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sentences

Id Subject Object Predicate Lexical cue
T1 0-54 Sentence denotes Tissue-specific expression of the platelet GPIIb gene.
T2 55-238 Sentence denotes One of the major objectives in the study of thrombogenesis is to determine the mechanisms by which a hematopoietic progenitor is activated and committed to the megakaryocytic lineage.
T3 239-480 Sentence denotes Recent development of primary cultures of human megakaryocytes and the molecular cloning of genes that are specific to this lineage offer the possibility of getting some insights into the genetic mechanisms that control megakaryocytopoiesis.
T4 481-756 Sentence denotes One gene of interest is the glycoprotein IIb (GPIIb) gene; GPIIb, the alpha subunit of the platelet cytoadhesin GPIIb-IIIa, is produced in megakaryocytes at an early stage of the differentiation, whereas the other subunit of this complex, GPIIIa, is expressed in other cells.
T5 757-897 Sentence denotes For these reasons, the 5'-flanking region of the GPIIb gene was used to identify the regions that interact with DNA-binding nuclear factors.
T6 898-1037 Sentence denotes A fragment extending from -643 to +33 is capable of controlling the tissue-specific expression of the CAT gene in transfection experiments.
T7 1038-1204 Sentence denotes Within this region, we have identified several sequences that are implicated in DNA protein interactions as shown in DNAse I footprints and gel mobility shift assays.
T8 1205-1343 Sentence denotes One region, centered at -54, is similar to a nuclear factor E1-binding site, and a region located at position -233 contains a CCAAT motif.
T9 1344-1491 Sentence denotes Two domains centered at positions -345 and -540, respectively, bind proteins that are present in megakaryocytic cells and nonrelated cells as well.
T10 1492-1625 Sentence denotes Finally, two other domains, located at positions -460 and -510, interact with proteins that are only present in megakaryocytic cells.
T11 1626-1750 Sentence denotes In addition, deletion of the region containing these two domains results in a significant decrease of the promoter activity.
T12 1751-1874 Sentence denotes It is very likely that these domains bind megakaryocyte-specific nuclear proteins acting as positive transcription factors.
T1 0-54 Sentence denotes Tissue-specific expression of the platelet GPIIb gene.
T2 55-238 Sentence denotes One of the major objectives in the study of thrombogenesis is to determine the mechanisms by which a hematopoietic progenitor is activated and committed to the megakaryocytic lineage.
T3 239-480 Sentence denotes Recent development of primary cultures of human megakaryocytes and the molecular cloning of genes that are specific to this lineage offer the possibility of getting some insights into the genetic mechanisms that control megakaryocytopoiesis.
T4 481-756 Sentence denotes One gene of interest is the glycoprotein IIb (GPIIb) gene; GPIIb, the alpha subunit of the platelet cytoadhesin GPIIb-IIIa, is produced in megakaryocytes at an early stage of the differentiation, whereas the other subunit of this complex, GPIIIa, is expressed in other cells.
T5 757-897 Sentence denotes For these reasons, the 5'-flanking region of the GPIIb gene was used to identify the regions that interact with DNA-binding nuclear factors.
T6 898-1037 Sentence denotes A fragment extending from -643 to +33 is capable of controlling the tissue-specific expression of the CAT gene in transfection experiments.
T7 1038-1204 Sentence denotes Within this region, we have identified several sequences that are implicated in DNA protein interactions as shown in DNAse I footprints and gel mobility shift assays.
T8 1205-1343 Sentence denotes One region, centered at -54, is similar to a nuclear factor E1-binding site, and a region located at position -233 contains a CCAAT motif.
T9 1344-1491 Sentence denotes Two domains centered at positions -345 and -540, respectively, bind proteins that are present in megakaryocytic cells and nonrelated cells as well.
T10 1492-1625 Sentence denotes Finally, two other domains, located at positions -460 and -510, interact with proteins that are only present in megakaryocytic cells.
T11 1626-1750 Sentence denotes In addition, deletion of the region containing these two domains results in a significant decrease of the promoter activity.
T12 1751-1874 Sentence denotes It is very likely that these domains bind megakaryocyte-specific nuclear proteins acting as positive transcription factors.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 34-53 DNA denotes platelet GPIIb gene
T2 156-180 cell_type denotes hematopoietic progenitor
T3 215-237 cell_type denotes megakaryocytic lineage
T4 261-277 cell_line denotes primary cultures
T5 281-301 cell_line denotes human megakaryocytes
T6 509-538 DNA denotes glycoprotein IIb (GPIIb) gene
T7 540-545 DNA denotes GPIIb
T8 551-564 protein denotes alpha subunit
T9 572-603 protein denotes platelet cytoadhesin GPIIb-IIIa
T10 620-634 cell_line denotes megakaryocytes
T11 720-726 protein denotes GPIIIa
T12 780-798 DNA denotes 5'-flanking region
T13 806-816 DNA denotes GPIIb gene
T14 869-896 protein denotes DNA-binding nuclear factors
T15 924-935 DNA denotes -643 to +33
T16 1000-1008 DNA denotes CAT gene
T17 1155-1162 protein denotes DNAse I
T18 1250-1280 DNA denotes nuclear factor E1-binding site
T19 1331-1342 DNA denotes CCAAT motif
T20 1441-1461 cell_line denotes megakaryocytic cells
T21 1466-1482 cell_type denotes nonrelated cells
T22 1604-1624 cell_line denotes megakaryocytic cells
T23 1732-1740 DNA denotes promoter
T24 1793-1832 protein denotes megakaryocyte-specific nuclear proteins
T25 1843-1873 protein denotes positive transcription factors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-54 Sentence denotes Tissue-specific expression of the platelet GPIIb gene.
S2 55-238 Sentence denotes One of the major objectives in the study of thrombogenesis is to determine the mechanisms by which a hematopoietic progenitor is activated and committed to the megakaryocytic lineage.
S3 239-480 Sentence denotes Recent development of primary cultures of human megakaryocytes and the molecular cloning of genes that are specific to this lineage offer the possibility of getting some insights into the genetic mechanisms that control megakaryocytopoiesis.
S4 481-756 Sentence denotes One gene of interest is the glycoprotein IIb (GPIIb) gene; GPIIb, the alpha subunit of the platelet cytoadhesin GPIIb-IIIa, is produced in megakaryocytes at an early stage of the differentiation, whereas the other subunit of this complex, GPIIIa, is expressed in other cells.
S5 757-897 Sentence denotes For these reasons, the 5'-flanking region of the GPIIb gene was used to identify the regions that interact with DNA-binding nuclear factors.
S6 898-1037 Sentence denotes A fragment extending from -643 to +33 is capable of controlling the tissue-specific expression of the CAT gene in transfection experiments.
S7 1038-1204 Sentence denotes Within this region, we have identified several sequences that are implicated in DNA protein interactions as shown in DNAse I footprints and gel mobility shift assays.
S8 1205-1343 Sentence denotes One region, centered at -54, is similar to a nuclear factor E1-binding site, and a region located at position -233 contains a CCAAT motif.
S9 1344-1491 Sentence denotes Two domains centered at positions -345 and -540, respectively, bind proteins that are present in megakaryocytic cells and nonrelated cells as well.
S10 1492-1625 Sentence denotes Finally, two other domains, located at positions -460 and -510, interact with proteins that are only present in megakaryocytic cells.
S11 1626-1750 Sentence denotes In addition, deletion of the region containing these two domains results in a significant decrease of the promoter activity.
S12 1751-1874 Sentence denotes It is very likely that these domains bind megakaryocyte-specific nuclear proteins acting as positive transcription factors.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 43-53 NP denotes GPIIb gene
C2 211-237 NP denotes the megakaryocytic lineage
C3 281-301 NP denotes human megakaryocytes
C4 331-336 NP denotes genes
C5 337-341 NP denotes that
C6 358-370 NP denotes this lineage
C7 423-445 NP denotes the genetic mechanisms
C8 446-450 NP denotes that
C9 505-538 NP denotes the glycoprotein IIb (GPIIb) gene
C10 540-545 NP denotes GPIIb
C11 547-603 NP denotes the alpha subunit of the platelet cytoadhesin GPIIb-IIIa
C12 620-634 NP denotes megakaryocytes
C13 802-816 NP denotes the GPIIb gene
C14 838-849 NP denotes the regions
C15 850-854 NP denotes that
C16 898-935 NP denotes A fragment extending from -643 to +33
C17 1038-1056 NP denotes Within this region
C18 1077-1094 NP denotes several sequences
C19 1095-1099 NP denotes that
C20 1412-1420 NP denotes proteins
C21 1421-1425 NP denotes that
C22 1441-1461 NP denotes megakaryocytic cells
C23 1501-1518 NP denotes two other domains
C24 1570-1578 NP denotes proteins
C25 1579-1583 NP denotes that
C26 1604-1624 NP denotes megakaryocytic cells
C27 1673-1690 NP denotes these two domains
C28 1774-1787 NP denotes these domains
R6 C11 C10 coref-appos the alpha subunit of the platelet cytoadhesin GPIIb-IIIa,GPIIb
R7 C12 C3 coref-other megakaryocytes,human megakaryocytes
R8 C13 C10 coref-ident the GPIIb gene,GPIIb
R9 C15 C14 coref-relat that,the regions
R10 C17 C16 coref-ident Within this region,A fragment extending from -643 to +33
R1 C5 C4 coref-relat that,genes
R2 C6 C2 coref-other this lineage,the megakaryocytic lineage
R3 C8 C7 coref-relat that,the genetic mechanisms
R4 C9 C1 coref-ident the glycoprotein IIb (GPIIb) gene,GPIIb gene
R5 C10 C9 coref-ident GPIIb,the glycoprotein IIb (GPIIb) gene
R11 C19 C18 coref-relat that,several sequences
R12 C21 C20 coref-relat that,proteins
R13 C25 C24 coref-relat that,proteins
R14 C26 C22 coref-ident megakaryocytic cells,megakaryocytic cells
R15 C27 C23 coref-ident these two domains,two other domains
R16 C28 C27 coref-ident these domains,these two domains

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-26 other_name denotes Tissue-specific expression
T2 34-53 DNA_domain_or_region denotes platelet GPIIb gene
T3 99-113 other_name denotes thrombogenesis
T4 156-180 cell_type denotes hematopoietic progenitor
T5 215-237 cell_type denotes megakaryocytic lineage
T6 261-277 cell_line denotes primary cultures
T7 281-301 cell_line denotes human megakaryocytes
T8 310-327 other_name denotes molecular cloning
T9 459-479 other_name denotes megakaryocytopoiesis
T10 509-538 DNA_domain_or_region denotes glycoprotein IIb (GPIIb) gene
T11 540-545 DNA_domain_or_region denotes GPIIb
T12 551-564 protein_subunit denotes alpha subunit
T13 572-603 protein_molecule denotes platelet cytoadhesin GPIIb-IIIa
T14 620-634 cell_line denotes megakaryocytes
T15 720-726 protein_molecule denotes GPIIIa
T16 780-798 DNA_domain_or_region denotes 5'-flanking region
T17 806-816 DNA_domain_or_region denotes GPIIb gene
T18 869-896 protein_family_or_group denotes DNA-binding nuclear factors
T19 924-935 DNA_domain_or_region denotes -643 to +33
T20 966-992 other_name denotes tissue-specific expression
T21 1000-1008 DNA_family_or_group denotes CAT gene
T22 1012-1036 other_name denotes transfection experiments
T23 1118-1142 other_name denotes DNA protein interactions
T24 1155-1162 protein_molecule denotes DNAse I
T25 1178-1203 other_name denotes gel mobility shift assays
T26 1250-1280 DNA_domain_or_region denotes nuclear factor E1-binding site
T27 1331-1342 DNA_domain_or_region denotes CCAAT motif
T28 1441-1461 cell_line denotes megakaryocytic cells
T29 1466-1482 cell_type denotes nonrelated cells
T30 1604-1624 cell_line denotes megakaryocytic cells
T31 1732-1740 DNA_domain_or_region denotes promoter
T32 1793-1832 protein_family_or_group denotes megakaryocyte-specific nuclear proteins
T33 1843-1851 protein_family_or_group denotes positive
T34 1852-1865 other_name denotes transcription

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 281-286 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-6 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 34-42 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T3 215-229 Body_part denotes megakaryocytic http://purl.obolibrary.org/obo/CL_0000556
T4 287-301 Body_part denotes megakaryocytes http://purl.obolibrary.org/obo/CL_0000556
T5 572-580 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T6 620-634 Body_part denotes megakaryocytes http://purl.obolibrary.org/obo/CL_0000556
T7 966-972 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T8 1441-1455 Body_part denotes megakaryocytic http://purl.obolibrary.org/obo/CL_0000556
T9 1604-1618 Body_part denotes megakaryocytic http://purl.obolibrary.org/obo/CL_0000556
T10 1793-1806 Body_part denotes megakaryocyte http://purl.obolibrary.org/obo/CL_0000556

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 34-42 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T2 215-229 Cell denotes megakaryocytic http://purl.obolibrary.org/obo/CL:0000556
T3 287-301 Cell denotes megakaryocytes http://purl.obolibrary.org/obo/CL:0000556
T4 572-580 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T5 620-634 Cell denotes megakaryocytes http://purl.obolibrary.org/obo/CL:0000556
T6 1441-1455 Cell denotes megakaryocytic http://purl.obolibrary.org/obo/CL:0000556
T7 1604-1618 Cell denotes megakaryocytic http://purl.obolibrary.org/obo/CL:0000556
T8 1793-1806 Cell denotes megakaryocyte http://purl.obolibrary.org/obo/CL:0000556