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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7375 0-12 ChemicalEntity denotes Coenzyme Q10 MESH:C024989
7376 41-50 ChemicalEntity denotes cisplatin MESH:D002945
7377 51-65 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
7378 69-73 OrganismTaxon denotes mice NCBITaxon:10090
7379 106-118 ChemicalEntity denotes coenzyme Q10 MESH:C024989
7380 139-143 OrganismTaxon denotes mice NCBITaxon:10090
7381 149-167 DiseaseOrPhenotypicFeature denotes acute renal injury MESH:D058186
7382 206-215 ChemicalEntity denotes cisplatin MESH:D002945
7383 227-239 ChemicalEntity denotes Coenzyme Q10 MESH:C024989
7384 329-338 ChemicalEntity denotes cisplatin MESH:D002945
7385 355-367 ChemicalEntity denotes Coenzyme Q10 MESH:C024989
7386 390-409 ChemicalEntity denotes blood urea nitrogen MESH:D001806
7387 420-430 ChemicalEntity denotes creatinine MESH:D003404
7388 462-471 ChemicalEntity denotes cisplatin MESH:D002945
7389 473-485 ChemicalEntity denotes Coenzyme Q10 MESH:C024989
7390 568-579 ChemicalEntity denotes glutathione MESH:D005978
7391 590-610 GeneOrGeneProduct denotes superoxide dismutase NCBIGene:20655
7392 633-638 ChemicalEntity denotes lipid MESH:D008055
7393 681-708 GeneOrGeneProduct denotes tumor necrosis factor-alpha NCBIGene:21926
7394 710-722 ChemicalEntity denotes nitric oxide MESH:D009569
7395 727-735 ChemicalEntity denotes platinum MESH:D010984
7396 788-796 ChemicalEntity denotes selenium MESH:D012643
7397 801-805 ChemicalEntity denotes zinc MESH:D015032
7398 841-850 ChemicalEntity denotes cisplatin MESH:D002945
7399 891-910 DiseaseOrPhenotypicFeature denotes renal tissue damage MESH:D007674
7400 923-932 ChemicalEntity denotes cisplatin MESH:D002945
7401 952-964 ChemicalEntity denotes coenzyme Q10 MESH:C024989
7402 1019-1031 ChemicalEntity denotes coenzyme Q10 MESH:C024989
7403 1060-1069 ChemicalEntity denotes cisplatin MESH:D002945
7404 1106-1127 GeneOrGeneProduct denotes nitric oxide synthase NCBIGene:18125
7405 1129-1150 GeneOrGeneProduct denotes nuclear factor-kappaB NCBIGene:18033
7406 1152-1161 GeneOrGeneProduct denotes caspase-3 NCBIGene:12367
7407 1166-1169 GeneOrGeneProduct denotes p53 NCBIGene:22060
7408 1209-1221 ChemicalEntity denotes coenzyme Q10 MESH:C024989
7409 1289-1298 ChemicalEntity denotes cisplatin MESH:D002945
7410 1299-1313 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.
T2 75-226 Sentence denotes The nephroprotective effect of coenzyme Q10 was investigated in mice with acute renal injury induced by a single i.p. injection of cisplatin (5 mg/kg).
T3 227-354 Sentence denotes Coenzyme Q10 treatment (10 mg/kg/day, i.p.) was applied for 6 consecutive days, starting 1 day before cisplatin administration.
T4 355-472 Sentence denotes Coenzyme Q10 significantly reduced blood urea nitrogen and serum creatinine levels which were increased by cisplatin.
T5 473-866 Sentence denotes Coenzyme Q10 significantly compensated deficits in the antioxidant defense mechanisms (reduced glutathione level and superoxide dismutase activity), suppressed lipid peroxidation, decreased the elevations of tumor necrosis factor-alpha, nitric oxide and platinum ion concentration, and attenuated the reductions of selenium and zinc ions in renal tissue resulted from cisplatin administration.
T6 867-975 Sentence denotes Also, histopathological renal tissue damage mediated by cisplatin was ameliorated by coenzyme Q10 treatment.
T7 976-1186 Sentence denotes Immunohistochemical analysis revealed that coenzyme Q10 significantly decreased the cisplatin-induced overexpression of inducible nitric oxide synthase, nuclear factor-kappaB, caspase-3 and p53 in renal tissue.
T8 1187-1356 Sentence denotes It was concluded that coenzyme Q10 represents a potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly encountered in clinical practice.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 69-73 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T3 139-143 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 161-167 DiseaseOrPhenotypicFeature denotes injury 0021178

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-12 GeneOrGeneProduct denotes Coenzyme Q10
T2 41-50 GeneOrGeneProduct denotes cisplatin
T3 69-73 GeneOrGeneProduct denotes mice
T4 106-118 GeneOrGeneProduct denotes coenzyme Q10
T5 139-143 GeneOrGeneProduct denotes mice
T6 168-175 GeneOrGeneProduct denotes induced
T7 206-215 GeneOrGeneProduct denotes cisplatin
T8 219-221 GeneOrGeneProduct denotes mg
T9 227-239 GeneOrGeneProduct denotes Coenzyme Q10
T10 254-256 GeneOrGeneProduct denotes mg
T11 307-317 GeneOrGeneProduct denotes starting 1
T12 329-338 GeneOrGeneProduct denotes cisplatin
T13 355-367 GeneOrGeneProduct denotes Coenzyme Q10
T14 382-389 GeneOrGeneProduct denotes reduced
T15 396-400 GeneOrGeneProduct denotes urea
T16 420-437 GeneOrGeneProduct denotes creatinine levels
T17 462-471 GeneOrGeneProduct denotes cisplatin
T18 473-485 GeneOrGeneProduct denotes Coenzyme Q10
T19 540-547 GeneOrGeneProduct denotes defense
T20 560-567 GeneOrGeneProduct denotes reduced
T21 568-579 GeneOrGeneProduct denotes glutathione
T22 590-610 GeneOrGeneProduct denotes superoxide dismutase
T23 611-619 GeneOrGeneProduct denotes activity
T24 639-651 GeneOrGeneProduct denotes peroxidation
T25 681-708 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T26 727-735 GeneOrGeneProduct denotes platinum
T27 759-769 GeneOrGeneProduct denotes attenuated
T28 801-805 GeneOrGeneProduct denotes zinc
T29 841-850 GeneOrGeneProduct denotes cisplatin
T30 904-910 GeneOrGeneProduct denotes damage
T31 911-919 GeneOrGeneProduct denotes mediated
T32 923-932 GeneOrGeneProduct denotes cisplatin
T33 952-964 GeneOrGeneProduct denotes coenzyme Q10
T34 1019-1031 GeneOrGeneProduct denotes coenzyme Q10
T35 1060-1069 GeneOrGeneProduct denotes cisplatin
T36 1070-1077 GeneOrGeneProduct denotes induced
T37 1096-1127 GeneOrGeneProduct denotes inducible nitric oxide synthase
T38 1137-1143 GeneOrGeneProduct denotes factor
T39 1152-1161 GeneOrGeneProduct denotes caspase-3
T40 1209-1221 GeneOrGeneProduct denotes coenzyme Q10
T41 1289-1298 GeneOrGeneProduct denotes cisplatin

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-12 GeneOrGeneProduct denotes Coenzyme Q10
T2 41-50 GeneOrGeneProduct denotes cisplatin
T3 106-118 GeneOrGeneProduct denotes coenzyme Q10
T4 206-215 GeneOrGeneProduct denotes cisplatin
T5 227-239 GeneOrGeneProduct denotes Coenzyme Q10
T6 329-338 GeneOrGeneProduct denotes cisplatin
T7 355-367 GeneOrGeneProduct denotes Coenzyme Q10
T8 382-389 GeneOrGeneProduct denotes reduced
T9 420-437 GeneOrGeneProduct denotes creatinine levels
T10 462-471 GeneOrGeneProduct denotes cisplatin
T11 473-485 GeneOrGeneProduct denotes Coenzyme Q10
T12 560-567 GeneOrGeneProduct denotes reduced
T13 568-579 GeneOrGeneProduct denotes glutathione
T14 590-610 GeneOrGeneProduct denotes superoxide dismutase
T15 681-708 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T16 727-735 GeneOrGeneProduct denotes platinum
T17 759-769 GeneOrGeneProduct denotes attenuated
T18 841-850 GeneOrGeneProduct denotes cisplatin
T19 923-932 GeneOrGeneProduct denotes cisplatin
T20 952-964 GeneOrGeneProduct denotes coenzyme Q10
T21 1019-1031 GeneOrGeneProduct denotes coenzyme Q10
T22 1060-1069 GeneOrGeneProduct denotes cisplatin
T23 1096-1127 GeneOrGeneProduct denotes inducible nitric oxide synthase
T24 1137-1143 GeneOrGeneProduct denotes factor
T25 1152-1161 GeneOrGeneProduct denotes caspase-3
T26 1209-1221 GeneOrGeneProduct denotes coenzyme Q10
T27 1289-1298 GeneOrGeneProduct denotes cisplatin

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 51-65 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 149-167 DiseaseOrPhenotypicFeature denotes acute renal injury D058186
T3 681-686 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 687-695 DiseaseOrPhenotypicFeature denotes necrosis D009336
T5 1299-1313 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 590-610 GeneOrGeneProduct denotes superoxide dismutase
T2 681-708 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T3 727-735 GeneOrGeneProduct denotes platinum
T4 1096-1127 GeneOrGeneProduct denotes inducible nitric oxide synthase
T5 1129-1150 GeneOrGeneProduct denotes nuclear factor-kappaB
T6 1152-1161 GeneOrGeneProduct denotes caspase-3

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 161-167 DiseaseOrPhenotypicFeature denotes injury 0021178
T2 681-686 DiseaseOrPhenotypicFeature denotes tumor 0005070
T3 736-739 DiseaseOrPhenotypicFeature denotes ion 0044688

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 51-65 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 149-167 DiseaseOrPhenotypicFeature denotes acute renal injury D058186
T3 681-686 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 687-695 DiseaseOrPhenotypicFeature denotes necrosis D009336
T5 891-910 DiseaseOrPhenotypicFeature denotes renal tissue damage DISEASE
T6 1299-1313 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 51-65 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 149-167 DiseaseOrPhenotypicFeature denotes acute renal injury D058186
T3 681-686 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 891-910 DiseaseOrPhenotypicFeature denotes renal tissue damage DISEASE
T5 1299-1313 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-12 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T2 41-50 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T4 106-118 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T5 206-215 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T7 227-239 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T8 329-338 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T10 355-367 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T11 396-400 ChemicalEntity denotes urea D014508|http://purl.obolibrary.org/obo/CHEBI_16199
T13 401-409 ChemicalEntity denotes nitrogen D009584|http://purl.obolibrary.org/obo/CHEBI_25555
T15 420-430 ChemicalEntity denotes creatinine D003404|http://purl.obolibrary.org/obo/CHEBI_16737
T17 462-471 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T19 473-485 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T20 528-539 ChemicalEntity denotes antioxidant ChemicalEntity
T21 568-579 ChemicalEntity denotes glutathione http://purl.obolibrary.org/obo/CHEBI_16856
T22 590-610 ChemicalEntity denotes superoxide dismutase D013482
T23 710-722 ChemicalEntity denotes nitric oxide D009569|http://purl.obolibrary.org/obo/CHEBI_16480
T25 727-735 ChemicalEntity denotes platinum D010984|http://purl.obolibrary.org/obo/CHEBI_33400|http://purl.obolibrary.org/obo/CHEBI_33364
T28 736-739 ChemicalEntity denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T29 788-796 ChemicalEntity denotes selenium D012643|http://purl.obolibrary.org/obo/CHEBI_27568
T31 801-810 ChemicalEntity denotes zinc ions http://purl.obolibrary.org/obo/CHEBI_27365
T32 841-850 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T34 923-932 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T36 952-964 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T37 1019-1031 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T38 1060-1069 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899
T40 1106-1127 ChemicalEntity denotes nitric oxide synthase D019001
T41 1209-1221 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T42 1289-1298 ChemicalEntity denotes cisplatin D002945|http://purl.obolibrary.org/obo/CHEBI_27899

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 69-73 OrganismTaxon denotes mice
T2 139-143 OrganismTaxon denotes mice

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T42 1289-1298 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T41 1209-1221 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T40 1106-1127 ChemicalEntity denotes nitric oxide synthase D019001
T38 1060-1069 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T37 1019-1031 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T36 952-964 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T34 923-932 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T32 841-850 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T31 801-810 ChemicalEntity denotes zinc ions http://purl.obolibrary.org/obo/CHEBI_27365
T29 788-796 ChemicalEntity denotes selenium http://purl.obolibrary.org/obo/CHEBI_27568|D012643
T28 736-739 ChemicalEntity denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T25 727-735 ChemicalEntity denotes platinum http://purl.obolibrary.org/obo/CHEBI_33364|http://purl.obolibrary.org/obo/CHEBI_33400|D010984
T23 710-722 ChemicalEntity denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480|D009569
T22 590-610 ChemicalEntity denotes superoxide dismutase D013482
T21 568-579 ChemicalEntity denotes glutathione http://purl.obolibrary.org/obo/CHEBI_16856
T20 528-539 ChemicalEntity denotes antioxidant ChemicalEntity
T19 473-485 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T17 462-471 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T15 420-430 ChemicalEntity denotes creatinine http://purl.obolibrary.org/obo/CHEBI_16737|D003404
T13 401-409 ChemicalEntity denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555|D009584
T11 396-400 ChemicalEntity denotes urea http://purl.obolibrary.org/obo/CHEBI_16199|D014508
T10 355-367 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T8 329-338 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T7 227-239 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T5 206-215 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T4 106-118 ChemicalEntity denotes coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T2 41-50 ChemicalEntity denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899|D002945
T1 0-12 ChemicalEntity denotes Coenzyme Q10 http://purl.obolibrary.org/obo/CHEBI_46245
T6 1152-1161 GeneOrGeneProduct denotes caspase-3
T87703 1129-1150 GeneOrGeneProduct denotes nuclear factor-kappaB
T71534 1096-1127 GeneOrGeneProduct denotes inducible nitric oxide synthase
T3 727-735 GeneOrGeneProduct denotes platinum
T12899 681-708 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T5523 590-610 GeneOrGeneProduct denotes superoxide dismutase
T51029 1299-1313 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T26749 891-910 DiseaseOrPhenotypicFeature denotes renal tissue damage DISEASE
T83288 681-686 DiseaseOrPhenotypicFeature denotes tumor D009369
T50113 149-167 DiseaseOrPhenotypicFeature denotes acute renal injury D058186
T145 51-65 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T93760 139-143 OrganismTaxon denotes mice
T1252 69-73 OrganismTaxon denotes mice

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 681-686 HP_0002664 denotes tumor

bc5cdr-valid-experiment

Id Subject Object Predicate Lexical cue
T1 0-12 Chemical denotes Coenzyme Q10
T2 41-50 Chemical denotes cisplatin
T3 51-65 Disease denotes nephrotoxicity
T4 106-118 Chemical denotes coenzyme Q10
T5 149-167 Disease denotes acute renal injury
T6 206-215 Chemical denotes cisplatin
T7 227-239 Chemical denotes Coenzyme Q10
T8 329-338 Chemical denotes cisplatin
T9 355-367 Chemical denotes Coenzyme Q10
T10 390-409 Chemical denotes blood urea nitrogen
T11 420-430 Chemical denotes creatinine
T12 462-471 Chemical denotes cisplatin
T13 473-485 Chemical denotes Coenzyme Q10
T14 560-579 Chemical denotes reduced glutathione
T15 590-600 Chemical denotes superoxide
T16 681-686 Disease denotes tumor
T17 687-695 Disease denotes necrosis
T18 710-722 Chemical denotes nitric oxide
T19 727-735 Chemical denotes platinum
T20 788-796 Chemical denotes selenium
T21 801-805 Chemical denotes zinc
T22 841-850 Chemical denotes cisplatin
T23 891-910 Disease denotes renal tissue damage
T24 923-932 Chemical denotes cisplatin
T25 952-964 Chemical denotes coenzyme Q10
T26 1019-1031 Chemical denotes coenzyme Q10
T27 1060-1069 Chemical denotes cisplatin
T28 1106-1118 Chemical denotes nitric oxide
T29 1209-1221 Chemical denotes coenzyme Q10
T30 1289-1298 Chemical denotes cisplatin
T31 1299-1313 Disease denotes nephrotoxicity