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PubMed:20427278 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 704-718 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010

sentences

Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein.
T2 140-344 Sentence denotes Ectodomain shedding of the amyloid precursor protein (APP) by the two proteases alpha- and beta-secretase is a key regulatory event in the generation of the Alzheimer disease amyloid beta peptide (Abeta).
T3 345-450 Sentence denotes At present, little is known about the cellular mechanisms that control APP shedding and Abeta generation.
T4 451-558 Sentence denotes Here, we identified a novel protein, transmembrane protein 59 (TMEM59), as a new modulator of APP shedding.
T5 559-632 Sentence denotes TMEM59 was found to be a ubiquitously expressed, Golgi-localized protein.
T6 633-719 Sentence denotes TMEM59 transfection inhibited complex N- and O-glycosylation of APP in cultured cells.
T7 720-940 Sentence denotes Additionally, TMEM59 induced APP retention in the Golgi and inhibited Abeta generation as well as APP cleavage by alpha- and beta-secretase cleavage, which occur at the plasma membrane and in the endosomes, respectively.
T8 941-1088 Sentence denotes Moreover, TMEM59 inhibited the complex N-glycosylation of the prion protein, suggesting a more general modulation of Golgi glycosylation reactions.
T9 1089-1296 Sentence denotes Importantly, TMEM59 did not affect the secretion of soluble proteins or the alpha-secretase like shedding of tumor necrosis factor alpha, demonstrating that TMEM59 did not disturb the general Golgi function.
T10 1297-1473 Sentence denotes The phenotype of TMEM59 transfection on APP glycosylation and shedding was similar to the one observed in cells lacking conserved oligomeric Golgi (COG) proteins COG1 and COG2.
T11 1474-1569 Sentence denotes Both proteins are required for normal localization and activity of Golgi glycosylation enzymes.
T12 1570-1823 Sentence denotes In summary, this study shows that TMEM59 expression modulates complex N- and O-glycosylation and suggests that TMEM59 affects APP shedding by reducing access of APP to the cellular compartments, where it is normally cleaved by alpha- and beta-secretase.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 167-174 HP_0011034 denotes amyloid
T2 297-314 HP_0002511 denotes Alzheimer disease
T3 315-322 HP_0011034 denotes amyloid
T4 1198-1203 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_20427278_1_0 167-192 expanded denotes amyloid precursor protein
SS2_20427278_1_0 194-197 abbr denotes APP
SS1_20427278_3_0 488-512 expanded denotes transmembrane protein 59
SS2_20427278_3_0 514-520 abbr denotes TMEM59
SS1_20427278_9_0 1417-1443 expanded denotes conserved oligomeric Golgi
SS2_20427278_9_0 1445-1448 abbr denotes COG
AE1_20427278_1_0 SS1_20427278_1_0 SS2_20427278_1_0 abbreviatedTo amyloid precursor protein,APP
AE1_20427278_3_0 SS1_20427278_3_0 SS2_20427278_3_0 abbreviatedTo transmembrane protein 59,TMEM59
AE1_20427278_9_0 SS1_20427278_9_0 SS2_20427278_9_0 abbreviatedTo conserved oligomeric Golgi,COG

LocText

Id Subject Object Predicate Lexical cue
T1 10-18 go:GO:0016020 denotes membrane
T2 27-33 uniprot:Q9BXS4 denotes TMEM59
T3 67-79 go:GO:0009986 denotes cell surface
T4 96-105 go:GO:0005576 denotes secretion
T5 113-138 uniprot:P05067 denotes amyloid precursor protein
T6 167-192 uniprot:P05067 denotes amyloid precursor protein
T7 194-197 uniprot:P05067 denotes APP
T8 297-335 uniprot:P05067 denotes Alzheimer disease amyloid beta peptide
T9 337-342 uniprot:P05067 denotes Abeta
T10 416-419 uniprot:P05067 denotes APP
T11 433-438 uniprot:P05067 denotes Abeta
T12 488-512 uniprot:Q9BXS4 denotes transmembrane protein 59
T13 514-520 uniprot:Q9BXS4 denotes TMEM59
T14 545-548 uniprot:P05067 denotes APP
T15 559-565 uniprot:Q9BXS4 denotes TMEM59
T16 608-613 go:GO:0005794 denotes Golgi
T17 633-639 uniprot:Q9BXS4 denotes TMEM59
T18 697-700 uniprot:P05067 denotes APP
T19 734-740 uniprot:Q9BXS4 denotes TMEM59
T20 749-752 uniprot:P05067 denotes APP
T21 770-775 go:GO:0005794 denotes Golgi
T22 790-795 uniprot:P05067 denotes Abeta
T23 818-821 uniprot:P05067 denotes APP
T24 889-904 go:GO:0005886 denotes plasma membrane
T25 916-925 go:GO:0005768 denotes endosomes
T26 951-957 uniprot:Q9BXS4 denotes TMEM59
T27 1003-1008 uniprot:uniprot: denotes prion
T28 1058-1063 go:GO:0005794 denotes Golgi
T29 1102-1108 uniprot:Q9BXS4 denotes TMEM59
T30 1128-1137 go:GO:0005576 denotes secretion
T31 1246-1252 uniprot:Q9BXS4 denotes TMEM59
T32 1281-1286 go:GO:0005794 denotes Golgi
T33 1314-1320 uniprot:Q9BXS4 denotes TMEM59
T34 1337-1340 uniprot:P05067 denotes APP
T35 1438-1443 go:GO:0005794 denotes Golgi
T36 1459-1463 uniprot:Q8WTW3 denotes COG1
T37 1468-1472 uniprot:Q14746 denotes COG2
T38 1541-1546 go:GO:0005794 denotes Golgi
T39 1604-1610 uniprot:Q9BXS4 denotes TMEM59
T40 1681-1687 uniprot:Q9BXS4 denotes TMEM59
T41 1696-1699 uniprot:P05067 denotes APP
T42 1731-1734 uniprot:P05067 denotes APP
R1 T2 T1 localizeTo TMEM59,membrane
R2 T5 T3 localizeTo amyloid precursor protein,cell surface
R3 T5 T4 localizeTo amyloid precursor protein,secretion
R4 T15 T16 localizeTo TMEM59,Golgi
R5 T19 T21 localizeTo TMEM59,Golgi
R6 T20 T21 localizeTo APP,Golgi
R7 T22 T24 localizeTo Abeta,plasma membrane
R8 T23 T25 localizeTo APP,endosomes
R9 T23 T24 localizeTo APP,plasma membrane
R10 T22 T25 localizeTo Abeta,endosomes
R11 T26 T28 localizeTo TMEM59,Golgi
R12 T27 T28 localizeTo prion,Golgi
R13 T31 T32 localizeTo TMEM59,Golgi
R14 T36 T35 localizeTo COG1,Golgi
R15 T36 T38 localizeTo COG1,Golgi
R16 T37 T35 localizeTo COG2,Golgi
R17 T37 T38 localizeTo COG2,Golgi

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 297-314 Phenotype denotes Alzheimer disease HP:0002511
T2 1198-1203 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 113-120 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 167-174 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T3 297-314 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975
T4 315-322 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T5 1198-1203 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 10-18 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 488-501 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T5 608-613 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T6 770-775 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T7 889-904 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T8 1058-1063 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T9 1281-1286 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T10 1438-1443 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T11 1541-1546 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794