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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7344 0-7 ChemicalEntity denotes Cocaine MESH:D003042
7345 15-46 DiseaseOrPhenotypicFeature denotes memory and learning impairments MESH:D007859|MESH:D008569
7346 50-54 OrganismTaxon denotes rats NCBITaxon:10116
7347 71-93 GeneOrGeneProduct denotes nuclear factor kappa B NCBIGene:81736
7348 134-144 ChemicalEntity denotes topiramate MESH:D000077236
7349 191-198 ChemicalEntity denotes cocaine MESH:D003042
7350 199-207 DiseaseOrPhenotypicFeature denotes toxicity MESH:D064420
7351 312-319 ChemicalEntity denotes cocaine MESH:D003042
7352 360-382 GeneOrGeneProduct denotes Nuclear factor kappa B NCBIGene:81736
7353 384-392 GeneOrGeneProduct denotes NFkappaB NCBIGene:81736
7354 494-502 DiseaseOrPhenotypicFeature denotes toxicity MESH:D064420
7355 539-547 GeneOrGeneProduct denotes NFkappaB NCBIGene:81736
7356 576-606 GeneOrGeneProduct denotes neuronal nitric oxide synthase NCBIGene:24598
7357 608-612 GeneOrGeneProduct denotes nNOS NCBIGene:24598
7358 677-687 ChemicalEntity denotes topiramate MESH:D000077236
7359 723-740 DiseaseOrPhenotypicFeature denotes cocaine addiction MESH:D019970
7360 785-792 ChemicalEntity denotes cocaine MESH:D003042
7361 811-815 OrganismTaxon denotes rats NCBITaxon:10116
7362 817-825 GeneOrGeneProduct denotes NFkappaB NCBIGene:81736
7363 874-881 ChemicalEntity denotes cocaine MESH:D003042
7364 890-894 OrganismTaxon denotes rats NCBITaxon:10116
7365 907-910 ChemicalEntity denotes GSH MESH:D005978
7366 929-940 ChemicalEntity denotes glutathione MESH:D005978
7367 989-993 GeneOrGeneProduct denotes nNOS NCBIGene:24598
7368 1087-1094 ChemicalEntity denotes cocaine MESH:D003042
7369 1154-1162 GeneOrGeneProduct denotes NFkappaB NCBIGene:81736
7370 1279-1283 GeneOrGeneProduct denotes nNOS NCBIGene:24598
7371 1313-1324 ChemicalEntity denotes glutathione MESH:D005978
7372 1440-1448 GeneOrGeneProduct denotes NFkappaB NCBIGene:81736
7373 1479-1486 ChemicalEntity denotes cocaine MESH:D003042
7374 1488-1498 ChemicalEntity denotes Topiramate MESH:D000077236

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-145 Sentence denotes Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramate.
T2 146-359 Sentence denotes Different mechanisms have been suggested for cocaine toxicity including an increase in oxidative stress but the association between oxidative status in the brain and cocaine induced-behaviour is poorly understood.
T3 360-528 Sentence denotes Nuclear factor kappa B (NFkappaB) is a sensor of oxidative stress and participates in memory formation that could be involved in drug toxicity and addiction mechanisms.
T4 529-816 Sentence denotes Therefore NFkappaB activity, oxidative stress, neuronal nitric oxide synthase (nNOS) activity, spatial learning and memory as well as the effect of topiramate, a previously proposed therapy for cocaine addiction, were evaluated in an experimental model of cocaine administration in rats.
T5 817-1036 Sentence denotes NFkappaB activity was decreased in the frontal cortex of cocaine treated rats, as well as GSH concentration and glutathione peroxidase activity in the hippocampus, whereas nNOS activity in the hippocampus was increased.
T6 1037-1194 Sentence denotes Memory retrieval of experiences acquired prior to cocaine administration was impaired and negatively correlated with NFkappaB activity in the frontal cortex.
T7 1195-1336 Sentence denotes In contrast, learning of new tasks was enhanced and correlated with the increase of nNOS activity and the decrease of glutathione peroxidase.
T8 1337-1487 Sentence denotes These results provide evidence for a possible mechanistic role of oxidative and nitrosative stress and NFkappaB in the alterations induced by cocaine.
T9 1488-1580 Sentence denotes Topiramate prevented all the alterations observed, showing novel neuroprotective properties.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 50-54 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T4 811-815 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T7 890-894 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T10 968-979 OrganismTaxon denotes hippocampus NCBItxid:72046
T11 1010-1021 OrganismTaxon denotes hippocampus NCBItxid:72046

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 576-584 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T2 1069-1077 DiseaseOrPhenotypicFeature denotes acquired 0021141

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 71-93 GeneOrGeneProduct denotes nuclear factor kappa B
T2 302-307 GeneOrGeneProduct denotes brain
T3 320-327 GeneOrGeneProduct denotes induced
T4 360-374 GeneOrGeneProduct denotes Nuclear factor
T5 375-380 GeneOrGeneProduct denotes kappa
T6 384-392 GeneOrGeneProduct denotes NFkappaB
T7 453-462 GeneOrGeneProduct denotes formation
T8 539-547 GeneOrGeneProduct denotes NFkappaB
T9 548-556 GeneOrGeneProduct denotes activity
T10 576-606 GeneOrGeneProduct denotes neuronal nitric oxide synthase
T11 608-612 GeneOrGeneProduct denotes nNOS
T12 614-622 GeneOrGeneProduct denotes activity
T13 624-631 GeneOrGeneProduct denotes spatial
T14 817-825 GeneOrGeneProduct denotes NFkappaB
T15 826-834 GeneOrGeneProduct denotes activity
T16 864-870 GeneOrGeneProduct denotes cortex
T17 929-951 GeneOrGeneProduct denotes glutathione peroxidase
T18 952-960 GeneOrGeneProduct denotes activity
T19 989-993 GeneOrGeneProduct denotes nNOS
T20 994-1002 GeneOrGeneProduct denotes activity
T21 1154-1162 GeneOrGeneProduct denotes NFkappaB
T22 1163-1171 GeneOrGeneProduct denotes activity
T23 1187-1193 GeneOrGeneProduct denotes cortex
T24 1198-1206 GeneOrGeneProduct denotes contrast
T25 1224-1229 GeneOrGeneProduct denotes tasks
T26 1279-1283 GeneOrGeneProduct denotes nNOS
T27 1284-1292 GeneOrGeneProduct denotes activity
T28 1313-1335 GeneOrGeneProduct denotes glutathione peroxidase
T29 1440-1448 GeneOrGeneProduct denotes NFkappaB
T30 1468-1475 GeneOrGeneProduct denotes induced
T31 1509-1512 GeneOrGeneProduct denotes all
T32 1547-1552 GeneOrGeneProduct denotes novel

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 71-93 GeneOrGeneProduct denotes nuclear factor kappa B
T2 302-307 GeneOrGeneProduct denotes brain
T3 360-374 GeneOrGeneProduct denotes Nuclear factor
T4 375-380 GeneOrGeneProduct denotes kappa
T5 384-392 GeneOrGeneProduct denotes NFkappaB
T6 539-547 GeneOrGeneProduct denotes NFkappaB
T7 576-606 GeneOrGeneProduct denotes neuronal nitric oxide synthase
T8 608-612 GeneOrGeneProduct denotes nNOS
T9 624-631 GeneOrGeneProduct denotes spatial
T10 817-825 GeneOrGeneProduct denotes NFkappaB
T11 864-870 GeneOrGeneProduct denotes cortex
T12 929-951 GeneOrGeneProduct denotes glutathione peroxidase
T13 989-993 GeneOrGeneProduct denotes nNOS
T14 1154-1162 GeneOrGeneProduct denotes NFkappaB
T15 1187-1193 GeneOrGeneProduct denotes cortex
T16 1279-1283 GeneOrGeneProduct denotes nNOS
T17 1313-1335 GeneOrGeneProduct denotes glutathione peroxidase
T18 1440-1448 GeneOrGeneProduct denotes NFkappaB
T19 1547-1552 GeneOrGeneProduct denotes novel

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 199-207 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T2 489-502 DiseaseOrPhenotypicFeature denotes drug toxicity D064420
T3 723-740 DiseaseOrPhenotypicFeature denotes cocaine addiction D019970

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 723-740 DiseaseOrPhenotypicFeature denotes cocaine addiction 0005186

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 71-93 GeneOrGeneProduct denotes nuclear factor kappa B
T2 360-374 GeneOrGeneProduct denotes Nuclear factor
T3 384-392 GeneOrGeneProduct denotes NFkappaB
T4 539-547 GeneOrGeneProduct denotes NFkappaB
T5 576-606 GeneOrGeneProduct denotes neuronal nitric oxide synthase
T6 608-612 GeneOrGeneProduct denotes nNOS
T7 817-825 GeneOrGeneProduct denotes NFkappaB
T8 941-951 GeneOrGeneProduct denotes peroxidase
T9 989-993 GeneOrGeneProduct denotes nNOS
T10 1154-1162 GeneOrGeneProduct denotes NFkappaB
T11 1279-1283 GeneOrGeneProduct denotes nNOS
T12 1325-1335 GeneOrGeneProduct denotes peroxidase
T13 1440-1448 GeneOrGeneProduct denotes NFkappaB

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 15-46 DiseaseOrPhenotypicFeature denotes memory and learning impairments DISEASE
T2 199-207 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T3 489-502 DiseaseOrPhenotypicFeature denotes drug toxicity D064420
T4 723-740 DiseaseOrPhenotypicFeature denotes cocaine addiction D019970

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 15-46 DiseaseOrPhenotypicFeature denotes memory and learning impairments DISEASE
T2 199-207 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T3 489-502 DiseaseOrPhenotypicFeature denotes drug toxicity D064420
T4 723-740 DiseaseOrPhenotypicFeature denotes cocaine addiction D019970

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-7 ChemicalEntity denotes Cocaine http://purl.obolibrary.org/obo/CHEBI_27958
T2 134-144 ChemicalEntity denotes topiramate D000077236|http://purl.obolibrary.org/obo/CHEBI_63631
T4 191-198 ChemicalEntity denotes cocaine D003042|http://purl.obolibrary.org/obo/CHEBI_60056|http://purl.obolibrary.org/obo/CHEBI_27958
T7 312-319 ChemicalEntity denotes cocaine D003042|http://purl.obolibrary.org/obo/CHEBI_60056|http://purl.obolibrary.org/obo/CHEBI_27958
T10 576-606 ChemicalEntity denotes neuronal nitric oxide synthase D052248
T11 677-687 ChemicalEntity denotes topiramate D000077236|http://purl.obolibrary.org/obo/CHEBI_63631
T13 723-730 ChemicalEntity denotes cocaine D003042|http://purl.obolibrary.org/obo/CHEBI_60056|http://purl.obolibrary.org/obo/CHEBI_27958
T16 785-792 ChemicalEntity denotes cocaine D003042|http://purl.obolibrary.org/obo/CHEBI_60056|http://purl.obolibrary.org/obo/CHEBI_27958
T19 874-881 ChemicalEntity denotes cocaine D003042|http://purl.obolibrary.org/obo/CHEBI_60056|http://purl.obolibrary.org/obo/CHEBI_27958
T22 907-910 ChemicalEntity denotes GSH http://purl.obolibrary.org/obo/CHEBI_16856
T23 929-951 ChemicalEntity denotes glutathione peroxidase D005979
T24 1087-1094 ChemicalEntity denotes cocaine D003042|http://purl.obolibrary.org/obo/CHEBI_60056|http://purl.obolibrary.org/obo/CHEBI_27958
T27 1313-1335 ChemicalEntity denotes glutathione peroxidase D005979
T28 1479-1486 ChemicalEntity denotes cocaine D003042|http://purl.obolibrary.org/obo/CHEBI_60056|http://purl.obolibrary.org/obo/CHEBI_27958
T31 1488-1498 ChemicalEntity denotes Topiramate http://purl.obolibrary.org/obo/CHEBI_63631

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 50-54 OrganismTaxon denotes rats
T2 811-815 OrganismTaxon denotes rats
T3 890-894 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T31 1488-1498 ChemicalEntity denotes Topiramate http://purl.obolibrary.org/obo/CHEBI_63631
T28 1479-1486 ChemicalEntity denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056|D003042
T27 1313-1335 ChemicalEntity denotes glutathione peroxidase D005979
T24 1087-1094 ChemicalEntity denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056|D003042
T23 929-951 ChemicalEntity denotes glutathione peroxidase D005979
T22 907-910 ChemicalEntity denotes GSH http://purl.obolibrary.org/obo/CHEBI_16856
T19 874-881 ChemicalEntity denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056|D003042
T16 785-792 ChemicalEntity denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056|D003042
T13 723-730 ChemicalEntity denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056|D003042
T11 677-687 ChemicalEntity denotes topiramate http://purl.obolibrary.org/obo/CHEBI_63631|D000077236
T10 576-606 ChemicalEntity denotes neuronal nitric oxide synthase D052248
T7 312-319 ChemicalEntity denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056|D003042
T4 191-198 ChemicalEntity denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056|D003042
T2 134-144 ChemicalEntity denotes topiramate http://purl.obolibrary.org/obo/CHEBI_63631|D000077236
T1 0-7 ChemicalEntity denotes Cocaine http://purl.obolibrary.org/obo/CHEBI_27958
T8133 1440-1448 GeneOrGeneProduct denotes NFkappaB
T12 1325-1335 GeneOrGeneProduct denotes peroxidase
T94342 1279-1283 GeneOrGeneProduct denotes nNOS
T86019 1154-1162 GeneOrGeneProduct denotes NFkappaB
T9 989-993 GeneOrGeneProduct denotes nNOS
T8 941-951 GeneOrGeneProduct denotes peroxidase
T71620 817-825 GeneOrGeneProduct denotes NFkappaB
T6 608-612 GeneOrGeneProduct denotes nNOS
T5 576-606 GeneOrGeneProduct denotes neuronal nitric oxide synthase
T64439 539-547 GeneOrGeneProduct denotes NFkappaB
T3 384-392 GeneOrGeneProduct denotes NFkappaB
T98929 360-374 GeneOrGeneProduct denotes Nuclear factor
T20366 71-93 GeneOrGeneProduct denotes nuclear factor kappa B
T8370 723-740 DiseaseOrPhenotypicFeature denotes cocaine addiction D019970
T56954 489-502 DiseaseOrPhenotypicFeature denotes drug toxicity D064420
T88420 199-207 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T66664 15-46 DiseaseOrPhenotypicFeature denotes memory and learning impairments DISEASE
T77430 890-894 OrganismTaxon denotes rats
T82136 811-815 OrganismTaxon denotes rats
T84808 50-54 OrganismTaxon denotes rats

Allie

Id Subject Object Predicate Lexical cue
SS1_20477932_2_0 360-382 expanded denotes Nuclear factor kappa B
SS2_20477932_2_0 384-392 abbr denotes NFkappaB
SS1_20477932_3_0 576-606 expanded denotes neuronal nitric oxide synthase
SS2_20477932_3_0 608-612 abbr denotes nNOS
AE1_20477932_2_0 SS1_20477932_2_0 SS2_20477932_2_0 abbreviatedTo Nuclear factor kappa B,NFkappaB
AE1_20477932_3_0 SS1_20477932_3_0 SS2_20477932_3_0 abbreviatedTo neuronal nitric oxide synthase,nNOS