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PubMed:2024810 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-23 protein denotes Glucocorticoid receptor
T2 43-52 cell_type denotes monocytes
T3 317-343 cell_type denotes peripheral blood monocytes
T4 473-477 protein denotes LTB4
T5 493-510 cell_type denotes human neutrophils
T6 512-515 cell_type denotes PMN
T7 700-709 cell_type denotes monocytes
T8 917-926 cell_type denotes monocytes

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 159-175 HP_0002099 denotes bronchial asthma
T2 169-175 HP_0002099 denotes asthma
T3 1478-1494 HP_0002099 denotes bronchial asthma
T4 1488-1494 HP_0002099 denotes asthma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-112 Sentence denotes Glucocorticoid receptor characteristics in monocytes of patients with corticosteroid-resistant bronchial asthma.
S2 113-549 Sentence denotes The mechanism of corticosteroid resistance in bronchial asthma has been studied by determining the rank order of potency for different corticosteroids in inhibiting the generation of a 3 kD molecule from peripheral blood monocytes isolated from corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic subjects, which augments leukotriene B4 (LTB4) generation by human neutrophils (PMN) stimulated by calcium ionophore.
S3 550-742 Sentence denotes In addition, binding studies with (3H) dexamethasone have been performed to determine the dissociation constant (Kd) and receptor numbers (Ro) in the monocytes of these two groups of subjects.
S4 743-947 Sentence denotes The concentration of corticosteroid producing 50% inhibition (IC50) was 600 nM, 70 nM, and 0.5 nM for hydrocortisone, methylprednisolone, and dexamethasone, respectively, in monocytes from CS individuals.
S5 948-1074 Sentence denotes There was only weak inhibition of the generation of enhancing activity by the corticosteroids in the CR asthmatic individuals.
S6 1075-1236 Sentence denotes The dexamethasone Kd was 2.45 +/- 0.58 nM (mean +/- SEM, n = 6) in the CS group and 1.6 +/- 0.35 nM (mean +/- SEM, n = 6) in the CR group of patients (p = 0.14).
S7 1237-1419 Sentence denotes The Ro in the CS group was 3,605 +/- 984 binding sites per nucleus (mean +/- SEM, n = 6) and 4,757 +/- 692 binding sites per nucleus (mean +/- SEM, n = 6) in the CR group (p = 0.23).
S8 1420-1575 Sentence denotes These findings indicate that corticosteroid resistance in bronchial asthma cannot be explained by abnormalities in corticosteroid receptor characteristics.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 43-52 NP denotes monocytes
C2 70-111 NP denotes corticosteroid-resistant bronchial asthma
C3 130-175 NP denotes corticosteroid resistance in bronchial asthma
C4 248-263 NP denotes corticosteroids
C6 358-387 NP denotes corticosteroid-sensitive (CS)
C7 392-421 NP denotes corticosteroid-resistant (CR)
C5 358-440 NP denotes corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic subjects
C8 442-447 NP denotes which
C9 636-666 NP denotes the dissociation constant (Kd)
C10 671-692 NP denotes receptor numbers (Ro)
C11 696-709 NP denotes the monocytes
C12 713-741 NP denotes these two groups of subjects
C13 764-778 NP denotes corticosteroid
C14 917-926 NP denotes monocytes
C15 932-934 NP denotes CS
C16 1022-1041 NP denotes the corticosteroids
C17 1049-1051 NP denotes CR
C18 1093-1095 NP denotes Kd
C20 1146-1148 NP denotes CS
C19 1142-1154 NP denotes the CS group
C22 1204-1206 NP denotes CR
C21 1200-1212 NP denotes the CR group
C23 1237-1243 NP denotes The Ro
C25 1251-1253 NP denotes CS
C24 1247-1259 NP denotes the CS group
C27 1399-1401 NP denotes CR
C26 1395-1407 NP denotes the CR group
C28 1449-1494 NP denotes corticosteroid resistance in bronchial asthma
R1 C3 C2 coref-ident corticosteroid resistance in bronchial asthma,corticosteroid-resistant bronchial asthma
R2 C8 C5 coref-relat which,corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic subjects
R3 C11 C1 coref-other the monocytes,monocytes
R4 C12 C5 coref-ident these two groups of subjects,corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic subjects
R5 C13 C4 coref-ident corticosteroid,corticosteroids
R6 C14 C11 coref-ident monocytes,the monocytes
R7 C15 C6 coref-ident CS,corticosteroid-sensitive (CS)
R8 C16 C13 coref-ident the corticosteroids,corticosteroid
R9 C17 C7 coref-ident CR,corticosteroid-resistant (CR)
R10 C18 C9 coref-ident Kd,the dissociation constant (Kd)
R11 C20 C15 coref-ident CS,CS
R12 C19 C5 coref-other the CS group,corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic subjects
R13 C22 C17 coref-ident CR,CR
R14 C21 C5 coref-other the CR group,corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic subjects
R15 C23 C10 coref-ident The Ro,receptor numbers (Ro)
R16 C25 C20 coref-ident CS,CS
R17 C24 C19 coref-ident the CS group,the CS group
R18 C27 C22 coref-ident CR,CR
R19 C26 C21 coref-ident the CR group,the CR group
R20 C28 C3 coref-ident corticosteroid resistance in bronchial asthma,corticosteroid resistance in bronchial asthma

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-23 protein_molecule denotes Glucocorticoid receptor
T2 43-52 cell_type denotes monocytes
T3 56-64 multi_cell denotes patients
T4 70-84 lipid denotes corticosteroid
T5 130-144 lipid denotes corticosteroid
T15 640-661 other_name denotes dissociation constant
T16 663-665 other_name denotes Kd
T17 671-687 other_name denotes receptor numbers
T18 689-691 other_name denotes Ro
T19 700-709 cell_type denotes monocytes
T20 733-741 multi_cell denotes subjects
T21 764-778 lipid denotes corticosteroid
T22 805-809 other_name denotes IC50
T23 845-859 lipid denotes hydrocortisone
T24 861-879 lipid denotes methylprednisolone
T6 159-175 other_name denotes bronchial asthma
T25 885-898 lipid denotes dexamethasone
T26 917-926 cell_type denotes monocytes
T27 932-946 multi_cell denotes CS individuals
T7 248-263 lipid denotes corticosteroids
T28 1026-1041 lipid denotes corticosteroids
T29 1049-1073 multi_cell denotes CR asthmatic individuals
T30 1079-1092 lipid denotes dexamethasone
T8 317-343 cell_type denotes peripheral blood monocytes
T31 1093-1095 other_name denotes Kd
T32 1146-1154 multi_cell denotes CS group
T33 1216-1224 multi_cell denotes patients
T34 1241-1243 other_name denotes Ro
T35 1251-1259 multi_cell denotes CS group
T36 1278-1295 other_name denotes binding sites per
T37 1296-1303 cell_component denotes nucleus
T38 1344-1361 other_name denotes binding sites per
T39 1362-1369 cell_component denotes nucleus
T40 1449-1463 lipid denotes corticosteroid
T41 1478-1494 other_name denotes bronchial asthma
T42 1518-1531 other_name denotes abnormalities
T43 1535-1549 lipid denotes corticosteroid
T9 457-473 other_name denotes leukotriene B4 (
T10 473-477 protein_molecule denotes LTB4
T11 493-510 cell_type denotes human neutrophils
T12 512-515 cell_type denotes PMN
T13 531-548 other_organic_compound denotes calcium ionophore
T14 584-602 lipid denotes (3H) dexamethasone