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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-56 Sentence denotes Association between idiopathic achalasia and IL23R gene.
T2 57-68 Sentence denotes BACKGROUND:
T3 69-149 Sentence denotes Idiopathic achalasia is a primary esophageal motor disorder of unknown etiology.
T4 150-299 Sentence denotes Different evidences have been reported in support of achalasia as the result of an autoimmune and inflammatory process leading to neuronal cell loss.
T5 300-533 Sentence denotes According to this, idiopathic achalasia has been significantly associated with specific alleles of the human leukocyte antigen system class II, although few reports studying association with other loci can be found in the literature.
T6 534-704 Sentence denotes Recent studies have shown association of a non-synonymous polymorphism within the IL23R gene with different chronic inflammatory disorders, including Barrett's esophagus.
T7 705-855 Sentence denotes The purpose of this study was to assess whether the IL23R coding variant Arg381Gln polymorphism is involved in susceptibility to idiopathic achalasia.
T8 856-864 Sentence denotes METHODS:
T9 865-1002 Sentence denotes We performed a case-control study including 262 patients with idiopathic achalasia and 802 healthy subjects, all of them white Spaniards.
T10 1003-1113 Sentence denotes Achalasia patients were diagnosed on the basis of clinical, radiographic, endoscopic, and manometric criteria.
T11 1114-1202 Sentence denotes All samples were genotyped for the IL23R Arg381Gln polymorphism using TaqMan technology.
T12 1203-1215 Sentence denotes KEY RESULTS:
T13 1216-1377 Sentence denotes The minor allele of the Arg381Gln polymorphism was significantly increased in patients compared with healthy controls (OR = 1.46, 95% CI = 1.01-2.11, P = 0.036).
T14 1378-1510 Sentence denotes This association seems to be specific to male patients with disease onset after 40 years (OR = 2.33, 95% CI = 1.29-4.16, P = 0.002).
T15 1511-1536 Sentence denotes CONCLUSIONS & INFERENCES:
T16 1537-1714 Sentence denotes Our results suggest a role of IL23R in idiopathic achalasia predisposition and extend the evidence of the general influence of this gene in autoimmune and inflammatory diseases.
T1 0-56 Sentence denotes Association between idiopathic achalasia and IL23R gene.
T2 57-68 Sentence denotes BACKGROUND:
T3 69-149 Sentence denotes Idiopathic achalasia is a primary esophageal motor disorder of unknown etiology.
T4 150-299 Sentence denotes Different evidences have been reported in support of achalasia as the result of an autoimmune and inflammatory process leading to neuronal cell loss.
T5 300-533 Sentence denotes According to this, idiopathic achalasia has been significantly associated with specific alleles of the human leukocyte antigen system class II, although few reports studying association with other loci can be found in the literature.
T6 534-704 Sentence denotes Recent studies have shown association of a non-synonymous polymorphism within the IL23R gene with different chronic inflammatory disorders, including Barrett's esophagus.
T7 705-855 Sentence denotes The purpose of this study was to assess whether the IL23R coding variant Arg381Gln polymorphism is involved in susceptibility to idiopathic achalasia.
T8 856-864 Sentence denotes METHODS:
T9 865-1002 Sentence denotes We performed a case-control study including 262 patients with idiopathic achalasia and 802 healthy subjects, all of them white Spaniards.
T10 1003-1113 Sentence denotes Achalasia patients were diagnosed on the basis of clinical, radiographic, endoscopic, and manometric criteria.
T11 1114-1202 Sentence denotes All samples were genotyped for the IL23R Arg381Gln polymorphism using TaqMan technology.
T12 1203-1215 Sentence denotes KEY RESULTS:
T13 1216-1377 Sentence denotes The minor allele of the Arg381Gln polymorphism was significantly increased in patients compared with healthy controls (OR = 1.46, 95% CI = 1.01-2.11, P = 0.036).
T14 1378-1510 Sentence denotes This association seems to be specific to male patients with disease onset after 40 years (OR = 2.33, 95% CI = 1.29-4.16, P = 0.002).
T15 1511-1536 Sentence denotes CONCLUSIONS & INFERENCES:
T16 1537-1714 Sentence denotes Our results suggest a role of IL23R in idiopathic achalasia predisposition and extend the evidence of the general influence of this gene in autoimmune and inflammatory diseases.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 409-426 gene:3126 denotes leukocyte antigen
T1 330-339 disease:C0014848 denotes achalasia
T2 757-762 gene:149233 denotes IL23R
T3 845-854 disease:C0014848 denotes achalasia
R1 T0 T1 associated_with leukocyte antigen,achalasia
R2 T2 T3 associated_with IL23R,achalasia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 80-89 HP_0002571 denotes achalasia
T2 203-212 HP_0002571 denotes achalasia
T3 233-243 HP_0002960 denotes autoimmune
T4 330-339 HP_0002571 denotes achalasia
T5 684-703 HP_0100580 denotes Barrett's esophagus
T6 845-854 HP_0002571 denotes achalasia

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
20367798-5#73#82#geners11209026 778-787 geners11209026 denotes Arg381Gln
20367798-5#129#149#diseaseC0859976 834-854 diseaseC0859976 denotes idiopathic achalasia
73#82#geners11209026129#149#diseaseC0859976 20367798-5#73#82#geners11209026 20367798-5#129#149#diseaseC0859976 associated_with Arg381Gln,idiopathic achalasia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20367798-0#45#50#gene149233 1484-1572 gene149233 denotes I = 1.29-4.16, P = 0.002). CONCLUSIONS & INFERENCES: Our results suggest a role of IL23R
20367798-0#20#40#diseaseC0859976 1028-1390 diseaseC0859976 denotes iagnosed on the basis of clinical, radiographic, endoscopic, and manometric criteria. All samples were genotyped for the IL23R Arg381Gln polymorphism using TaqMan technology. KEY RESULTS: The minor allele of the Arg381Gln polymorphism was significantly increased in patients compared with healthy controls (OR = 1.46, 95% CI = 1.01-2.11, P = 0.036). This associa
20367798-4#82#87#gene149233 616-621 gene149233 denotes IL23R
20367798-4#150#169#diseaseC0004763 684-703 diseaseC0004763 denotes Barrett's esophagus
45#50#gene14923320#40#diseaseC0859976 20367798-0#45#50#gene149233 20367798-0#20#40#diseaseC0859976 associated_with "I = 1.29-4.16, P = 0.002). CONCLUSIONS & INFERENCES: Our results suggest a role of IL23R","iagnosed on the basis of clinical, radiographic, endoscopic, and manometric criteria. All samples were genotyped for the IL23R Arg381Gln polymorphism using TaqMan technology. KEY RESULTS: The minor allele of the Arg381Gln polymorphism was significantly increased in patients compared with healthy controls (OR = 1.46, 95% CI = 1.01-2.11, P = 0.036). This associa"
82#87#gene149233150#169#diseaseC0004763 20367798-4#82#87#gene149233 20367798-4#150#169#diseaseC0004763 associated_with IL23R,Barrett's esophagus