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GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-8 SO:0001027 denotes Genotype
T2 34-40 UBERON:0000479 denotes tissue
T3 51-67 D053840 denotes Brugada syndrome
T4 51-67 D053840 denotes Brugada syndrome
T5 93-99 CHEBI:26708 denotes sodium
T6 104-111 1895 denotes calcium
T7 104-111 CHEBI:29320 denotes calcium
T8 104-111 CHEBI:22984 denotes calcium
T9 112-127 D053447 denotes channelopathies
T10 112-127 D053447 denotes channelopathies
T12 164-178 D015222 denotes sodium channel
T13 189-196 1895 denotes calcium
T16 189-204 D015220 denotes calcium channel
T17 243-259 D053840 denotes Brugada syndrome
T18 243-259 D053840 denotes Brugada syndrome
T19 300-308 SO:0001027 denotes genotype
T20 406-425 D045506 denotes therapeutic effects
T21 406-425 D045506 denotes therapeutic effects
T23 438-452 D015222 denotes sodium channel
T24 457-464 1895 denotes calcium
T27 457-472 D015220 denotes calcium channel
T28 589-595 UBERON:0003674 denotes canine
T30 632-646 D015222 denotes sodium channel
T32 687-699 C042288 denotes pilsicainide
T33 687-699 C042288 denotes pilsicainide
T34 687-699 CHEBI:135127 denotes pilsicainide
T35 704-713 D020110 denotes pinacidil
T36 704-713 CHEBI:34923 denotes pinacidil
T37 704-713 CHEBI:91706 denotes pinacidil
T38 704-713 D020110 denotes pinacidil
T40 722-729 1895 denotes calcium
T43 722-737 D015220 denotes calcium channel
T45 777-786 11170 denotes verapamil
T44 777-786 CHEBI:77734 denotes verapamil
T46 777-786 CHEBI:9948 denotes verapamil
T47 777-786 D014700 denotes verapamil
T48 777-786 D014700 denotes verapamil
T49 777-786 CHEBI:77736 denotes verapamil
T50 824-827 PR:P04802 denotes APs
T51 824-827 PR:Q9JID9 denotes APs
T54 824-827 PR:O14492 denotes APs
T55 824-827 P22325 denotes APs
T56 824-827 PR:000003015 denotes APs
T57 824-827 PR:Q9Z200 denotes APs
T58 824-827 PR:P07288 denotes APs
T59 824-827 PR:000014810 denotes APs
T60 824-827 PR:P55228 denotes APs
T52 824-827 UBERON:0002919 denotes APs
T53 824-827 CHEBI:17709 denotes APs
T61 872-875 PR:P04802 denotes APs
T62 872-875 PR:Q9JID9 denotes APs
T65 872-875 PR:O14492 denotes APs
T66 872-875 P22325 denotes APs
T67 872-875 PR:000003015 denotes APs
T68 872-875 PR:Q9Z200 denotes APs
T69 872-875 PR:P07288 denotes APs
T70 872-875 PR:000014810 denotes APs
T71 872-875 PR:P55228 denotes APs
T63 872-875 UBERON:0002919 denotes APs
T64 872-875 CHEBI:17709 denotes APs
T72 931-934 PR:000033489 denotes CLs
T73 931-934 Q9UJA2 denotes CLs
T74 931-934 Q8H8U0 denotes CLs
T75 931-934 PR:Q8MZC4 denotes CLs
T77 931-934 Q07560 denotes CLs
T78 931-934 Q80ZM8 denotes CLs
T79 931-934 Q5U2V5 denotes CLs
T80 931-934 Q8MZC4 denotes CLs
T81 931-934 Q93YW7 denotes CLs
T82 931-934 O01916 denotes CLs
T83 931-934 PR:Q93YW7 denotes CLs
T84 931-934 PR:P0A6H8 denotes CLs
T85 931-934 PR:000005888 denotes CLs
T76 931-934 D038921 denotes CLs
T108 1030-1033 CHEBI:70255 denotes ECG
T109 1055-1058 CVCL_E459 denotes APD
T110 1067-1077 UBERON:0002425 denotes epicardium
T111 1067-1077 UBERON:0002348 denotes epicardium
T112 1090-1101 UBERON:0002165 denotes endocardium
T128 1306-1316 192213 denotes saddleback
T129 1348-1352 615513 denotes APDs
T130 1360-1370 UBERON:0002425 denotes epicardium
T131 1360-1370 UBERON:0002348 denotes epicardium
T132 1383-1394 UBERON:0002165 denotes endocardium
T133 1462-1466 615513 denotes APDs
T134 1474-1484 UBERON:0002425 denotes epicardium
T135 1474-1484 UBERON:0002348 denotes epicardium
T137 1650-1664 D015222 denotes sodium channel
T138 1669-1676 1895 denotes calcium
T141 1669-1684 D015220 denotes calcium channel
T142 1754-1761 1895 denotes calcium
T145 1754-1769 D015220 denotes calcium channel
T147 1904-1918 D015222 denotes sodium channel

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 141-350 BACKGROUND denotes Genetic defects in the sodium channel or in the calcium channel have been identified in patients with Brugada syndrome (BS). However, the differences in their genotype-phenotype correlations are still unclear.
T2 362-512 OBJECTIVE denotes We evaluated the phenotypic differences and therapeutic effects between the sodium channel and calcium channel abnormalities in in vitro models of BS.
T3 522-958 METHODS denotes We created two models of BS in 18 isolated and arterially perfused canine right ventricular preparations: (1) sodium channel dysfunction model (Na model, n = 11) by pilsicainide and pinacidil and (2) calcium channel dysfunction model (Ca model, n = 7) by verapamil; optically mapped action potentials (APs) on their transmural surface; and evaluated APs and electrocardiograms (ECGs) at pacing cycle lengths (CLs) of 2,000 and 1,000 ms.
T4 968-1623 RESULTS denotes CL = 1,000 ms: Both models had coved-type ST elevation in the ECG, longer AP duration (APD) in the epicardium than in the endocardium, and a similar incidence of spontaneous ventricular arrhythmias. However, the Ca model had a higher incidence of T wave alternans (TWA) than the Na-model. CL = 2,000 ms: ECGs of the Ca model converted to saddleback-type ST elevation with shorter APDs in the epicardium than in the endocardium, whereas the Na model still had coved-type ST elevation and longer APDs in the epicardium. None of the Ca model preparations had ventricular arrhythmias or TWA, although the Na model had frequent ventricular arrhythmias and TWA.
T5 1636-1931 CONCLUSIONS denotes Although both sodium channel and calcium channel dysfunction produced similar BS ECGs and arrhythmogenesis at 60 bpm, calcium channel dysfunction was associated with a higher incidence of TWA at 60 bpm, less ST elevation, and fewer arrhythmias at 30 bpm compared with sodium channel dysfunction.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 261-263 CVCL_QW64|Transformed_cell_line|Homo sapiens denotes BS
T2 362-364 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T3 509-511 CVCL_QW64|Transformed_cell_line|Homo sapiens denotes BS
T4 522-524 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T5 547-549 CVCL_QW64|Transformed_cell_line|Homo sapiens denotes BS
T6 553-555 CVCL_T367|Transformed_cell_line|Chlorocebus aethiops denotes 18
T7 666-668 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T8 676-682 CVCL_D426|Transformed_cell_line|Mus musculus denotes n = 11
T9 680-682 CVCL_5986|Cancer_cell_line|Homo sapiens denotes 11
T10 714-721 CVCL_B527|Embryonic_stem_cell|Homo sapiens denotes and (2)
T11 757-759 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T12 767-772 CVCL_D462|Transformed_cell_line|Mus musculus denotes n = 7
T13 1010-1012 CVCL_7025|Cancer_cell_line|Homo sapiens denotes ST
T14 1042-1044 CVCL_E457|Transformed_cell_line|Homo sapiens denotes AP
T15 1055-1058 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T16 1107-1108 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T17 1180-1182 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T18 1193-1194 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T19 1247-1249 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T20 1284-1286 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T21 1322-1324 CVCL_7025|Cancer_cell_line|Homo sapiens denotes ST
T22 1348-1352 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APDs
T23 1408-1410 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T24 1438-1440 CVCL_7025|Cancer_cell_line|Homo sapiens denotes ST
T25 1462-1466 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APDs
T26 1498-1500 CVCL_Z839|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes Ca
T27 1569-1571 CVCL_7082|Cancer_cell_line|Homo sapiens denotes Na
T28 1714-1716 CVCL_QW64|Transformed_cell_line|Homo sapiens denotes BS
T29 1746-1748 CVCL_C917|Induced_pluripotent_stem_cell|Homo sapiens denotes 60
T30 1802-1803 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T31 1831-1833 CVCL_C917|Induced_pluripotent_stem_cell|Homo sapiens denotes 60
T32 1844-1846 CVCL_7025|Cancer_cell_line|Homo sapiens denotes ST
T33 1883-1885 CVCL_J925|Hybridoma|Mus musculus denotes 30

Allie

Id Subject Object Predicate Lexical cue
SS1_20206324_2_0 243-259 expanded denotes Brugada syndrome
SS2_20206324_2_0 261-263 abbr denotes BS
SS1_20206324_7_0 805-822 expanded denotes action potentials
SS2_20206324_7_0 824-827 abbr denotes APs
SS1_20206324_7_1 880-898 expanded denotes electrocardiograms
SS2_20206324_7_1 900-904 abbr denotes ECGs
SS1_20206324_7_2 916-929 expanded denotes cycle lengths
SS2_20206324_7_2 931-934 abbr denotes CLs
SS1_20206324_9_0 1042-1053 expanded denotes AP duration
SS2_20206324_9_0 1055-1058 abbr denotes APD
SS1_20206324_10_0 1215-1231 expanded denotes T wave alternans
SS2_20206324_10_0 1233-1236 abbr denotes TWA
AE1_20206324_2_0 SS1_20206324_2_0 SS2_20206324_2_0 abbreviatedTo Brugada syndrome,BS
AE1_20206324_7_0 SS1_20206324_7_0 SS2_20206324_7_0 abbreviatedTo action potentials,APs
AE1_20206324_7_1 SS1_20206324_7_1 SS2_20206324_7_1 abbreviatedTo electrocardiograms,ECGs
AE1_20206324_7_2 SS1_20206324_7_2 SS2_20206324_7_2 abbreviatedTo cycle lengths,CLs
AE1_20206324_9_0 SS1_20206324_9_0 SS2_20206324_9_0 abbreviatedTo AP duration,APD
AE1_20206324_10_0 SS1_20206324_10_0 SS2_20206324_10_0 abbreviatedTo T wave alternans,TWA