PubMed:2019586 JSON TXT

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GlyCosmos6-Glycan-Motif-Image

Id	Subject	Object	Predicate	Lexical cue	image
T1	0-9	Glycan_Motif	denotes	Sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T4	144-153	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T7	334-343	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T10	396-405	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T13	580-589	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T16	722-731	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T19	818-827	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T22	1162-1171	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T25	1499-1508	Glycan_Motif	denotes	sulfatide	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY

GlyCosmos6-Glycan-Motif-Structure

Id	Subject	Object	Predicate	Lexical cue
T1	0-9	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	Sulfatide
T2	0-9	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	Sulfatide
T3	0-9	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	Sulfatide
T4	144-153	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T5	144-153	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T6	144-153	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide
T7	334-343	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T8	334-343	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T9	334-343	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide
T10	396-405	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T11	396-405	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T12	396-405	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide
T13	580-589	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T14	580-589	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T15	580-589	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide
T16	722-731	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T17	722-731	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T18	722-731	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide
T19	818-827	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T20	818-827	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T21	818-827	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide
T22	1162-1171	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T23	1162-1171	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T24	1162-1171	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide
T25	1499-1508	https://glytoucan.org/Structures/Glycans/G40843KY	denotes	sulfatide
T26	1499-1508	https://glytoucan.org/Structures/Glycans/G72548RZ	denotes	sulfatide
T27	1499-1508	https://glytoucan.org/Structures/Glycans/G95090DW	denotes	sulfatide

sentences

Id	Subject	Object	Predicate	Lexical cue
TextSentencer_T1	0-28	Sentence	denotes	Sulfatide activator protein.
TextSentencer_T2	29-139	Sentence	denotes	Alternative splicing that generates three mRNAs and a newly found mutation responsible for a clinical disease.
TextSentencer_T3	140-276	Sentence	denotes	The sulfatide activator protein, also known as SAP-1, is derived from a gene that generates an mRNA coding for four homologous proteins.
TextSentencer_T4	277-371	Sentence	denotes	Its physiological function is to stimulate hydrolysis of sulfatide by arylsulfatase A in vivo.
TextSentencer_T5	372-561	Sentence	denotes	A genetic defect in the sulfatide activator results in a metabolic disorder similar to classical metachromatic leukodystrophy, which is itself caused by a genetic defect in arylsulfatase A.
TextSentencer_T6	562-838	Sentence	denotes	In a patient with sulfatide activator deficiency, a nucleotide transversion G722----C (counted from A of the initiation codon ATG) was found in the mRNA of the sulfatide activator precursor, resulting in the substitution of serine for Cys241 in the mature sulfatide activator.
TextSentencer_T7	839-995	Sentence	denotes	The remainder of the coding sequence was completely normal except for a polymorphism C to T in position 1389, which does not change the amino acid sequence.
TextSentencer_T8	996-1074	Sentence	denotes	The patient produces at least three different forms of mRNA for the precursor.
TextSentencer_T9	1075-1196	Sentence	denotes	Two of them include a stretch of an additional 9 and 6 bases, respectively, within the sulfatide activator coding region.
TextSentencer_T10	1197-1275	Sentence	denotes	In normal individuals this stretch of additional bases has also been observed.
TextSentencer_T11	1276-1451	Sentence	denotes	This could be explained by the presence of a small 9-base pair exon which can be introduced, or not, by alternative splicing as a stretch of 9 or 6 bases into the mature mRNA.
TextSentencer_T12	1452-1569	Sentence	denotes	The shortest form of the mRNA yields an active sulfatide activator (Fürst, W., Schubert, J., Machleidt, W., Meier, H.
TextSentencer_T13	1570-1602	Sentence	denotes	E., and Sandhoff, K. (1990) Eur.
TextSentencer_T14	1603-1605	Sentence	denotes	J.
TextSentencer_T15	1606-1614	Sentence	denotes	Biochem.
TextSentencer_T16	1615-1629	Sentence	denotes	192, 709-714).
T1	0-28	Sentence	denotes	Sulfatide activator protein.
T2	29-139	Sentence	denotes	Alternative splicing that generates three mRNAs and a newly found mutation responsible for a clinical disease.
T3	140-276	Sentence	denotes	The sulfatide activator protein, also known as SAP-1, is derived from a gene that generates an mRNA coding for four homologous proteins.
T4	277-371	Sentence	denotes	Its physiological function is to stimulate hydrolysis of sulfatide by arylsulfatase A in vivo.
T5	372-561	Sentence	denotes	A genetic defect in the sulfatide activator results in a metabolic disorder similar to classical metachromatic leukodystrophy, which is itself caused by a genetic defect in arylsulfatase A.
T6	562-838	Sentence	denotes	In a patient with sulfatide activator deficiency, a nucleotide transversion G722----C (counted from A of the initiation codon ATG) was found in the mRNA of the sulfatide activator precursor, resulting in the substitution of serine for Cys241 in the mature sulfatide activator.
T7	839-995	Sentence	denotes	The remainder of the coding sequence was completely normal except for a polymorphism C to T in position 1389, which does not change the amino acid sequence.
T8	996-1074	Sentence	denotes	The patient produces at least three different forms of mRNA for the precursor.
T9	1075-1196	Sentence	denotes	Two of them include a stretch of an additional 9 and 6 bases, respectively, within the sulfatide activator coding region.
T10	1197-1275	Sentence	denotes	In normal individuals this stretch of additional bases has also been observed.
T11	1276-1451	Sentence	denotes	This could be explained by the presence of a small 9-base pair exon which can be introduced, or not, by alternative splicing as a stretch of 9 or 6 bases into the mature mRNA.
T12	1452-1569	Sentence	denotes	The shortest form of the mRNA yields an active sulfatide activator (Fürst, W., Schubert, J., Machleidt, W., Meier, H.
T13	1570-1602	Sentence	denotes	E., and Sandhoff, K. (1990) Eur.
T14	1603-1605	Sentence	denotes	J.
T15	1606-1614	Sentence	denotes	Biochem.
T16	1615-1629	Sentence	denotes	192, 709-714).

PubmedHPO

Id	Subject	Object	Predicate	Lexical cue
T1	429-447	HP_0001939	denotes	metabolic disorder
T2	483-497	HP_0002415	denotes	leukodystrophy

PubCasesHPO

Id	Subject	Object	Predicate	Lexical cue
AB1	483-497	HP:0002415	denotes	leukodystrophy

PubCasesORDO

Id	Subject	Object	Predicate	Lexical cue
AB1	469-497	ORDO:512	denotes	metachromatic leukodystrophy

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	429-447	Disease	denotes	metabolic disorder	http://purl.obolibrary.org/obo/MONDO_0005066
T2	469-497	Disease	denotes	metachromatic leukodystrophy	http://purl.obolibrary.org/obo/MONDO_0009591\|http://purl.obolibrary.org/obo/MONDO_0018868

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	567-574	OrganismTaxon	denotes	patient	9606
T2	1000-1007	OrganismTaxon	denotes	patient	9606

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	483-497	Phenotype	denotes	leukodystrophy	HP:0002415