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PubMed:20382224 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q5S006 denotes LRRK2
T2 0-5 PR:000003033 denotes LRRK2
T3 0-5 PR:Q5S007 denotes LRRK2
T5 78-100 D017173 denotes Caenorhabditis elegans
T6 78-100 6239 denotes Caenorhabditis elegans
T11 110-129 D010300 denotes Parkinson's disease
T12 110-129 D010300 denotes Parkinson's disease
T15 144-149 PR:Q5S006 denotes LRRK2
T16 144-149 PR:000003033 denotes LRRK2
T17 144-149 PR:Q5S007 denotes LRRK2
T18 196-214 C566739 denotes autosomal dominant
T23 219-249 D010300 denotes idiopathic Parkinson's disease
T24 219-249 D010300 denotes idiopathic Parkinson's disease
T33 303-309 D020558 denotes GTPase
T34 453-468 GO:0016301 denotes kinase activity
T35 491-496 PR:Q5S006 denotes LRRK2
T36 491-496 PR:000003033 denotes LRRK2
T37 491-496 PR:Q5S007 denotes LRRK2
T38 507-519 GO:0009405 denotes pathogenesis
T39 547-557 SO:0000781 denotes transgenic
T40 584-589 D006801 denotes human
T41 590-595 PR:Q5S006 denotes LRRK2
T42 590-595 PR:000003033 denotes LRRK2
T43 590-595 PR:Q5S007 denotes LRRK2
T44 596-605 SO:0000817 denotes wild type
T45 679-684 PR:Q5S006 denotes LRRK2
T46 679-684 PR:000003033 denotes LRRK2
T47 679-684 PR:Q5S007 denotes LRRK2
T48 685-693 CHEBI:36080 denotes proteins
T49 810-819 MOP:0000569 denotes reduction
T54 823-831 3628 denotes dopamine
T50 823-831 CHEBI:59905 denotes dopamine
T51 823-831 CHEBI:18243 denotes dopamine
T52 823-831 D004298 denotes dopamine
T53 823-831 D004298 denotes dopamine
T55 927-936 SO:0000817 denotes wild type
T59 937-944 PR:000000001 denotes protein
T56 937-944 GO:0003675 denotes protein
T60 937-944 SO:0000104 denotes protein
T57 937-944 CHEBI:36080 denotes protein
T58 937-944 CHEBI:11122 denotes protein
T65 986-994 3628 denotes dopamine
T61 986-994 CHEBI:59905 denotes dopamine
T62 986-994 CHEBI:18243 denotes dopamine
T63 986-994 D004298 denotes dopamine
T64 986-994 D004298 denotes dopamine
T66 1007-1012 PR:Q5S006 denotes LRRK2
T67 1007-1012 PR:000003033 denotes LRRK2
T68 1007-1012 PR:Q5S007 denotes LRRK2
T69 1089-1092 D006160 denotes GTP
T70 1089-1092 CHEBI:37565 denotes GTP
T71 1089-1092 D006160 denotes GTP
T72 1089-1092 CHEBI:15996 denotes GTP
T73 1089-1100 GO:0005525 denotes GTP binding
T74 1093-1100 SO:0100018 denotes binding
T75 1093-1100 SO:0001091 denotes binding
T77 1157-1162 PR:Q5S006 denotes LRRK2
T78 1157-1162 PR:000003033 denotes LRRK2
T79 1157-1162 PR:Q5S007 denotes LRRK2
T80 1163-1170 SO:0000853 denotes homolog
T81 1172-1177 PR:Q9TZM3 denotes LRK-1
T82 1172-1177 PR:O80939 denotes LRK-1
T83 1192-1197 PR:Q5S006 denotes LRRK2
T84 1192-1197 PR:000003033 denotes LRRK2
T85 1192-1197 PR:Q5S007 denotes LRRK2
T86 1265-1275 SO:0000781 denotes transgenic
T87 1276-1281 PR:Q5S006 denotes LRRK2
T88 1276-1281 PR:000003033 denotes LRRK2
T89 1276-1281 PR:Q5S007 denotes LRRK2
T90 1387-1395 CHEBI:59905 denotes dopamine
T91 1387-1395 CHEBI:18243 denotes dopamine
T92 1387-1395 D004298 denotes dopamine
T93 1387-1395 D004298 denotes dopamine
T94 1387-1395 3628 denotes dopamine
T95 1443-1452 MOP:0000569 denotes reduction
T96 1456-1464 CHEBI:59905 denotes dopamine
T97 1456-1464 CHEBI:18243 denotes dopamine
T98 1456-1464 D004298 denotes dopamine
T99 1456-1464 D004298 denotes dopamine
T100 1456-1464 3628 denotes dopamine
T101 1547-1553 D020558 denotes GTPase
T102 1554-1569 GO:0016301 denotes kinase activity
T103 1573-1578 PR:Q5S006 denotes LRRK2
T104 1573-1578 PR:000003033 denotes LRRK2
T105 1573-1578 PR:Q5S007 denotes LRRK2
T106 1605-1617 D007448 denotes invertebrate
T107 1653-1665 GO:0009405 denotes pathogenesis
T108 1726-1733 D004194 denotes disease
T109 1726-1733 D004194 denotes disease

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 196-214 HP_0000006 denotes autosomal dominant
T2 230-239 HP_0001300 denotes Parkinson
T3 718-735 HP_0002180 denotes neurodegeneration
T4 1206-1223 HP_0002180 denotes neurodegeneration
T5 1228-1252 HP_0000708 denotes behavioral abnormalities
T6 1342-1371 HP_0002344 denotes progressive neurodegeneration
T7 1354-1371 HP_0002180 denotes neurodegeneration

Allie

Id Subject Object Predicate Lexical cue
SS1_20382224_1_0 230-249 expanded denotes Parkinson's disease
SS2_20382224_1_0 251-253 abbr denotes PD
SS1_20382224_3_0 628-640 expanded denotes dopaminergic
SS2_20382224_3_0 642-644 abbr denotes DA
AE1_20382224_1_0 SS1_20382224_1_0 SS2_20382224_1_0 abbreviatedTo Parkinson's disease,PD
AE1_20382224_3_0 SS1_20382224_3_0 SS2_20382224_3_0 abbreviatedTo dopaminergic,DA

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-130 DRI_Challenge denotes LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
T2 131-349 DRI_Background denotes Mutations in LRRK2 are thus far the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease (PD) with prevalent mutations being found within the GTPase (R1441C/G) and kinase (G2019S) domains.
T3 350-469 DRI_Background denotes Previous in vitro studies have revealed that R1441C and G2019S mutations are associated with increased kinase activity.
T4 470-654 DRI_Outcome denotes To better understand LRRK2-linked PD pathogenesis in vivo, we have generated transgenic C. elegans overexpressing human LRRK2 wild type, R1441C and G2019S in dopaminergic (DA) neurons.
T5 655-847 DRI_Challenge denotes Overexpression of these LRRK2 proteins causes age-dependent DA neurodegeneration, behavioral deficits, and locomotor dysfunction that are accompanied by a reduction of dopamine levels in vivo.
T6 848-945 DRI_Outcome denotes In comparison, R1441C and G2019S mutants cause more severe phenotypes than the wild type protein.
T7 946-1057 DRI_Background denotes Interestingly, treatment with exogenous dopamine rescues the LRRK2-induced behavioral and locomotor phenotypes.
T8 1058-1253 DRI_Challenge denotes In contrast, expression of the GTP binding defective mutant, K1347A, or knockout of the C. elegans LRRK2 homolog, LRK-1, prevents the LRRK2-induced neurodegeneration and behavioral abnormalities.
T9 1254-1472 DRI_Outcome denotes Hence, our transgenic LRRK2 C. elegans models recapitulate key features of PD including progressive neurodegeneration, impairment of dopamine-dependent behavior and locomotor function, and reduction in dopamine levels.
T10 1473-1598 DRI_Outcome denotes Furthermore, our findings provide strong support for the critical role of GTPase/kinase activity in LRRK2-linked pathologies.
T11 1599-1734 DRI_Challenge denotes These invertebrate models will be useful for studying pathogenesis of PD and for development of potential therapeutics for the disease.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 131-349 DRI_Background denotes Mutations in LRRK2 are thus far the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease (PD) with prevalent mutations being found within the GTPase (R1441C/G) and kinase (G2019S) domains.
T2 350-469 DRI_Background denotes Previous in vitro studies have revealed that R1441C and G2019S mutations are associated with increased kinase activity.
T3 470-654 DRI_Outcome denotes To better understand LRRK2-linked PD pathogenesis in vivo, we have generated transgenic C. elegans overexpressing human LRRK2 wild type, R1441C and G2019S in dopaminergic (DA) neurons.
T4 655-847 DRI_Challenge denotes Overexpression of these LRRK2 proteins causes age-dependent DA neurodegeneration, behavioral deficits, and locomotor dysfunction that are accompanied by a reduction of dopamine levels in vivo.
T5 848-945 DRI_Outcome denotes In comparison, R1441C and G2019S mutants cause more severe phenotypes than the wild type protein.
T6 946-1057 DRI_Background denotes Interestingly, treatment with exogenous dopamine rescues the LRRK2-induced behavioral and locomotor phenotypes.
T7 1058-1253 DRI_Challenge denotes In contrast, expression of the GTP binding defective mutant, K1347A, or knockout of the C. elegans LRRK2 homolog, LRK-1, prevents the LRRK2-induced neurodegeneration and behavioral abnormalities.
T8 1254-1472 DRI_Outcome denotes Hence, our transgenic LRRK2 C. elegans models recapitulate key features of PD including progressive neurodegeneration, impairment of dopamine-dependent behavior and locomotor function, and reduction in dopamine levels.
T9 1473-1598 DRI_Outcome denotes Furthermore, our findings provide strong support for the critical role of GTPase/kinase activity in LRRK2-linked pathologies.
T10 1599-1734 DRI_Challenge denotes These invertebrate models will be useful for studying pathogenesis of PD and for development of potential therapeutics for the disease.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
20382224-3#137#143#geners33939927 607-613 geners33939927 denotes R1441C
20382224-3#148#154#geners34637584 618-624 geners34637584 denotes G2019S
20382224-3#34#36#diseaseC0030567 504-506 diseaseC0030567 denotes PD
137#143#geners3393992734#36#diseaseC0030567 20382224-3#137#143#geners33939927 20382224-3#34#36#diseaseC0030567 associated_with R1441C,PD
148#154#geners3463758434#36#diseaseC0030567 20382224-3#148#154#geners34637584 20382224-3#34#36#diseaseC0030567 associated_with G2019S,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20382224-0#0#5#gene120892 0-5 gene120892 denotes LRRK2
20382224-0#37#48#diseaseC3887505 37-48 diseaseC3887505 denotes dysfunction
20382224-0#110#129#diseaseC0030567 110-129 diseaseC0030567 denotes Parkinson's disease
20382224-7#31#34#gene92170 1089-1092 gene92170 denotes GTP
20382224-7#99#104#gene120892 1157-1162 gene120892 denotes LRRK2
20382224-7#134#139#gene120892 1192-1197 gene120892 denotes LRRK2
20382224-7#170#194#diseaseC0233514 1228-1252 diseaseC0233514 denotes behavioral abnormalities
0#5#gene12089237#48#diseaseC3887505 20382224-0#0#5#gene120892 20382224-0#37#48#diseaseC3887505 associated_with LRRK2,dysfunction
0#5#gene120892110#129#diseaseC0030567 20382224-0#0#5#gene120892 20382224-0#110#129#diseaseC0030567 associated_with LRRK2,Parkinson's disease
31#34#gene92170170#194#diseaseC0233514 20382224-7#31#34#gene92170 20382224-7#170#194#diseaseC0233514 associated_with GTP,behavioral abnormalities
99#104#gene120892170#194#diseaseC0233514 20382224-7#99#104#gene120892 20382224-7#170#194#diseaseC0233514 associated_with LRRK2,behavioral abnormalities
134#139#gene120892170#194#diseaseC0233514 20382224-7#134#139#gene120892 20382224-7#170#194#diseaseC0233514 associated_with LRRK2,behavioral abnormalities