PubMed:20299331 / 129-707
Annnotations
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20299331_2_0 | 8-34 | expanded | denotes | mineralocorticoid receptor |
| SS2_20299331_2_0 | 36-38 | abbr | denotes | MR |
| SS1_20299331_3_0 | 241-255 | expanded | denotes | embryonic stem |
| SS2_20299331_3_0 | 257-259 | abbr | denotes | ES |
| AE1_20299331_2_0 | SS1_20299331_2_0 | SS2_20299331_2_0 | abbreviatedTo | mineralocorticoid receptor,MR |
| AE1_20299331_3_0 | SS1_20299331_3_0 | SS2_20299331_3_0 | abbreviatedTo | embryonic stem,ES |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 404-418 | HP_0001638 | denotes | cardiomyopathy |
| T2 | 420-431 | HP_0001649 | denotes | tachycardia |
| T3 | 437-447 | HP_0011675 | denotes | arrhythmia |
PubMed_Structured_Abstracts
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-578 | OBJECTIVE | denotes | Cardiac mineralocorticoid receptor (MR) activation triggers adverse cardiovascular events that could be efficiently prevented by mineralocorticoid antagonists. To gain insights into the pathophysiological role of MR function, we established embryonic stem (ES) cell lines from blastocysts of transgenic mice overexpressing the human MR driven by its proximal P1 or distal P2 promoter and presenting with cardiomyopathy, tachycardia, and arrhythmia. Cardiomyocyte differentiation allowed us to investigate the molecular mechanisms contributing to MR-mediated cardiac dysfunction. |