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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T2 179-290 Sentence denotes Disequilibrium of dermal wound repair can result in continued accumulation of ECM and excessive scar formation.
T1 0-178 Sentence denotes Effect of the abrogation of TGF-beta1 by antisense oligonucleotides on the expression of TGF-beta-isoforms and their receptors I and II in isolated fibroblasts from keloid scars.
T3 291-376 Sentence denotes In susceptible genetically predisposed individuals, keloid formation can be observed.
T4 377-469 Sentence denotes Keloid disease represents a benign dermal fibroproliferative tumor that is unique to humans.
T5 470-579 Sentence denotes TGF-beta is known to play a key role in the pathogenesis of this disease which is still not fully understood.
T6 580-696 Sentence denotes The isoforms TGF-beta1 and TGF-beta2 have profibrotic properties, whereas TGF-beta3 may have antifibrotic functions.
T7 697-860 Sentence denotes TGF-beta exerts its influence by binding to type I and type II TGF-beta receptors, thereby forming a complex and activating specific downstream effector molecules.
T8 861-1081 Sentence denotes The aim of this study was to investigate the effect of TGF-beta1 targeting by antisense oligonucleotides on the RNA synthesis and protein expression of TGF-beta isoforms and their receptors in keloid-derived fibroblasts.
T9 1082-1331 Sentence denotes In tissue samples with normal fibroblasts (NFs) serving as control samples, expression of TGF-beta1 and -beta2 was decreased when compared to keloid fibroblasts (KFs), while expression of TGF-beta3 and of TGF-betaRII was significantly higher in NFs.
T10 1332-1439 Sentence denotes In the ELISA assay, abrogation of TGF-beta1 led to a significant decrease in TGF-beta1 and -beta2 (p<0.05).
T11 1440-1481 Sentence denotes Expression of TGF-beta2 mRNA was reduced.
T12 1482-1652 Sentence denotes Expression of TGF-beta3 mRNA revealed contrary patterns in KFs from different patients while expression of TGF-betaRI was found to be equal during the measurement period.
T13 1653-1726 Sentence denotes TGF-betaRII mRNA expression was increased after 48 and 72 h respectively.
T14 1727-1816 Sentence denotes There is growing evidence for a regulatory mechanism between TGF-beta1 and its receptors.
T15 1817-1939 Sentence denotes Our findings support this theory by suggesting interrelations between the different TGF-beta isoforms and their receptors.
T16 1940-2103 Sentence denotes Abnormal response of KFs to TGF-betamight reflect a modification in the regulatory pathway that occurs at the receptor level or during intracellular trans-duction.
T17 2104-2322 Sentence denotes Improving the understanding of TGF-beta in keloid disease could lead to the development of clinically useful therapeutic modalities for treatment of keloid disease or even allow identification of preventive strategies.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 462-468 OrganismTaxon denotes humans NCBItxid:9605

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7260 28-37 GeneOrGeneProduct denotes TGF-beta1 NCBIGene:4052
7261 51-67 ChemicalEntity denotes oligonucleotides MESH:D009841
7262 89-135 GeneOrGeneProduct denotes TGF-beta-isoforms and their receptors I and II NCBIGene:7046|NCBIGene:7048
7263 165-177 DiseaseOrPhenotypicFeature denotes keloid scars MESH:D007627
7264 343-349 DiseaseOrPhenotypicFeature denotes keloid MESH:D007627
7265 377-391 DiseaseOrPhenotypicFeature denotes Keloid disease MESH:D007627
7266 438-443 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
7267 462-468 OrganismTaxon denotes humans NCBITaxon:9606
7268 470-478 GeneOrGeneProduct denotes TGF-beta NCBIGene:7040|NCBIGene:7042|NCBIGene:7043
7269 593-602 GeneOrGeneProduct denotes TGF-beta1 NCBIGene:4052
7270 607-616 GeneOrGeneProduct denotes TGF-beta2 NCBIGene:7042
7271 654-663 GeneOrGeneProduct denotes TGF-beta3 NCBIGene:7043
7272 697-705 GeneOrGeneProduct denotes TGF-beta NCBIGene:7040|NCBIGene:7042|NCBIGene:7043
7273 741-778 GeneOrGeneProduct denotes type I and type II TGF-beta receptors NCBIGene:7046|NCBIGene:7048
7274 916-925 GeneOrGeneProduct denotes TGF-beta1 NCBIGene:4052
7275 949-965 ChemicalEntity denotes oligonucleotides MESH:D009841
7276 1013-1021 GeneOrGeneProduct denotes TGF-beta NCBIGene:7040|NCBIGene:7042|NCBIGene:7043
7277 1054-1060 DiseaseOrPhenotypicFeature denotes keloid MESH:D007627
7278 1172-1192 GeneOrGeneProduct denotes TGF-beta1 and -beta2 NCBIGene:4052|NCBIGene:7042
7279 1224-1230 DiseaseOrPhenotypicFeature denotes keloid MESH:D007627
7280 1270-1279 GeneOrGeneProduct denotes TGF-beta3 NCBIGene:7043
7281 1287-1298 GeneOrGeneProduct denotes TGF-betaRII NCBIGene:7048
7282 1366-1375 GeneOrGeneProduct denotes TGF-beta1 NCBIGene:4052
7283 1409-1429 GeneOrGeneProduct denotes TGF-beta1 and -beta2 NCBIGene:4052|NCBIGene:7042
7284 1454-1463 GeneOrGeneProduct denotes TGF-beta2 NCBIGene:7042
7285 1496-1505 GeneOrGeneProduct denotes TGF-beta3 NCBIGene:7043
7286 1560-1568 OrganismTaxon denotes patients NCBITaxon:9606
7287 1589-1599 GeneOrGeneProduct denotes TGF-betaRI NCBIGene:7046
7288 1653-1664 GeneOrGeneProduct denotes TGF-betaRII NCBIGene:7048
7289 1788-1797 GeneOrGeneProduct denotes TGF-beta1 NCBIGene:4052
7290 1901-1909 GeneOrGeneProduct denotes TGF-beta NCBIGene:7040|NCBIGene:7042|NCBIGene:7043
7291 2135-2143 GeneOrGeneProduct denotes TGF-beta NCBIGene:7040|NCBIGene:7042|NCBIGene:7043
7292 2147-2161 DiseaseOrPhenotypicFeature denotes keloid disease MESH:D007627
7293 2253-2267 DiseaseOrPhenotypicFeature denotes keloid disease MESH:D007627

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 165-171 DiseaseOrPhenotypicFeature denotes keloid 0005348
T2 343-359 DiseaseOrPhenotypicFeature denotes keloid formation 0007847
T3 343-349 DiseaseOrPhenotypicFeature denotes keloid 0005348
T4 377-383 DiseaseOrPhenotypicFeature denotes Keloid 0005348
T5 1054-1060 DiseaseOrPhenotypicFeature denotes keloid 0005348
T6 1224-1230 DiseaseOrPhenotypicFeature denotes keloid 0005348
T7 2147-2153 DiseaseOrPhenotypicFeature denotes keloid 0005348
T8 2253-2259 DiseaseOrPhenotypicFeature denotes keloid 0005348

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 28-37 GeneOrGeneProduct denotes TGF-beta1
T2 89-97 GeneOrGeneProduct denotes TGF-beta
T3 117-126 GeneOrGeneProduct denotes receptors
T4 133-135 GeneOrGeneProduct denotes II
T5 172-177 GeneOrGeneProduct denotes scars
T6 265-274 GeneOrGeneProduct denotes excessive
T7 275-279 GeneOrGeneProduct denotes scar
T8 280-289 GeneOrGeneProduct denotes formation
T9 350-359 GeneOrGeneProduct denotes formation
T10 438-443 GeneOrGeneProduct denotes tumor
T11 470-478 GeneOrGeneProduct denotes TGF-beta
T12 593-602 GeneOrGeneProduct denotes TGF-beta1
T13 607-616 GeneOrGeneProduct denotes TGF-beta2
T14 654-663 GeneOrGeneProduct denotes TGF-beta3
T15 697-705 GeneOrGeneProduct denotes TGF-beta
T16 730-737 GeneOrGeneProduct denotes binding
T17 741-747 GeneOrGeneProduct denotes type I
T18 752-759 GeneOrGeneProduct denotes type II
T19 760-768 GeneOrGeneProduct denotes TGF-beta
T20 769-778 GeneOrGeneProduct denotes receptors
T21 810-820 GeneOrGeneProduct denotes activating
T22 841-849 GeneOrGeneProduct denotes effector
T23 916-925 GeneOrGeneProduct denotes TGF-beta1
T24 991-998 GeneOrGeneProduct denotes protein
T25 1013-1021 GeneOrGeneProduct denotes TGF-beta
T26 1041-1050 GeneOrGeneProduct denotes receptors
T27 1130-1137 GeneOrGeneProduct denotes serving
T28 1172-1181 GeneOrGeneProduct denotes TGF-beta1
T29 1187-1192 GeneOrGeneProduct denotes beta2
T30 1270-1279 GeneOrGeneProduct denotes TGF-beta3
T31 1287-1298 GeneOrGeneProduct denotes TGF-betaRII
T32 1366-1375 GeneOrGeneProduct denotes TGF-beta1
T33 1409-1418 GeneOrGeneProduct denotes TGF-beta1
T34 1424-1429 GeneOrGeneProduct denotes beta2
T35 1454-1463 GeneOrGeneProduct denotes TGF-beta2
T36 1464-1468 GeneOrGeneProduct denotes mRNA
T37 1473-1480 GeneOrGeneProduct denotes reduced
T38 1496-1505 GeneOrGeneProduct denotes TGF-beta3
T39 1506-1510 GeneOrGeneProduct denotes mRNA
T40 1645-1651 GeneOrGeneProduct denotes period
T41 1653-1664 GeneOrGeneProduct denotes TGF-betaRII
T42 1665-1669 GeneOrGeneProduct denotes mRNA
T43 1736-1743 GeneOrGeneProduct denotes growing
T44 1788-1797 GeneOrGeneProduct denotes TGF-beta1
T45 1806-1815 GeneOrGeneProduct denotes receptors
T46 1821-1829 GeneOrGeneProduct denotes findings
T47 1901-1909 GeneOrGeneProduct denotes TGF-beta
T48 1929-1938 GeneOrGeneProduct denotes receptors
T49 2050-2058 GeneOrGeneProduct denotes receptor
T50 2089-2094 GeneOrGeneProduct denotes trans
T51 2135-2143 GeneOrGeneProduct denotes TGF-beta
T52 2271-2275 GeneOrGeneProduct denotes even

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 28-37 GeneOrGeneProduct denotes TGF-beta1
T2 89-97 GeneOrGeneProduct denotes TGF-beta
T3 275-279 GeneOrGeneProduct denotes scar
T4 470-478 GeneOrGeneProduct denotes TGF-beta
T5 593-602 GeneOrGeneProduct denotes TGF-beta1
T6 607-616 GeneOrGeneProduct denotes TGF-beta2
T7 654-663 GeneOrGeneProduct denotes TGF-beta3
T8 697-705 GeneOrGeneProduct denotes TGF-beta
T9 730-737 GeneOrGeneProduct denotes binding
T10 741-747 GeneOrGeneProduct denotes type I
T11 752-759 GeneOrGeneProduct denotes type II
T12 760-768 GeneOrGeneProduct denotes TGF-beta
T13 841-849 GeneOrGeneProduct denotes effector
T14 916-925 GeneOrGeneProduct denotes TGF-beta1
T15 991-998 GeneOrGeneProduct denotes protein
T16 1013-1021 GeneOrGeneProduct denotes TGF-beta
T17 1172-1181 GeneOrGeneProduct denotes TGF-beta1
T18 1187-1192 GeneOrGeneProduct denotes beta2
T19 1270-1279 GeneOrGeneProduct denotes TGF-beta3
T20 1287-1298 GeneOrGeneProduct denotes TGF-betaRII
T21 1366-1375 GeneOrGeneProduct denotes TGF-beta1
T22 1409-1418 GeneOrGeneProduct denotes TGF-beta1
T23 1424-1429 GeneOrGeneProduct denotes beta2
T24 1454-1463 GeneOrGeneProduct denotes TGF-beta2
T25 1464-1468 GeneOrGeneProduct denotes mRNA
T26 1473-1480 GeneOrGeneProduct denotes reduced
T27 1496-1505 GeneOrGeneProduct denotes TGF-beta3
T28 1506-1510 GeneOrGeneProduct denotes mRNA
T29 1645-1651 GeneOrGeneProduct denotes period
T30 1653-1664 GeneOrGeneProduct denotes TGF-betaRII
T31 1665-1669 GeneOrGeneProduct denotes mRNA
T32 1788-1797 GeneOrGeneProduct denotes TGF-beta1
T33 1901-1909 GeneOrGeneProduct denotes TGF-beta
T34 2050-2058 GeneOrGeneProduct denotes receptor
T35 2135-2143 GeneOrGeneProduct denotes TGF-beta
T36 2271-2275 GeneOrGeneProduct denotes even

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 165-171 DiseaseOrPhenotypicFeature denotes keloid D007627
T2 172-177 DiseaseOrPhenotypicFeature denotes scars D002921
T3 204-209 DiseaseOrPhenotypicFeature denotes wound D014947
T4 275-279 DiseaseOrPhenotypicFeature denotes scar D002921
T5 343-349 DiseaseOrPhenotypicFeature denotes keloid D007627
T6 377-383 DiseaseOrPhenotypicFeature denotes Keloid D007627
T7 384-391 DiseaseOrPhenotypicFeature denotes disease D004194
T8 438-443 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 535-542 DiseaseOrPhenotypicFeature denotes disease D004194
T10 1054-1060 DiseaseOrPhenotypicFeature denotes keloid D007627
T11 1224-1230 DiseaseOrPhenotypicFeature denotes keloid D007627
T12 2147-2153 DiseaseOrPhenotypicFeature denotes keloid D007627
T13 2154-2161 DiseaseOrPhenotypicFeature denotes disease D004194
T14 2253-2259 DiseaseOrPhenotypicFeature denotes keloid D007627
T15 2260-2267 DiseaseOrPhenotypicFeature denotes disease D004194

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 28-37 GeneOrGeneProduct denotes TGF-beta1
T2 89-97 GeneOrGeneProduct denotes TGF-beta
T3 275-279 GeneOrGeneProduct denotes scar
T4 470-478 GeneOrGeneProduct denotes TGF-beta
T5 593-602 GeneOrGeneProduct denotes TGF-beta1
T6 607-616 GeneOrGeneProduct denotes TGF-beta2
T7 654-663 GeneOrGeneProduct denotes TGF-beta3
T8 697-705 GeneOrGeneProduct denotes TGF-beta
T9 752-778 GeneOrGeneProduct denotes type II TGF-beta receptors
T10 916-925 GeneOrGeneProduct denotes TGF-beta1
T11 991-1009 GeneOrGeneProduct denotes protein expression
T12 1013-1021 GeneOrGeneProduct denotes TGF-beta
T13 1172-1181 GeneOrGeneProduct denotes TGF-beta1
T14 1187-1192 GeneOrGeneProduct denotes beta2
T15 1270-1279 GeneOrGeneProduct denotes TGF-beta3
T16 1287-1298 GeneOrGeneProduct denotes TGF-betaRII
T17 1366-1375 GeneOrGeneProduct denotes TGF-beta1
T18 1409-1418 GeneOrGeneProduct denotes TGF-beta1
T19 1424-1429 GeneOrGeneProduct denotes beta2
T20 1454-1463 GeneOrGeneProduct denotes TGF-beta2
T21 1496-1505 GeneOrGeneProduct denotes TGF-beta3
T22 1645-1651 GeneOrGeneProduct denotes period
T23 1653-1664 GeneOrGeneProduct denotes TGF-betaRII
T24 1788-1797 GeneOrGeneProduct denotes TGF-beta1
T25 1901-1909 GeneOrGeneProduct denotes TGF-beta
T26 2135-2143 GeneOrGeneProduct denotes TGF-beta

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 165-171 DiseaseOrPhenotypicFeature denotes keloid 0005348
T2 204-209 DiseaseOrPhenotypicFeature denotes wound 0021178
T3 217-220 DiseaseOrPhenotypicFeature denotes can 0012833
T4 343-359 DiseaseOrPhenotypicFeature denotes keloid formation 0007847
T5 360-363 DiseaseOrPhenotypicFeature denotes can 0012833
T6 438-443 DiseaseOrPhenotypicFeature denotes tumor 0005070
T7 1054-1060 DiseaseOrPhenotypicFeature denotes keloid 0005348
T8 1224-1230 DiseaseOrPhenotypicFeature denotes keloid 0005348
T9 2147-2153 DiseaseOrPhenotypicFeature denotes keloid 0005348
T10 2253-2259 DiseaseOrPhenotypicFeature denotes keloid 0005348

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 165-171 DiseaseOrPhenotypicFeature denotes keloid D007627
T2 172-177 DiseaseOrPhenotypicFeature denotes scars D002921
T3 204-209 DiseaseOrPhenotypicFeature denotes wound D014947
T4 275-279 DiseaseOrPhenotypicFeature denotes scar D002921
T5 343-349 DiseaseOrPhenotypicFeature denotes keloid D007627
T6 377-383 DiseaseOrPhenotypicFeature denotes Keloid D007627
T7 384-391 DiseaseOrPhenotypicFeature denotes disease D004194
T8 438-443 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 535-542 DiseaseOrPhenotypicFeature denotes disease D004194
T10 1054-1060 DiseaseOrPhenotypicFeature denotes keloid D007627
T11 1224-1230 DiseaseOrPhenotypicFeature denotes keloid D007627
T12 2147-2153 DiseaseOrPhenotypicFeature denotes keloid D007627
T13 2154-2161 DiseaseOrPhenotypicFeature denotes disease D004194
T14 2253-2259 DiseaseOrPhenotypicFeature denotes keloid D007627
T15 2260-2267 DiseaseOrPhenotypicFeature denotes disease D004194

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 165-171 DiseaseOrPhenotypicFeature denotes keloid D007627
T2 172-177 DiseaseOrPhenotypicFeature denotes scars D002921
T3 343-349 DiseaseOrPhenotypicFeature denotes keloid D007627
T4 377-383 DiseaseOrPhenotypicFeature denotes Keloid D007627
T5 438-443 DiseaseOrPhenotypicFeature denotes tumor D009369
T6 1054-1060 DiseaseOrPhenotypicFeature denotes keloid D007627
T7 1224-1230 DiseaseOrPhenotypicFeature denotes keloid D007627
T8 2147-2153 DiseaseOrPhenotypicFeature denotes keloid D007627
T9 2253-2259 DiseaseOrPhenotypicFeature denotes keloid D007627

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 2168-2172 ChemicalEntity denotes lead D007854

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 462-468 OrganismTaxon denotes humans
T2 1560-1568 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T1 2168-2172 ChemicalEntity denotes lead D007854
T26 2135-2143 GeneOrGeneProduct denotes TGF-beta
T25 1901-1909 GeneOrGeneProduct denotes TGF-beta
T24 1788-1797 GeneOrGeneProduct denotes TGF-beta1
T23 1653-1664 GeneOrGeneProduct denotes TGF-betaRII
T22 1645-1651 GeneOrGeneProduct denotes period
T21 1496-1505 GeneOrGeneProduct denotes TGF-beta3
T20 1454-1463 GeneOrGeneProduct denotes TGF-beta2
T19 1424-1429 GeneOrGeneProduct denotes beta2
T18 1409-1418 GeneOrGeneProduct denotes TGF-beta1
T17 1366-1375 GeneOrGeneProduct denotes TGF-beta1
T16 1287-1298 GeneOrGeneProduct denotes TGF-betaRII
T15 1270-1279 GeneOrGeneProduct denotes TGF-beta3
T14 1187-1192 GeneOrGeneProduct denotes beta2
T13 1172-1181 GeneOrGeneProduct denotes TGF-beta1
T12 1013-1021 GeneOrGeneProduct denotes TGF-beta
T11 991-1009 GeneOrGeneProduct denotes protein expression
T10 916-925 GeneOrGeneProduct denotes TGF-beta1
T9 752-778 GeneOrGeneProduct denotes type II TGF-beta receptors
T8 697-705 GeneOrGeneProduct denotes TGF-beta
T7 654-663 GeneOrGeneProduct denotes TGF-beta3
T6 607-616 GeneOrGeneProduct denotes TGF-beta2
T5 593-602 GeneOrGeneProduct denotes TGF-beta1
T4 470-478 GeneOrGeneProduct denotes TGF-beta
T3 275-279 GeneOrGeneProduct denotes scar
T2 89-97 GeneOrGeneProduct denotes TGF-beta
T89134 28-37 GeneOrGeneProduct denotes TGF-beta1
T29189 2253-2259 DiseaseOrPhenotypicFeature denotes keloid D007627
T22461 2147-2153 DiseaseOrPhenotypicFeature denotes keloid D007627
T38462 1224-1230 DiseaseOrPhenotypicFeature denotes keloid D007627
T92637 1054-1060 DiseaseOrPhenotypicFeature denotes keloid D007627
T74442 438-443 DiseaseOrPhenotypicFeature denotes tumor D009369
T47679 377-383 DiseaseOrPhenotypicFeature denotes Keloid D007627
T11221 343-349 DiseaseOrPhenotypicFeature denotes keloid D007627
T63304 172-177 DiseaseOrPhenotypicFeature denotes scars D002921
T78368 165-171 DiseaseOrPhenotypicFeature denotes keloid D007627
T88968 1560-1568 OrganismTaxon denotes patients
T25519 462-468 OrganismTaxon denotes humans

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1270-1279 gene:7043 denotes TGF-beta3
T1 1224-1230 disease:C0022548 denotes keloid
R1 T0 T1 associated_with TGF-beta3,keloid

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 275-279 HP_0100699 denotes scar
T2 343-349 HP_0010562 denotes keloid
T3 377-383 HP_0010562 denotes Keloid
T4 438-443 HP_0002664 denotes tumor
T5 1054-1060 HP_0010562 denotes keloid
T6 1224-1230 HP_0010562 denotes keloid
T7 2147-2153 HP_0010562 denotes keloid
T8 2253-2259 HP_0010562 denotes keloid

Allie

Id Subject Object Predicate Lexical cue
SS1_20428796_8_0 1105-1123 expanded denotes normal fibroblasts
SS2_20428796_8_0 1125-1128 abbr denotes NFs
SS1_20428796_8_1 1224-1242 expanded denotes keloid fibroblasts
SS2_20428796_8_1 1244-1247 abbr denotes KFs
AE1_20428796_8_0 SS1_20428796_8_0 SS2_20428796_8_0 abbreviatedTo normal fibroblasts,NFs
AE1_20428796_8_1 SS1_20428796_8_1 SS2_20428796_8_1 abbreviatedTo keloid fibroblasts,KFs