PubMed:20197146
Annnotations
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 5-10 | D009369 | denotes | tumor |
| T2 | 5-10 | D009369 | denotes | tumor |
| T3 | 11-26 | GO:0006955 | denotes | immune response |
| T4 | 70-73 | D004285 | denotes | dog |
| T5 | 91-102 | D001254 | denotes | astrocytoma |
| T6 | 91-102 | D001254 | denotes | astrocytoma |
| T7 | 114-118 | SO:0000704 | denotes | gene |
| T8 | 189-205 | D005910 | denotes | malignant glioma |
| T9 | 189-205 | D005910 | denotes | malignant glioma |
| T12 | 390-414 | D001254 | denotes | Gemistocytic astrocytoma |
| T13 | 390-414 | D001254 | denotes | Gemistocytic astrocytoma |
| T16 | 416-420 | PR:Q55G45 | denotes | GemA |
| T17 | 437-443 | D005910 | denotes | glioma |
| T18 | 437-443 | D005910 | denotes | glioma |
| T19 | 480-490 | D009369 | denotes | malignancy |
| T20 | 480-490 | D009369 | denotes | malignancy |
| T21 | 558-564 | UBERON:3010325 | denotes | animal |
| T22 | 558-564 | UBERON:0000468 | denotes | animal |
| T23 | 574-578 | PR:Q55G45 | denotes | GemA |
| T24 | 614-617 | D004285 | denotes | dog |
| T25 | 635-639 | PR:Q55G45 | denotes | GemA |
| T31 | 699-715 | P07353 | denotes | interferon gamma |
| T32 | 699-715 | Q4ZH68 | denotes | interferon gamma |
| T33 | 699-715 | P01581 | denotes | interferon gamma |
| T34 | 699-715 | Q25BC0 | denotes | interferon gamma |
| T36 | 699-715 | P01580 | denotes | interferon gamma |
| T37 | 699-715 | O77763 | denotes | interferon gamma |
| T38 | 699-715 | PR:000000017 | denotes | interferon gamma |
| T39 | 699-715 | P28333 | denotes | interferon gamma |
| T40 | 699-715 | Q5I6S9 | denotes | interferon gamma |
| T41 | 699-715 | P17803 | denotes | interferon gamma |
| T42 | 699-715 | P49708 | denotes | interferon gamma |
| T43 | 699-715 | A4PIZ9 | denotes | interferon gamma |
| T44 | 699-715 | Q647G2 | denotes | interferon gamma |
| T45 | 699-715 | O57571 | denotes | interferon gamma |
| T46 | 699-715 | Q62574 | denotes | interferon gamma |
| T47 | 699-715 | Q865W6 | denotes | interferon gamma |
| T48 | 699-715 | O57608 | denotes | interferon gamma |
| T49 | 699-715 | Q1WM28 | denotes | interferon gamma |
| T50 | 699-715 | PR:000024990 | denotes | interferon gamma |
| T52 | 699-715 | Q865Y4 | denotes | interferon gamma |
| T53 | 699-715 | P63309 | denotes | interferon gamma |
| T54 | 699-715 | Q8MKF5 | denotes | interferon gamma |
| T55 | 699-715 | P28341 | denotes | interferon gamma |
| T56 | 699-715 | P79154 | denotes | interferon gamma |
| T57 | 699-715 | Q5CCK0 | denotes | interferon gamma |
| T58 | 699-715 | Q8SPW9 | denotes | interferon gamma |
| T59 | 699-715 | O57603 | denotes | interferon gamma |
| T60 | 699-715 | O73915 | denotes | interferon gamma |
| T61 | 699-715 | B5B3U4 | denotes | interferon gamma |
| T62 | 699-715 | P17773 | denotes | interferon gamma |
| T63 | 699-715 | Q9YGB9 | denotes | interferon gamma |
| T64 | 699-715 | P42162 | denotes | interferon gamma |
| T65 | 699-715 | P63311 | denotes | interferon gamma |
| T66 | 699-715 | O35735 | denotes | interferon gamma |
| T67 | 699-715 | Q9TTB0 | denotes | interferon gamma |
| T68 | 699-715 | P01579 | denotes | interferon gamma |
| T69 | 699-715 | P42161 | denotes | interferon gamma |
| T70 | 699-715 | O35497 | denotes | interferon gamma |
| T71 | 699-715 | Q2PE75 | denotes | interferon gamma |
| T72 | 699-715 | P63310 | denotes | interferon gamma |
| T73 | 699-715 | Q866Y6 | denotes | interferon gamma |
| T75 | 699-715 | B3IXK1 | denotes | interferon gamma |
| T76 | 699-715 | P30123 | denotes | interferon gamma |
| T77 | 699-715 | Q7TSP4 | denotes | interferon gamma |
| T78 | 699-715 | Q9QXX2 | denotes | interferon gamma |
| T79 | 699-715 | Q9TV67 | denotes | interferon gamma |
| T80 | 699-715 | P42160 | denotes | interferon gamma |
| T81 | 699-715 | Q865X1 | denotes | interferon gamma |
| T82 | 699-715 | P46402 | denotes | interferon gamma |
| T35 | 699-715 | D007371 | denotes | interferon gamma |
| T74 | 699-715 | D007371 | denotes | interferon gamma |
| T51 | 699-715 | GO:0005133 | denotes | interferon gamma |
| T85 | 727-731 | SO:0000704 | denotes | gene |
| T86 | 763-769 | D005910 | denotes | glioma |
| T87 | 763-769 | D005910 | denotes | glioma |
| T88 | 794-797 | CVCL_1G78 | denotes | CpG |
| T89 | 798-819 | D009838 | denotes | oligodeoxynucleotides |
| T90 | 798-819 | D009838 | denotes | oligodeoxynucleotides |
| T91 | 830-835 | D009369 | denotes | tumor |
| T92 | 830-835 | D009369 | denotes | tumor |
| T93 | 893-899 | UBERON:0002553 | denotes | cavity |
| T94 | 927-932 | D009369 | denotes | tumor |
| T95 | 927-932 | D009369 | denotes | tumor |
| T96 | 1005-1010 | D009369 | denotes | tumor |
| T97 | 1005-1010 | D009369 | denotes | tumor |
| T98 | 1073-1082 | D001766 | denotes | blindness |
| T99 | 1073-1082 | D001766 | denotes | blindness |
| T100 | 1087-1098 | D010291 | denotes | hemiparesis |
| T101 | 1087-1098 | D010291 | denotes | hemiparesis |
| T102 | 1221-1226 | D009369 | denotes | tumor |
| T103 | 1221-1226 | D009369 | denotes | tumor |
| T104 | 1236-1239 | D007074 | denotes | IgG |
| T105 | 1313-1316 | D004285 | denotes | dog |
| T106 | 1325-1330 | D009369 | denotes | tumor |
| T107 | 1325-1330 | D009369 | denotes | tumor |
| T108 | 1441-1445 | D004285 | denotes | dogs |
| T109 | 1463-1469 | D005910 | denotes | glioma |
| T110 | 1463-1469 | D005910 | denotes | glioma |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 140-255 | DRI_Background | denotes | Gene therapy and vaccination have been tested in malignant glioma patients with modest, albeit encouraging results. |
| T2 | 256-389 | DRI_Background | denotes | The combination of these therapies has demonstrated synergistic efficacy in murine models but has not been reported in large animals. |
| T3 | 390-522 | DRI_Background | denotes | Gemistocytic astrocytoma (GemA) is a low-grade glioma that typically progresses to lethal malignancy despite conventional therapies. |
| T4 | 523-579 | DRI_Outcome | denotes | Until now there has been no useful animal model of GemA. |
| T5 | 580-673 | DRI_Outcome | denotes | Here we report the treatment of a dog with spontaneous GemA using the combination of surgery, |
| T6 | 699-820 | DRI_Outcome | denotes | interferon gamma (IFNgamma) gene transfer, and vaccination with glioma cell lysates mixed with CpG oligodeoxynucleotides. |
| T7 | 821-915 | DRI_Background | denotes | Surgical tumor debulking and delivery of Ad-IFNgamma into the resection cavity were performed. |
| T8 | 916-1051 | DRI_Approach | denotes | Autologous tumor cells grew slowly in culture, necessitating vaccination with allogeneic tumor lysate in four of the five vaccinations. |
| T9 | 1153-1281 | DRI_Background | denotes | These neurological symptoms correlated with a peak in the levels of tumor-reactive IgG and CD8(+) T cells measured in the blood. |
| T10 | 1282-1368 | DRI_Approach | denotes | All symptoms resolved and this dog remains tumor-free over 450 days following surgery. |
| T11 | 1369-1556 | DRI_Outcome | denotes | This case report preliminarily demonstrates the feasibility of treating dogs with spontaneous glioma using immune-based therapy and warrants further study using this therapeutic approach. |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 68-69 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T2 | 291-294 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
| T3 | 291-294 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
| T4 | 350-353 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
| T5 | 350-353 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
| T6 | 425-426 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T7 | 539-542 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
| T8 | 539-542 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
| T9 | 585-587 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T10 | 612-613 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T11 | 794-797 | CVCL_1G78|Spontaneously_immortalized_cell_line|Channa punctata | denotes | CpG |
| T12 | 862-864 | CVCL_M606|Cancer_cell_line|Homo sapiens | denotes | Ad |
| T13 | 1197-1198 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T14 | 1199-1203 | CVCL_3772|Transformed_cell_line|Homo sapiens | denotes | peak |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 199-205 | HP_0009733 | denotes | glioma |
| T2 | 403-414 | HP_0009592 | denotes | astrocytoma |
| T3 | 437-443 | HP_0009733 | denotes | glioma |
| T4 | 763-769 | HP_0009733 | denotes | glioma |
| T5 | 830-835 | HP_0002664 | denotes | tumor |
| T6 | 927-932 | HP_0002664 | denotes | tumor |
| T7 | 1005-1010 | HP_0002664 | denotes | tumor |
| T8 | 1073-1082 | HP_0000618 | denotes | blindness |
| T9 | 1087-1098 | HP_0001269 | denotes | hemiparesis |
| T10 | 1221-1226 | HP_0002664 | denotes | tumor |
| T11 | 1325-1330 | HP_0002664 | denotes | tumor |
| T12 | 1463-1469 | HP_0009733 | denotes | glioma |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20197146_3_0 | 390-414 | expanded | denotes | Gemistocytic astrocytoma |
| SS2_20197146_3_0 | 416-420 | abbr | denotes | GemA |
| SS1_20197146_5_0 | 699-715 | expanded | denotes | interferon gamma |
| SS2_20197146_5_0 | 717-725 | abbr | denotes | IFNgamma |
| AE1_20197146_3_0 | SS1_20197146_3_0 | SS2_20197146_3_0 | abbreviatedTo | Gemistocytic astrocytoma,GemA |
| AE1_20197146_5_0 | SS1_20197146_5_0 | SS2_20197146_5_0 | abbreviatedTo | interferon gamma,IFNgamma |