> top > docs > PubMed:20332301 > annotations

PubMed:20332301 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-169 Sentence denotes Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.
T2 170-342 Sentence denotes Association of chronic inflammation with an increased risk of cancer is well established, but the contributions of innate versus adaptive immunity are not fully delineated.
T3 343-553 Sentence denotes There has furthermore been little consideration of the role played by chronic inflammation-associated antigens, including cancer antigens, and the possibility of using them as vaccines to lower the cancer risk.
T4 554-744 Sentence denotes We studied the human tumor antigen MUC1 which is abnormally expressed in colon cancers and also in inflammatory bowel disease (IBD) that gives rise to colitis-associated colon cancer (CACC).
T5 745-957 Sentence denotes Using our new mouse model of MUC1(+) IBD that progresses to CACC, interleukin-10 knockout mice crossed with MUC1 transgenic mice, we show that vaccination against MUC1 delays IBD and prevents progression to CACC.
T6 958-1121 Sentence denotes One mechanism is the induction of MUC1-specific adaptive immunity (anti-MUC1 IgG and anti-MUC1 CTL), which seems to eliminate abnormal MUC1(+) cells in IBD colons.
T7 1122-1204 Sentence denotes The other mechanism is the change in the local and the systemic microenvironments.
T8 1205-1441 Sentence denotes Compared with IBD in vaccinated mice, IBD in control mice is dominated by larger numbers of neutrophils in the colon and myeloid-derived suppressor cells in the spleen, which can compromise adaptive immunity and facilitate tumor growth.
T9 1442-1642 Sentence denotes This suggests that the tumor-promoting microenvironment of chronic inflammation can be converted to a tumor-inhibiting environment by increasing adaptive immunity against a disease-associated antigen.
T1 0-169 Sentence denotes Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.
T2 170-342 Sentence denotes Association of chronic inflammation with an increased risk of cancer is well established, but the contributions of innate versus adaptive immunity are not fully delineated.
T3 343-553 Sentence denotes There has furthermore been little consideration of the role played by chronic inflammation-associated antigens, including cancer antigens, and the possibility of using them as vaccines to lower the cancer risk.
T4 554-744 Sentence denotes We studied the human tumor antigen MUC1 which is abnormally expressed in colon cancers and also in inflammatory bowel disease (IBD) that gives rise to colitis-associated colon cancer (CACC).
T5 745-957 Sentence denotes Using our new mouse model of MUC1(+) IBD that progresses to CACC, interleukin-10 knockout mice crossed with MUC1 transgenic mice, we show that vaccination against MUC1 delays IBD and prevents progression to CACC.
T6 958-1121 Sentence denotes One mechanism is the induction of MUC1-specific adaptive immunity (anti-MUC1 IgG and anti-MUC1 CTL), which seems to eliminate abnormal MUC1(+) cells in IBD colons.
T7 1122-1204 Sentence denotes The other mechanism is the change in the local and the systemic microenvironments.
T8 1205-1441 Sentence denotes Compared with IBD in vaccinated mice, IBD in control mice is dominated by larger numbers of neutrophils in the colon and myeloid-derived suppressor cells in the spleen, which can compromise adaptive immunity and facilitate tumor growth.
T9 1442-1642 Sentence denotes This suggests that the tumor-promoting microenvironment of chronic inflammation can be converted to a tumor-inhibiting environment by increasing adaptive immunity against a disease-associated antigen.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-169 Sentence denotes Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.
TextSentencer_T2 170-342 Sentence denotes Association of chronic inflammation with an increased risk of cancer is well established, but the contributions of innate versus adaptive immunity are not fully delineated.
TextSentencer_T3 343-553 Sentence denotes There has furthermore been little consideration of the role played by chronic inflammation-associated antigens, including cancer antigens, and the possibility of using them as vaccines to lower the cancer risk.
TextSentencer_T4 554-744 Sentence denotes We studied the human tumor antigen MUC1 which is abnormally expressed in colon cancers and also in inflammatory bowel disease (IBD) that gives rise to colitis-associated colon cancer (CACC).
TextSentencer_T5 745-957 Sentence denotes Using our new mouse model of MUC1(+) IBD that progresses to CACC, interleukin-10 knockout mice crossed with MUC1 transgenic mice, we show that vaccination against MUC1 delays IBD and prevents progression to CACC.
TextSentencer_T6 958-1121 Sentence denotes One mechanism is the induction of MUC1-specific adaptive immunity (anti-MUC1 IgG and anti-MUC1 CTL), which seems to eliminate abnormal MUC1(+) cells in IBD colons.
TextSentencer_T7 1122-1204 Sentence denotes The other mechanism is the change in the local and the systemic microenvironments.
TextSentencer_T8 1205-1441 Sentence denotes Compared with IBD in vaccinated mice, IBD in control mice is dominated by larger numbers of neutrophils in the colon and myeloid-derived suppressor cells in the spleen, which can compromise adaptive immunity and facilitate tumor growth.
TextSentencer_T9 1442-1642 Sentence denotes This suggests that the tumor-promoting microenvironment of chronic inflammation can be converted to a tumor-inhibiting environment by increasing adaptive immunity against a disease-associated antigen.
T1 0-169 Sentence denotes Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.
T2 170-342 Sentence denotes Association of chronic inflammation with an increased risk of cancer is well established, but the contributions of innate versus adaptive immunity are not fully delineated.
T3 343-553 Sentence denotes There has furthermore been little consideration of the role played by chronic inflammation-associated antigens, including cancer antigens, and the possibility of using them as vaccines to lower the cancer risk.
T4 554-744 Sentence denotes We studied the human tumor antigen MUC1 which is abnormally expressed in colon cancers and also in inflammatory bowel disease (IBD) that gives rise to colitis-associated colon cancer (CACC).
T5 745-957 Sentence denotes Using our new mouse model of MUC1(+) IBD that progresses to CACC, interleukin-10 knockout mice crossed with MUC1 transgenic mice, we show that vaccination against MUC1 delays IBD and prevents progression to CACC.
T6 958-1121 Sentence denotes One mechanism is the induction of MUC1-specific adaptive immunity (anti-MUC1 IgG and anti-MUC1 CTL), which seems to eliminate abnormal MUC1(+) cells in IBD colons.
T7 1122-1204 Sentence denotes The other mechanism is the change in the local and the systemic microenvironments.
T8 1205-1441 Sentence denotes Compared with IBD in vaccinated mice, IBD in control mice is dominated by larger numbers of neutrophils in the colon and myeloid-derived suppressor cells in the spleen, which can compromise adaptive immunity and facilitate tumor growth.
T9 1442-1642 Sentence denotes This suggests that the tumor-promoting microenvironment of chronic inflammation can be converted to a tumor-inhibiting environment by increasing adaptive immunity against a disease-associated antigen.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1048-1052 gene:4582 denotes MUC1
T1 1110-1113 disease:C0021390 denotes IBD
T2 1093-1097 gene:4582 denotes MUC1
T3 1110-1113 disease:C0021390 denotes IBD
R1 T0 T1 associated_with MUC1,IBD
R2 T2 T3 associated_with MUC1,IBD

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 232-238 HP_0002664 denotes cancer
T2 465-471 HP_0002664 denotes cancer
T3 541-547 HP_0002664 denotes cancer
T4 575-580 HP_0002664 denotes tumor
T5 627-640 HP_0003003 denotes colon cancers
T6 627-640 HP_0100273 denotes colon cancers
T7 633-640 HP_0002664 denotes cancers
T8 724-736 HP_0003003 denotes colon cancer
T9 724-736 HP_0100273 denotes colon cancer
T10 730-736 HP_0002664 denotes cancer
T11 1428-1433 HP_0002664 denotes tumor
T12 1465-1470 HP_0002664 denotes tumor
T13 1544-1549 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_20332301_3_0 653-679 expanded denotes inflammatory bowel disease
SS2_20332301_3_0 681-684 abbr denotes IBD
SS1_20332301_3_1 705-736 expanded denotes colitis-associated colon cancer
SS2_20332301_3_1 738-742 abbr denotes CACC
AE1_20332301_3_0 SS1_20332301_3_0 SS2_20332301_3_0 abbreviatedTo inflammatory bowel disease,IBD
AE1_20332301_3_1 SS1_20332301_3_1 SS2_20332301_3_1 abbreviatedTo colitis-associated colon cancer,CACC

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20332301-0#16#20#gene4582 16-20 gene4582 denotes MUC1
20332301-0#156#168#diseaseC0007102 156-168 diseaseC0007102 denotes colon cancer
20332301-0#156#168#diseaseC0699790 156-168 diseaseC0699790 denotes colon cancer
20332301-0#42#68#diseaseC0021390 42-68 diseaseC0021390 denotes inflammatory bowel disease
20332301-0#137#144#diseaseC0009319 137-144 diseaseC0009319 denotes colitis
20332301-3#21#34#gene404663 575-588 gene404663 denotes tumor antigen
20332301-3#73#86#diseaseC0007102 627-640 diseaseC0007102 denotes colon cancers
20332301-3#99#125#diseaseC0021390 653-679 diseaseC0021390 denotes inflammatory bowel disease
20332301-3#127#130#diseaseC0021390 681-684 diseaseC0021390 denotes IBD
20332301-3#151#158#diseaseC0009319 705-712 diseaseC0009319 denotes colitis
20332301-4#66#80#gene3586 811-825 gene3586 denotes interleukin-10
20332301-4#175#178#diseaseC0021390 920-923 diseaseC0021390 denotes IBD
16#20#gene4582156#168#diseaseC0007102 20332301-0#16#20#gene4582 20332301-0#156#168#diseaseC0007102 associated_with MUC1,colon cancer
16#20#gene4582156#168#diseaseC0699790 20332301-0#16#20#gene4582 20332301-0#156#168#diseaseC0699790 associated_with MUC1,colon cancer
16#20#gene458242#68#diseaseC0021390 20332301-0#16#20#gene4582 20332301-0#42#68#diseaseC0021390 associated_with MUC1,inflammatory bowel disease
16#20#gene4582137#144#diseaseC0009319 20332301-0#16#20#gene4582 20332301-0#137#144#diseaseC0009319 associated_with MUC1,colitis
21#34#gene40466373#86#diseaseC0007102 20332301-3#21#34#gene404663 20332301-3#73#86#diseaseC0007102 associated_with tumor antigen,colon cancers
21#34#gene40466399#125#diseaseC0021390 20332301-3#21#34#gene404663 20332301-3#99#125#diseaseC0021390 associated_with tumor antigen,inflammatory bowel disease
21#34#gene404663127#130#diseaseC0021390 20332301-3#21#34#gene404663 20332301-3#127#130#diseaseC0021390 associated_with tumor antigen,IBD
21#34#gene404663151#158#diseaseC0009319 20332301-3#21#34#gene404663 20332301-3#151#158#diseaseC0009319 associated_with tumor antigen,colitis
66#80#gene3586175#178#diseaseC0021390 20332301-4#66#80#gene3586 20332301-4#175#178#diseaseC0021390 associated_with interleukin-10,IBD

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2463 16-20 gene:4582 denotes MUC1
T2464 156-168 disease:C0007102 denotes colon cancer
R1 T2463 T2464 associated_with MUC1,colon cancer
R2 T2463 T2464 associated_with MUC1,colon cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 88-95 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
PD-UBERON-AE-B_T2 156-161 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T3 627-632 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T4 724-729 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T5 1316-1321 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T6 1366-1372 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 88-95 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
PD-UBERON-AE-B_T2 156-161 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T3 627-632 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T4 724-729 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T5 1114-1120 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colons
PD-UBERON-AE-B_T6 1316-1321 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T7 1366-1372 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen