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GoldHamster

Id Subject Object Predicate Lexical cue
T2 0-11 36453 denotes Sevoflurane
T1 0-11 D000077149 denotes Sevoflurane
T3 0-11 CHEBI:9130 denotes Sevoflurane
T4 0-11 D000077149 denotes Sevoflurane
T5 38-48 GO:0030112 denotes glycocalyx
T6 67-85 D015427 denotes reperfusion injury
T7 67-85 D015427 denotes reperfusion injury
T8 116-127 UBERON:0001986 denotes endothelium
T9 145-155 GO:0030112 denotes glycocalyx
T10 246-252 PR:Q54JW9 denotes impact
T11 246-252 PR:Q642J4 denotes impact
T12 265-277 CHEBI:38867 denotes anaesthetics
T15 366-369 SO:0002045 denotes pre
T14 366-369 PR:Q8LLD0 denotes pre
T16 366-369 UBERON:0001782 denotes pre
T13 366-369 GO:0003904 denotes pre
T18 398-409 36453 denotes sevoflurane
T17 398-409 D000077149 denotes sevoflurane
T19 398-409 CHEBI:9130 denotes sevoflurane
T20 398-409 D000077149 denotes sevoflurane
T21 442-452 GO:0030112 denotes glycocalyx
T22 519-529 D006168 denotes guinea pig
T23 519-529 10141 denotes guinea pig
T25 526-529 P30941 denotes pig
T26 551-573 C074097 denotes Krebs-Henseleit buffer
T27 551-573 C074097 denotes Krebs-Henseleit buffer
T29 587-590 CVCL_E777 denotes min
T30 655-658 GO:0005579 denotes MAC
T31 655-658 GO:0097423 denotes MAC
T33 659-670 36453 denotes sevoflurane
T32 659-670 D000077149 denotes sevoflurane
T34 659-670 CHEBI:9130 denotes sevoflurane
T35 659-670 D000077149 denotes sevoflurane
T36 696-699 CVCL_E777 denotes min
T40 715-718 CVCL_E777 denotes min
T41 762-772 UBERON:0007779 denotes Transudate
T42 814-819 UBERON:0006314 denotes fluid
T44 838-847 5333 denotes histamine
T43 838-847 CHEBI:58432 denotes histamine
T45 838-847 CHEBI:18295 denotes histamine
T46 838-847 D006632 denotes histamine
T47 838-847 D006632 denotes histamine
T48 859-863 PR:Q9NBD7 denotes mast
T49 859-863 PR:000008154 denotes mast
T51 859-863 Q9NBD7 denotes mast
T52 859-863 Q7TPM5 denotes mast
T50 859-863 CVCL_M374 denotes mast
T53 891-899 GO:0015023 denotes syndecan
T56 891-901 P18827 denotes syndecan-1
T57 891-901 Q08DZ5 denotes syndecan-1
T58 891-901 P26260 denotes syndecan-1
T59 891-901 PR:000001935 denotes syndecan-1
T60 891-901 P18828 denotes syndecan-1
T61 891-901 P34740 denotes syndecan-1
T63 891-901 P47951 denotes syndecan-1
T62 891-901 D053668 denotes syndecan-1
T65 906-922 CHEBI:28815 denotes heparan sulphate
T68 991-1002 36453 denotes sevoflurane
T67 991-1002 D000077149 denotes sevoflurane
T69 991-1002 CHEBI:9130 denotes sevoflurane
T70 991-1002 D000077149 denotes sevoflurane
T74 1004-1015 P00787 denotes cathepsin B
T75 1004-1015 P07688 denotes cathepsin B
T76 1004-1015 P81494 denotes cathepsin B
T77 1004-1015 P83205 denotes cathepsin B
T78 1004-1015 Q54QD9 denotes cathepsin B
T79 1004-1015 P07858 denotes cathepsin B
T80 1004-1015 Q4R5M2 denotes cathepsin B
T81 1004-1015 A1E295 denotes cathepsin B
T82 1004-1015 P43233 denotes cathepsin B
T83 1004-1015 PR:000006023 denotes cathepsin B
T84 1004-1015 Q5R6D1 denotes cathepsin B
T85 1004-1015 P10605 denotes cathepsin B
T73 1004-1015 D002401 denotes cathepsin B
T87 1020-1028 PR:000016935 denotes tryptase
T88 1020-1028 P15944 denotes tryptase
T89 1020-1028 Q02844 denotes tryptase
T90 1020-1028 P27435 denotes tryptase
T91 1020-1028 Q9N2D1 denotes tryptase
T86 1020-1028 D053802 denotes tryptase
T92 1029-1033 CHEBI:10545 denotes beta
T93 1029-1033 CHEBI:30225 denotes beta
T94 1039-1047 P68985 denotes protease
T95 1039-1047 P30202 denotes protease
T96 1039-1047 P42672 denotes protease
T97 1039-1047 P11826 denotes protease
T98 1039-1047 Q5TJ03 denotes protease
T99 1039-1047 O71070 denotes protease
T100 1039-1047 P63122 denotes protease
T101 1039-1047 P63131 denotes protease
T102 1039-1047 Q9IIH4 denotes protease
T103 1039-1047 P10270 denotes protease
T104 1039-1047 Q8JN66 denotes protease
T105 1039-1047 O40958 denotes protease
T106 1039-1047 P10265 denotes protease
T107 1039-1047 Q9QM72 denotes protease
T108 1039-1047 P63119 denotes protease
T109 1039-1047 Q9WF19 denotes protease
T110 1039-1047 P63120 denotes protease
T111 1039-1047 P63125 denotes protease
T112 1039-1047 P63124 denotes protease
T113 1039-1047 P68986 denotes protease
T114 1039-1047 Q96629 denotes protease
T115 1039-1047 P63121 denotes protease
T116 1039-1047 P09569 denotes protease
T117 1039-1047 P03253 denotes protease
T118 1039-1047 P63129 denotes protease
T119 1039-1047 P10381 denotes protease
T120 1039-1047 P07885 denotes protease
T121 1039-1047 Q83906 denotes protease
T122 1039-1047 P19119 denotes protease
T123 1039-1047 P63127 denotes protease
T124 1039-1047 Q84177 denotes protease
T125 1039-1047 P19151 denotes protease
T126 1039-1047 Q9Y6I0 denotes protease
T127 1039-1047 P63123 denotes protease
T128 1039-1047 P68984 denotes protease
T129 1039-1047 P87563 denotes protease
T130 1039-1047 P03252 denotes protease
T131 1039-1047 O71150 denotes protease
T132 1039-1047 P11825 denotes protease
T133 1039-1056 GO:0008233 denotes protease activity
T134 1141-1151 GO:0030112 denotes glycocalyx
T136 1221-1231 UBERON:0007779 denotes transudate
T137 1232-1241 GO:0009058 denotes formation
T139 1284-1295 36453 denotes sevoflurane
T138 1284-1295 D000077149 denotes sevoflurane
T140 1284-1295 CHEBI:9130 denotes sevoflurane
T141 1284-1295 D000077149 denotes sevoflurane
T143 1355-1371 CHEBI:28815 denotes heparan sulphate
T145 1378-1382 PR:000022679 denotes fold
T146 1378-1382 PR:Q2FZJ6 denotes fold
T147 1378-1382 PR:A5I112 denotes fold
T148 1378-1382 PR:P24186 denotes fold
T150 1388-1396 P49415 denotes syndecan
T151 1388-1396 D053667 denotes syndecan
T149 1388-1396 GO:0015023 denotes syndecan
T152 1410-1414 PR:000022679 denotes fold
T153 1410-1414 PR:Q2FZJ6 denotes fold
T154 1410-1414 PR:A5I112 denotes fold
T155 1410-1414 PR:P24186 denotes fold
T156 1422-1430 CHEBI:10545 denotes electron
T157 1460-1471 GO:0009056 denotes degradation
T158 1475-1485 GO:0030112 denotes glycocalyx
T160 1504-1513 5333 denotes histamine
T159 1504-1513 CHEBI:58432 denotes histamine
T161 1504-1513 CHEBI:18295 denotes histamine
T162 1504-1513 D006632 denotes histamine
T163 1504-1513 D006632 denotes histamine
T164 1532-1542 UBERON:0007779 denotes transudate
T168 1548-1559 P00787 denotes cathepsin B
T169 1548-1559 P07688 denotes cathepsin B
T170 1548-1559 P81494 denotes cathepsin B
T171 1548-1559 P83205 denotes cathepsin B
T172 1548-1559 Q54QD9 denotes cathepsin B
T173 1548-1559 P07858 denotes cathepsin B
T174 1548-1559 Q4R5M2 denotes cathepsin B
T175 1548-1559 A1E295 denotes cathepsin B
T176 1548-1559 P43233 denotes cathepsin B
T177 1548-1559 PR:000006023 denotes cathepsin B
T178 1548-1559 Q5R6D1 denotes cathepsin B
T179 1548-1559 P10605 denotes cathepsin B
T167 1548-1559 D002401 denotes cathepsin B
T180 1548-1568 GO:0004213 denotes cathepsin B activity
T182 1601-1612 36453 denotes Sevoflurane
T181 1601-1612 D000077149 denotes Sevoflurane
T183 1601-1612 CHEBI:9130 denotes Sevoflurane
T184 1601-1612 D000077149 denotes Sevoflurane
T186 1666-1675 5333 denotes histamine
T185 1666-1675 CHEBI:58432 denotes histamine
T187 1666-1675 CHEBI:18295 denotes histamine
T188 1666-1675 D006632 denotes histamine
T189 1666-1675 D006632 denotes histamine
T191 1698-1709 36453 denotes Sevoflurane
T190 1698-1709 D000077149 denotes Sevoflurane
T192 1698-1709 CHEBI:9130 denotes Sevoflurane
T193 1698-1709 D000077149 denotes Sevoflurane
T194 1735-1745 GO:0030112 denotes glycocalyx
T195 1781-1792 GO:0009056 denotes degradation
T199 1922-1933 P00787 denotes cathepsin B
T200 1922-1933 P07688 denotes cathepsin B
T201 1922-1933 P81494 denotes cathepsin B
T202 1922-1933 P83205 denotes cathepsin B
T203 1922-1933 Q54QD9 denotes cathepsin B
T204 1922-1933 P07858 denotes cathepsin B
T205 1922-1933 Q4R5M2 denotes cathepsin B
T206 1922-1933 A1E295 denotes cathepsin B
T207 1922-1933 P43233 denotes cathepsin B
T208 1922-1933 PR:000006023 denotes cathepsin B
T209 1922-1933 Q5R6D1 denotes cathepsin B
T210 1922-1933 P10605 denotes cathepsin B
T198 1922-1933 D002401 denotes cathepsin B
T211 1969-1975 UBERON:0000479 denotes tissue
T212 1976-1980 PR:Q9NBD7 denotes mast
T213 1976-1980 PR:000008154 denotes mast
T215 1976-1980 Q9NBD7 denotes mast
T216 1976-1980 Q7TPM5 denotes mast
T214 1976-1980 CVCL_M374 denotes mast
T219 1976-1985 CL:0000097 denotes mast cell
T217 1976-1985 D008415 denotes mast cell
T218 1976-1985 D008415 denotes mast cell
T220 1976-1999 GO:0043303 denotes mast cell degranulation

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 99-500 BACKGROUND denotes Healthy vascular endothelium is coated by the glycocalyx, important in multiple endothelial functions, but destroyed by ischaemia-reperfusion. The impact of volatile anaesthetics on this fragile structure has not been investigated. We evaluated the effect of cardiac pre- and post-conditioning with sevoflurane on integrity of the endothelial glycocalyx in conjunction with coronary vascular function.
T2 510-1152 METHODS denotes Isolated guinea pig hearts perfused with Krebs-Henseleit buffer underwent 20 min stopped-flow ischaemia (37 degrees C), either without or with 1 MAC sevoflurane. This was applied for 15 min before, for 20 min after, or both before and after ischaemia. Transudate was collected for assessing coronary net fluid extravasation and histamine release by mast cells. Coronary release of syndecan-1 and heparan sulphate was measured. In additional experiments with and without continuous sevoflurane, cathepsin B and tryptase beta-like protease activity were measured in effluent. Hearts were perfusion-fixed to visualize the endothelial glycocalyx.
T3 1162-1684 RESULTS denotes Ischaemia led to a significant (P<0.05) increase by 70% in transudate formation during reperfusion only in hearts without sevoflurane. This was accompanied by significant (P<0.05) increases in heparan sulphate (four-fold) and syndecan release (6.5-fold), with electron microscopy revealing massive degradation of glycocalyx. After ischaemia, histamine was released into transudate, and cathepsin B activity increased in effluent (P<0.05). Sevoflurane application attenuated all these changes, except for histamine release.
T4 1698-2000 CONCLUSIONS denotes Sevoflurane protects the endothelial glycocalyx from ischaemia-reperfusion-induced degradation, with both preconditioning and rapid post-conditioning being successful. The mechanism seems to involve attenuation of lysosomal cathepsin B release and to be independent from tissue mast cell degranulation.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 304-307 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T2 304-307 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T3 331-333 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T4 584-586 CVCL_J923|Hybridoma|Mus musculus denotes 20
T5 587-590 CVCL_E777|Transformed_cell_line|Homo sapiens denotes min
T6 626-627 CVCL_S361|Finite_cell_line|Mus musculus denotes C
T7 696-699 CVCL_E777|Transformed_cell_line|Homo sapiens denotes min
T8 712-714 CVCL_J923|Hybridoma|Mus musculus denotes 20
T9 715-718 CVCL_E777|Transformed_cell_line|Homo sapiens denotes min
T10 859-863 CVCL_M374|Cancer_cell_line|Homo sapiens denotes mast
T11 1014-1015 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T12 1029-1033 CVCL_R799|Transformed_cell_line|Gorilla gorilla gorilla denotes beta
T13 1048-1056 CVCL_C410|Hybridoma|Mus musculus denotes activity
T14 1179-1180 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T15 1558-1559 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T16 1560-1568 CVCL_C410|Hybridoma|Mus musculus denotes activity
T17 1646-1653 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T18 1932-1933 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T19 1976-1980 CVCL_M374|Cancer_cell_line|Homo sapiens denotes mast