PubMed:20484118
Annnotations
Glycan-Motif
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 424-443 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
T2 | 445-453 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T3 | 445-453 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
T4 | 1039-1047 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T5 | 1039-1047 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 424-443 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
T2 | 445-453 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
T4 | 1039-1047 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-105 | Sentence | denotes | Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. |
TextSentencer_T2 | 106-222 | Sentence | denotes | Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. |
TextSentencer_T3 | 223-309 | Sentence | denotes | Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. |
TextSentencer_T4 | 310-542 | Sentence | denotes | Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. |
TextSentencer_T5 | 543-739 | Sentence | denotes | Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation. |
TextSentencer_T6 | 740-928 | Sentence | denotes | In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells. |
TextSentencer_T7 | 929-988 | Sentence | denotes | Simultaneously, Ser(16)-phosphorylation of PLN was reduced. |
TextSentencer_T8 | 989-1171 | Sentence | denotes | In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls. |
TextSentencer_T9 | 1172-1243 | Sentence | denotes | The same results were observed in heart homogenates from diabetic rats. |
TextSentencer_T10 | 1244-1390 | Sentence | denotes | In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes. |
TextSentencer_T11 | 1391-1584 | Sentence | denotes | Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine. |
TextSentencer_T12 | 1585-1738 | Sentence | denotes | These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. |
TextSentencer_T13 | 1739-1910 | Sentence | denotes | This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes. |
T1 | 0-105 | Sentence | denotes | Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. |
T2 | 106-222 | Sentence | denotes | Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. |
T3 | 223-309 | Sentence | denotes | Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. |
T4 | 310-542 | Sentence | denotes | Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. |
T5 | 543-739 | Sentence | denotes | Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation. |
T6 | 740-928 | Sentence | denotes | In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells. |
T7 | 929-988 | Sentence | denotes | Simultaneously, Ser(16)-phosphorylation of PLN was reduced. |
T8 | 989-1171 | Sentence | denotes | In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls. |
T9 | 1172-1243 | Sentence | denotes | The same results were observed in heart homogenates from diabetic rats. |
T10 | 1244-1390 | Sentence | denotes | In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes. |
T11 | 1391-1584 | Sentence | denotes | Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine. |
T12 | 1585-1738 | Sentence | denotes | These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. |
T13 | 1739-1910 | Sentence | denotes | This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes. |
T1 | 0-105 | Sentence | denotes | Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. |
T2 | 106-222 | Sentence | denotes | Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. |
T3 | 223-309 | Sentence | denotes | Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. |
T4 | 310-542 | Sentence | denotes | Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. |
T5 | 543-739 | Sentence | denotes | Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation. |
T6 | 740-928 | Sentence | denotes | In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells. |
T7 | 929-988 | Sentence | denotes | Simultaneously, Ser(16)-phosphorylation of PLN was reduced. |
T8 | 989-1171 | Sentence | denotes | In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls. |
T9 | 1172-1243 | Sentence | denotes | The same results were observed in heart homogenates from diabetic rats. |
T10 | 1244-1390 | Sentence | denotes | In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes. |
T11 | 1391-1584 | Sentence | denotes | Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine. |
T12 | 1585-1738 | Sentence | denotes | These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. |
T13 | 1739-1910 | Sentence | denotes | This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 424-443 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
T2 | 445-453 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T3 | 445-453 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
T4 | 1039-1047 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T5 | 1039-1047 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 445-453 | http://www.glycoepitope.jp/epitopes/EP0004 | denotes | O-GlcNAc |
T2 | 1039-1047 | http://www.glycoepitope.jp/epitopes/EP0004 | denotes | O-GlcNAc |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 193-207 | http://purl.obolibrary.org/obo/MAT_0000453 | denotes | cardiac muscle |
T2 | 201-207 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T3 | 1206-1211 | http://purl.obolibrary.org/obo/MAT_0000036 | denotes | heart |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 1784-1787 | gene:5350 | denotes | PLN |
T1 | 1901-1909 | disease:C0011847 | denotes | diabetes |
T2 | 1784-1787 | gene:5350 | denotes | PLN |
T3 | 1901-1909 | disease:C0011849 | denotes | diabetes |
R1 | T0 | T1 | associated_with | PLN,diabetes |
R2 | T2 | T3 | associated_with | PLN,diabetes |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 90-104 | http://purl.bioontology.org/ontology/ICD10/I42.9 | denotes | cardiomyopathy |
T2 | 90-104 | http://purl.bioontology.org/ontology/ICD10/I42 | denotes | cardiomyopathy |
GlycoBiology-FMA
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 125-147 | FMAID:162308 | denotes | endo)plasmic reticulum |
_T2 | 125-147 | FMAID:63842 | denotes | endo)plasmic reticulum |
_T3 | 138-147 | FMAID:94520 | denotes | reticulum |
_T4 | 138-147 | FMAID:7646 | denotes | reticulum |
_T5 | 193-207 | FMAID:165844 | denotes | cardiac muscle |
_T6 | 201-207 | FMAID:30316 | denotes | muscle |
_T7 | 201-207 | FMAID:123535 | denotes | muscle |
_T8 | 201-207 | FMAID:172175 | denotes | muscle |
_T9 | 363-377 | FMAID:210660 | denotes | on cytoplasmic |
_T10 | 366-377 | FMAID:165187 | denotes | cytoplasmic |
_T11 | 366-377 | FMAID:66835 | denotes | cytoplasmic |
_T12 | 366-377 | FMAID:164989 | denotes | cytoplasmic |
_T13 | 382-398 | FMAID:61930 | denotes | nuclear proteins |
_T14 | 382-398 | FMAID:165400 | denotes | nuclear proteins |
_T15 | 390-398 | FMAID:165447 | denotes | proteins |
_T16 | 390-398 | FMAID:67257 | denotes | proteins |
_T17 | 424-443 | FMAID:196781 | denotes | N-acetylglucosamine |
_T18 | 424-443 | FMAID:82787 | denotes | N-acetylglucosamine |
_T19 | 527-541 | FMAID:197267 | denotes | cardiomyocytes |
_T20 | 527-541 | FMAID:197296 | denotes | cardiomyocytes |
_T21 | 527-541 | FMAID:83808 | denotes | cardiomyocytes |
_T22 | 743-757 | FMAID:197267 | denotes | cardiomyocytes |
_T23 | 743-757 | FMAID:83808 | denotes | cardiomyocytes |
_T24 | 743-757 | FMAID:197296 | denotes | cardiomyocytes |
_T25 | 922-927 | FMAID:68646 | denotes | cells |
_T26 | 922-927 | FMAID:169002 | denotes | cells |
_T27 | 1008-1013 | FMAID:7209 | denotes | ovary |
_T28 | 1008-1013 | FMAID:93687 | denotes | ovary |
_T29 | 1014-1019 | FMAID:68646 | denotes | cells |
_T30 | 1014-1019 | FMAID:169002 | denotes | cells |
_T31 | 1206-1211 | FMAID:7088 | denotes | heart |
_T32 | 1206-1211 | FMAID:93457 | denotes | heart |
_T33 | 1334-1342 | FMAID:67257 | denotes | proteins |
_T34 | 1334-1342 | FMAID:165447 | denotes | proteins |
_T35 | 1375-1389 | FMAID:83808 | denotes | cardiomyocytes |
_T36 | 1375-1389 | FMAID:197267 | denotes | cardiomyocytes |
_T37 | 1375-1389 | FMAID:197296 | denotes | cardiomyocytes |
_T38 | 1410-1415 | FMAID:68646 | denotes | cells |
_T39 | 1410-1415 | FMAID:169002 | denotes | cells |
_T40 | 1498-1512 | FMAID:197296 | denotes | cardiomyocytes |
_T41 | 1498-1512 | FMAID:83808 | denotes | cardiomyocytes |
_T42 | 1498-1512 | FMAID:197267 | denotes | cardiomyocytes |
_T43 | 1570-1583 | FMAID:166114 | denotes | catecholamine |
_T44 | 1570-1583 | FMAID:61791 | denotes | catecholamine |
uniprot-human
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 238-241 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T2 | 501-504 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T3 | 643-646 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T4 | 659-662 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T5 | 697-700 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T6 | 972-975 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T7 | 1026-1029 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T8 | 1118-1121 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T9 | 1275-1278 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T10 | 1609-1612 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T11 | 1784-1787 | http://www.uniprot.org/uniprot/P26678 | denotes | PLN |
T12 | 1048-1059 | http://www.uniprot.org/uniprot/Q99484 | denotes | transferase |
uniprot-mouse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1048-1059 | http://www.uniprot.org/uniprot/P38649 | denotes | transferase |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 580-582 | http://purl.bioontology.org/ontology/NCBITAXON/13893 | denotes | co |
T2 | 910-913 | http://purl.bioontology.org/ontology/NCBITAXON/604139 | denotes | non |
T3 | 922-927 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T4 | 1014-1019 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T5 | 1071-1073 | http://purl.bioontology.org/ontology/NCBITAXON/13893 | denotes | co |
T6 | 1249-1251 | http://purl.bioontology.org/ontology/NCBITAXON/13893 | denotes | co |
T7 | 1398-1401 | http://purl.bioontology.org/ontology/NCBITAXON/604139 | denotes | non |
T8 | 1410-1415 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T9 | 1765-1774 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanism |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 28-43 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T2 | 293-308 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T3 | 953-968 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4 | 1099-1114 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T5 | 1663-1678 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T6 | 148-150 | http://purl.obolibrary.org/obo/GO_0033968 | denotes | Ca |
T7 | 243-252 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulates |
T8 | 1788-1798 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T9 | 1039-1059 | http://purl.obolibrary.org/obo/GO_0097363 | denotes | O-GlcNAc transferase |
T10 | 1410-1429 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cells, the activity |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 285-288 | http://purl.obolibrary.org/obo/GO_0005790 | denotes | Ser |
T2 | 346-349 | http://purl.obolibrary.org/obo/GO_0005790 | denotes | Ser |
T3 | 686-689 | http://purl.obolibrary.org/obo/GO_0005790 | denotes | Ser |
T4 | 945-948 | http://purl.obolibrary.org/obo/GO_0005790 | denotes | Ser |
T5 | 1091-1094 | http://purl.obolibrary.org/obo/GO_0005790 | denotes | Ser |
T6 | 366-377 | http://purl.obolibrary.org/obo/GO_0005737 | denotes | cytoplasmic |
T7 | 922-927 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T8 | 1014-1019 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T9 | 1410-1415 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10 | 1039-1059 | http://purl.obolibrary.org/obo/GO_0017122 | denotes | O-GlcNAc transferase |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1206-1211 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_20484118_1_0 | 119-160 | expanded | denotes | sarco(endo)plasmic reticulum Ca(2)-ATPase |
SS2_20484118_1_0 | 162-169 | abbr | denotes | SERCA2a |
SS1_20484118_2_0 | 223-236 | expanded | denotes | Phospholamban |
SS2_20484118_2_0 | 238-241 | abbr | denotes | PLN |
SS1_20484118_3_0 | 415-443 | expanded | denotes | O-linked N-acetylglucosamine |
SS2_20484118_3_0 | 445-453 | abbr | denotes | O-GlcNAc |
AE1_20484118_1_0 | SS1_20484118_1_0 | SS2_20484118_1_0 | abbreviatedTo | sarco(endo)plasmic reticulum Ca(2)-ATPase,SERCA2a |
AE1_20484118_2_0 | SS1_20484118_2_0 | SS2_20484118_2_0 | abbreviatedTo | Phospholamban,PLN |
AE1_20484118_3_0 | SS1_20484118_3_0 | SS2_20484118_3_0 | abbreviatedTo | O-linked N-acetylglucosamine,O-GlcNAc |
EDAM-topics
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 366-377 | http://edamontology.org/topic_0616 | denotes | cytoplasmic |
T2 | 390-398 | http://edamontology.org/topic_0078 | denotes | proteins |
T3 | 543-550 | http://edamontology.org/topic_3678 | denotes | Studies |
T4 | 580-602 | http://edamontology.org/topic_3557 | denotes | co-immunoprecipitation |
T5 | 1030-1034 | http://edamontology.org/topic_3512 | denotes | cDNA |
T6 | 1060-1065 | http://edamontology.org/topic_0659 | denotes | siRNA |
T7 | 1249-1271 | http://edamontology.org/topic_3557 | denotes | co-immunoprecipitation |
T8 | 1297-1305 | http://edamontology.org/topic_3318 | denotes | physical |
T9 | 1306-1317 | http://edamontology.org/topic_0602 | denotes | interaction |
T10 | 1334-1342 | http://edamontology.org/topic_0078 | denotes | proteins |
EDAM-DFO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 354-362 | http://edamontology.org/data_1756 | denotes | residues |
T2 | 390-398 | http://edamontology.org/format_1208 | denotes | proteins |
T3 | 390-398 | http://edamontology.org/data_1467 | denotes | proteins |
T4 | 505-516 | http://edamontology.org/operation_0004 | denotes | function in |
T5 | 1334-1342 | http://edamontology.org/data_1467 | denotes | proteins |
T6 | 1334-1342 | http://edamontology.org/format_1208 | denotes | proteins |
T7 | 1591-1595 | http://edamontology.org/data_0006 | denotes | data |
T8 | 1686-1696 | http://edamontology.org/operation_3465 | denotes | correlates |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 208-221 | HP_0001371 | denotes | contractility |
NGLY1-deficiency
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-NGLY1-deficiency-B_T1 | 424-443 | chem:24139 | denotes | N-acetylglucosamine |
PD-NGLY1-deficiency-B_T2 | 447-453 | chem:24139 | denotes | GlcNAc |
PD-NGLY1-deficiency-B_T3 | 1041-1047 | chem:24139 | denotes | GlcNAc |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
20484118-0#14#27#gene5350 | 14-27 | gene5350 | denotes | phospholamban |
20484118-0#81#104#diseaseC0853897 | 81-104 | diseaseC0853897 | denotes | diabetic cardiomyopathy |
20484118-12#45#48#gene5350 | 1784-1787 | gene5350 | denotes | PLN |
20484118-12#162#170#diseaseC0011847 | 1901-1909 | diseaseC0011847 | denotes | diabetes |
20484118-12#162#170#diseaseC0011849 | 1901-1909 | diseaseC0011849 | denotes | diabetes |
14#27#gene535081#104#diseaseC0853897 | 20484118-0#14#27#gene5350 | 20484118-0#81#104#diseaseC0853897 | associated_with | phospholamban,diabetic cardiomyopathy |
45#48#gene5350162#170#diseaseC0011847 | 20484118-12#45#48#gene5350 | 20484118-12#162#170#diseaseC0011847 | associated_with | PLN,diabetes |
45#48#gene5350162#170#diseaseC0011849 | 20484118-12#45#48#gene5350 | 20484118-12#162#170#diseaseC0011849 | associated_with | PLN,diabetes |
GlycoBiology-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 193-207 | http://purl.obolibrary.org/obo/MAT_0000453 | denotes | cardiac muscle |
T2 | 201-207 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
T3 | 1206-1211 | http://purl.obolibrary.org/obo/MAT_0000036 | denotes | heart |
Lectin
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
Lectin_T1 | 148-150 | https://acgg.asia/db/lfdb/LfDB0227 | denotes | Ca |
GlycoBiology-Epitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-GlycoEpitope-B_T1 | 567-575 | id | denotes | labeling |
PD-GlycoEpitope-B_T2 | 445-453 | http://www.glycoepitope.jp/epitopes/EP0004 | denotes | O-GlcNAc |
PD-GlycoEpitope-B_T3 | 1039-1047 | http://www.glycoepitope.jp/epitopes/EP0004 | denotes | O-GlcNAc |
GlyTouCan-IUPAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
GlycanIUPAC_T1 | 350-353 | "http://rdf.glycoinfo.org/glycan/G69371PB" | denotes | Thr |
GlycanIUPAC_T2 | 350-353 | "http://rdf.glycoinfo.org/glycan/G04439TG" | denotes | Thr |
GlycanIUPAC_T3 | 350-353 | "http://rdf.glycoinfo.org/glycan/G01418RR" | denotes | Thr |
GlycanIUPAC_T4 | 350-353 | "http://rdf.glycoinfo.org/glycan/G98605AX" | denotes | Thr |
GlycanIUPAC_T5 | 350-353 | "http://rdf.glycoinfo.org/glycan/G24282OK" | denotes | Thr |
GlycanIUPAC_T6 | 350-353 | "http://rdf.glycoinfo.org/glycan/G55879EK" | denotes | Thr |
GlycanIUPAC_T7 | 350-353 | "http://rdf.glycoinfo.org/glycan/G12116BQ" | denotes | Thr |
GlycanIUPAC_T8 | 350-353 | "http://rdf.glycoinfo.org/glycan/G54590PA" | denotes | Thr |
GlycanIUPAC_T9 | 350-353 | "http://rdf.glycoinfo.org/glycan/G31652HG" | denotes | Thr |
GlycanIUPAC_T10 | 350-353 | "http://rdf.glycoinfo.org/glycan/G15155WL" | denotes | Thr |
GlycanIUPAC_T11 | 350-353 | "http://rdf.glycoinfo.org/glycan/G52301ZX" | denotes | Thr |
GlycanIUPAC_T12 | 350-353 | "http://rdf.glycoinfo.org/glycan/G04075BC" | denotes | Thr |
GlycanIUPAC_T13 | 350-353 | "http://rdf.glycoinfo.org/glycan/G40829OF" | denotes | Thr |
GlycanIUPAC_T14 | 350-353 | "http://rdf.glycoinfo.org/glycan/G29274DI" | denotes | Thr |
GlycanIUPAC_T15 | 350-353 | "http://rdf.glycoinfo.org/glycan/G50601AY" | denotes | Thr |
GlycanIUPAC_T16 | 350-353 | "http://rdf.glycoinfo.org/glycan/G52865ZM" | denotes | Thr |
GlycanIUPAC_T17 | 350-353 | "http://rdf.glycoinfo.org/glycan/G73633QJ" | denotes | Thr |
GlycanIUPAC_T18 | 350-353 | "http://rdf.glycoinfo.org/glycan/G33319MN" | denotes | Thr |
GlycanIUPAC_T19 | 350-353 | "http://rdf.glycoinfo.org/glycan/G94717IQ" | denotes | Thr |
GlycanIUPAC_T20 | 350-353 | "http://rdf.glycoinfo.org/glycan/G50452ZL" | denotes | Thr |
GlycanIUPAC_T21 | 350-353 | "http://rdf.glycoinfo.org/glycan/G90753WM" | denotes | Thr |
GlycanIUPAC_T22 | 350-353 | "http://rdf.glycoinfo.org/glycan/G27898GL" | denotes | Thr |
GlycanIUPAC_T23 | 350-353 | "http://rdf.glycoinfo.org/glycan/G03827YH" | denotes | Thr |
GlycanIUPAC_T24 | 350-353 | "http://rdf.glycoinfo.org/glycan/G64500BA" | denotes | Thr |
GlycanIUPAC_T25 | 350-353 | "http://rdf.glycoinfo.org/glycan/G89743XV" | denotes | Thr |
GlycanIUPAC_T26 | 350-353 | "http://rdf.glycoinfo.org/glycan/G62576QG" | denotes | Thr |
GlycanIUPAC_T27 | 350-353 | "http://rdf.glycoinfo.org/glycan/G70212CQ" | denotes | Thr |
GlycanIUPAC_T28 | 350-353 | "http://rdf.glycoinfo.org/glycan/G74708KP" | denotes | Thr |
GlycanIUPAC_T29 | 350-353 | "http://rdf.glycoinfo.org/glycan/G02394PC" | denotes | Thr |
GlycanIUPAC_T30 | 350-353 | "http://rdf.glycoinfo.org/glycan/G57814GP" | denotes | Thr |
GlycanIUPAC_T31 | 350-353 | "http://rdf.glycoinfo.org/glycan/G81521LC" | denotes | Thr |
GlycanIUPAC_T32 | 350-353 | "http://rdf.glycoinfo.org/glycan/G42918SL" | denotes | Thr |
GlycanIUPAC_T33 | 350-353 | "http://rdf.glycoinfo.org/glycan/G95238FE" | denotes | Thr |
GlycanIUPAC_T34 | 350-353 | "http://rdf.glycoinfo.org/glycan/G28403TD" | denotes | Thr |
GlycanIUPAC_T35 | 350-353 | "http://rdf.glycoinfo.org/glycan/G30379UC" | denotes | Thr |
GlycanIUPAC_T36 | 350-353 | "http://rdf.glycoinfo.org/glycan/G83583TH" | denotes | Thr |
GlycanIUPAC_T37 | 350-353 | "http://rdf.glycoinfo.org/glycan/G59548EJ" | denotes | Thr |
GlycanIUPAC_T38 | 350-353 | "http://rdf.glycoinfo.org/glycan/G47410OV" | denotes | Thr |
GlycanIUPAC_T39 | 350-353 | "http://rdf.glycoinfo.org/glycan/G88663EK" | denotes | Thr |
GlycanIUPAC_T40 | 350-353 | "http://rdf.glycoinfo.org/glycan/G90684PG" | denotes | Thr |
GlycanIUPAC_T41 | 350-353 | "http://rdf.glycoinfo.org/glycan/G44881OW" | denotes | Thr |
GlycanIUPAC_T42 | 350-353 | "http://rdf.glycoinfo.org/glycan/G54691YO" | denotes | Thr |
GlycanIUPAC_T43 | 350-353 | "http://rdf.glycoinfo.org/glycan/G19289PT" | denotes | Thr |
GlycanIUPAC_T44 | 350-353 | "http://rdf.glycoinfo.org/glycan/G23779KC" | denotes | Thr |
GlycanIUPAC_T45 | 350-353 | "http://rdf.glycoinfo.org/glycan/G94729UX" | denotes | Thr |
GlycanIUPAC_T46 | 350-353 | "http://rdf.glycoinfo.org/glycan/G34038TZ" | denotes | Thr |
GlycanIUPAC_T47 | 350-353 | "http://rdf.glycoinfo.org/glycan/G90659JR" | denotes | Thr |
GlycanIUPAC_T48 | 350-353 | "http://rdf.glycoinfo.org/glycan/G74977VW" | denotes | Thr |
GlycanIUPAC_T49 | 350-353 | "http://rdf.glycoinfo.org/glycan/G42696WA" | denotes | Thr |
GlycanIUPAC_T50 | 350-353 | "http://rdf.glycoinfo.org/glycan/G82531XS" | denotes | Thr |
GlycanIUPAC_T51 | 350-353 | "http://rdf.glycoinfo.org/glycan/G47639GO" | denotes | Thr |
GlycanIUPAC_T52 | 350-353 | "http://rdf.glycoinfo.org/glycan/G69282NX" | denotes | Thr |
GlycanIUPAC_T53 | 350-353 | "http://rdf.glycoinfo.org/glycan/G49708JS" | denotes | Thr |
GlycanIUPAC_T54 | 350-353 | "http://rdf.glycoinfo.org/glycan/G63317ON" | denotes | Thr |
GlycanIUPAC_T55 | 350-353 | "http://rdf.glycoinfo.org/glycan/G60349YI" | denotes | Thr |
GlycanIUPAC_T56 | 350-353 | "http://rdf.glycoinfo.org/glycan/G81659AQ" | denotes | Thr |
GlycanIUPAC_T57 | 350-353 | "http://rdf.glycoinfo.org/glycan/G16289GE" | denotes | Thr |
GlycanIUPAC_T58 | 350-353 | "http://rdf.glycoinfo.org/glycan/G69569AG" | denotes | Thr |
GlycanIUPAC_T59 | 350-353 | "http://rdf.glycoinfo.org/glycan/G16884LK" | denotes | Thr |
GlycanIUPAC_T60 | 350-353 | "http://rdf.glycoinfo.org/glycan/G23450NH" | denotes | Thr |
GlycanIUPAC_T61 | 350-353 | "http://rdf.glycoinfo.org/glycan/G85052FR" | denotes | Thr |
GlycanIUPAC_T62 | 350-353 | "http://rdf.glycoinfo.org/glycan/G55485RI" | denotes | Thr |
GlycanIUPAC_T63 | 350-353 | "http://rdf.glycoinfo.org/glycan/G80596GL" | denotes | Thr |
GlycanIUPAC_T64 | 350-353 | "http://rdf.glycoinfo.org/glycan/G39656RU" | denotes | Thr |
GlycanIUPAC_T65 | 350-353 | "http://rdf.glycoinfo.org/glycan/G71284FA" | denotes | Thr |
GlycanIUPAC_T66 | 350-353 | "http://rdf.glycoinfo.org/glycan/G42091PK" | denotes | Thr |
GlycanIUPAC_T67 | 350-353 | "http://rdf.glycoinfo.org/glycan/G38798SL" | denotes | Thr |
GlycanIUPAC_T68 | 350-353 | "http://rdf.glycoinfo.org/glycan/G36670NA" | denotes | Thr |
GlycanIUPAC_T69 | 350-353 | "http://rdf.glycoinfo.org/glycan/G91582QV" | denotes | Thr |
GlycanIUPAC_T70 | 350-353 | "http://rdf.glycoinfo.org/glycan/G28625IE" | denotes | Thr |
GlycanIUPAC_T71 | 350-353 | "http://rdf.glycoinfo.org/glycan/G81304ZT" | denotes | Thr |
GlycanIUPAC_T72 | 350-353 | "http://rdf.glycoinfo.org/glycan/G82883BK" | denotes | Thr |
GlycanIUPAC_T73 | 350-353 | "http://rdf.glycoinfo.org/glycan/G46290DK" | denotes | Thr |
GlycanIUPAC_T74 | 350-353 | "http://rdf.glycoinfo.org/glycan/G68202TJ" | denotes | Thr |
GlycanIUPAC_T75 | 350-353 | "http://rdf.glycoinfo.org/glycan/G39722QK" | denotes | Thr |
GlycanIUPAC_T76 | 350-353 | "http://rdf.glycoinfo.org/glycan/G76637LW" | denotes | Thr |
GlycanIUPAC_T77 | 350-353 | "http://rdf.glycoinfo.org/glycan/G51390WF" | denotes | Thr |
GlycanIUPAC_T78 | 350-353 | "http://rdf.glycoinfo.org/glycan/G35392PX" | denotes | Thr |
GlycanIUPAC_T79 | 350-353 | "http://rdf.glycoinfo.org/glycan/G27815EZ" | denotes | Thr |
GlycanIUPAC_T80 | 350-353 | "http://rdf.glycoinfo.org/glycan/G64374OT" | denotes | Thr |
GlycanIUPAC_T81 | 350-353 | "http://rdf.glycoinfo.org/glycan/G58333PU" | denotes | Thr |
GlycanIUPAC_T82 | 350-353 | "http://rdf.glycoinfo.org/glycan/G19695IE" | denotes | Thr |
GlycanIUPAC_T83 | 350-353 | "http://rdf.glycoinfo.org/glycan/G65617GK" | denotes | Thr |
GlycanIUPAC_T84 | 350-353 | "http://rdf.glycoinfo.org/glycan/G29832KZ" | denotes | Thr |
GlycanIUPAC_T85 | 350-353 | "http://rdf.glycoinfo.org/glycan/G05333AM" | denotes | Thr |
GlycanIUPAC_T86 | 350-353 | "http://rdf.glycoinfo.org/glycan/G46130CG" | denotes | Thr |
GlycanIUPAC_T87 | 350-353 | "http://rdf.glycoinfo.org/glycan/G57766RG" | denotes | Thr |
GlycanIUPAC_T88 | 350-353 | "http://rdf.glycoinfo.org/glycan/G03334HH" | denotes | Thr |
GlycanIUPAC_T89 | 350-353 | "http://rdf.glycoinfo.org/glycan/G46094SV" | denotes | Thr |
GlycanIUPAC_T90 | 350-353 | "http://rdf.glycoinfo.org/glycan/G98365FX" | denotes | Thr |
GlycanIUPAC_T91 | 350-353 | "http://rdf.glycoinfo.org/glycan/G85392EJ" | denotes | Thr |
GlycanIUPAC_T92 | 350-353 | "http://rdf.glycoinfo.org/glycan/G59996WL" | denotes | Thr |
GlycanIUPAC_T93 | 350-353 | "http://rdf.glycoinfo.org/glycan/G49141OD" | denotes | Thr |
GlycanIUPAC_T94 | 350-353 | "http://rdf.glycoinfo.org/glycan/G88793VU" | denotes | Thr |
GlycanIUPAC_T95 | 350-353 | "http://rdf.glycoinfo.org/glycan/G88801WQ" | denotes | Thr |
GlycanIUPAC_T96 | 350-353 | "http://rdf.glycoinfo.org/glycan/G61612EQ" | denotes | Thr |
GlycanIUPAC_T97 | 350-353 | "http://rdf.glycoinfo.org/glycan/G23181BS" | denotes | Thr |
GlycanIUPAC_T98 | 350-353 | "http://rdf.glycoinfo.org/glycan/G77428YW" | denotes | Thr |
GlycanIUPAC_T99 | 350-353 | "http://rdf.glycoinfo.org/glycan/G06824UZ" | denotes | Thr |
GlycanIUPAC_T100 | 350-353 | "http://rdf.glycoinfo.org/glycan/G15142RK" | denotes | Thr |
GlycanIUPAC_T101 | 350-353 | "http://rdf.glycoinfo.org/glycan/G18198RM" | denotes | Thr |
GlycanIUPAC_T102 | 350-353 | "http://rdf.glycoinfo.org/glycan/G70750SS" | denotes | Thr |
GlycanIUPAC_T103 | 350-353 | "http://rdf.glycoinfo.org/glycan/G04998YJ" | denotes | Thr |
GlycanIUPAC_T104 | 350-353 | "http://rdf.glycoinfo.org/glycan/G44379HX" | denotes | Thr |
GlycanIUPAC_T105 | 350-353 | "http://rdf.glycoinfo.org/glycan/G25683ZO" | denotes | Thr |
GlycanIUPAC_T106 | 350-353 | "http://rdf.glycoinfo.org/glycan/G35036BA" | denotes | Thr |
GlycanIUPAC_T107 | 350-353 | "http://rdf.glycoinfo.org/glycan/G98129RB" | denotes | Thr |
GlycanIUPAC_T108 | 350-353 | "http://rdf.glycoinfo.org/glycan/G00134PL" | denotes | Thr |
GlycanIUPAC_T109 | 350-353 | "http://rdf.glycoinfo.org/glycan/G26488SP" | denotes | Thr |
GlycanIUPAC_T110 | 350-353 | "http://rdf.glycoinfo.org/glycan/G02441UD" | denotes | Thr |
GlycanIUPAC_T111 | 350-353 | "http://rdf.glycoinfo.org/glycan/G21668ZD" | denotes | Thr |
GlycanIUPAC_T112 | 350-353 | "http://rdf.glycoinfo.org/glycan/G67040OT" | denotes | Thr |
GlycanIUPAC_T113 | 350-353 | "http://rdf.glycoinfo.org/glycan/G56431YZ" | denotes | Thr |
GlycanIUPAC_T114 | 350-353 | "http://rdf.glycoinfo.org/glycan/G29667IS" | denotes | Thr |
GlycanIUPAC_T115 | 350-353 | "http://rdf.glycoinfo.org/glycan/G94122LM" | denotes | Thr |
GlycanIUPAC_T116 | 350-353 | "http://rdf.glycoinfo.org/glycan/G93233YT" | denotes | Thr |
GlycanIUPAC_T117 | 350-353 | "http://rdf.glycoinfo.org/glycan/G72035WK" | denotes | Thr |
GlycanIUPAC_T118 | 350-353 | "http://rdf.glycoinfo.org/glycan/G99855SM" | denotes | Thr |
GlycanIUPAC_T119 | 350-353 | "http://rdf.glycoinfo.org/glycan/G48723MN" | denotes | Thr |
GlycanIUPAC_T120 | 350-353 | "http://rdf.glycoinfo.org/glycan/G28558MB" | denotes | Thr |
GlycanIUPAC_T121 | 350-353 | "http://rdf.glycoinfo.org/glycan/G92768RX" | denotes | Thr |
GlycanIUPAC_T122 | 350-353 | "http://rdf.glycoinfo.org/glycan/G70136KU" | denotes | Thr |
GlycanIUPAC_T123 | 350-353 | "http://rdf.glycoinfo.org/glycan/G37935YM" | denotes | Thr |
GlycanIUPAC_T124 | 350-353 | "http://rdf.glycoinfo.org/glycan/G96902PQ" | denotes | Thr |
GlycanIUPAC_T125 | 350-353 | "http://rdf.glycoinfo.org/glycan/G14015DN" | denotes | Thr |
GlycanIUPAC_T126 | 350-353 | "http://rdf.glycoinfo.org/glycan/G83153IV" | denotes | Thr |
GlycanIUPAC_T127 | 350-353 | "http://rdf.glycoinfo.org/glycan/G73174QP" | denotes | Thr |
GlycanIUPAC_T128 | 350-353 | "http://rdf.glycoinfo.org/glycan/G67188XY" | denotes | Thr |
GlycanIUPAC_T129 | 350-353 | "http://rdf.glycoinfo.org/glycan/G35093GE" | denotes | Thr |
GlycanIUPAC_T130 | 350-353 | "http://rdf.glycoinfo.org/glycan/G13364VQ" | denotes | Thr |
GlycanIUPAC_T131 | 350-353 | "http://rdf.glycoinfo.org/glycan/G72068FB" | denotes | Thr |
GlycanIUPAC_T132 | 350-353 | "http://rdf.glycoinfo.org/glycan/G93329DU" | denotes | Thr |
GlycanIUPAC_T133 | 350-353 | "http://rdf.glycoinfo.org/glycan/G54073VB" | denotes | Thr |
GlycanIUPAC_T134 | 350-353 | "http://rdf.glycoinfo.org/glycan/G41447UI" | denotes | Thr |
GlycanIUPAC_T135 | 350-353 | "http://rdf.glycoinfo.org/glycan/G85878MY" | denotes | Thr |
GlycanIUPAC_T136 | 350-353 | "http://rdf.glycoinfo.org/glycan/G92835HR" | denotes | Thr |
GlycanIUPAC_T137 | 350-353 | "http://rdf.glycoinfo.org/glycan/G34845TQ" | denotes | Thr |
GlycanIUPAC_T138 | 350-353 | "http://rdf.glycoinfo.org/glycan/G38916XK" | denotes | Thr |
GlycanIUPAC_T139 | 350-353 | "http://rdf.glycoinfo.org/glycan/G87709OA" | denotes | Thr |
GlycanIUPAC_T140 | 350-353 | "http://rdf.glycoinfo.org/glycan/G46661GX" | denotes | Thr |
GlycanIUPAC_T141 | 350-353 | "http://rdf.glycoinfo.org/glycan/G53431DX" | denotes | Thr |
GlycanIUPAC_T142 | 350-353 | "http://rdf.glycoinfo.org/glycan/G71815PL" | denotes | Thr |
GlycanIUPAC_T143 | 350-353 | "http://rdf.glycoinfo.org/glycan/G97173UR" | denotes | Thr |
GlycanIUPAC_T144 | 350-353 | "http://rdf.glycoinfo.org/glycan/G53453JD" | denotes | Thr |
GlycanIUPAC_T145 | 350-353 | "http://rdf.glycoinfo.org/glycan/G48975CP" | denotes | Thr |
GlycanIUPAC_T146 | 350-353 | "http://rdf.glycoinfo.org/glycan/G87775XT" | denotes | Thr |
GlycanIUPAC_T147 | 350-353 | "http://rdf.glycoinfo.org/glycan/G48463GY" | denotes | Thr |
GlycanIUPAC_T148 | 350-353 | "http://rdf.glycoinfo.org/glycan/G54042BQ" | denotes | Thr |
GlycanIUPAC_T149 | 350-353 | "http://rdf.glycoinfo.org/glycan/G99993MV" | denotes | Thr |
GlycanIUPAC_T150 | 350-353 | "http://rdf.glycoinfo.org/glycan/G81407LL" | denotes | Thr |
GlycanIUPAC_T151 | 350-353 | "http://rdf.glycoinfo.org/glycan/G46430YF" | denotes | Thr |
GlycanIUPAC_T152 | 350-353 | "http://rdf.glycoinfo.org/glycan/G86548QQ" | denotes | Thr |
GlycanIUPAC_T153 | 350-353 | "http://rdf.glycoinfo.org/glycan/G25645HZ" | denotes | Thr |
GlycanIUPAC_T154 | 350-353 | "http://rdf.glycoinfo.org/glycan/G73880WZ" | denotes | Thr |
GlycanIUPAC_T155 | 350-353 | "http://rdf.glycoinfo.org/glycan/G12979RT" | denotes | Thr |
GlycanIUPAC_T156 | 350-353 | "http://rdf.glycoinfo.org/glycan/G36146RU" | denotes | Thr |
GlycanIUPAC_T157 | 350-353 | "http://rdf.glycoinfo.org/glycan/G23944RZ" | denotes | Thr |
GlycanIUPAC_T158 | 350-353 | "http://rdf.glycoinfo.org/glycan/G67041BN" | denotes | Thr |
GlycanIUPAC_T159 | 350-353 | "http://rdf.glycoinfo.org/glycan/G95408HX" | denotes | Thr |
GlycanIUPAC_T160 | 350-353 | "http://rdf.glycoinfo.org/glycan/G31094CC" | denotes | Thr |
GlycanIUPAC_T161 | 350-353 | "http://rdf.glycoinfo.org/glycan/G99598GU" | denotes | Thr |
GlycanIUPAC_T162 | 350-353 | "http://rdf.glycoinfo.org/glycan/G94072IC" | denotes | Thr |
GlycanIUPAC_T163 | 350-353 | "http://rdf.glycoinfo.org/glycan/G09523ZS" | denotes | Thr |
GlycanIUPAC_T164 | 447-453 | "http://rdf.glycoinfo.org/glycan/G26693XF" | denotes | GlcNAc |
GlycanIUPAC_T165 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G26693XF" | denotes | GlcNAc |
GlycanIUPAC_T166 | 447-453 | "http://rdf.glycoinfo.org/glycan/G01864SU" | denotes | GlcNAc |
GlycanIUPAC_T167 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G01864SU" | denotes | GlcNAc |
GlycanIUPAC_T168 | 447-453 | "http://rdf.glycoinfo.org/glycan/G17605FD" | denotes | GlcNAc |
GlycanIUPAC_T169 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G17605FD" | denotes | GlcNAc |
GlycanIUPAC_T170 | 447-453 | "http://rdf.glycoinfo.org/glycan/G41950LU" | denotes | GlcNAc |
GlycanIUPAC_T171 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G41950LU" | denotes | GlcNAc |
GlycanIUPAC_T172 | 447-453 | "http://rdf.glycoinfo.org/glycan/G57195RJ" | denotes | GlcNAc |
GlycanIUPAC_T173 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G57195RJ" | denotes | GlcNAc |
GlycanIUPAC_T174 | 447-453 | "http://rdf.glycoinfo.org/glycan/G85391SA" | denotes | GlcNAc |
GlycanIUPAC_T175 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G85391SA" | denotes | GlcNAc |
GlycanIUPAC_T176 | 447-453 | "http://rdf.glycoinfo.org/glycan/G89565QL" | denotes | GlcNAc |
GlycanIUPAC_T177 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G89565QL" | denotes | GlcNAc |
GlycanIUPAC_T178 | 447-453 | "http://rdf.glycoinfo.org/glycan/G80869MR" | denotes | GlcNAc |
GlycanIUPAC_T179 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G80869MR" | denotes | GlcNAc |
GlycanIUPAC_T180 | 447-453 | "http://rdf.glycoinfo.org/glycan/G55978NL" | denotes | GlcNAc |
GlycanIUPAC_T181 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G55978NL" | denotes | GlcNAc |
GlycanIUPAC_T182 | 447-453 | "http://rdf.glycoinfo.org/glycan/G54644LT" | denotes | GlcNAc |
GlycanIUPAC_T183 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G54644LT" | denotes | GlcNAc |
GlycanIUPAC_T184 | 447-453 | "http://rdf.glycoinfo.org/glycan/G25694UG" | denotes | GlcNAc |
GlycanIUPAC_T185 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G25694UG" | denotes | GlcNAc |
GlycanIUPAC_T186 | 447-453 | "http://rdf.glycoinfo.org/glycan/G25126RB" | denotes | GlcNAc |
GlycanIUPAC_T187 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G25126RB" | denotes | GlcNAc |
GlycanIUPAC_T188 | 447-453 | "http://rdf.glycoinfo.org/glycan/G51848AD" | denotes | GlcNAc |
GlycanIUPAC_T189 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G51848AD" | denotes | GlcNAc |
GlycanIUPAC_T190 | 447-453 | "http://rdf.glycoinfo.org/glycan/G94667GM" | denotes | GlcNAc |
GlycanIUPAC_T191 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G94667GM" | denotes | GlcNAc |
GlycanIUPAC_T192 | 447-453 | "http://rdf.glycoinfo.org/glycan/G30124BO" | denotes | GlcNAc |
GlycanIUPAC_T193 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G30124BO" | denotes | GlcNAc |
GlycanIUPAC_T194 | 447-453 | "http://rdf.glycoinfo.org/glycan/G82777EZ" | denotes | GlcNAc |
GlycanIUPAC_T195 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G82777EZ" | denotes | GlcNAc |
GlycanIUPAC_T196 | 447-453 | "http://rdf.glycoinfo.org/glycan/G10151YZ" | denotes | GlcNAc |
GlycanIUPAC_T197 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G10151YZ" | denotes | GlcNAc |
GlycanIUPAC_T198 | 447-453 | "http://rdf.glycoinfo.org/glycan/G17585ZM" | denotes | GlcNAc |
GlycanIUPAC_T199 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G17585ZM" | denotes | GlcNAc |
GlycanIUPAC_T200 | 447-453 | "http://rdf.glycoinfo.org/glycan/G04411CJ" | denotes | GlcNAc |
GlycanIUPAC_T201 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G04411CJ" | denotes | GlcNAc |
GlycanIUPAC_T202 | 447-453 | "http://rdf.glycoinfo.org/glycan/G38254HJ" | denotes | GlcNAc |
GlycanIUPAC_T203 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G38254HJ" | denotes | GlcNAc |
GlycanIUPAC_T204 | 447-453 | "http://rdf.glycoinfo.org/glycan/G75188FS" | denotes | GlcNAc |
GlycanIUPAC_T205 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G75188FS" | denotes | GlcNAc |
GlycanIUPAC_T206 | 447-453 | "http://rdf.glycoinfo.org/glycan/G70374VG" | denotes | GlcNAc |
GlycanIUPAC_T207 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G70374VG" | denotes | GlcNAc |
GlycanIUPAC_T208 | 447-453 | "http://rdf.glycoinfo.org/glycan/G45176LJ" | denotes | GlcNAc |
GlycanIUPAC_T209 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G45176LJ" | denotes | GlcNAc |
GlycanIUPAC_T210 | 447-453 | "http://rdf.glycoinfo.org/glycan/G30874VW" | denotes | GlcNAc |
GlycanIUPAC_T211 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G30874VW" | denotes | GlcNAc |
GlycanIUPAC_T212 | 447-453 | "http://rdf.glycoinfo.org/glycan/G69333MI" | denotes | GlcNAc |
GlycanIUPAC_T213 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G69333MI" | denotes | GlcNAc |
GlycanIUPAC_T214 | 447-453 | "http://rdf.glycoinfo.org/glycan/G10676XO" | denotes | GlcNAc |
GlycanIUPAC_T215 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G10676XO" | denotes | GlcNAc |
GlycanIUPAC_T216 | 447-453 | "http://rdf.glycoinfo.org/glycan/G14843DJ" | denotes | GlcNAc |
GlycanIUPAC_T217 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G14843DJ" | denotes | GlcNAc |
GlycanIUPAC_T218 | 447-453 | "http://rdf.glycoinfo.org/glycan/G47546FR" | denotes | GlcNAc |
GlycanIUPAC_T219 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G47546FR" | denotes | GlcNAc |
GlycanIUPAC_T220 | 447-453 | "http://rdf.glycoinfo.org/glycan/G73695ZM" | denotes | GlcNAc |
GlycanIUPAC_T221 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G73695ZM" | denotes | GlcNAc |
GlycanIUPAC_T222 | 447-453 | "http://rdf.glycoinfo.org/glycan/G31923TJ" | denotes | GlcNAc |
GlycanIUPAC_T223 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G31923TJ" | denotes | GlcNAc |
GlycanIUPAC_T224 | 447-453 | "http://rdf.glycoinfo.org/glycan/G60519EP" | denotes | GlcNAc |
GlycanIUPAC_T225 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G60519EP" | denotes | GlcNAc |
GlycanIUPAC_T226 | 447-453 | "http://rdf.glycoinfo.org/glycan/G07933IA" | denotes | GlcNAc |
GlycanIUPAC_T227 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G07933IA" | denotes | GlcNAc |
GlycanIUPAC_T228 | 447-453 | "http://rdf.glycoinfo.org/glycan/G40745NH" | denotes | GlcNAc |
GlycanIUPAC_T229 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G40745NH" | denotes | GlcNAc |
GlycanIUPAC_T230 | 447-453 | "http://rdf.glycoinfo.org/glycan/G54496YV" | denotes | GlcNAc |
GlycanIUPAC_T231 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G54496YV" | denotes | GlcNAc |
GlycanIUPAC_T232 | 447-453 | "http://rdf.glycoinfo.org/glycan/G62953SQ" | denotes | GlcNAc |
GlycanIUPAC_T233 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G62953SQ" | denotes | GlcNAc |
GlycanIUPAC_T234 | 447-453 | "http://rdf.glycoinfo.org/glycan/G70070AY" | denotes | GlcNAc |
GlycanIUPAC_T235 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G70070AY" | denotes | GlcNAc |
GlycanIUPAC_T236 | 447-453 | "http://rdf.glycoinfo.org/glycan/G78792WC" | denotes | GlcNAc |
GlycanIUPAC_T237 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G78792WC" | denotes | GlcNAc |
GlycanIUPAC_T238 | 447-453 | "http://rdf.glycoinfo.org/glycan/G25238AV" | denotes | GlcNAc |
GlycanIUPAC_T239 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G25238AV" | denotes | GlcNAc |
GlycanIUPAC_T240 | 447-453 | "http://rdf.glycoinfo.org/glycan/G40510DP" | denotes | GlcNAc |
GlycanIUPAC_T241 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G40510DP" | denotes | GlcNAc |
GlycanIUPAC_T242 | 447-453 | "http://rdf.glycoinfo.org/glycan/G61120TK" | denotes | GlcNAc |
GlycanIUPAC_T243 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G61120TK" | denotes | GlcNAc |
GlycanIUPAC_T244 | 447-453 | "http://rdf.glycoinfo.org/glycan/G41342KV" | denotes | GlcNAc |
GlycanIUPAC_T245 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G41342KV" | denotes | GlcNAc |
GlycanIUPAC_T246 | 447-453 | "http://rdf.glycoinfo.org/glycan/G90703NA" | denotes | GlcNAc |
GlycanIUPAC_T247 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G90703NA" | denotes | GlcNAc |
GlycanIUPAC_T248 | 447-453 | "http://rdf.glycoinfo.org/glycan/G01591HR" | denotes | GlcNAc |
GlycanIUPAC_T249 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G01591HR" | denotes | GlcNAc |
GlycanIUPAC_T250 | 447-453 | "http://rdf.glycoinfo.org/glycan/G56520XN" | denotes | GlcNAc |
GlycanIUPAC_T251 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G56520XN" | denotes | GlcNAc |
GlycanIUPAC_T252 | 447-453 | "http://rdf.glycoinfo.org/glycan/G81830JX" | denotes | GlcNAc |
GlycanIUPAC_T253 | 1041-1047 | "http://rdf.glycoinfo.org/glycan/G81830JX" | denotes | GlcNAc |
GlycanIUPAC_T254 | 910-913 | "http://rdf.glycoinfo.org/glycan/G02780QX" | denotes | non |
GlycanIUPAC_T255 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G02780QX" | denotes | non |
GlycanIUPAC_T256 | 910-913 | "http://rdf.glycoinfo.org/glycan/G18425DX" | denotes | non |
GlycanIUPAC_T257 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G18425DX" | denotes | non |
GlycanIUPAC_T258 | 910-913 | "http://rdf.glycoinfo.org/glycan/G18630JE" | denotes | non |
GlycanIUPAC_T259 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G18630JE" | denotes | non |
GlycanIUPAC_T260 | 910-913 | "http://rdf.glycoinfo.org/glycan/G01004IT" | denotes | non |
GlycanIUPAC_T261 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G01004IT" | denotes | non |
GlycanIUPAC_T262 | 910-913 | "http://rdf.glycoinfo.org/glycan/G87301QZ" | denotes | non |
GlycanIUPAC_T263 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G87301QZ" | denotes | non |
GlycanIUPAC_T264 | 910-913 | "http://rdf.glycoinfo.org/glycan/G39790GW" | denotes | non |
GlycanIUPAC_T265 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G39790GW" | denotes | non |
GlycanIUPAC_T266 | 910-913 | "http://rdf.glycoinfo.org/glycan/G42928BB" | denotes | non |
GlycanIUPAC_T267 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G42928BB" | denotes | non |
GlycanIUPAC_T268 | 910-913 | "http://rdf.glycoinfo.org/glycan/G51134HC" | denotes | non |
GlycanIUPAC_T269 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G51134HC" | denotes | non |
GlycanIUPAC_T270 | 910-913 | "http://rdf.glycoinfo.org/glycan/G68183GR" | denotes | non |
GlycanIUPAC_T271 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G68183GR" | denotes | non |
GlycanIUPAC_T272 | 910-913 | "http://rdf.glycoinfo.org/glycan/G46883FA" | denotes | non |
GlycanIUPAC_T273 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G46883FA" | denotes | non |
GlycanIUPAC_T274 | 910-913 | "http://rdf.glycoinfo.org/glycan/G54702VY" | denotes | non |
GlycanIUPAC_T275 | 1398-1401 | "http://rdf.glycoinfo.org/glycan/G54702VY" | denotes | non |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 1206-1211 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 193-207 | Body_part | denotes | cardiac muscle | http://purl.obolibrary.org/obo/MAT_0000453 |
T2 | 1206-1211 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 90-104 | Phenotype | denotes | cardiomyopathy | HP:0001638 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 90-104 | Disease | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0004994 |
T2 | 1901-1909 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 445-453 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T2 | 1039-1047 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 90-104 | Phenotype | denotes | cardiomyopathy | HP:0001638 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 90-104 | Disease | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0004994 |
T2 | 1901-1909 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 517-520 | OrganismTaxon | denotes | rat | 10114|10116 |
T3 | 992-1007 | OrganismTaxon | denotes | Chinese hamster | 10029 |
T4 | 1238-1242 | OrganismTaxon | denotes | rats | 10114|10116 |
GlyCosmos15-CL
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 527-541 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |
T2 | 743-757 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |
T3 | 1375-1389 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |
T4 | 1498-1512 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 138-147 | Body_part | denotes | reticulum | http://purl.obolibrary.org/obo/UBERON_0007361 |
T2 | 193-207 | Body_part | denotes | cardiac muscle | http://purl.obolibrary.org/obo/UBERON_0001133|http://purl.obolibrary.org/obo/UBERON_0002349 |
T4 | 366-377 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
T5 | 527-541 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
T6 | 743-757 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
T7 | 1008-1013 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
T8 | 1206-1211 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
T12 | 1375-1389 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
T13 | 1498-1512 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
GlyCosmos15-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 193-207 | Body_part | denotes | cardiac muscle | http://purl.obolibrary.org/obo/MAT_0000453 |
T2 | 1206-1211 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-105 | Sentence | denotes | Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. |
TextSentencer_T2 | 106-222 | Sentence | denotes | Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. |
TextSentencer_T3 | 223-309 | Sentence | denotes | Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. |
TextSentencer_T4 | 310-542 | Sentence | denotes | Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. |
TextSentencer_T5 | 543-739 | Sentence | denotes | Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation. |
TextSentencer_T6 | 740-928 | Sentence | denotes | In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells. |
TextSentencer_T7 | 929-988 | Sentence | denotes | Simultaneously, Ser(16)-phosphorylation of PLN was reduced. |
TextSentencer_T8 | 989-1171 | Sentence | denotes | In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls. |
TextSentencer_T9 | 1172-1243 | Sentence | denotes | The same results were observed in heart homogenates from diabetic rats. |
TextSentencer_T10 | 1244-1390 | Sentence | denotes | In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes. |
TextSentencer_T11 | 1391-1584 | Sentence | denotes | Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine. |
TextSentencer_T12 | 1585-1738 | Sentence | denotes | These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. |
TextSentencer_T13 | 1739-1910 | Sentence | denotes | This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes. |
T1 | 0-105 | Sentence | denotes | Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. |
T2 | 106-222 | Sentence | denotes | Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. |
T3 | 223-309 | Sentence | denotes | Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. |
T4 | 310-542 | Sentence | denotes | Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. |
T5 | 543-739 | Sentence | denotes | Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation. |
T6 | 740-928 | Sentence | denotes | In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells. |
T7 | 929-988 | Sentence | denotes | Simultaneously, Ser(16)-phosphorylation of PLN was reduced. |
T8 | 989-1171 | Sentence | denotes | In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls. |
T9 | 1172-1243 | Sentence | denotes | The same results were observed in heart homogenates from diabetic rats. |
T10 | 1244-1390 | Sentence | denotes | In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes. |
T11 | 1391-1584 | Sentence | denotes | Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine. |
T12 | 1585-1738 | Sentence | denotes | These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. |
T13 | 1739-1910 | Sentence | denotes | This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes. |
T1 | 0-105 | Sentence | denotes | Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. |
T2 | 106-222 | Sentence | denotes | Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. |
T3 | 223-309 | Sentence | denotes | Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. |
T4 | 310-542 | Sentence | denotes | Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. |
T5 | 543-739 | Sentence | denotes | Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation. |
T6 | 740-928 | Sentence | denotes | In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells. |
T7 | 929-988 | Sentence | denotes | Simultaneously, Ser(16)-phosphorylation of PLN was reduced. |
T8 | 989-1171 | Sentence | denotes | In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls. |
T9 | 1172-1243 | Sentence | denotes | The same results were observed in heart homogenates from diabetic rats. |
T10 | 1244-1390 | Sentence | denotes | In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes. |
T11 | 1391-1584 | Sentence | denotes | Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine. |
T12 | 1585-1738 | Sentence | denotes | These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. |
T13 | 1739-1910 | Sentence | denotes | This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-105 | Sentence | denotes | Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. |
T2 | 106-222 | Sentence | denotes | Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. |
T3 | 223-309 | Sentence | denotes | Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. |
T4 | 310-542 | Sentence | denotes | Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes. |
T5 | 543-739 | Sentence | denotes | Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation. |
T6 | 740-928 | Sentence | denotes | In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells. |
T7 | 929-988 | Sentence | denotes | Simultaneously, Ser(16)-phosphorylation of PLN was reduced. |
T8 | 989-1171 | Sentence | denotes | In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls. |
T9 | 1172-1243 | Sentence | denotes | The same results were observed in heart homogenates from diabetic rats. |
T10 | 1244-1390 | Sentence | denotes | In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes. |
T11 | 1391-1584 | Sentence | denotes | Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine. |
T12 | 1585-1738 | Sentence | denotes | These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. |
T13 | 1739-1910 | Sentence | denotes | This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 445-453 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T2 | 1039-1047 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 445-453 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T2 | 1039-1047 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 517-520 | OrganismTaxon | denotes | rat | 10114|10116 |
T3 | 992-1007 | OrganismTaxon | denotes | Chinese hamster | 10029 |
T4 | 1238-1242 | OrganismTaxon | denotes | rats | 10114|10116 |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 445-453 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T2 | 1039-1047 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 138-147 | Body_part | denotes | reticulum | http://purl.obolibrary.org/obo/UBERON_0007361 |
T2 | 193-207 | Body_part | denotes | cardiac muscle | http://purl.obolibrary.org/obo/UBERON_0001133|http://purl.obolibrary.org/obo/UBERON_0002349 |
T4 | 366-377 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
T5 | 527-541 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
T6 | 743-757 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
T7 | 1008-1013 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
T8 | 1206-1211 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
T12 | 1375-1389 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
T13 | 1498-1512 | Body_part | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL_0000746 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 527-541 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |
T2 | 743-757 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |
T3 | 1375-1389 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |
T4 | 1498-1512 | Cell | denotes | cardiomyocytes | http://purl.obolibrary.org/obo/CL:0000746 |