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GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
72 1189-1194 Species denotes human 9606

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 73-81 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T3 763-771 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T5 833-841 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 73-81 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 763-771 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 833-841 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 73-81 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T2 73-81 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T3 763-771 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T4 763-771 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T5 833-841 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T6 833-841 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-134 Sentence denotes The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
TextSentencer_T2 135-294 Sentence denotes THAP1 is a sequence-specific DNA binding factor that regulates cell proliferation through modulation of target genes such as the cell cycle-specific gene RRM1.
TextSentencer_T3 295-503 Sentence denotes Mutations in the THAP1 DNA binding domain, an atypical zinc finger (THAP-zf), have recently been found to cause DYT6 dystonia, a neurological disease characterized by twisting movements and abnormal postures.
TextSentencer_T4 504-658 Sentence denotes In this study, we report that THAP1 shares sequence characteristics, in vivo expression patterns and protein partners with THAP3, another THAP-zf protein.
TextSentencer_T5 659-879 Sentence denotes Proteomic analyses identified HCF-1, a potent transcriptional coactivator and cell cycle regulator, and O-GlcNAc transferase (OGT), the enzyme that catalyzes the addition of O-GlcNAc, as major cellular partners of THAP3.
TextSentencer_T6 880-992 Sentence denotes THAP3 interacts with HCF-1 through a consensus HCF-1-binding motif (HBM), a motif that is also present in THAP1.
TextSentencer_T7 993-1089 Sentence denotes Accordingly, THAP1 was found to bind HCF-1 in vitro and to associate with HCF-1 and OGT in vivo.
TextSentencer_T8 1090-1294 Sentence denotes THAP1 and THAP3 belong to a large family of HCF-1 binding factors since seven other members of the human THAP-zf protein family were identified, which harbor evolutionary conserved HBMs and bind to HCF-1.
TextSentencer_T9 1295-1561 Sentence denotes Chromatin immunoprecipitation (ChIP) assays and RNA interference experiments showed that endogenous THAP1 mediates the recruitment of HCF-1 to the RRM1 promoter during endothelial cell proliferation and that HCF-1 is essential for transcriptional activation of RRM1.
TextSentencer_T10 1562-1634 Sentence denotes Together, our findings suggest HCF-1 is an important cofactor for THAP1.
TextSentencer_T11 1635-1867 Sentence denotes Interestingly, our results also provide an unexpected link between DYT6 and DYT3 (X-linked dystonia-parkinsonism) dystonias because the gene encoding the THAP1/DYT6 protein partner OGT maps within the DYT3 critical region on Xq13.1.
T1 0-134 Sentence denotes The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
T2 135-294 Sentence denotes THAP1 is a sequence-specific DNA binding factor that regulates cell proliferation through modulation of target genes such as the cell cycle-specific gene RRM1.
T3 295-503 Sentence denotes Mutations in the THAP1 DNA binding domain, an atypical zinc finger (THAP-zf), have recently been found to cause DYT6 dystonia, a neurological disease characterized by twisting movements and abnormal postures.
T4 504-658 Sentence denotes In this study, we report that THAP1 shares sequence characteristics, in vivo expression patterns and protein partners with THAP3, another THAP-zf protein.
T5 659-879 Sentence denotes Proteomic analyses identified HCF-1, a potent transcriptional coactivator and cell cycle regulator, and O-GlcNAc transferase (OGT), the enzyme that catalyzes the addition of O-GlcNAc, as major cellular partners of THAP3.
T6 880-992 Sentence denotes THAP3 interacts with HCF-1 through a consensus HCF-1-binding motif (HBM), a motif that is also present in THAP1.
T7 993-1089 Sentence denotes Accordingly, THAP1 was found to bind HCF-1 in vitro and to associate with HCF-1 and OGT in vivo.
T8 1090-1294 Sentence denotes THAP1 and THAP3 belong to a large family of HCF-1 binding factors since seven other members of the human THAP-zf protein family were identified, which harbor evolutionary conserved HBMs and bind to HCF-1.
T9 1295-1561 Sentence denotes Chromatin immunoprecipitation (ChIP) assays and RNA interference experiments showed that endogenous THAP1 mediates the recruitment of HCF-1 to the RRM1 promoter during endothelial cell proliferation and that HCF-1 is essential for transcriptional activation of RRM1.
T10 1562-1634 Sentence denotes Together, our findings suggest HCF-1 is an important cofactor for THAP1.
T11 1635-1867 Sentence denotes Interestingly, our results also provide an unexpected link between DYT6 and DYT3 (X-linked dystonia-parkinsonism) dystonias because the gene encoding the THAP1/DYT6 protein partner OGT maps within the DYT3 critical region on Xq13.1.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 29-34 gene:55145 denotes THAP1
T1 124-133 disease:C0013421 denotes dystonias
T2 63-68 gene:3054 denotes HCF-1
T3 124-133 disease:C0013421 denotes dystonias
T4 73-81 gene:8473 denotes O-GlcNAc
T5 124-133 disease:C0013421 denotes dystonias
T6 119-123 gene:6872 denotes DYT3
T7 124-133 disease:C0013421 denotes dystonias
R1 T0 T1 associated_with THAP1,dystonias
R2 T2 T3 associated_with HCF-1,dystonias
R3 T4 T5 associated_with O-GlcNAc,dystonias
R4 T6 T7 associated_with DYT3,dystonias

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 412-420 HP_0001332 denotes dystonia
T2 485-502 HP_0002533 denotes abnormal postures
T3 1717-1725 HP_0001417 denotes X-linked
T4 1726-1734 HP_0001332 denotes dystonia
T5 1735-1747 HP_0001300 denotes parkinsonism
T6 1749-1758 HP_0001332 denotes dystonias

Allie

Id Subject Object Predicate Lexical cue
SS1_20200153_4_0 763-783 expanded denotes O-GlcNAc transferase
SS2_20200153_4_0 785-788 abbr denotes OGT
SS1_20200153_5_0 927-946 expanded denotes HCF-1-binding motif
SS2_20200153_5_0 948-951 abbr denotes HBM
SS1_20200153_8_0 1295-1324 expanded denotes Chromatin immunoprecipitation
SS2_20200153_8_0 1326-1330 abbr denotes ChIP
AE1_20200153_4_0 SS1_20200153_4_0 SS2_20200153_4_0 abbreviatedTo O-GlcNAc transferase,OGT
AE1_20200153_5_0 SS1_20200153_5_0 SS2_20200153_5_0 abbreviatedTo HCF-1-binding motif,HBM
AE1_20200153_8_0 SS1_20200153_8_0 SS2_20200153_8_0 abbreviatedTo Chromatin immunoprecipitation,ChIP

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 75-81 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 765-771 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 835-841 chem:24139 denotes GlcNAc

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20200153-0#29#34#gene55145 29-34 gene55145 denotes THAP1
20200153-0#119#123#gene6872 119-123 gene6872 denotes DYT3
20200153-0#124#133#diseaseC0013421 124-133 diseaseC0013421 denotes dystonias
20200153-10#67#71#gene55145 1702-1706 gene55145 denotes DYT6
20200153-10#76#80#gene6872 1711-1715 gene6872 denotes DYT3
20200153-10#154#159#gene55145 1789-1794 gene55145 denotes THAP1
20200153-10#160#164#gene55145 1795-1799 gene55145 denotes DYT6
20200153-10#201#205#gene6872 1836-1840 gene6872 denotes DYT3
20200153-10#82#112#diseaseC1839130 1717-1747 diseaseC1839130 denotes X-linked dystonia-parkinsonism
20200153-2#112#116#gene55145 407-411 gene55145 denotes DYT6
20200153-2#117#125#diseaseC0393593 412-420 diseaseC0393593 denotes dystonia
29#34#gene55145124#133#diseaseC0013421 20200153-0#29#34#gene55145 20200153-0#124#133#diseaseC0013421 associated_with THAP1,dystonias
119#123#gene6872124#133#diseaseC0013421 20200153-0#119#123#gene6872 20200153-0#124#133#diseaseC0013421 associated_with DYT3,dystonias
67#71#gene5514582#112#diseaseC1839130 20200153-10#67#71#gene55145 20200153-10#82#112#diseaseC1839130 associated_with DYT6,X-linked dystonia-parkinsonism
76#80#gene687282#112#diseaseC1839130 20200153-10#76#80#gene6872 20200153-10#82#112#diseaseC1839130 associated_with DYT3,X-linked dystonia-parkinsonism
154#159#gene5514582#112#diseaseC1839130 20200153-10#154#159#gene55145 20200153-10#82#112#diseaseC1839130 associated_with THAP1,X-linked dystonia-parkinsonism
160#164#gene5514582#112#diseaseC1839130 20200153-10#160#164#gene55145 20200153-10#82#112#diseaseC1839130 associated_with DYT6,X-linked dystonia-parkinsonism
201#205#gene687282#112#diseaseC1839130 20200153-10#201#205#gene6872 20200153-10#82#112#diseaseC1839130 associated_with DYT3,X-linked dystonia-parkinsonism
112#116#gene55145117#125#diseaseC0393593 20200153-2#112#116#gene55145 20200153-2#117#125#diseaseC0393593 associated_with DYT6,dystonia

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1784 407-411 gene:55145 denotes DYT6
T1785 412-420 disease:C0393593 denotes dystonia
R1 T1784 T1785 associated_with DYT6,dystonia

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 73-81 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 763-771 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 833-841 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 4-8 Disease denotes THAP http://purl.obolibrary.org/obo/MONDO_0006468
T2 110-114 Disease denotes DYT6 http://purl.obolibrary.org/obo/MONDO_0011264
T3 119-123 Disease denotes DYT3 http://purl.obolibrary.org/obo/MONDO_0010747
T4 124-133 Disease denotes dystonias http://purl.obolibrary.org/obo/MONDO_0003441
T5 363-367 Disease denotes THAP http://purl.obolibrary.org/obo/MONDO_0006468
T6 407-411 Disease denotes DYT6 http://purl.obolibrary.org/obo/MONDO_0011264
T7 412-420 Disease denotes dystonia http://purl.obolibrary.org/obo/MONDO_0003441
T8 424-444 Disease denotes neurological disease http://purl.obolibrary.org/obo/MONDO_0005071
T9 642-646 Disease denotes THAP http://purl.obolibrary.org/obo/MONDO_0006468
T10 1195-1199 Disease denotes THAP http://purl.obolibrary.org/obo/MONDO_0006468
T11 1271-1275 Disease denotes HBMs http://purl.obolibrary.org/obo/MONDO_0014833
T12 1702-1706 Disease denotes DYT6 http://purl.obolibrary.org/obo/MONDO_0011264
T13 1711-1715 Disease denotes DYT3 http://purl.obolibrary.org/obo/MONDO_0010747
T14 1717-1747 Disease denotes X-linked dystonia-parkinsonism http://purl.obolibrary.org/obo/MONDO_0010747
T15 1749-1758 Disease denotes dystonias http://purl.obolibrary.org/obo/MONDO_0003441
T16 1795-1799 Disease denotes DYT6 http://purl.obolibrary.org/obo/MONDO_0011264
T17 1836-1840 Disease denotes DYT3 http://purl.obolibrary.org/obo/MONDO_0010747

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 412-420 Phenotype denotes dystonia HP:0001332
T2 485-502 Phenotype denotes abnormal postures HP:0002533
T3 1726-1734 Phenotype denotes dystonia HP:0001332
T4 1735-1747 Phenotype denotes parkinsonism HP:0001300

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 73-81 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 763-771 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 833-841 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 73-81 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 763-771 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 833-841 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 412-420 Phenotype denotes dystonia HP:0001332
T2 485-502 Phenotype denotes abnormal postures HP:0002533
T3 1726-1734 Phenotype denotes dystonia HP:0001332
T4 1735-1747 Phenotype denotes parkinsonism HP:0001300

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1463-1479 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 412-420 Disease denotes dystonia MONDO:0003441
T2 424-444 Disease denotes neurological disease MONDO:0005071
T3 1717-1747 Disease denotes X-linked dystonia-parkinsonism MONDO:0010747

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-134 Sentence denotes The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
T2 135-294 Sentence denotes THAP1 is a sequence-specific DNA binding factor that regulates cell proliferation through modulation of target genes such as the cell cycle-specific gene RRM1.
T3 295-503 Sentence denotes Mutations in the THAP1 DNA binding domain, an atypical zinc finger (THAP-zf), have recently been found to cause DYT6 dystonia, a neurological disease characterized by twisting movements and abnormal postures.
T4 504-658 Sentence denotes In this study, we report that THAP1 shares sequence characteristics, in vivo expression patterns and protein partners with THAP3, another THAP-zf protein.
T5 659-879 Sentence denotes Proteomic analyses identified HCF-1, a potent transcriptional coactivator and cell cycle regulator, and O-GlcNAc transferase (OGT), the enzyme that catalyzes the addition of O-GlcNAc, as major cellular partners of THAP3.
T6 880-992 Sentence denotes THAP3 interacts with HCF-1 through a consensus HCF-1-binding motif (HBM), a motif that is also present in THAP1.
T7 993-1089 Sentence denotes Accordingly, THAP1 was found to bind HCF-1 in vitro and to associate with HCF-1 and OGT in vivo.
T8 1090-1294 Sentence denotes THAP1 and THAP3 belong to a large family of HCF-1 binding factors since seven other members of the human THAP-zf protein family were identified, which harbor evolutionary conserved HBMs and bind to HCF-1.
T9 1295-1561 Sentence denotes Chromatin immunoprecipitation (ChIP) assays and RNA interference experiments showed that endogenous THAP1 mediates the recruitment of HCF-1 to the RRM1 promoter during endothelial cell proliferation and that HCF-1 is essential for transcriptional activation of RRM1.
T10 1562-1634 Sentence denotes Together, our findings suggest HCF-1 is an important cofactor for THAP1.
T11 1635-1867 Sentence denotes Interestingly, our results also provide an unexpected link between DYT6 and DYT3 (X-linked dystonia-parkinsonism) dystonias because the gene encoding the THAP1/DYT6 protein partner OGT maps within the DYT3 critical region on Xq13.1.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 73-81 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 763-771 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 833-841 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 14-20 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T2 264-274 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T3 355-361 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T4 737-747 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T5 1463-1479 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1189-1194 OrganismTaxon denotes human 9606

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 14-20 Body_part denotes finger FMA:9666
T2 355-361 Body_part denotes finger FMA:9666
T3 1295-1304 Body_part denotes Chromatin FMA:67526
T4 1463-1479 Body_part denotes endothelial cell FMA:66772

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1189-1194 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 14-20 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T2 264-274 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T3 355-361 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T4 737-747 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T5 1463-1479 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1463-1479 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115