PubMed:20304916
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 40-49 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
| T3 | 381-390 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
| T5 | 392-395 | Glycan_Motif | denotes | Gal | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT |
| T6 | 583-586 | Glycan_Motif | denotes | Gal | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT |
| T7 | 591-612 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T8 | 1500-1519 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-164 | Sentence | denotes | Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. |
| T2 | 165-326 | Sentence | denotes | Dendritic cells (DCs) express cell surface lectins that are potentially involved in the recognition, uptake, and presentation of glycosylated foreign substances. |
| T3 | 327-622 | Sentence | denotes | A unique calcium-type (C-type) lectin, the macrophage galactose (Gal)-type C-type lectin (MGL/CD301) expressed on DCs, is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). |
| T4 | 623-727 | Sentence | denotes | Although mice have two MGL genes, Mgl1 and Mgl2, their distinct roles have not been previously explored. |
| T5 | 728-858 | Sentence | denotes | The present report characterizes the properties of MGL2 by examining its distribution and its role in antigen presentation by DCs. |
| T6 | 859-1013 | Sentence | denotes | We generated an MGL2-specific monoclonal antibody and examined MGL2 expression in tissues by immunohistochemistry and in isolated cells by flow cytometry. |
| T7 | 1014-1129 | Sentence | denotes | The cells reactive with this antibody were shown to be a portion of MGL1-expressing cells, mostly conventional DCs. |
| T8 | 1130-1369 | Sentence | denotes | Internalization of soluble polyacrylamide polymers (PAA) with alpha-GalNAc residues (GalNAc-PAA) by bone marrow-derived DCs (BM-DCs) was mediated by MGL2, as revealed by a comparison of Mgl1(-/-) and Mgl2(-/-) BM-DCs with wild-type BM-DCs. |
| T9 | 1370-1608 | Sentence | denotes | Biotinylated GalNAc-PAA conjugated to streptavidin (SAv) was more efficiently presented to SAv-primed T cells by BM-DCs than beta-N-acetylglucosamine-PAA conjugated to SAv or SAv alone as shown by thymidine uptake and cytokine production. |
| T10 | 1609-1767 | Sentence | denotes | This is the first report that demonstrates the involvement of GalNAc residues in antigen uptake and presentation by DCs that lead to CD4(+) T cell activation. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 40-49 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
| T2 | 40-49 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
| T3 | 381-390 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
| T4 | 381-390 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
| T5 | 591-612 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T6 | 1500-1519 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1230-1241 | http://purl.obolibrary.org/obo/MAT_0000084 | denotes | bone marrow |
| T2 | 1230-1234 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20304916_1_0 | 165-180 | expanded | denotes | Dendritic cells |
| SS2_20304916_1_0 | 182-185 | abbr | denotes | DCs |
| SS1_20304916_2_0 | 336-348 | expanded | denotes | calcium-type |
| SS2_20304916_2_0 | 350-356 | abbr | denotes | C-type |
| SS1_20304916_2_1 | 381-390 | expanded | denotes | galactose |
| SS2_20304916_2_1 | 392-395 | abbr | denotes | Gal |
| SS1_20304916_2_2 | 583-612 | expanded | denotes | Gal and N-acetylgalactosamine |
| SS2_20304916_2_2 | 614-620 | abbr | denotes | GalNAc |
| SS1_20304916_7_0 | 1157-1180 | expanded | denotes | polyacrylamide polymers |
| SS2_20304916_7_0 | 1182-1185 | abbr | denotes | PAA |
| SS1_20304916_7_1 | 1192-1213 | expanded | denotes | alpha-GalNAc residues |
| SS2_20304916_7_1 | 1215-1225 | abbr | denotes | GalNAc-PAA |
| SS1_20304916_7_2 | 1230-1253 | expanded | denotes | bone marrow-derived DCs |
| SS2_20304916_7_2 | 1255-1261 | abbr | denotes | BM-DCs |
| SS1_20304916_8_0 | 1408-1420 | expanded | denotes | streptavidin |
| SS2_20304916_8_0 | 1422-1425 | abbr | denotes | SAv |
| AE1_20304916_1_0 | SS1_20304916_1_0 | SS2_20304916_1_0 | abbreviatedTo | Dendritic cells,DCs |
| AE1_20304916_2_0 | SS1_20304916_2_0 | SS2_20304916_2_0 | abbreviatedTo | calcium-type,C-type |
| AE1_20304916_2_1 | SS1_20304916_2_1 | SS2_20304916_2_1 | abbreviatedTo | galactose,Gal |
| AE1_20304916_2_2 | SS1_20304916_2_2 | SS2_20304916_2_2 | abbreviatedTo | Gal and N-acetylgalactosamine,GalNAc |
| AE1_20304916_7_0 | SS1_20304916_7_0 | SS2_20304916_7_0 | abbreviatedTo | polyacrylamide polymers,PAA |
| AE1_20304916_7_1 | SS1_20304916_7_1 | SS2_20304916_7_1 | abbreviatedTo | alpha-GalNAc residues,GalNAc-PAA |
| AE1_20304916_7_2 | SS1_20304916_7_2 | SS2_20304916_7_2 | abbreviatedTo | bone marrow-derived DCs,BM-DCs |
| AE1_20304916_8_0 | SS1_20304916_8_0 | SS2_20304916_8_0 | abbreviatedTo | streptavidin,SAv |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 614-620 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 1198-1204 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 1215-1221 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 1383-1389 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 1671-1677 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 632-636 | OrganismTaxon | denotes | mice | 10088 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 29-39 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 148-163 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T5 | 165-180 | Cell | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T7 | 182-185 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T8 | 370-380 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T10 | 441-444 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T11 | 854-857 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T12 | 1125-1128 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T13 | 1250-1253 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T14 | 1258-1261 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T15 | 1343-1346 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T16 | 1365-1368 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T17 | 1472-1479 | Cell | denotes | T cells | http://purl.obolibrary.org/obo/CL:0000084 |
| T18 | 1486-1489 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T19 | 1725-1728 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T20 | 1749-1755 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 29-39 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 148-163 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T3 | 165-180 | Body_part | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T4 | 182-185 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T5 | 370-380 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T6 | 441-444 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T7 | 854-857 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T8 | 1125-1128 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T9 | 1230-1241 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
| T10 | 1250-1253 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T11 | 1258-1261 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T12 | 1343-1346 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T13 | 1365-1368 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T14 | 1486-1489 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T15 | 1725-1728 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T16 | 1749-1755 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1230-1241 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-164 | Sentence | denotes | Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. |
| T2 | 165-326 | Sentence | denotes | Dendritic cells (DCs) express cell surface lectins that are potentially involved in the recognition, uptake, and presentation of glycosylated foreign substances. |
| T3 | 327-622 | Sentence | denotes | A unique calcium-type (C-type) lectin, the macrophage galactose (Gal)-type C-type lectin (MGL/CD301) expressed on DCs, is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). |
| T4 | 623-727 | Sentence | denotes | Although mice have two MGL genes, Mgl1 and Mgl2, their distinct roles have not been previously explored. |
| T5 | 728-858 | Sentence | denotes | The present report characterizes the properties of MGL2 by examining its distribution and its role in antigen presentation by DCs. |
| T6 | 859-1013 | Sentence | denotes | We generated an MGL2-specific monoclonal antibody and examined MGL2 expression in tissues by immunohistochemistry and in isolated cells by flow cytometry. |
| T7 | 1014-1129 | Sentence | denotes | The cells reactive with this antibody were shown to be a portion of MGL1-expressing cells, mostly conventional DCs. |
| T8 | 1130-1369 | Sentence | denotes | Internalization of soluble polyacrylamide polymers (PAA) with alpha-GalNAc residues (GalNAc-PAA) by bone marrow-derived DCs (BM-DCs) was mediated by MGL2, as revealed by a comparison of Mgl1(-/-) and Mgl2(-/-) BM-DCs with wild-type BM-DCs. |
| T9 | 1370-1608 | Sentence | denotes | Biotinylated GalNAc-PAA conjugated to streptavidin (SAv) was more efficiently presented to SAv-primed T cells by BM-DCs than beta-N-acetylglucosamine-PAA conjugated to SAv or SAv alone as shown by thymidine uptake and cytokine production. |
| T10 | 1609-1767 | Sentence | denotes | This is the first report that demonstrates the involvement of GalNAc residues in antigen uptake and presentation by DCs that lead to CD4(+) T cell activation. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-164 | Sentence | denotes | Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. |
| T2 | 165-326 | Sentence | denotes | Dendritic cells (DCs) express cell surface lectins that are potentially involved in the recognition, uptake, and presentation of glycosylated foreign substances. |
| T3 | 327-622 | Sentence | denotes | A unique calcium-type (C-type) lectin, the macrophage galactose (Gal)-type C-type lectin (MGL/CD301) expressed on DCs, is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). |
| T4 | 623-727 | Sentence | denotes | Although mice have two MGL genes, Mgl1 and Mgl2, their distinct roles have not been previously explored. |
| T5 | 728-858 | Sentence | denotes | The present report characterizes the properties of MGL2 by examining its distribution and its role in antigen presentation by DCs. |
| T6 | 859-1013 | Sentence | denotes | We generated an MGL2-specific monoclonal antibody and examined MGL2 expression in tissues by immunohistochemistry and in isolated cells by flow cytometry. |
| T7 | 1014-1129 | Sentence | denotes | The cells reactive with this antibody were shown to be a portion of MGL1-expressing cells, mostly conventional DCs. |
| T8 | 1130-1369 | Sentence | denotes | Internalization of soluble polyacrylamide polymers (PAA) with alpha-GalNAc residues (GalNAc-PAA) by bone marrow-derived DCs (BM-DCs) was mediated by MGL2, as revealed by a comparison of Mgl1(-/-) and Mgl2(-/-) BM-DCs with wild-type BM-DCs. |
| T9 | 1370-1608 | Sentence | denotes | Biotinylated GalNAc-PAA conjugated to streptavidin (SAv) was more efficiently presented to SAv-primed T cells by BM-DCs than beta-N-acetylglucosamine-PAA conjugated to SAv or SAv alone as shown by thymidine uptake and cytokine production. |
| T10 | 1609-1767 | Sentence | denotes | This is the first report that demonstrates the involvement of GalNAc residues in antigen uptake and presentation by DCs that lead to CD4(+) T cell activation. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 614-620 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 1198-1204 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 1215-1221 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 1383-1389 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 1671-1677 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 632-636 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 29-39 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 148-163 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T3 | 165-180 | Body_part | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T4 | 182-185 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T5 | 370-380 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T6 | 441-444 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T7 | 854-857 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T8 | 1125-1128 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T9 | 1230-1241 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
| T10 | 1250-1253 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T11 | 1258-1261 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T12 | 1343-1346 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T13 | 1365-1368 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T14 | 1486-1489 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T15 | 1725-1728 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T16 | 1749-1755 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1230-1241 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 29-39 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 148-163 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T5 | 165-180 | Cell | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T7 | 182-185 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T8 | 370-380 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T10 | 441-444 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T11 | 854-857 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T12 | 1125-1128 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T13 | 1250-1253 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T14 | 1258-1261 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T15 | 1343-1346 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T16 | 1365-1368 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T17 | 1472-1479 | Cell | denotes | T cells | http://purl.obolibrary.org/obo/CL:0000084 |
| T18 | 1486-1489 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T19 | 1725-1728 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T20 | 1749-1755 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |