PubMed:2021946 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2021946","sourcedb":"PubMed","sourceid":"2021946","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2021946","text":"High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area.\nUsing polymerase chain reaction and sequence-specific oligonucleotide hybridization, the frequency of three ras oncogene mutations (N-ras, Ha-ras, and K-ras) in thyroid tumors (25 adenomas, 16 follicular carcinomas, and 22 papillary carcinomas) was investigated in both iodide-deficient and iodide-sufficient areas. The ras oncogene mutation rate was significantly higher in the iodide-deficient area, being 85 versus 17% in the adenomas, and 50 versus 10% in the follicular carcinomas. No mutations were found in papillary carcinomas. The most common mutation site was Ha-ras codon 61 with Gln----Arg substitution. Two ras mutations at codon 61 (Gln----Lys in N-ras and Gln----Arg in Ha-ras) were found in a microfollicular adenoma specimen from Eastern Hungary. We conclude that dietary iodine may modulate ras oncogene mutations, and that in the iodide-deficient area, ras oncogene activation may play a more important role in the initiation and/or maintenance of follicular tumors. Additional factors are, however, necessary to initiate carcinogenesis.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":252,"end":258},"obj":"HP_0002664"},{"id":"T2","span":{"begin":1061,"end":1067},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"PennBioIE","denotations":[{"id":"T1","span":{"begin":14,"end":17},"obj":"protein"},{"id":"T2","span":{"begin":18,"end":26},"obj":"protein"},{"id":"T3","span":{"begin":27,"end":35},"obj":"protein"},{"id":"T4","span":{"begin":89,"end":99},"obj":"protein"},{"id":"T5","span":{"begin":191,"end":194},"obj":"protein"},{"id":"T6","span":{"begin":215,"end":220},"obj":"protein"},{"id":"T7","span":{"begin":222,"end":228},"obj":"protein"},{"id":"T8","span":{"begin":234,"end":239},"obj":"protein"},{"id":"T9","span":{"begin":403,"end":406},"obj":"protein"},{"id":"T10","span":{"begin":635,"end":643},"obj":"protein"},{"id":"T11","span":{"begin":653,"end":659},"obj":"protein"},{"id":"T12","span":{"begin":660,"end":668},"obj":"protein"},{"id":"T13","span":{"begin":674,"end":677},"obj":"protein"},{"id":"T14","span":{"begin":681,"end":684},"obj":"protein"},{"id":"T15","span":{"begin":685,"end":697},"obj":"protein"},{"id":"T16","span":{"begin":703,"end":706},"obj":"protein"},{"id":"T17","span":{"begin":707,"end":716},"obj":"protein"},{"id":"T18","span":{"begin":720,"end":728},"obj":"protein"},{"id":"T19","span":{"begin":730,"end":733},"obj":"protein"},{"id":"T20","span":{"begin":737,"end":740},"obj":"protein"},{"id":"T21","span":{"begin":744,"end":749},"obj":"protein"},{"id":"T22","span":{"begin":754,"end":757},"obj":"protein"},{"id":"T23","span":{"begin":761,"end":764},"obj":"protein"},{"id":"T24","span":{"begin":768,"end":774},"obj":"protein"},{"id":"T25","span":{"begin":892,"end":895},"obj":"protein"},{"id":"T26","span":{"begin":955,"end":958},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"PennBioIE"},{"subj":"T2","pred":"source","obj":"PennBioIE"},{"subj":"T3","pred":"source","obj":"PennBioIE"},{"subj":"T4","pred":"source","obj":"PennBioIE"},{"subj":"T5","pred":"source","obj":"PennBioIE"},{"subj":"T6","pred":"source","obj":"PennBioIE"},{"subj":"T7","pred":"source","obj":"PennBioIE"},{"subj":"T8","pred":"source","obj":"PennBioIE"},{"subj":"T9","pred":"source","obj":"PennBioIE"},{"subj":"T10","pred":"source","obj":"PennBioIE"},{"subj":"T11","pred":"source","obj":"PennBioIE"},{"subj":"T12","pred":"source","obj":"PennBioIE"},{"subj":"T13","pred":"source","obj":"PennBioIE"},{"subj":"T14","pred":"source","obj":"PennBioIE"},{"subj":"T15","pred":"source","obj":"PennBioIE"},{"subj":"T16","pred":"source","obj":"PennBioIE"},{"subj":"T17","pred":"source","obj":"PennBioIE"},{"subj":"T18","pred":"source","obj":"PennBioIE"},{"subj":"T19","pred":"source","obj":"PennBioIE"},{"subj":"T20","pred":"source","obj":"PennBioIE"},{"subj":"T21","pred":"source","obj":"PennBioIE"},{"subj":"T22","pred":"source","obj":"PennBioIE"},{"subj":"T23","pred":"source","obj":"PennBioIE"},{"subj":"T24","pred":"source","obj":"PennBioIE"},{"subj":"T25","pred":"source","obj":"PennBioIE"},{"subj":"T26","pred":"source","obj":"PennBioIE"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":768,"end":774},"obj":"gene:3265"},{"id":"T1","span":{"begin":792,"end":815},"obj":"disease:C0334328"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"2021946-5#27#41#geners28933406","span":{"begin":726,"end":740},"obj":"geners28933406"},{"id":"2021946-5#93#116#diseaseC0334328","span":{"begin":792,"end":815},"obj":"diseaseC0334328"}],"relations":[{"id":"27#41#geners2893340693#116#diseaseC0334328","pred":"associated_with","subj":"2021946-5#27#41#geners28933406","obj":"2021946-5#93#116#diseaseC0334328"}],"attributes":[{"subj":"2021946-5#27#41#geners28933406","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"2021946-5#93#116#diseaseC0334328","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"2021946-1#139#145#gene3265","span":{"begin":222,"end":228},"obj":"gene3265"},{"id":"2021946-1#161#175#diseaseC0040136","span":{"begin":244,"end":258},"obj":"diseaseC0040136"},{"id":"2021946-1#223#243#diseaseC0007133","span":{"begin":306,"end":326},"obj":"diseaseC0007133"},{"id":"2021946-5#69#75#gene3265","span":{"begin":768,"end":774},"obj":"gene3265"},{"id":"2021946-5#93#116#diseaseC0334328","span":{"begin":792,"end":815},"obj":"diseaseC0334328"}],"relations":[{"id":"139#145#gene3265161#175#diseaseC0040136","pred":"associated_with","subj":"2021946-1#139#145#gene3265","obj":"2021946-1#161#175#diseaseC0040136"},{"id":"139#145#gene3265223#243#d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