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GoldHamster

Id Subject Object Predicate Lexical cue
T1 26-37 P02719 denotes Na+ channel
T8 39-42 UBERON:0002034 denotes SCN
T3 39-42 CHEBI:29441 denotes SCN
T5 39-42 CHEBI:29425 denotes SCN
T13 39-42 CHEBI:18022 denotes SCN
T16 39-42 CHEBI:29426 denotes SCN
T17 39-43 615285 denotes SCN5
T18 39-44 PR:000002101 denotes SCN5A
T19 39-44 PR:P15389 denotes SCN5A
T20 39-44 PR:Q14524 denotes SCN5A
T21 39-44 PR:Q9JJV9 denotes SCN5A
T22 91-95 PR:Q9VIQ9 denotes sick
T23 91-110 D012804 denotes sick sinus syndrome
T24 91-110 D012804 denotes sick sinus syndrome
T25 96-101 UBERON:0001825 denotes sinus
T26 132-136 PR:Q9VIQ9 denotes sick
T27 132-151 D012804 denotes sick sinus syndrome
T28 132-151 D012804 denotes sick sinus syndrome
T29 137-142 UBERON:0001825 denotes sinus
T30 153-156 F1CKJ1 denotes SSS
T31 153-156 PR:B5A5T4 denotes SSS
T34 153-156 O81193 denotes SSS
T35 153-156 Q9FNF2 denotes SSS
T32 153-156 CHEBI:29834 denotes SSS
T33 153-156 CHEBI:29399 denotes SSS
T42 211-214 UBERON:0002034 denotes SCN
T37 211-214 CHEBI:29441 denotes SCN
T39 211-214 CHEBI:29425 denotes SCN
T47 211-214 CHEBI:18022 denotes SCN
T50 211-214 CHEBI:29426 denotes SCN
T51 211-215 615285 denotes SCN5
T52 211-216 PR:000002101 denotes SCN5A
T53 211-216 PR:P15389 denotes SCN5A
T54 211-216 PR:Q14524 denotes SCN5A
T55 211-216 PR:Q9JJV9 denotes SCN5A
T56 217-221 SO:0000704 denotes gene
T57 312-318 CHEBI:13412 denotes Na) in
T59 400-410 UBERON:0002351 denotes sinus node
T62 400-422 D012804 denotes sinus node dysfunction
T63 400-422 D012804 denotes sinus node dysfunction
T65 426-429 F1CKJ1 denotes SSS
T66 426-429 PR:B5A5T4 denotes SSS
T69 426-429 O81193 denotes SSS
T70 426-429 Q9FNF2 denotes SSS
T67 426-429 CHEBI:29834 denotes SSS
T68 426-429 CHEBI:29399 denotes SSS
T77 491-494 UBERON:0002034 denotes SCN
T72 491-494 CHEBI:29441 denotes SCN
T74 491-494 CHEBI:29425 denotes SCN
T82 491-494 CHEBI:18022 denotes SCN
T85 491-494 CHEBI:29426 denotes SCN
T86 491-495 615285 denotes SCN5
T87 491-496 PR:000002101 denotes SCN5A
T88 491-496 PR:P15389 denotes SCN5A
T89 491-496 PR:Q14524 denotes SCN5A
T90 491-496 PR:Q9JJV9 denotes SCN5A
T91 542-545 1481724 denotes AND
T92 555-561 CHEBI:5133 denotes Action
T93 555-571 GO:0001508 denotes Action potential
T95 588-594 813859 denotes rabbit
T94 588-594 D011817 denotes rabbit
T96 588-594 9986 denotes rabbit
T97 595-610 UBERON:0002351 denotes sinoatrial node
T99 612-615 PR:000010998 denotes SAN
T106 713-716 UBERON:0002034 denotes SCN
T101 713-716 CHEBI:29441 denotes SCN
T103 713-716 CHEBI:29425 denotes SCN
T111 713-716 CHEBI:18022 denotes SCN
T114 713-716 CHEBI:29426 denotes SCN
T115 713-717 615285 denotes SCN5
T116 713-718 PR:000002101 denotes SCN5A
T117 713-718 PR:P15389 denotes SCN5A
T118 713-718 PR:Q14524 denotes SCN5A
T119 713-718 PR:Q9JJV9 denotes SCN5A
T120 719-723 SO:0000704 denotes gene
T121 889-892 PR:000010998 denotes SAN
T122 893-899 UBERON:0003165 denotes atrium
T123 893-899 UBERON:0002081 denotes atrium
T124 930-941 UBERON:0001759 denotes vagal nerve
T126 996-1002 UBERON:0000479 denotes tissue
T127 1039-1052 GO:0005576 denotes extracellular
T128 1108-1111 PR:000010998 denotes SAN
T129 1112-1118 UBERON:0003165 denotes atrium
T130 1112-1118 UBERON:0002081 denotes atrium
T131 1285-1288 PR:000010998 denotes SAN
T132 1318-1324 GO:0048511 denotes rhythm
T133 1338-1344 UBERON:0000479 denotes tissue
T134 1451-1454 PR:000010998 denotes SAN
T135 1455-1461 UBERON:0003165 denotes atrium
T136 1455-1461 UBERON:0002081 denotes atrium
T138 1485-1488 PR:000010998 denotes SAN
T139 1503-1508 UBERON:0001825 denotes sinus
T140 1539-1542 F1CKJ1 denotes SSS
T141 1539-1542 PR:B5A5T4 denotes SSS
T144 1539-1542 O81193 denotes SSS
T145 1539-1542 Q9FNF2 denotes SSS
T142 1539-1542 CHEBI:29834 denotes SSS
T143 1539-1542 CHEBI:29399 denotes SSS
T146 1554-1565 UBERON:0001759 denotes vagal nerve
T154 1642-1645 UBERON:0002034 denotes SCN
T149 1642-1645 CHEBI:29441 denotes SCN
T151 1642-1645 CHEBI:29425 denotes SCN
T159 1642-1645 CHEBI:18022 denotes SCN
T162 1642-1645 CHEBI:29426 denotes SCN
T163 1642-1646 615285 denotes SCN5
T164 1642-1647 PR:000002101 denotes SCN5A
T165 1642-1647 PR:P15389 denotes SCN5A
T166 1642-1647 PR:Q14524 denotes SCN5A
T167 1642-1647 PR:Q9JJV9 denotes SCN5A
T168 1716-1719 PR:000010998 denotes SAN
T169 1745-1751 UBERON:0003165 denotes atrium
T170 1745-1751 UBERON:0002081 denotes atrium
T171 1875-1887 D013779 denotes tetrodotoxin
T172 1875-1887 D013779 denotes tetrodotoxin
T173 1875-1887 CHEBI:9506 denotes tetrodotoxin
T175 1892-1901 1999 denotes carbachol
T174 1892-1901 CHEBI:3385 denotes carbachol
T176 1892-1901 D002217 denotes carbachol
T177 1892-1901 D002217 denotes carbachol
T184 2001-2004 UBERON:0002034 denotes SCN
T179 2001-2004 CHEBI:29441 denotes SCN
T181 2001-2004 CHEBI:29425 denotes SCN
T189 2001-2004 CHEBI:18022 denotes SCN
T192 2001-2004 CHEBI:29426 denotes SCN
T193 2001-2005 615285 denotes SCN5
T194 2001-2006 PR:000002101 denotes SCN5A
T195 2001-2006 PR:P15389 denotes SCN5A
T196 2001-2006 PR:Q14524 denotes SCN5A
T197 2001-2006 PR:Q9JJV9 denotes SCN5A
T198 2007-2011 SO:0000704 denotes gene
T199 2026-2029 F1CKJ1 denotes SSS
T200 2026-2029 PR:B5A5T4 denotes SSS
T203 2026-2029 O81193 denotes SSS
T204 2026-2029 Q9FNF2 denotes SSS
T201 2026-2029 CHEBI:29834 denotes SSS
T202 2026-2029 CHEBI:29399 denotes SSS
T205 2114-2117 PR:000010998 denotes SAN

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 123-442 BACKGROUND denotes Familial sick sinus syndrome (SSS) has been linked to loss-of-function mutations of the SCN5A gene, which result in decreased inward Na(+) current, I(Na). However, the functional role of I(Na) in cardiac pacemaking is controversial, and mechanistic links between mutations and sinus node dysfunction in SSS are unclear.
T2 454-533 OBJECTIVE denotes To determine mechanisms by which the SCN5A mutations impair cardiac pacemaking.
T3 555-1936 RESULTS denotes Action potential (AP) models for rabbit sinoatrial node (SAN) cells were modified to incorporate experimentally reported I(Na) changes induced by 2 groups of SCN5A gene mutations (affecting the activation and inactivation of I(Na), respectively). The cell models were incorporated into an anatomically detailed 2D model of the intact SAN-atrium. Effects of the mutations and vagal nerve activity on cardiac pacemaking at the single-cell and tissue levels were studied. Multielectrode extracellular potential recordings of activation pattern from intact SAN-atrium preparations were performed to test predictions of the models. At the single-cell level, the mutations slowed down pacemaking rates in peripheral, but not in central SAN cells that control the heart rhythm. However, in tissue simulations, the mutations not only slowed down pacemaking, but also compromised AP conduction across the SAN-atrium, leading to a possible SAN exit block or sinus arrest, the major features of SSS. Simulated vagal nerve activity amplified the bradycardiac effects of the mutations. Two groups of SCN5A mutations showed subtle differences in impairing the ability of the SAN to drive the surrounding atrium, primarily attributable to their differential effects on atrial excitability and conduction safety. Experimental data with tetrodotoxin and carbachol confirmed the simulation outcomes.
T4 1950-2118 CONCLUSIONS denotes Our study substantiates the causative link between SCN5A gene mutations and SSS and illustrates mechanisms by which the mutations impair the driving ability of the SAN.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 26-28 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T2 158-161 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T3 158-161 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T4 256-258 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T5 273-275 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T6 312-314 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T7 573-575 CVCL_E457|Transformed_cell_line|Homo sapiens denotes AP
T8 612-615 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN
T9 678-680 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T10 682-689 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T11 749-759 CVCL_C410|Hybridoma|Mus musculus denotes activation
T12 782-784 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T13 841-843 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T14 841-843 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T15 889-892 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN
T16 942-950 CVCL_C410|Hybridoma|Mus musculus denotes activity
T17 1077-1087 CVCL_C410|Hybridoma|Mus musculus denotes activation
T18 1108-1111 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN
T19 1285-1288 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN
T20 1426-1428 CVCL_E457|Transformed_cell_line|Homo sapiens denotes AP
T21 1451-1454 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN
T22 1474-1475 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T23 1485-1488 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN
T24 1566-1574 CVCL_C410|Hybridoma|Mus musculus denotes activity
T25 1716-1719 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN
T26 2114-2117 CVCL_8754|Cancer_cell_line|Homo sapiens denotes SAN

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 132-151 HP_0011704 denotes sick sinus syndrome

Allie

Id Subject Object Predicate Lexical cue
SS1_20448214_2_0 256-272 expanded denotes Na(+) current, I
SS2_20448214_2_0 273-275 abbr denotes Na
SS1_20448214_2_1 132-151 expanded denotes sick sinus syndrome
SS2_20448214_2_1 153-156 abbr denotes SSS
SS1_20448214_7_0 555-571 expanded denotes Action potential
SS2_20448214_7_0 573-575 abbr denotes AP
SS1_20448214_7_1 595-610 expanded denotes sinoatrial node
SS2_20448214_7_1 612-615 abbr denotes SAN
AE1_20448214_2_0 SS1_20448214_2_0 SS2_20448214_2_0 abbreviatedTo "Na(+) current, I",Na
AE1_20448214_2_1 SS1_20448214_2_1 SS2_20448214_2_1 abbreviatedTo sick sinus syndrome,SSS
AE1_20448214_7_0 SS1_20448214_7_0 SS2_20448214_7_0 abbreviatedTo Action potential,AP
AE1_20448214_7_1 SS1_20448214_7_1 SS2_20448214_7_1 abbreviatedTo sinoatrial node,SAN