PubMed:20414141 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":120,"end":146},"obj":"HP_0007302"}],"text":"Family-based association study for bipolar affective disorder.\nIn this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences."}

{"project":"Allie","denotations":[{"id":"SS1_20414141_1_0","span":{"begin":120,"end":146},"obj":"expanded"},{"id":"SS2_20414141_1_0","span":{"begin":148,"end":152},"obj":"abbr"}],"relations":[{"id":"AE1_20414141_1_0","pred":"abbreviatedTo","subj":"SS1_20414141_1_0","obj":"SS2_20414141_1_0"}],"text":"Family-based association study for bipolar affective disorder.\nIn this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"20414141-4#48#57#geners9834970","span":{"begin":572,"end":581},"obj":"geners9834970"},{"id":"20414141-4#142#146#diseaseC0005586","span":{"begin":666,"end":670},"obj":"diseaseC0005586"}],"relations":[{"id":"48#57#geners9834970142#146#diseaseC0005586","pred":"associated_with","subj":"20414141-4#48#57#geners9834970","obj":"20414141-4#142#146#diseaseC0005586"}],"text":"Family-based association study for bipolar affective disorder.\nIn this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences."}

{"project":"PubTator4TogoVar","denotations":[{"id":"18","span":{"begin":572,"end":581},"obj":"SNP"},{"id":"21","span":{"begin":843,"end":852},"obj":"SNP"}],"attributes":[{"id":"A18","pred":"resolved_to","subj":"18","obj":"tmVar:rs9834970;VariantGroup:0;RS#:9834970"},{"id":"A21","pred":"resolved_to","subj":"21","obj":"tmVar:rs9834970;VariantGroup:0;RS#:9834970"}],"text":"Family-based association study for bipolar affective disorder.\nIn this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"18","span":{"begin":572,"end":581},"obj":"SNP"},{"id":"21","span":{"begin":843,"end":852},"obj":"SNP"},{"id":"T1","span":{"begin":572,"end":581},"obj":"SNP"},{"id":"T2","span":{"begin":843,"end":852},"obj":"SNP"}],"attributes":[{"id":"A18","pred":"resolved_to","subj":"18","obj":"tmVar:rs9834970;VariantGroup:0;RS#:9834970"},{"id":"A21","pred":"resolved_to","subj":"21","obj":"tmVar:rs9834970;VariantGroup:0;RS#:9834970"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs9834970;VariantGroup:0;RS#:9834970"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs9834970;VariantGroup:0;RS#:9834970"}],"text":"Family-based association study for bipolar affective disorder.\nIn this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences."}