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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7545 35-55 GeneOrGeneProduct denotes phosphodiesterase 4D NCBIGene:5144
7546 57-62 GeneOrGeneProduct denotes PDE4D NCBIGene:5144
7547 67-90 DiseaseOrPhenotypicFeature denotes carotid atherosclerosis MESH:D002340
7548 108-128 GeneOrGeneProduct denotes phosphodiesterase 4D NCBIGene:5144
7549 130-135 GeneOrGeneProduct denotes PDE4D NCBIGene:5144
7550 183-189 DiseaseOrPhenotypicFeature denotes stroke MESH:D020521
7551 260-271 DiseaseOrPhenotypicFeature denotes atherogenic MESH:D050197
7552 460-475 DiseaseOrPhenotypicFeature denotes atherosclerosis MESH:D050197
7553 532-538 DiseaseOrPhenotypicFeature denotes stroke MESH:D020521
7554 629-632 OrganismTaxon denotes men NCBITaxon:9606
7555 983-986 OrganismTaxon denotes men NCBITaxon:9606
7556 991-996 OrganismTaxon denotes women NCBITaxon:9606
7557 1078-1086 SequenceVariant denotes Rs702553 DBSNP:rs702553
7558 1094-1099 GeneOrGeneProduct denotes PDE4D NCBIGene:5144
7559 1156-1162 DiseaseOrPhenotypicFeature denotes stroke MESH:D020521
7560 1202-1208 DiseaseOrPhenotypicFeature denotes stroke MESH:D020521
7561 1421-1429 SequenceVariant denotes rs702553 DBSNP:rs702553
7562 1568-1571 OrganismTaxon denotes men NCBITaxon:9606
7563 1583-1588 OrganismTaxon denotes women NCBITaxon:9606
7564 1770-1773 OrganismTaxon denotes men NCBITaxon:9606
7565 1909-1914 OrganismTaxon denotes women NCBITaxon:9606
7566 1965-1973 SequenceVariant denotes rs702553 DBSNP:rs702553
7567 1990-1998 SequenceVariant denotes rs702553 DBSNP:rs702553
7568 2029-2035 DiseaseOrPhenotypicFeature denotes stroke MESH:D020521
7569 2036-2039 OrganismTaxon denotes men NCBITaxon:9606
7570 2073-2078 OrganismTaxon denotes women NCBITaxon:9606
7571 2164-2169 GeneOrGeneProduct denotes PDE4D NCBIGene:5144
7572 2195-2201 DiseaseOrPhenotypicFeature denotes stroke MESH:D020521
7573 2256-2269 DiseaseOrPhenotypicFeature denotes atherogenesis MESH:D050197

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-91 Sentence denotes Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis.
T2 92-103 Sentence denotes BACKGROUND:
T3 104-190 Sentence denotes The phosphodiesterase 4D (PDE4D) gene was reported as a susceptibility gene to stroke.
T4 191-304 Sentence denotes The genetic effect might be attributed to its role in modulating the atherogenic process in the carotid arteries.
T5 305-476 Sentence denotes Using carotid intima-media thickness (IMT) and plaque index as phenotypes, the present study sought to determine the influence of this gene on subclinical atherosclerosis.
T6 477-485 Sentence denotes METHODS:
T7 486-634 Sentence denotes Carotid ultrasonography was performed on 1013 stroke-free subjects who participated in the health screening programs (age 52.6 +/- 12.2; 47.6% men).
T8 635-772 Sentence denotes Genotype distribution was compared among the high-risk (plaque index > or = 4), low-risk (index = 1-3), and reference (index = 0) groups.
T9 773-898 Sentence denotes We analyzed continuous IMT data and further dichotomized IMT data using mean plus one standard deviation as the cutoff level.
T10 899-1077 Sentence denotes Because the plaque prevalence and IMT values displayed a notable difference between men and women, we carried out sex-specific analyses in addition to analyzing the overall data.
T11 1078-1186 Sentence denotes Rs702553 at the PDE4D gene was selected because it conferred a risk for young stroke in our previous report.
T12 1187-1363 Sentence denotes Previous young stroke data (190 cases and 211 controls) with an additional 532 control subjects without ultrasonic data were shown as a cross-validation for the genetic effect.
T13 1364-1372 Sentence denotes RESULTS:
T14 1373-1490 Sentence denotes In the overall analyses, the rare homozygote of rs702553 led to an OR of 3.1 (p = 0.034) for a plaque index > or = 4.
T15 1491-1589 Sentence denotes When subjects were stratified by sex, the genetic effect was only evident in men but not in women.
T16 1590-1740 Sentence denotes Comparing male subjects with plaque index > or = 4 and those with plaque index = 0, the TT genotype was over-represented (27.6% vs. 13.4%, p = 0.008).
T17 1741-1905 Sentence denotes For dichotomized IMT data in men, the TT genotype had an OR of 2.1 (p = 0.032) for a thicker IMT at the common carotid artery compared with the (AA + AT) genotypes.
T18 1906-1974 Sentence denotes In women, neither IMT nor plaque index was associated with rs702553.
T19 1975-2090 Sentence denotes Similarly, SNP rs702553 was only significant in young stroke men (OR = 1.8, p = 0.025) but not in women (p = 0.27).
T20 2091-2103 Sentence denotes CONCLUSIONS:
T21 2104-2270 Sentence denotes The present study demonstrates a sex-differential effect of PDE4D on IMT, plaque index and stroke, which highlights its influence on various aspects of atherogenesis.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 75-90 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311
T2 460-475 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311
T3 1402-1406 DiseaseOrPhenotypicFeature denotes rare 0021136

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 1421-1429 SequenceVariant denotes rs702553
T2 1965-1973 SequenceVariant denotes rs702553
T3 1990-1998 SequenceVariant denotes rs702553

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 35-55 GeneOrGeneProduct denotes phosphodiesterase 4D
T2 57-62 GeneOrGeneProduct denotes PDE4D
T3 108-128 GeneOrGeneProduct denotes phosphodiesterase 4D
T4 130-135 GeneOrGeneProduct denotes PDE4D
T5 272-282 GeneOrGeneProduct denotes process in
T6 326-331 GeneOrGeneProduct denotes media
T7 332-341 GeneOrGeneProduct denotes thickness
T8 408-417 GeneOrGeneProduct denotes determine
T9 477-484 GeneOrGeneProduct denotes METHODS
T10 680-684 GeneOrGeneProduct denotes high
T11 706-712 GeneOrGeneProduct denotes or = 4
T12 885-891 GeneOrGeneProduct denotes cutoff
T13 937-943 GeneOrGeneProduct denotes values
T14 1009-1012 GeneOrGeneProduct denotes out
T15 1094-1099 GeneOrGeneProduct denotes PDE4D
T16 1150-1155 GeneOrGeneProduct denotes young
T17 1196-1201 GeneOrGeneProduct denotes young
T18 1219-1224 GeneOrGeneProduct denotes cases
T19 1402-1406 GeneOrGeneProduct denotes rare
T20 1483-1489 GeneOrGeneProduct denotes or = 4
T21 1600-1604 GeneOrGeneProduct denotes male
T22 1634-1640 GeneOrGeneProduct denotes or = 4
T23 1798-1807 GeneOrGeneProduct denotes OR of 2.1
T24 1975-1984 GeneOrGeneProduct denotes Similarly
T25 2023-2028 GeneOrGeneProduct denotes young
T26 2164-2169 GeneOrGeneProduct denotes PDE4D

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 35-55 GeneOrGeneProduct denotes phosphodiesterase 4D
T2 57-62 GeneOrGeneProduct denotes PDE4D
T3 108-128 GeneOrGeneProduct denotes phosphodiesterase 4D
T4 130-135 GeneOrGeneProduct denotes PDE4D
T5 326-331 GeneOrGeneProduct denotes media
T6 680-684 GeneOrGeneProduct denotes high
T7 885-891 GeneOrGeneProduct denotes cutoff
T8 1094-1099 GeneOrGeneProduct denotes PDE4D
T9 1150-1155 GeneOrGeneProduct denotes young
T10 1196-1201 GeneOrGeneProduct denotes young
T11 1402-1406 GeneOrGeneProduct denotes rare
T12 2023-2028 GeneOrGeneProduct denotes young
T13 2164-2169 GeneOrGeneProduct denotes PDE4D

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 67-90 DiseaseOrPhenotypicFeature denotes carotid atherosclerosis D002340
T2 183-189 DiseaseOrPhenotypicFeature denotes stroke D020521
T3 260-271 DiseaseOrPhenotypicFeature denotes atherogenic DISEASE
T4 460-475 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T5 532-538 DiseaseOrPhenotypicFeature denotes stroke D020521
T6 1156-1162 DiseaseOrPhenotypicFeature denotes stroke D020521
T7 1202-1208 DiseaseOrPhenotypicFeature denotes stroke D020521
T8 2029-2035 DiseaseOrPhenotypicFeature denotes stroke D020521
T9 2195-2201 DiseaseOrPhenotypicFeature denotes stroke D020521
T10 2256-2269 DiseaseOrPhenotypicFeature denotes atherogenesis D050197

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 35-55 GeneOrGeneProduct denotes phosphodiesterase 4D
T2 57-62 GeneOrGeneProduct denotes PDE4D
T3 108-128 GeneOrGeneProduct denotes phosphodiesterase 4D
T4 130-135 GeneOrGeneProduct denotes PDE4D
T5 885-891 GeneOrGeneProduct denotes cutoff
T6 1094-1099 GeneOrGeneProduct denotes PDE4D
T7 2164-2169 GeneOrGeneProduct denotes PDE4D

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 75-90 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311
T2 183-189 DiseaseOrPhenotypicFeature denotes stroke 0005098
T3 343-346 DiseaseOrPhenotypicFeature denotes IMT 0015798
T4 460-475 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311
T5 532-538 DiseaseOrPhenotypicFeature denotes stroke 0005098
T6 629-632 DiseaseOrPhenotypicFeature denotes men 0017169
T7 796-799 DiseaseOrPhenotypicFeature denotes IMT 0015798
T8 830-833 DiseaseOrPhenotypicFeature denotes IMT 0015798
T9 933-936 DiseaseOrPhenotypicFeature denotes IMT 0015798
T10 983-986 DiseaseOrPhenotypicFeature denotes men 0017169
T11 1156-1162 DiseaseOrPhenotypicFeature denotes stroke 0005098
T12 1202-1208 DiseaseOrPhenotypicFeature denotes stroke 0005098
T13 1568-1571 DiseaseOrPhenotypicFeature denotes men 0017169
T14 1758-1761 DiseaseOrPhenotypicFeature denotes IMT 0015798
T15 1770-1773 DiseaseOrPhenotypicFeature denotes men 0017169
T16 1834-1837 DiseaseOrPhenotypicFeature denotes IMT 0015798
T17 1924-1927 DiseaseOrPhenotypicFeature denotes IMT 0015798
T18 2029-2035 DiseaseOrPhenotypicFeature denotes stroke 0005098
T19 2036-2039 DiseaseOrPhenotypicFeature denotes men 0017169
T20 2173-2176 DiseaseOrPhenotypicFeature denotes IMT 0015798
T21 2195-2201 DiseaseOrPhenotypicFeature denotes stroke 0005098

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 67-90 DiseaseOrPhenotypicFeature denotes carotid atherosclerosis D002340
T2 183-189 DiseaseOrPhenotypicFeature denotes stroke DISEASE|D020521
T4 260-271 DiseaseOrPhenotypicFeature denotes atherogenic DISEASE
T5 460-475 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T6 532-538 DiseaseOrPhenotypicFeature denotes stroke DISEASE|D020521
T8 1156-1162 DiseaseOrPhenotypicFeature denotes stroke DISEASE|D020521
T10 1202-1208 DiseaseOrPhenotypicFeature denotes stroke DISEASE|D020521
T12 2029-2035 DiseaseOrPhenotypicFeature denotes stroke DISEASE|D020521
T14 2195-2201 DiseaseOrPhenotypicFeature denotes stroke DISEASE|D020521
T16 2256-2269 DiseaseOrPhenotypicFeature denotes atherogenesis D050197

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 629-632 OrganismTaxon denotes men
T2 983-986 OrganismTaxon denotes men
T3 991-996 OrganismTaxon denotes women
T4 1568-1571 OrganismTaxon denotes men
T5 1583-1588 OrganismTaxon denotes women
T6 1770-1773 OrganismTaxon denotes men
T7 1909-1914 OrganismTaxon denotes women
T8 2036-2039 OrganismTaxon denotes men
T9 2073-2078 OrganismTaxon denotes women

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 67-90 DiseaseOrPhenotypicFeature denotes carotid atherosclerosis D002340
T2 183-189 DiseaseOrPhenotypicFeature denotes stroke D020521
T3 260-271 DiseaseOrPhenotypicFeature denotes atherogenic DISEASE
T4 460-475 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T5 532-538 DiseaseOrPhenotypicFeature denotes stroke D020521
T6 1156-1162 DiseaseOrPhenotypicFeature denotes stroke D020521
T7 1202-1208 DiseaseOrPhenotypicFeature denotes stroke D020521
T8 2029-2035 DiseaseOrPhenotypicFeature denotes stroke D020521
T9 2195-2201 DiseaseOrPhenotypicFeature denotes stroke D020521
T10 2256-2269 DiseaseOrPhenotypicFeature denotes atherogenesis D050197

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 35-52 ChemicalEntity denotes phosphodiesterase D010727
T2 108-125 ChemicalEntity denotes phosphodiesterase D010727

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T2 108-125 ChemicalEntity denotes phosphodiesterase D010727
T1 35-52 ChemicalEntity denotes phosphodiesterase D010727
T7 2164-2169 GeneOrGeneProduct denotes PDE4D
T6 1094-1099 GeneOrGeneProduct denotes PDE4D
T5 885-891 GeneOrGeneProduct denotes cutoff
T4 130-135 GeneOrGeneProduct denotes PDE4D
T3 108-128 GeneOrGeneProduct denotes phosphodiesterase 4D
T20700 57-62 GeneOrGeneProduct denotes PDE4D
T17844 35-55 GeneOrGeneProduct denotes phosphodiesterase 4D
T10 2256-2269 DiseaseOrPhenotypicFeature denotes atherogenesis D050197
T9 2195-2201 DiseaseOrPhenotypicFeature denotes stroke D020521
T8 2029-2035 DiseaseOrPhenotypicFeature denotes stroke D020521
T95667 1202-1208 DiseaseOrPhenotypicFeature denotes stroke D020521
T65416 1156-1162 DiseaseOrPhenotypicFeature denotes stroke D020521
T86255 532-538 DiseaseOrPhenotypicFeature denotes stroke D020521
T85028 460-475 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T89601 260-271 DiseaseOrPhenotypicFeature denotes atherogenic DISEASE
T20574 183-189 DiseaseOrPhenotypicFeature denotes stroke D020521
T50333 67-90 DiseaseOrPhenotypicFeature denotes carotid atherosclerosis D002340
T71394 2073-2078 OrganismTaxon denotes women
T50813 2036-2039 OrganismTaxon denotes men
T57784 1909-1914 OrganismTaxon denotes women
T38231 1770-1773 OrganismTaxon denotes men
T67414 1583-1588 OrganismTaxon denotes women
T81591 1568-1571 OrganismTaxon denotes men
T14055 991-996 OrganismTaxon denotes women
T42261 983-986 OrganismTaxon denotes men
T17795 629-632 OrganismTaxon denotes men
T84871 1990-1998 SequenceVariant denotes rs702553
T69829 1965-1973 SequenceVariant denotes rs702553
T70878 1421-1429 SequenceVariant denotes rs702553

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 183-189 HP_0001297 denotes stroke
T2 460-475 HP_0002621 denotes atherosclerosis

Allie

Id Subject Object Predicate Lexical cue
SS1_20540798_0_0 35-55 expanded denotes phosphodiesterase 4D
SS2_20540798_0_0 57-62 abbr denotes PDE4D
SS1_20540798_2_0 108-128 expanded denotes phosphodiesterase 4D
SS2_20540798_2_0 130-135 abbr denotes PDE4D
SS1_20540798_4_0 319-341 expanded denotes intima-media thickness
SS2_20540798_4_0 343-346 abbr denotes IMT
AE1_20540798_0_0 SS1_20540798_0_0 SS2_20540798_0_0 abbreviatedTo phosphodiesterase 4D,PDE4D
AE1_20540798_2_0 SS1_20540798_2_0 SS2_20540798_2_0 abbreviatedTo phosphodiesterase 4D,PDE4D
AE1_20540798_4_0 SS1_20540798_4_0 SS2_20540798_4_0 abbreviatedTo intima-media thickness,IMT