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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 D006801 denotes Human
T2 10-16 UBERON:0000310 denotes breast
T3 10-32 CL:0002327 denotes breast epithelial cell
T5 39-44 CVCL_Z366 denotes mimic
T6 45-51 UBERON:0000310 denotes breast
T7 45-58 D001943 denotes breast cancer
T8 45-58 D001943 denotes breast cancer
T9 116-120 SO:0000704 denotes gene
T10 116-131 GO:0010467 denotes gene expression
T11 148-154 UBERON:0000310 denotes breast
T12 148-161 D001943 denotes breast cancer
T13 148-161 D001943 denotes breast cancer
T14 243-270 D002285 denotes atypical ductal hyperplasia
T15 243-270 D002285 denotes atypical ductal hyperplasia
T18 272-275 P0A388 denotes ADH
T19 272-275 PR:P06525 denotes ADH
T20 272-275 Q8NXU1 denotes ADH
T21 272-275 Q6GBM4 denotes ADH
T22 272-275 Q47945 denotes ADH
T23 272-275 P0A389 denotes ADH
T24 272-275 Q5HRD6 denotes ADH
T25 272-275 P28036 denotes ADH
T26 272-275 P42327 denotes ADH
T27 272-275 PR:P00332 denotes ADH
T30 272-275 P81786 denotes ADH
T31 272-275 P18278 denotes ADH
T32 272-275 Q44002 denotes ADH
T33 272-275 Q7A742 denotes ADH
T34 272-275 O05542 denotes ADH
T35 272-275 Q2YSX0 denotes ADH
T36 272-275 Q6GJ63 denotes ADH
T37 272-275 PR:P00334 denotes ADH
T39 272-275 Q24857 denotes ADH
T40 272-275 Q8CQ56 denotes ADH
T41 272-275 Q2FJ31 denotes ADH
T42 272-275 Q2G0G1 denotes ADH
T43 272-275 PR:Q2G0G1 denotes ADH
T45 272-275 Q5HI63 denotes ADH
T46 272-275 Q99W07 denotes ADH
T47 272-275 Q04983 denotes ADH
T28 272-275 CHEBI:34543 denotes ADH
T44 272-275 CHEBI:9937 denotes ADH
T29 272-275 GO:0047636 denotes ADH
T38 272-275 GO:0004022 denotes ADH
T50 278-302 D002285 denotes ductal carcinoma in situ
T51 278-302 D002285 denotes ductal carcinoma in situ
T57 304-308 CVCL_5552 denotes DCIS
T56 304-308 D002285 denotes DCIS
T58 304-308 D002285 denotes DCIS
T59 331-340 D002277 denotes carcinoma
T60 331-340 D002277 denotes carcinoma
T61 385-391 SO:0000987 denotes linear
T62 461-465 SO:0000704 denotes gene
T63 461-476 GO:0010467 denotes gene expression
T64 492-498 UBERON:0000310 denotes breast
T65 642-652 SO:1000009 denotes transition
T66 774-780 UBERON:0000310 denotes breast
T67 774-787 D001943 denotes breast cancer
T68 774-787 D001943 denotes breast cancer
T69 831-836 D009369 denotes tumor
T70 831-836 D009369 denotes tumor
T71 892-898 CL:0000084 denotes T cell
T72 912-917 CVCL_Z366 denotes mimic
T73 937-942 D006801 denotes human
T74 943-949 UBERON:0000310 denotes breast
T75 943-956 D001943 denotes breast cancer
T76 943-956 D001943 denotes breast cancer
T77 970-974 CVCL_7934 denotes 21PT
T78 990-993 P0A388 denotes ADH
T79 990-993 PR:P06525 denotes ADH
T80 990-993 Q8NXU1 denotes ADH
T81 990-993 Q6GBM4 denotes ADH
T82 990-993 Q47945 denotes ADH
T83 990-993 P0A389 denotes ADH
T84 990-993 Q5HRD6 denotes ADH
T85 990-993 P28036 denotes ADH
T86 990-993 P42327 denotes ADH
T87 990-993 PR:P00332 denotes ADH
T90 990-993 P81786 denotes ADH
T91 990-993 P18278 denotes ADH
T92 990-993 Q44002 denotes ADH
T93 990-993 Q7A742 denotes ADH
T94 990-993 O05542 denotes ADH
T95 990-993 Q2YSX0 denotes ADH
T96 990-993 Q6GJ63 denotes ADH
T97 990-993 PR:P00334 denotes ADH
T99 990-993 Q24857 denotes ADH
T100 990-993 Q8CQ56 denotes ADH
T101 990-993 Q2FJ31 denotes ADH
T102 990-993 Q2G0G1 denotes ADH
T103 990-993 PR:Q2G0G1 denotes ADH
T105 990-993 Q5HI63 denotes ADH
T106 990-993 Q99W07 denotes ADH
T107 990-993 Q04983 denotes ADH
T88 990-993 CHEBI:34543 denotes ADH
T104 990-993 CHEBI:9937 denotes ADH
T89 990-993 GO:0047636 denotes ADH
T98 990-993 GO:0004022 denotes ADH
T108 995-999 CVCL_7933 denotes 21NT
T110 1015-1019 CVCL_5552 denotes DCIS
T109 1015-1019 D002285 denotes DCIS
T111 1015-1019 D002285 denotes DCIS
T112 1021-1027 CVCL_7931 denotes 21MT-1
T113 1023-1027 O13269 denotes MT-1
T114 1023-1027 P43396 denotes MT-1
T115 1023-1027 P61874 denotes MT-1
T116 1023-1027 P81030 denotes MT-1
T117 1023-1027 PR:Q96290 denotes MT-1
T118 1023-1027 P02803 denotes MT-1
T119 1023-1027 O19000 denotes MT-1
T121 1023-1027 PR:P02802 denotes MT-1
T122 1023-1027 P15786 denotes MT-1
T123 1023-1027 PR:P02803 denotes MT-1
T124 1023-1027 P02804 denotes MT-1
T125 1023-1027 P58280 denotes MT-1
T126 1023-1027 P15113 denotes MT-1
T127 1023-1027 Q39511 denotes MT-1
T128 1023-1027 P61873 denotes MT-1
T130 1023-1027 O97388 denotes MT-1
T131 1023-1027 P17511 denotes MT-1
T132 1023-1027 P55942 denotes MT-1
T133 1023-1027 P04357 denotes MT-1
T134 1023-1027 P26571 denotes MT-1
T136 1023-1027 P02802 denotes MT-1
T137 1023-1027 O24528 denotes MT-1
T139 1023-1027 P43400 denotes MT-1
T140 1023-1027 P02805 denotes MT-1
T141 1023-1027 Q9BT22 denotes MT-1
T142 1023-1027 PR:000010925 denotes MT-1
T143 1023-1027 Q39458 denotes MT-1
T144 1023-1027 PR:000003937 denotes MT-1
T145 1023-1027 P02797 denotes MT-1
T146 1023-1027 P52722 denotes MT-1
T147 1023-1027 P20238 denotes MT-1
T148 1023-1027 P30571 denotes MT-1
T149 1023-1027 P20830 denotes MT-1
T150 1023-1027 O48951 denotes MT-1
T151 1023-1027 P41927 denotes MT-1
T152 1023-1027 P80394 denotes MT-1
T153 1023-1027 Q8T6B3 denotes MT-1
T120 1023-1027 GO:0047152 denotes MT-1
T129 1023-1027 GO:0043791 denotes MT-1
T138 1023-1027 GO:0043834 denotes MT-1
T154 1058-1073 UBERON:0012282 denotes mammary fat pad
T156 1066-1069 CHEBI:24021 denotes fat
T160 1070-1073 O07006 denotes pad
T161 1070-1073 P33751 denotes pad
T162 1070-1073 PR:000022589 denotes pad
T163 1070-1073 C0H3U9 denotes pad
T164 1070-1073 O06837 denotes pad
T165 1070-1073 Q8X7Z8 denotes pad
T166 1070-1073 Q9X697 denotes pad
T167 1070-1073 Q9X698 denotes pad
T168 1070-1073 Q7DBA7 denotes pad
T169 1070-1073 P94404 denotes pad
T170 1070-1073 Q4R101 denotes pad
T171 1070-1073 Q9KPX2 denotes pad
T172 1070-1073 Q9S4M7 denotes pad
T173 1070-1073 P69772 denotes pad
T174 1070-1073 Q4R102 denotes pad
T175 1070-1073 Q9X696 denotes pad
T176 1070-1073 P94405 denotes pad
T177 1070-1073 P80668 denotes pad
T178 1077-1081 PR:Q9CZA6 denotes nude
T179 1077-1081 PR:Q9VT70 denotes nude
T180 1077-1081 Q9CZA6 denotes nude
T181 1077-1081 PR:000023423 denotes nude
T182 1077-1081 PR:P45799 denotes nude
T183 1077-1081 PR:000011051 denotes nude
T184 1077-1081 PR:Q9NXR1 denotes nude
T185 1077-1081 Q9ES39 denotes nude
T186 1077-1081 Q9NXR1 denotes nude
T187 1077-1081 PR:Q9ES39 denotes nude
T188 1077-1086 10090 denotes nude mice
T189 1077-1086 D008819 denotes nude mice
T190 1082-1086 PR:000005054 denotes mice
T192 1082-1086 O89094 denotes mice
T195 1256-1264 C059485 denotes Matrigel
T197 1316-1324 C059485 denotes Matrigel
T198 1470-1479 GO:0009058 denotes formation
T199 1481-1498 GO:0030010 denotes cell polarization
T200 1500-1517 GO:0007149 denotes colony morphology
T201 1500-1517 GO:0001403 denotes colony morphology
T202 1519-1537 GO:0008283 denotes cell proliferation
T203 1524-1537 UBERON:2000098 denotes proliferation
T204 1600-1615 GO:0010467 denotes Gene expression
T205 1713-1720 CHEBI:34922 denotes pathway
T206 1775-1785 SO:1000009 denotes transition
T207 1799-1802 P0A388 denotes ADH
T208 1799-1802 PR:P06525 denotes ADH
T209 1799-1802 Q8NXU1 denotes ADH
T210 1799-1802 Q6GBM4 denotes ADH
T211 1799-1802 Q47945 denotes ADH
T212 1799-1802 P0A389 denotes ADH
T213 1799-1802 Q5HRD6 denotes ADH
T214 1799-1802 P28036 denotes ADH
T215 1799-1802 P42327 denotes ADH
T216 1799-1802 PR:P00332 denotes ADH
T219 1799-1802 P81786 denotes ADH
T220 1799-1802 P18278 denotes ADH
T221 1799-1802 Q44002 denotes ADH
T222 1799-1802 Q7A742 denotes ADH
T223 1799-1802 O05542 denotes ADH
T224 1799-1802 Q2YSX0 denotes ADH
T225 1799-1802 Q6GJ63 denotes ADH
T226 1799-1802 PR:P00334 denotes ADH
T228 1799-1802 Q24857 denotes ADH
T229 1799-1802 Q8CQ56 denotes ADH
T230 1799-1802 Q2FJ31 denotes ADH
T231 1799-1802 Q2G0G1 denotes ADH
T232 1799-1802 PR:Q2G0G1 denotes ADH
T234 1799-1802 Q5HI63 denotes ADH
T235 1799-1802 Q99W07 denotes ADH
T236 1799-1802 Q04983 denotes ADH
T217 1799-1802 CHEBI:34543 denotes ADH
T233 1799-1802 CHEBI:9937 denotes ADH
T218 1799-1802 GO:0047636 denotes ADH
T227 1799-1802 GO:0004022 denotes ADH
T238 1815-1819 CVCL_5552 denotes DCIS
T237 1815-1819 D002285 denotes DCIS
T239 1815-1819 D002285 denotes DCIS
T240 1892-1905 GO:0048870 denotes cell motility
T241 1961-1971 SO:1000009 denotes transition
T243 1983-1987 CVCL_5552 denotes DCIS
T242 1983-1987 D002285 denotes DCIS
T244 1983-1987 D002285 denotes DCIS
T245 1992-1998 CVCL_7931 denotes 21MT-1
T246 1994-1998 O13269 denotes MT-1
T247 1994-1998 P43396 denotes MT-1
T248 1994-1998 P61874 denotes MT-1
T249 1994-1998 P81030 denotes MT-1
T250 1994-1998 PR:Q96290 denotes MT-1
T251 1994-1998 P02803 denotes MT-1
T252 1994-1998 O19000 denotes MT-1
T254 1994-1998 PR:P02802 denotes MT-1
T255 1994-1998 P15786 denotes MT-1
T256 1994-1998 PR:P02803 denotes MT-1
T257 1994-1998 P02804 denotes MT-1
T258 1994-1998 P58280 denotes MT-1
T259 1994-1998 P15113 denotes MT-1
T260 1994-1998 Q39511 denotes MT-1
T261 1994-1998 P61873 denotes MT-1
T263 1994-1998 O97388 denotes MT-1
T264 1994-1998 P17511 denotes MT-1
T265 1994-1998 P55942 denotes MT-1
T266 1994-1998 P04357 denotes MT-1
T267 1994-1998 P26571 denotes MT-1
T269 1994-1998 P02802 denotes MT-1
T270 1994-1998 O24528 denotes MT-1
T272 1994-1998 P43400 denotes MT-1
T273 1994-1998 P02805 denotes MT-1
T274 1994-1998 Q9BT22 denotes MT-1
T275 1994-1998 PR:000010925 denotes MT-1
T276 1994-1998 Q39458 denotes MT-1
T277 1994-1998 PR:000003937 denotes MT-1
T278 1994-1998 P02797 denotes MT-1
T279 1994-1998 P52722 denotes MT-1
T280 1994-1998 P20238 denotes MT-1
T281 1994-1998 P30571 denotes MT-1
T282 1994-1998 P20830 denotes MT-1
T283 1994-1998 O48951 denotes MT-1
T284 1994-1998 P41927 denotes MT-1
T285 1994-1998 P80394 denotes MT-1
T286 1994-1998 Q8T6B3 denotes MT-1
T253 1994-1998 GO:0047152 denotes MT-1
T262 1994-1998 GO:0043791 denotes MT-1
T271 1994-1998 GO:0043834 denotes MT-1
T288 2171-2174 PR:Q8LLD0 denotes pre
T290 2171-2174 UBERON:0001782 denotes pre
T289 2171-2174 SO:0002045 denotes pre
T287 2171-2174 GO:0003904 denotes pre

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 148-161 HP_0003002 denotes breast cancer
T2 148-161 HP_0100013 denotes breast cancer
T3 155-161 HP_0002664 denotes cancer
T4 774-787 HP_0003002 denotes breast cancer
T5 774-787 HP_0100013 denotes breast cancer
T6 781-787 HP_0002664 denotes cancer
T7 831-836 HP_0002664 denotes tumor
T8 943-956 HP_0003002 denotes breast cancer
T9 943-956 HP_0100013 denotes breast cancer
T10 950-956 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_20458274_1_0 243-270 expanded denotes atypical ductal hyperplasia
SS2_20458274_1_0 272-275 abbr denotes ADH
SS1_20458274_1_1 278-302 expanded denotes ductal carcinoma in situ
SS2_20458274_1_1 304-308 abbr denotes DCIS
SS1_20458274_1_2 314-340 expanded denotes invasive mammary carcinoma
SS2_20458274_1_2 342-345 abbr denotes IMC
AE1_20458274_1_0 SS1_20458274_1_0 SS2_20458274_1_0 abbreviatedTo atypical ductal hyperplasia,ADH
AE1_20458274_1_1 SS1_20458274_1_1 SS2_20458274_1_1 abbreviatedTo ductal carcinoma in situ,DCIS
AE1_20458274_1_2 SS1_20458274_1_2 SS2_20458274_1_2 abbreviatedTo invasive mammary carcinoma,IMC

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 142-400 DRI_Background denotes Early breast cancer progression involves advancement through specific morphological stages including atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive mammary carcinoma (IMC), although not necessarily always in a linear fashion.
T2 401-685 DRI_Background denotes Observational studies have examined genetic, epigenetic and gene expression differences in breast tissues representing these stages of progression, but model systems which would allow for experimental testing of specific factors influencing transition through these stages are scarce.
T3 686-856 DRI_Approach denotes The 21T series cell lines, all originally derived from the same patient with metastatic breast cancer, have been proposed to represent a mammary tumor progression series.
T4 857-1108 DRI_Outcome denotes We report here that three of the 21T cell lines indeed mimic specific stages of human breast cancer progression (21PT-derived cells, ADH; 21NT-derived cells, DCIS; 21MT-1 cells, IMC) when grown in the mammary fat pad of nude mice, albeit after a year.
T5 1109-1272 DRI_Background denotes To develop a more rapid, readily manipulatable in vitro assay for examining the biological differences between these cell lines, we have used a 3D Matrigel system.
T6 1273-1599 DRI_Background denotes When the three cell lines were grown in 3D Matrigel, they showed characteristic morphologies, in which quantifiable aspects of stage-specific in vivo behaviors (ie, differences in acinar structure formation, cell polarization, colony morphology, cell proliferation, cell invasion) were recapitulated in a reproducible fashion.
T7 1600-1693 DRI_Approach denotes Gene expression profiling revealed a characteristic pattern for each of the three cell lines.
T8 1694-2005 DRI_Background denotes Interestingly, Wnt pathway alterations are particularly predominant in the early transition from 21PTci (ADH) to 21NTci (DCIS), whereas alterations in expression of genes associated with control of cell motility and invasion phenomena are more prominent in the later transition of 21NTci (DCIS) to 21MT-1 (IMC).
T9 2006-2205 DRI_Challenge denotes This system thus reveals potential therapeutic targets and will provide a means of testing the influences of identified genes on transitions between these stages of pre-malignant to malignant growth.