PubMed:2036808 JSON TXT

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sonoma2

sonoma

{"project":"sonoma","denotations":[{"id":"T-0","span":{"begin":30,"end":51},"obj":"DISEASE"},{"id":"T-1","span":{"begin":57,"end":68},"obj":"REG"},{"id":"T-2","span":{"begin":633,"end":647},"obj":"DISEASE"},{"id":"T-3","span":{"begin":715,"end":721},"obj":"POSREG"},{"id":"T-4","span":{"begin":758,"end":761},"obj":"GENE"},{"id":"T-5","span":{"begin":793,"end":807},"obj":"DISEASE"},{"id":"T-6","span":{"begin":822,"end":840},"obj":"CPA"},{"id":"T-7","span":{"begin":1174,"end":1182},"obj":"POSREG"},{"id":"T-8","span":{"begin":1183,"end":1187},"obj":"GENE"},{"id":"T-9","span":{"begin":75,"end":104},"obj":"DISEASE"},{"id":"T-10","span":{"begin":1241,"end":1255},"obj":"DISEASE"},{"id":"T-11","span":{"begin":1386,"end":1415},"obj":"DISEASE"},{"id":"T-12","span":{"begin":1421,"end":1425},"obj":"POSREG"},{"id":"T-13","span":{"begin":1426,"end":1444},"obj":"MPA"},{"id":"T-14","span":{"begin":1497,"end":1508},"obj":"REG"},{"id":"T-15","span":{"begin":1532,"end":1544},"obj":"REG"},{"id":"T-16","span":{"begin":1548,"end":1577},"obj":"DISEASE"},{"id":"T-17","span":{"begin":282,"end":291},"obj":"GENE"},{"id":"T-18","span":{"begin":408,"end":422},"obj":"DISEASE"},{"id":"T-19","span":{"begin":978,"end":991},"obj":"GENE"},{"id":"T-20","span":{"begin":993,"end":997},"obj":"GENE"},{"id":"T-21","span":{"begin":1188,"end":1194},"obj":"MPA"},{"id":"T-22","span":{"begin":580,"end":583},"obj":"GENE"},{"id":"T-23","span":{"begin":817,"end":821},"obj":"REG"},{"id":"T-24","span":{"begin":293,"end":297},"obj":"GENE"}],"relations":[{"id":"R-0","pred":"ThemeOf","subj":"T-9","obj":"T-1"},{"id":"R-1","pred":"ThemeOf","subj":"T-4","obj":"T-3"},{"id":"R-2","pred":"ThemeOf","subj":"T-8","obj":"T-7"},{"id":"R-3","pred":"ThemeOf","subj":"T-8","obj":"T-21"},{"id":"R-4","pred":"ThemeOf","subj":"T-13","obj":"T-12"},{"id":"R-5","pred":"ThemeOf","subj":"T-16","obj":"T-14"},{"id":"R-6","pred":"ThemeOf","subj":"T-16","obj":"T-15"},{"id":"R-7","pred":"ThemeOf","subj":"T-5","obj":"T-3"},{"id":"R-8","pred":"ThemeOf","subj":"T-5","obj":"T-23"},{"id":"R-9","pred":"ThemeOf","subj":"T-6","obj":"T-23"},{"id":"R-10","pred":"ThemeOf","subj":"T-10","obj":"T-7"},{"id":"R-11","pred":"ThemeOf","subj":"T-11","obj":"T-3"}],"text":"Analysis of aqueous humour in ocular onchocerciasis.\nThe development of an onchocercal chorioretinopathy from the first detectable signs to a full blown oncho fundus is not fully understood. We investigated the intraocular humoral immune response against Onchocerca volvulus, human S-antigen, IRBP and crude retinal extract (using an ELISA) by examining paired aqueous humour and serum samples obtained from onchocerciasis patients (without [n = 10] and with ocular symptoms [n = 8]) and endemic controls [n = 14] from Sierra Leone (West Africa). A local intraocular anti-retinal IgG antibody production could not be demonstrated in onchocerciasis patients, whether they had ocular symptoms or not. A significantly higher level of O. volvulus antibodies and IgG was measured in the aqueous of onchocerciasis patients with ocular involvement, as compared to patients without ocular symptoms (Mann-Whitney ranksum test; p less than 0.001 and p less than 0.02 respectively). Since interleukin-6 (IL-6) plays an essential role in the differentiation of B cells into immunoglobulin producing plasma cells, we therefore measured this cytokine in paired aqueous and serum samples. Elevated IL-6 levels were found in the aqueous of two out of eight onchocerciasis patients tested. In view of these findings it seems improbable that retinal autoimmunity is a major factor in the pathogenesis of onchocercal chorioretinopathy. The high intraocular levels of antibodies against the parasite suggest a direct involvement of the parasite in the pathogenesis of onchocercal chorioretinopathy."}

PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":266,"end":274},"obj":"HP_0002580"},{"id":"T2","span":{"begin":734,"end":742},"obj":"HP_0002580"},{"id":"T3","span":{"begin":1332,"end":1344},"obj":"HP_0002960"}],"text":"Analysis of aqueous humour in ocular onchocerciasis.\nThe development of an onchocercal chorioretinopathy from the first detectable signs to a full blown oncho fundus is not fully understood. We investigated the intraocular humoral immune response against Onchocerca volvulus, human S-antigen, IRBP and crude retinal extract (using an ELISA) by examining paired aqueous humour and serum samples obtained from onchocerciasis patients (without [n = 10] and with ocular symptoms [n = 8]) and endemic controls [n = 14] from Sierra Leone (West Africa). A local intraocular anti-retinal IgG antibody production could not be demonstrated in onchocerciasis patients, whether they had ocular symptoms or not. A significantly higher level of O. volvulus antibodies and IgG was measured in the aqueous of onchocerciasis patients with ocular involvement, as compared to patients without ocular symptoms (Mann-Whitney ranksum test; p less than 0.001 and p less than 0.02 respectively). Since interleukin-6 (IL-6) plays an essential role in the differentiation of B cells into immunoglobulin producing plasma cells, we therefore measured this cytokine in paired aqueous and serum samples. Elevated IL-6 levels were found in the aqueous of two out of eight onchocerciasis patients tested. In view of these findings it seems improbable that retinal autoimmunity is a major factor in the pathogenesis of onchocercal chorioretinopathy. The high intraocular levels of antibodies against the parasite suggest a direct involvement of the parasite in the pathogenesis of onchocercal chorioretinopathy."}

PubMed:2036808 JSONTXT

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sonoma2

sonoma

PubmedHPO

PubMed:2036808 JSON TXT