PubMed:20172950 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/20172950","sourcedb":"PubMed","sourceid":"20172950","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/20172950","text":"Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.\nTransforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFbeta1+/- mice had fewer number and incidence of benign papillomas, reduced epidermal and tumor cell proliferation and reduced epidermal TGFbeta1 and nuclear p-Smad2 localization in response to the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) compared with TGFbeta1+/+ mice. Maximal TPA activation of protein kinase C (PKCalpha) as measured by activity assays and activation of target genes and induction of cornified envelopes correlated with TGFbeta1 gene dosage in keratinocytes and addition of exogenous TGFbeta1 restored the cornification defect in TGFbeta1+/- keratinocytes. Similarly, inhibition of ALK5-suppressed TPA-mediated PKCalpha activation suggesting that physiological levels of TGFbeta1 are required for maximal activation of PKC-dependent mitogenic responses. Paradoxically, the TPA-induced inflammatory response was greater in TGFbeta1+/- skin, but TGFbeta1+/+ papillomas had more tumor infiltrating myeloperoxidase-positive cells and pro-inflammatory gene expression was elevated in v-ras(Ha)-transduced TGFbeta1+/+ but not TGFbeta1+/- keratinocytes. Thus, ras activation switches TGFbeta1 to a pro-inflammatory cytokine. Despite this differential proliferative and inflammatory response to TPA and enhanced papilloma formation in the TGFbeta1+/+ mice, the frequency of malignant conversion was reduced compared with TGFbeta1+/- mice. Therefore, TGFbeta1 promotes benign tumors by modifying tumor promoter-induced cell proliferation and inflammation but retains a suppressive function for malignant conversion.","tracks":[{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"4","span":{"begin":0,"end":32},"obj":"GeneOrGeneProduct"},{"id":"5","span":{"begin":42,"end":47},"obj":"DiseaseOrPhenotypicFeature"},{"id":"6","span":{"begin":61,"end":66},"obj":"OrganismTaxon"},{"id":"7","span":{"begin":67,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"54","span":{"begin":88,"end":120},"obj":"GeneOrGeneProduct"},{"id":"55","span":{"begin":122,"end":130},"obj":"GeneOrGeneProduct"},{"id":"56","span":{"begin":158,"end":163},"obj":"DiseaseOrPhenotypicFeature"},{"id":"57","span":{"begin":181,"end":186},"obj":"OrganismTaxon"},{"id":"58","span":{"begin":209,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"59","span":{"begin":290,"end":298},"obj":"GeneOrGeneProduct"},{"id":"60","span":{"begin":310,"end":314},"obj":"OrganismTaxon"},{"id":"61","span":{"begin":383,"end":391},"obj":"GeneOrGeneProduct"},{"id":"62","span":{"begin":395,"end":399},"obj":"OrganismTaxon"},{"id":"63","span":{"begin":434,"end":451},"obj":"DiseaseOrPhenotypicFeature"},{"id":"64","span":{"begin":475,"end":480},"obj":"DiseaseOrPhenotypicFeature"},{"id":"65","span":{"begin":522,"end":530},"obj":"GeneOrGeneProduct"},{"id":"66","span":{"begin":545,"end":550},"obj":"GeneOrGeneProduct"},{"id":"67","span":{"begin":583,"end":588},"obj":"DiseaseOrPhenotypicFeature"},{"id":"68","span":{"begin":598,"end":634},"obj":"ChemicalEntity"},{"id":"69","span":{"begin":636,"end":639},"obj":"ChemicalEntity"},{"id":"70","span":{"begin":655,"end":663},"obj":"GeneOrGeneProduct"},{"id":"71","span":{"begin":667,"end":671},"obj":"OrganismTaxon"},{"id":"72","span":{"begin":681,"end":684},"obj":"ChemicalEntity"},{"id":"73","span":{"begin":717,"end":725},"obj":"GeneOrGeneProduct"},{"id":"74","span":{"begin":842,"end":850},"obj":"GeneOrGeneProduct"},{"id":"75","span":{"begin":906,"end":914},"obj":"GeneOrGeneProduct"},{"id":"76","span":{"begin":952,"end":960},"obj":"GeneOrGeneProduct"},{"id":"77","span":{"begin":1004,"end":1008},"obj":"GeneOrGeneProduct"},{"id":"78","span":{"begin":1020,"end":1023},"obj":"ChemicalEntity"},{"id":"79","span":{"begin":1033,"end":1041},"obj":"GeneOrGeneProduct"},{"id":"80","span":{"begin":1093,"end":1101},"obj":"GeneOrGeneProduct"},{"id":"81","span":{"begin":1141,"end":1144},"obj":"GeneOrGeneProduct"},{"id":"82","span":{"begin":1195,"end":1198},"obj":"ChemicalEntity"},{"id":"83","span":{"begin":1244,"end":1252},"obj":"GeneOrGeneProduct"},{"id":"84","span":{"begin":1266,"end":1274},"obj":"GeneOrGeneProduct"},{"id":"85","span":{"begin":1278,"end":1288},"obj":"DiseaseOrPhenotypicFeature"},{"id":"86","span":{"begin":1298,"end":1303},"obj":"DiseaseOrPhenotypicFeature"},{"id":"87","span":{"begin":1422,"end":1430},"obj":"GeneOrGeneProduct"},{"id":"88","span":{"begin":1442,"end":1450},"obj":"GeneOrGeneProduct"},{"id":"89","span":{"begin":1499,"end":1507},"obj":"GeneOrGeneProduct"},{"id":"90","span":{"begin":1609,"end":1612},"obj":"ChemicalEntity"},{"id":"91","span":{"begin":1626,"end":1635},"obj":"DiseaseOrPhenotypicFeature"},{"id":"92","span":{"begin":1653,"end":1661},"obj":"GeneOrGeneProduct"},{"id":"93","span":{"begin":1665,"end":1669},"obj":"OrganismTaxon"},{"id":"94","span":{"begin":1735,"end":1743},"obj":"GeneOrGeneProduct"},{"id":"95","span":{"begin":1747,"end":1751},"obj":"OrganismTaxon"},{"id":"96","span":{"begin":1764,"end":1772},"obj":"GeneOrGeneProduct"},{"id":"97","span":{"begin":1782,"end":1795},"obj":"DiseaseOrPhenotypicFeature"},{"id":"98","span":{"begin":1809,"end":1814},"obj":"DiseaseOrPhenotypicFeature"},{"id":"99","span":{"begin":1855,"end":1867},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Tax:10090"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"Gene:21803"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Gene:21803"},{"id":"A7","pred":"tao:has_database_id","subj":"7","obj":"MESH:D063646"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"Gene:21803"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"Gene:21803"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"Gene:18750"},{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"MESH:D010212"},{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"Gene:21803"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"MESH:D013755"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"Gene:18750"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:D013755"},{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:D007249"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"MESH:D010212"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"MESH:D009369"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Gene:21803"},{"id":"A6","pred":"tao:has_database_id","subj":"6","obj":"Tax:10090"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"MESH:D009369"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"MESH:D010212"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:10090"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Gene:21803"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Gene:21803"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"Gene:21812"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"Tax:10090"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"Tax:10090"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Gene:21803"},{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"Tax:10090"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"MESH:D013755"},{"id":"A84","pred":"tao:has_database_id","subj":"84","obj":"Gene:21803"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Gene:21803"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:D009369"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Gene:17126"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Gene:21803"},{"id":"A98","pred":"tao:has_database_id","subj":"98","obj":"MESH:D009369"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"Gene:21803"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"MESH:D009369"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"Gene:21803"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"Gene:21803"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:D009369"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:D013755"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"Gene:21803"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"Gene:21803"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"MESH:D013755"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"Gene:21803"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"Tax:10090"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:D009369"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"MESH:D013755"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"Gene:18750"},{"id":"A96","pred":"tao:has_database_id","subj":"96","obj":"Gene:21803"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"MESH:D009369"},{"subj":"4","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"5","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"6","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"7","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"54","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"55","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"56","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"57","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"58","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"59","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"60","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"61","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"62","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"63","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"64","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"65","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"66","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"67","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"68","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"69","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"70","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"71","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"72","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"73","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"74","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"75","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"76","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"77","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"78","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"79","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"80","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"81","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"82","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"83","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"84","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"85","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"86","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"87","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"88","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"89","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"90","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"91","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"92","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"93","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"94","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"95","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"96","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"97","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"98","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"99","pred":"source","obj":"LitCoin-PubTator-for-Tuning"}]},{"project":"LitCoin-Disease-Tuning-1","denotations":[{"id":"T1","span":{"begin":42,"end":47},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":72,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":158,"end":163},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":209,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":344,"end":358},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":441,"end":451},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":475,"end":480},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":583,"end":588},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1207,"end":1219},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1278,"end":1288},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1298,"end":1303},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1356,"end":1368},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1517,"end":1529},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1584,"end":1596},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1626,"end":1635},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1789,"end":1795},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T18","span":{"begin":1809,"end":1814},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19","span":{"begin":1855,"end":1867},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A14","pred":"ID:","subj":"T14","obj":"DISEASE"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D009369"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D009369"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D009369"},{"id":"A9","pred":"ID:","subj":"T9","obj":"DISEASE"},{"id":"A18","pred":"ID:","subj":"T18","obj":"D009369"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D009369"},{"id":"A13","pred":"ID:","subj":"T13","obj":"DISEASE"},{"id":"A12","pred":"ID:","subj":"T12","obj":"DISEASE"},{"id":"A19","pred":"ID:","subj":"T19","obj":"DISEASE"},{"id":"A20","pred":"ID:","subj":"T19","obj":"D007249"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D010212"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D063646"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D063646"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D010212"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D009369"},{"id":"A16","pred":"ID:","subj":"T16","obj":"DISEASE"},{"id":"A17","pred":"ID:","subj":"T16","obj":"D009369"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D009369"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D010212"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T9","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T10","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T11","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T12","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T13","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T14","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T15","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T16","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T18","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T19","pred":"source","obj":"LitCoin-Disease-Tuning-1"}]},{"project":"LitCoin-PubTator-for-Tuning-SeqVar","denotations":[{"id":"T1","span":{"begin":598,"end":602},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-PubTator-for-Tuning-SeqVar"}]},{"project":"LitEisuke","denotations":[{"id":"T1","span":{"begin":42,"end":47},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":72,"end":86},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":158,"end":163},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":209,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":344,"end":358},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":441,"end":451},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":475,"end":480},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":583,"end":588},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1278,"end":1288},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1298,"end":1303},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1352,"end":1368},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1513,"end":1529},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1626,"end":1635},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1789,"end":1795},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1809,"end":1814},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1855,"end":1867},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D009369"},{"id":"A2","pred":"#label","subj":"T2","obj":"D063646"},{"id":"A3","pred":"#label","subj":"T3","obj":"D009369"},{"id":"A4","pred":"#label","subj":"T4","obj":"D009369"},{"id":"A5","pred":"#label","subj":"T5","obj":"D063646"},{"id":"A6","pred":"#label","subj":"T6","obj":"D010212"},{"id":"A7","pred":"#label","subj":"T7","obj":"D009369"},{"id":"A8","pred":"#label","subj":"T8","obj":"D009369"},{"id":"A9","pred":"#label","subj":"T9","obj":"D010212"},{"id":"A10","pred":"#label","subj":"T10","obj":"D009369"},{"id":"A11","pred":"#label","subj":"T11","obj":"DISEASE"},{"id":"A12","pred":"#label","subj":"T12","obj":"DISEASE"},{"id":"A13","pred":"#label","subj":"T13","obj":"D010212"},{"id":"A14","pred":"#label","subj":"T14","obj":"D009369"},{"id":"A15","pred":"#label","subj":"T15","obj":"D009369"},{"id":"A16","pred":"#label","subj":"T16","obj":"D007249"},{"subj":"T1","pred":"source","obj":"LitEisuke"},{"subj":"T2","pred":"source","obj":"LitEisuke"},{"subj":"T3","pred":"source","obj":"LitEisuke"},{"subj":"T4","pred":"source","obj":"LitEisuke"},{"subj":"T5","pred":"source","obj":"LitEisuke"},{"subj":"T6","pred":"source","obj":"LitEisuke"},{"subj":"T7","pred":"source","obj":"LitEisuke"},{"subj":"T8","pred":"source","obj":"LitEisuke"},{"subj":"T9","pred":"source","obj":"LitEisuke"},{"subj":"T10","pred":"source","obj":"LitEisuke"},{"subj":"T11","pred":"source","obj":"LitEisuke"},{"subj":"T12","pred":"source","obj":"LitEisuke"},{"subj":"T13","pred":"source","obj":"LitEisuke"},{"subj":"T14","pred":"source","obj":"LitEisuke"},{"subj":"T15","pred":"source","obj":"LitEisuke"},{"subj":"T16","pred":"source","obj":"LitEisuke"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":87},"obj":"Sentence"},{"id":"T2","span":{"begin":88,"end":251},"obj":"Sentence"},{"id":"T3","span":{"begin":252,"end":368},"obj":"Sentence"},{"id":"T4","span":{"begin":369,"end":672},"obj":"Sentence"},{"id":"T5","span":{"begin":673,"end":978},"obj":"Sentence"},{"id":"T6","span":{"begin":979,"end":1175},"obj":"Sentence"},{"id":"T7","span":{"begin":1176,"end":1468},"obj":"Sentence"},{"id":"T8","span":{"begin":1469,"end":1539},"obj":"Sentence"},{"id":"T9","span":{"begin":1540,"end":1752},"obj":"Sentence"},{"id":"T10","span":{"begin":1753,"end":1928},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":87},"obj":"Sentence"},{"id":"T2","span":{"begin":88,"end":251},"obj":"Sentence"},{"id":"T3","span":{"begin":252,"end":368},"obj":"Sentence"},{"id":"T4","span":{"begin":369,"end":672},"obj":"Sentence"},{"id":"T5","span":{"begin":673,"end":978},"obj":"Sentence"},{"id":"T6","span":{"begin":979,"end":1175},"obj":"Sentence"},{"id":"T7","span":{"begin":1176,"end":1468},"obj":"Sentence"},{"id":"T8","span":{"begin":1469,"end":1539},"obj":"Sentence"},{"id":"T9","span":{"begin":1540,"end":1752},"obj":"Sentence"},{"id":"T10","span":{"begin":1753,"end":1928},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":158,"end":163},"obj":"HP_0002664"},{"id":"T2","span":{"begin":209,"end":214},"obj":"HP_0002664"},{"id":"T3","span":{"begin":441,"end":451},"obj":"HP_0012740"},{"id":"T4","span":{"begin":475,"end":480},"obj":"HP_0002664"},{"id":"T5","span":{"begin":583,"end":588},"obj":"HP_0002664"},{"id":"T6","span":{"begin":1278,"end":1288},"obj":"HP_0012740"},{"id":"T7","span":{"begin":1298,"end":1303},"obj":"HP_0002664"},{"id":"T8","span":{"begin":1626,"end":1635},"obj":"HP_0012740"},{"id":"T9","span":{"begin":1789,"end":1795},"obj":"HP_0002664"},{"id":"T10","span":{"begin":1809,"end":1814},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"}]},{"project":"Allie","denotations":[{"id":"SS1_20172950_1_0","span":{"begin":88,"end":120},"obj":"expanded"},{"id":"SS2_20172950_1_0","span":{"begin":122,"end":130},"obj":"abbr"},{"id":"SS1_20172950_3_0","span":{"begin":598,"end":634},"obj":"expanded"},{"id":"SS2_20172950_3_0","span":{"begin":636,"end":639},"obj":"abbr"}],"relations":[{"id":"AE1_20172950_1_0","pred":"abbreviatedTo","subj":"SS1_20172950_1_0","obj":"SS2_20172950_1_0"},{"id":"AE1_20172950_3_0","pred":"abbreviatedTo","subj":"SS1_20172950_3_0","obj":"SS2_20172950_3_0"}],"attributes":[{"subj":"SS1_20172950_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_20172950_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_20172950_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_20172950_3_0","pred":"source","obj":"Allie"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-PubTator-for-Tuning","color":"#c993ec","default":true},{"id":"LitCoin-Disease-Tuning-1","color":"#93ecaf"},{"id":"LitCoin-PubTator-for-Tuning-SeqVar","color":"#ec9593"},{"id":"LitEisuke","color":"#93aaec"},{"id":"Inflammaging","color":"#c4ec93"},{"id":"PubmedHPO","color":"#ec93de"},{"id":"Allie","color":"#93ece0"}]}]}}