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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 123-285 METHODS denotes Whole ovine caudal intervertebral discs were cultured under simulated-physiologic or high-frequency loading and either sufficient or limited nutrition for 7 days.
T2 297-529 OBJECTIVE denotes To study the effect of high-frequency loading under sufficient or limited glucose conditions and to investigate the additive effects of load and nutrition on cell survival, gene expression, and cell activity after 7 days of culture.
T3 558-816 BACKGROUND denotes Limited nutrition and certain mechanical stimuli are generally believed to be etiologic factors for disc degeneration. Although these effects and their interactions have been demonstrated in cell culture, no investigations have been reported in entire discs.
T4 826-1263 METHODS denotes Discs were maintained in a whole organ culture bioreactor system under simulated-physiologic (0.2 Hz) or high-frequency (10 Hz) loading, in media with either limited (2 g/L) or sufficient (4.5 g/L) glucose concentration. After 7 days, cell viability, relative gene expression, newly synthesized chondroitin sulfate content, glycosaminoglycan synthesis rate, and disc morphology were assessed after culture and compared with fresh tissue.
T5 1273-1599 RESULTS denotes Culture under either limited glucose or high-frequency loading conditions led to a significant drop in cell viability. Combined treatment with limited glucose and high-frequency loading resulted in an additive increase in cell death in both the anulus fibrosus and nucleus pulposus and in an increase in MMP13 gene expression.
T6 1612-2088 CONCLUSIONS denotes Supporting in vivo studies and cell culture experiments, high-frequency loading simulating vibration conditions shows detrimental effects on intervertebral disc cells in whole organ culture. The effect on cell viability was exacerbated by limited nutrition culture. However, neither frequency nor limited glucose affected cell metabolism, measured by glycosaminoglycan synthesis rate. Longer culture periods may be required to detect changes at the extracellular matrix level.

GoldHamster

Id Subject Object Predicate Lexical cue
T1 129-134 D012757 denotes ovine
T2 129-134 D012757 denotes ovine
T5 371-378 4850 denotes glucose
T3 371-378 D005947 denotes glucose
T4 371-378 D005947 denotes glucose
T6 371-378 CHEBI:42758 denotes glucose
T7 371-378 CHEBI:4167 denotes glucose
T8 371-378 CHEBI:17234 denotes glucose
T9 470-474 SO:0000704 denotes gene
T10 470-485 GO:0010467 denotes gene expression
T11 658-675 D055959 denotes disc degeneration
T12 658-675 D055959 denotes disc degeneration
T13 859-864 UBERON:0000062 denotes organ
T14 859-864 UBERON:0003103 denotes organ
T15 1021-1031 CHEBI:37624 denotes L) glucose
T16 1021-1031 D005947 denotes L) glucose
T17 1021-1031 D005947 denotes L) glucose
T20 1024-1031 4850 denotes glucose
T24 1086-1090 SO:0000704 denotes gene
T25 1086-1101 GO:0010467 denotes gene expression
T29 1121-1140 CHEBI:37397 denotes chondroitin sulfate
T30 1121-1140 D002809 denotes chondroitin sulfate
T31 1121-1140 D002809 denotes chondroitin sulfate
T33 1150-1167 CHEBI:18085 denotes glycosaminoglycan
T34 1150-1177 GO:0006024 denotes glycosaminoglycan synthesis
T36 1256-1262 UBERON:0000479 denotes tissue
T39 1302-1309 4850 denotes glucose
T37 1302-1309 D005947 denotes glucose
T38 1302-1309 D005947 denotes glucose
T40 1302-1309 CHEBI:42758 denotes glucose
T41 1302-1309 CHEBI:4167 denotes glucose
T42 1302-1309 CHEBI:17234 denotes glucose
T46 1424-1431 4850 denotes glucose
T44 1424-1431 D005947 denotes glucose
T45 1424-1431 D005947 denotes glucose
T47 1424-1431 CHEBI:42758 denotes glucose
T48 1424-1431 CHEBI:4167 denotes glucose
T49 1424-1431 CHEBI:17234 denotes glucose
T50 1495-1505 GO:0008219 denotes cell death
T52 1518-1533 UBERON:0006444 denotes anulus fibrosus
T53 1538-1545 CHEBI:33252 denotes nucleus
T55 1538-1545 GO:0005634 denotes nucleus
T56 1538-1554 UBERON:0002242 denotes nucleus pulposus
T57 1577-1580 CHEBI:340824 denotes MMP
T60 1577-1580 CHEBI:59761 denotes MMP
T62 1577-1582 P45452 denotes MMP13
T63 1577-1582 PR:000010473 denotes MMP13
T64 1577-1582 O77656 denotes MMP13
T65 1577-1582 Q10835 denotes MMP13
T66 1577-1582 PR:P33435 denotes MMP13
T67 1577-1582 O18927 denotes MMP13
T68 1577-1582 PR:P23097 denotes MMP13
T69 1577-1582 P33435 denotes MMP13
T70 1577-1582 PR:P45452 denotes MMP13
T71 1577-1582 PR:O77656 denotes MMP13
T72 1577-1582 P23097 denotes MMP13
T73 1577-1582 O62806 denotes MMP13
T61 1577-1582 GO:0030404 denotes MMP13
T74 1583-1587 SO:0000704 denotes gene
T75 1583-1598 GO:0010467 denotes gene expression
T78 1753-1772 UBERON:0001066 denotes intervertebral disc
T76 1753-1772 C535531 denotes intervertebral disc
T77 1753-1772 C535531 denotes intervertebral disc
T79 1788-1793 UBERON:0000062 denotes organ
T80 1788-1793 UBERON:0003103 denotes organ
T83 1917-1924 4850 denotes glucose
T81 1917-1924 D005947 denotes glucose
T82 1917-1924 D005947 denotes glucose
T84 1917-1924 CHEBI:42758 denotes glucose
T85 1917-1924 CHEBI:4167 denotes glucose
T86 1917-1924 CHEBI:17234 denotes glucose
T87 1939-1949 GO:0008152 denotes metabolism
T88 1963-1980 CHEBI:18085 denotes glycosaminoglycan
T89 1963-1990 GO:0006024 denotes glycosaminoglycan synthesis
T92 2061-2081 GO:0031012 denotes extracellular matrix
T93 2075-2081 UBERON:0027368 denotes matrix

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 496-504 CVCL_C410|Hybridoma|Mus musculus denotes activity
T2 851-852 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 995-998 CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara denotes g/L
T4 1019-1022 CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara denotes g/L
T5 1354-1355 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 1471-1473 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T7 1471-1473 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T8 1562-1564 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T9 1562-1564 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T10 2020-2023 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T11 2046-2053 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes