid microinjection causes freezing, escape-like behavior, and immobility.
T4 582-638 Sentence denotes However, the nature of this immobility is still unclear.
T5 639-856 Sentence denotes The present study examined the influence of excitatory amino acid-mediated mechanisms in the IC on the catalepsy induced by the dopamine receptor blocker haloperidol administered systemically (1 or 0.5 mg/kg) in rats.
T6 857-1141 Sentence denotes Haloperidol-induced catalepsy was challenged with prior intracollicular microinjections of glutamate NMDA receptor antagonists, MK-801 (15 or 30 mmol/0.5 microl) and AP7 (10 or 20 nmol/0.5 microl), or of the NMDA receptor agonist N-methyl-d-aspartate (NMDA, 20 or 30 nmol/0.5 microl).
T7 1142-1371 Sentence denotes The results showed that intracollicular microinjection of MK-801 and AP7 previous to systemic injections of haloperidol significantly attenuated the catalepsy, as indicated by a reduced latency to step down from a horizontal bar.
T8 1372-1467 Sentence denotes Accordingly, intracollicular microinjection of NMDA increased the latency to step down the bar.
T9 1468-1657 Sentence denotes These findings suggest that glutamate-mediated mechanisms in the neural circuits at the IC level influence haloperidol-induced catalepsy and participate in the regulation of motor activity.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 851-855 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 32-40 GeneOrGeneProduct denotes mediated
T2 44-48 GeneOrGeneProduct denotes NMDA
T3 49-58 GeneOrGeneProduct denotes receptors
T4 111-118 GeneOrGeneProduct denotes induced
T5 188-198 GeneOrGeneProduct denotes processing
T6 253-258 GeneOrGeneProduct denotes other
T7 334-339 GeneOrGeneProduct denotes motor
T8 387-392 GeneOrGeneProduct denotes motor
T9 393-401 GeneOrGeneProduct denotes behavior
T10 440-450 GeneOrGeneProduct denotes activation
T11 501-511 GeneOrGeneProduct denotes amino acid
T12 534-542 GeneOrGeneProduct denotes freezing
T13 551-555 GeneOrGeneProduct denotes like
T14 556-564 GeneOrGeneProduct denotes behavior
T15 630-637 GeneOrGeneProduct denotes unclear
T16 694-704 GeneOrGeneProduct denotes amino acid
T17 705-713 GeneOrGeneProduct denotes mediated
T18 752-759 GeneOrGeneProduct denotes induced
T19 767-784 GeneOrGeneProduct denotes dopamine receptor
T20 785-792 GeneOrGeneProduct denotes blocker
T21 832-836 GeneOrGeneProduct denotes 1 or
T22 841-843 GeneOrGeneProduct denotes mg
T23 869-876 GeneOrGeneProduct denotes induced
T24 948-957 GeneOrGeneProduct denotes glutamate
T25 958-971 GeneOrGeneProduct denotes NMDA receptor
T26 972-983 GeneOrGeneProduct denotes antagonists
T27 993-998 GeneOrGeneProduct denotes 15 or
T28 1028-1033 GeneOrGeneProduct denotes 10 or
T29 1065-1078 GeneOrGeneProduct denotes NMDA receptor
T30 1098-1107 GeneOrGeneProduct denotes aspartate
T31 1109-1113 GeneOrGeneProduct denotes NMDA
T32 1115-1120 GeneOrGeneProduct denotes 20 or
T33 1276-1286 GeneOrGeneProduct denotes attenuated
T34 1320-1327 GeneOrGeneProduct denotes reduced
T35 1339-1343 GeneOrGeneProduct denotes step
T36 1367-1370 GeneOrGeneProduct denotes bar
T37 1419-1423 GeneOrGeneProduct denotes NMDA
T38 1449-1453 GeneOrGeneProduct denotes step
T39 1463-1466 GeneOrGeneProduct denotes bar
T40 1474-1482 GeneOrGeneProduct denotes findings
T41 1496-1505 GeneOrGeneProduct denotes glutamate
T42 1506-1514 GeneOrGeneProduct denotes mediated
T43 1533-1539 GeneOrGeneProduct denotes neural
T44 1587-1594 GeneOrGeneProduct denotes induced
T45 1628-1638 GeneOrGeneProduct denotes regulation
T46 1642-1647 GeneOrGeneProduct denotes motor
T47 1648-1656 GeneOrGeneProduct denotes activity

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 44-48 GeneOrGeneProduct denotes NMDA
T2 188-198 GeneOrGeneProduct denotes processing
T3 253-258 GeneOrGeneProduct denotes other
T4 334-339 GeneOrGeneProduct denotes motor
T5 387-392 GeneOrGeneProduct denotes motor
T6 393-401 GeneOrGeneProduct denotes behavior
T7 501-511 GeneOrGeneProduct denotes amino acid
T8 551-555 GeneOrGeneProduct denotes like
T9 556-564 GeneOrGeneProduct denotes behavior
T10 630-637 GeneOrGeneProduct denotes unclear
T11 694-704 GeneOrGeneProduct denotes amino acid
T12 767-784 GeneOrGeneProduct denotes dopamine receptor
T13 785-792 GeneOrGeneProduct denotes blocker
T14 948-957 GeneOrGeneProduct denotes glutamate
T15 958-971 GeneOrGeneProduct denotes NMDA receptor
T16 1065-1078 GeneOrGeneProduct denotes NMDA receptor
T17 1098-1107 GeneOrGeneProduct denotes aspartate
T18 1109-1113 GeneOrGeneProduct denotes NMDA
T19 1276-1286 GeneOrGeneProduct denotes attenuated
T20 1320-1327 GeneOrGeneProduct denotes reduced
T21 1339-1343 GeneOrGeneProduct denotes step
T22 1419-1423 GeneOrGeneProduct denotes NMDA
T23 1449-1453 GeneOrGeneProduct denotes step
T24 1496-1505 GeneOrGeneProduct denotes glutamate
T25 1642-1647 GeneOrGeneProduct denotes motor

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 119-128 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T2 742-751 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T3 877-886 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T4 1291-1300 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 1595-1604 DiseaseOrPhenotypicFeature denotes catalepsy D002375

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 44-58 GeneOrGeneProduct denotes NMDA receptors
T2 767-784 GeneOrGeneProduct denotes dopamine receptor
T3 948-957 GeneOrGeneProduct denotes glutamate
T4 958-971 GeneOrGeneProduct denotes NMDA receptor
T5 1065-1078 GeneOrGeneProduct denotes NMDA receptor
T6 1496-1505 GeneOrGeneProduct denotes glutamate

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 86-89 DiseaseOrPhenotypicFeature denotes can 0012833

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 119-128 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T2 742-751 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T3 877-886 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T4 1291-1300 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 1595-1604 DiseaseOrPhenotypicFeature denotes catalepsy D002375

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 851-855 OrganismTaxon denotes rats

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 119-128 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T2 742-751 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T3 877-886 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T4 1291-1300 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 1595-1604 DiseaseOrPhenotypicFeature denotes catalepsy D002375

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 44-48 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882
T3 99-110 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T5 767-775 ChemicalEntity denotes dopamine D004298|http://purl.obolibrary.org/obo/CHEBI_59905|http://purl.obolibrary.org/obo/CHEBI_18243
T8 793-804 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T10 857-868 ChemicalEntity denotes Haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T12 948-957 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_29987|http://purl.obolibrary.org/obo/CHEBI_14321
T14 958-962 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882
T16 985-991 ChemicalEntity denotes MK-801 D016291
T17 1023-1026 ChemicalEntity denotes AP7 ChemicalEntity
T18 1065-1069 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882
T20 1087-1107 ChemicalEntity denotes N-methyl-d-aspartate http://purl.obolibrary.org/obo/CHEBI_31882
T21 1109-1113 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882
T23 1200-1206 ChemicalEntity denotes MK-801 D016291
T24 1211-1214 ChemicalEntity denotes AP7 ChemicalEntity
T25 1250-1261 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T27 1419-1423 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882
T29 1496-1505 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_29987|http://purl.obolibrary.org/obo/CHEBI_14321
T31 1575-1586 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T31 1575-1586 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T29 1496-1505 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T27 1419-1423 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T25 1250-1261 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T24 1211-1214 ChemicalEntity denotes AP7 ChemicalEntity
T23 1200-1206 ChemicalEntity denotes MK-801 D016291
T21 1109-1113 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T20 1087-1107 ChemicalEntity denotes N-methyl-d-aspartate http://purl.obolibrary.org/obo/CHEBI_31882
T18 1065-1069 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T17 1023-1026 ChemicalEntity denotes AP7 ChemicalEntity
T16 985-991 ChemicalEntity denotes MK-801 D016291
T14 958-962 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T12 948-957 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T10 857-868 ChemicalEntity denotes Haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T8 793-804 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T5 767-775 ChemicalEntity denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905|D004298
T3 99-110 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T1 44-48 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T6 1496-1505 GeneOrGeneProduct denotes glutamate
T4140 1065-1078 GeneOrGeneProduct denotes NMDA receptor
T4 958-971 GeneOrGeneProduct denotes NMDA receptor
T77482 948-957 GeneOrGeneProduct denotes glutamate
T2 767-784 GeneOrGeneProduct denotes dopamine receptor
T49647 44-58 GeneOrGeneProduct denotes NMDA receptors
T89594 1595-1604 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T82712 1291-1300 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T71239 877-886 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T96275 742-751 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T46070 119-128 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T24233 851-855 OrganismTaxon denotes rats

Allie

Id Subject Object Predicate Lexical cue
SS1_20558148_1_0 134-153 expanded denotes inferior colliculus
SS2_20558148_1_0 155-157 abbr denotes IC
AE1_20558148_1_0 SS1_20558148_1_0 SS2_20558148_1_0 abbreviatedTo inferior colliculus,IC