| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
147-248 |
DRI_Background |
denotes |
Proper control of epithelial morphogenesis is vital to development and is often disrupted in disease. |
| T2 |
249-380 |
DRI_Background |
denotes |
After germ band extension, the cells of the Drosophila ventral embryonic epidermis are packed in a two-dimensional polygonal array. |
| T3 |
381-585 |
DRI_Background |
denotes |
Although epithelial cell rearrangements are being studied productively in several tissues, the ventral epidermis is of particular interest as the final cell arrangement is, uniquely, far from equilibrium. |
| T4 |
586-743 |
DRI_Outcome |
denotes |
We show that over the course of several hours, a subset of cells within each parasegment adopts a rectilinear configuration and aligns into parallel columns. |
| T5 |
744-894 |
DRI_Outcome |
denotes |
Live imaging shows that this is accomplished by the shrinkage of select cell interfaces, as three-cell junctions are converted to four-cell junctions. |
| T6 |
895-1148 |
DRI_Outcome |
denotes |
Additionally, we show that non-muscle Myosin II and the polarity proteins Discs large (Dlg) and Bazooka are enriched along cell interfaces in a complex but reproducible pattern that suggests their involvement in junctional conversion and cell alignment. |
| T7 |
1149-1212 |
DRI_Background |
denotes |
Indeed, depletion of Myosin II or dlg disrupts these processes. |
| T8 |
1213-1351 |
DRI_Challenge |
denotes |
These results show that tight spatial regulation of actomyosin contractility is required to produce this high-energy arrangement of cells. |
