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PubMed:20332088 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutant.
T2 109-262 Sentence denotes Coloration is one of the most variable characters in animals and provides rich material for studying the developmental genetic basis of pigment patterns.
T3 263-355 Sentence denotes In the silkworm, more than 100 gene mutation systems are related to aberrant color patterns.
T4 356-488 Sentence denotes The melanism (mln) is a rare body color mutant that exhibits an easily distinguishable phenotype in both larval and adult silkworms.
T5 489-700 Sentence denotes By positional cloning, we identified the candidate gene of the mln locus, Bm-iAANAT, whose homologous gene (Dat) converts dopamine into N-acetyldopamine, a precursor for N-acetyldopamine sclerotin in Drosophila.
T6 701-848 Sentence denotes In the mln mutant, two types of abnormal Bm-iAANAT transcripts were identified, whose expression levels are markedly lower than the wild type (WT).
T7 849-1048 Sentence denotes Moreover, dopamine content was approximately twice as high in the sclerified tissues (head, thoracic legs, and anal plate) of the mutant as in WT, resulting in phenotypic differences between the two.
T8 1049-1258 Sentence denotes Quantitative reverse transcription PCR analyses showed that other genes involved in the melanin metabolism pathway were regulated by the aberrant Bm-iAANAT activity in mln mutant in different ways and degrees.
T9 1259-1451 Sentence denotes We therefore propose that greater accumulation of dopamine results from the functional deficiency of Bm-iAANAT in the mutant, causing a darker pattern in the sclerified regions than in the WT.
T10 1452-1565 Sentence denotes In summary, our results indicate that Bm-iAANAT is responsible for the color pattern of the silkworm mutant, mln.
T11 1566-1705 Sentence denotes To our knowledge, this is the first report showing a role for arylalkylamine-N-acetyltransferases in color pattern mutation in Lepidoptera.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 245-252 http://purl.obolibrary.org/obo/MAT_0000159 denotes pigment
T2 935-939 http://purl.obolibrary.org/obo/MAT_0000294 denotes head

silkworm

Id Subject Object Predicate Lexical cue
T1 16-50 Gene:780849 denotes arylalkylamine-N-acetyltransferase
T2 83-91 Species:7091 denotes silkworm
T3 270-278 Species:7091 denotes silkworm
T4 478-487 Species:7091 denotes silkworms
T5 597-600 Gene:36849 denotes Dat
T6 611-619 Chemical:MESH:D004298 denotes dopamine
T7 625-641 Chemical:MESH:C006374 denotes N-acetyldopamine
T8 659-675 Chemical:MESH:C006374 denotes N-acetyldopamine
T9 689-699 Species:7227 denotes Drosophila
T10 859-867 Chemical:MESH:D004298 denotes dopamine
T11 1137-1144 Chemical:MESH:D008543 denotes melanin
T12 1309-1317 Chemical:MESH:D004298 denotes dopamine
T13 1544-1552 Species:7091 denotes silkworm

Allie

Id Subject Object Predicate Lexical cue
SS1_20332088_3_0 360-368 expanded denotes melanism
SS2_20332088_3_0 370-373 abbr denotes mln
SS1_20332088_5_0 833-842 expanded denotes wild type
SS2_20332088_5_0 844-846 abbr denotes WT
AE1_20332088_3_0 SS1_20332088_3_0 SS2_20332088_3_0 abbreviatedTo melanism,mln
AE1_20332088_5_0 SS1_20332088_5_0 SS2_20332088_5_0 abbreviatedTo wild type,WT

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 245-252 Body_part denotes pigment http://purl.obolibrary.org/obo/MAT_0000159
T2 935-939 Body_part denotes head http://purl.obolibrary.org/obo/MAT_0000294

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 83-91 OrganismTaxon denotes silkworm 7091
T2 270-278 OrganismTaxon denotes silkworm 7091
T3 478-487 OrganismTaxon denotes silkworms 7091
T4 689-699 OrganismTaxon denotes Drosophila 2081351|32281|7215
T7 1544-1552 OrganismTaxon denotes silkworm 7091
T8 1693-1704 OrganismTaxon denotes Lepidoptera 7088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 935-939 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T2 965-970 Body_part denotes plate http://purl.obolibrary.org/obo/UBERON_6004475