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PubMed:20489151 JSONTXT

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GoldHamster

Id Subject Object Predicate Lexical cue
T2 32-44 UBERON:0002137 denotes aortic valve
T1 32-44 109730 denotes aortic valve
T4 64-68 UBERON:0001474 denotes bone
T5 64-68 UBERON:0002481 denotes bone
T10 81-88 SO:0000104 denotes protein
T9 81-88 PR:000000001 denotes protein
T6 81-88 GO:0003675 denotes protein
T7 81-88 CHEBI:36080 denotes protein
T8 81-88 CHEBI:11122 denotes protein
T12 117-129 UBERON:0002137 denotes aortic valve
T11 117-129 109730 denotes aortic valve
T14 170-174 UBERON:0001474 denotes bone
T15 170-174 UBERON:0002481 denotes bone
T16 187-195 CHEBI:36080 denotes proteins
T19 207-238 PR:000000046 denotes transforming growth factor-beta
T20 207-238 GO:0005160 denotes transforming growth factor-beta
T23 207-239 D053773 denotes transforming growth factor-beta1
T24 207-239 D053773 denotes transforming growth factor-beta1
T32 234-239 Q60420 denotes beta1
T37 241-250 PR:000000182 denotes TGF-beta1
T36 241-250 D053773 denotes TGF-beta1
T38 241-250 D053773 denotes TGF-beta1
T42 323-329 UBERON:0027368 denotes matrix
T43 353-356 CVCL_N817 denotes pro
T47 353-356 SO:0001439 denotes pro
T44 353-356 CHEBI:32871 denotes pro
T45 353-356 CHEBI:32865 denotes pro
T46 353-356 CHEBI:50342 denotes pro
T48 353-356 CHEBI:32866 denotes pro
T49 370-378 CHEBI:36080 denotes proteins
T50 546-551 UBERON:0003978 denotes valve
T52 572-575 PR:000000034 denotes BMP
T53 572-575 P35855 denotes BMP
T51 572-575 CHEBI:60815 denotes BMP
T69 807-819 CHEBI:18367 denotes phosphate (3
T74 831-840 PR:000000182 denotes TGF-beta1
T73 831-840 D053773 denotes TGF-beta1
T75 831-840 D053773 denotes TGF-beta1
T80 867-870 PR:000000034 denotes BMP
T81 867-870 P35855 denotes BMP
T79 867-870 CHEBI:60815 denotes BMP
T82 871-880 CHEBI:35222 denotes inhibitor
T90 881-890 Q9W741 denotes noggin (1
T95 944-956 CHEBI:40863 denotes Alizarin red
T96 944-956 C010078 denotes Alizarin red
T97 944-956 CHEBI:16866 denotes Alizarin red
T98 944-956 C010078 denotes Alizarin red
T99 1124-1133 D010710 denotes phosphate
T100 1124-1133 CHEBI:26020 denotes phosphate
T101 1124-1133 CHEBI:14792 denotes phosphate
T102 1124-1133 CHEBI:35780 denotes phosphate
T103 1124-1133 CHEBI:18367 denotes phosphate
T104 1124-1133 CHEBI:26078 denotes phosphate
T105 1124-1133 D010710 denotes phosphate
T106 1124-1133 CHEBI:43474 denotes phosphate
T111 1138-1147 PR:000000182 denotes TGF-beta1
T110 1138-1147 D053773 denotes TGF-beta1
T112 1138-1147 D053773 denotes TGF-beta1
T116 1149-1152 CHEBI:60815 denotes BMP
T119 1149-1154 PR:P49001 denotes BMP-2
T120 1149-1154 PR:P21274 denotes BMP-2
T121 1149-1154 Q804S2 denotes BMP-2
T122 1149-1154 P49001 denotes BMP-2
T123 1149-1154 P12643 denotes BMP-2
T124 1149-1154 P21274 denotes BMP-2
T125 1149-1154 Q90751 denotes BMP-2
T126 1149-1154 O46564 denotes BMP-2
T127 1149-1154 PR:P12643 denotes BMP-2
T128 1149-1154 PR:000000164 denotes BMP-2
T129 1149-1154 O19006 denotes BMP-2
T130 1164-1169 PR:Q13950 denotes Runx2
T131 1164-1169 PR:Q08775 denotes Runx2
T132 1164-1169 PR:000014364 denotes Runx2
T133 1237-1242 UBERON:0003978 denotes valve
T134 1243-1247 PR:000016567 denotes cusp
T135 1243-1247 Q9H3D4 denotes cusp
T136 1243-1247 UBERON:0006844 denotes cusp
T137 1294-1303 GO:0097194 denotes apoptosis
T138 1294-1303 GO:0006915 denotes apoptosis
T139 1339-1346 1895 denotes calcium
T140 1339-1346 CHEBI:29320 denotes calcium
T141 1339-1346 CHEBI:22984 denotes calcium
T142 1359-1379 P19147 denotes alkaline phosphatase
T143 1359-1379 P83456 denotes alkaline phosphatase
T145 1359-1379 PR:000023540 denotes alkaline phosphatase
T146 1359-1379 O60109 denotes alkaline phosphatase
T147 1359-1379 P21948 denotes alkaline phosphatase
T148 1359-1379 P00634 denotes alkaline phosphatase
T149 1359-1379 P86348 denotes alkaline phosphatase
T150 1359-1379 P81800 denotes alkaline phosphatase
T151 1359-1379 Q05205 denotes alkaline phosphatase
T144 1359-1379 D000469 denotes alkaline phosphatase
T152 1359-1388 GO:0004035 denotes alkaline phosphatase activity
T156 1456-1462 P97466 denotes noggin
T157 1456-1462 Q13253 denotes noggin
T158 1456-1462 Q9YHT8 denotes noggin
T159 1456-1462 PR:000000021 denotes noggin
T160 1456-1462 O93525 denotes noggin
T161 1456-1462 P49011 denotes noggin
T162 1456-1462 Q62809 denotes noggin
T163 1545-1550 UBERON:0003978 denotes valve

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 107-252 DRI_Background denotes Calcified aortic valve (AV) cusps have increased expression of bone morphogenic proteins (BMPs) and transforming growth factor-beta1 (TGF-beta1).
T2 253-379 DRI_Approach denotes Elevated stretch loading on the AV is known to increase expression of matrix remodeling enzymes and pro-inflammatory proteins.
T3 380-482 DRI_Background denotes Little, however, is known about the mechanism by which elevated stretch might induce AV calcification.
T4 483-596 DRI_Approach denotes We investigated the hypothesis that elevated stretch may cause valve calcification via a BMP-dependent mechanism.
T5 597-911 DRI_Outcome denotes Porcine AV cusps were cultured in a stretch bioreactor, at 10% (physiological) or 15% (pathological) stretch and 70 beats per minute for 3, 7, and 14 days, in osteogenic media supplemented with or without high phosphate (3.8 mmol/L), TGF-beta1 (1 ng/ml), as well as the BMP inhibitor noggin (1, 10, and 100 ng/ml).
T6 912-943 DRI_Approach denotes Fresh cusps served as controls.
T7 944-1148 DRI_Outcome denotes Alizarin red and von Kossa staining demonstrated that 15% stretch elicited a stronger calcification response compared with 10% stretch in a fully osteogenic medium containing high phosphate and TGF-beta1.
T8 1149-1284 DRI_Background denotes BMP-2, -4, and Runx2 expression was observed after 3 days on the fibrosa surface of the valve cusp and was stretch magnitude-dependent.
T9 1285-1331 DRI_Background denotes Cellular apoptosis was highest at 15% stretch.
T10 1332-1490 DRI_Background denotes Tissue calcium content and alkaline phosphatase activity were similarly stretch-dependent and were significantly reduced by noggin in a dose dependent manner.
T11 1491-1588 DRI_Challenge denotes These results underline the potential role of BMPs in valve calcification due to altered stretch.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 62-63 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 64-68 CVCL_D953|Induced_pluripotent_stem_cell|Homo sapiens denotes bone
T3 170-174 CVCL_D953|Induced_pluripotent_stem_cell|Homo sapiens denotes bone
T4 353-356 CVCL_N817|Cancer_cell_line|Homo sapiens denotes pro
T5 483-485 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T6 536-539 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T7 570-571 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 631-632 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 744-746 CVCL_ZS48|Finite_cell_line|Homo sapiens denotes 14
T10 844-846 CVCL_6D57|Cancer_cell_line|Rattus norvegicus denotes ng
T11 847-849 CVCL_F566|Transformed_cell_line|Homo sapiens denotes ml
T12 847-849 CVCL_W799|Cancer_cell_line|Homo sapiens denotes ml
T13 904-906 CVCL_6D57|Cancer_cell_line|Rattus norvegicus denotes ng
T14 907-909 CVCL_F566|Transformed_cell_line|Homo sapiens denotes ml
T15 907-909 CVCL_W799|Cancer_cell_line|Homo sapiens denotes ml
T16 1019-1020 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T17 1082-1083 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T18 1380-1388 CVCL_C410|Hybridoma|Mus musculus denotes activity
T19 1466-1467 CVCL_6479|Finite_cell_line|Mus musculus denotes a

Allie

Id Subject Object Predicate Lexical cue
SS1_20489151_1_0 117-129 expanded denotes aortic valve
SS2_20489151_1_0 131-133 abbr denotes AV
SS1_20489151_1_1 170-195 expanded denotes bone morphogenic proteins
SS2_20489151_1_1 197-201 abbr denotes BMPs
SS1_20489151_1_2 207-239 expanded denotes transforming growth factor-beta1
SS2_20489151_1_2 241-250 abbr denotes TGF-beta1
AE1_20489151_1_0 SS1_20489151_1_0 SS2_20489151_1_0 abbreviatedTo aortic valve,AV
AE1_20489151_1_1 SS1_20489151_1_1 SS2_20489151_1_1 abbreviatedTo bone morphogenic proteins,BMPs
AE1_20489151_1_2 SS1_20489151_1_2 SS2_20489151_1_2 abbreviatedTo transforming growth factor-beta1,TGF-beta1

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 107-129 HP_0004380 denotes Calcified aortic valve