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PubMed:20164180 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-59 Sentence denotes A novel LZAP-binding protein, NLBP, inhibits cell invasion.
T2 60-254 Sentence denotes LXXLL/leucine zipper-containing alternative reading frame (ARF)-binding protein (LZAP) was recently shown to function as a tumor suppressor through inhibition of the NF-kappaB signaling pathway.
T3 255-391 Sentence denotes LZAP is also known as a negative regulator of cell invasion, and its expression was demonstrated to be reduced in several tumor tissues.
T4 392-484 Sentence denotes However, the molecular mechanism of the negative effect of LZAP on cell invasion is unclear.
T5 485-584 Sentence denotes In this study, we identify NLBP as a novel LZAP-binding protein using tandem affinity purification.
T6 585-682 Sentence denotes We demonstrate the negative effects of NLBP on cell invasion and the NF-kappaB signaling pathway.
T7 683-883 Sentence denotes NLBP expression was not detected in hepatocellular carcinoma cells with strong invasive activity, whereas its expression was detected in a hepatocellular carcinoma cell line with no invasive activity.
T8 884-1022 Sentence denotes We also demonstrate that these two proteins mutually affect the stability of each other by inhibiting ubiquitination of the other protein.
T9 1023-1208 Sentence denotes Based on these results, we suggest that NLBP may act as a novel tumor suppressor by inhibiting cell invasion, blocking NF-kappaB signaling, and increasing stability of the LZAP protein.

relna

Id Subject Object Predicate Lexical cue
T1 30-34 Protein denotes NLBP
T2 141-145 Protein denotes LZAP
T3 255-259 Protein denotes LZAP
T4 451-455 Protein denotes LZAP
T5 512-516 Protein denotes NLBP
T6 624-628 Protein denotes NLBP
T7 683-687 Protein denotes NLBP
T8 1063-1067 Protein denotes NLBP
T9 1195-1199 Protein denotes LZAP

DisGeNET

Id Subject Object Predicate Lexical cue
T0 683-687 gene:23376 denotes NLBP
T1 719-743 disease:C2239176 denotes hepatocellular carcinoma
T2 683-687 gene:23376 denotes NLBP
T3 822-846 disease:C2239176 denotes hepatocellular carcinoma
R1 T0 T1 associated_with NLBP,hepatocellular carcinoma
R2 T2 T3 associated_with NLBP,hepatocellular carcinoma

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 183-188 HP_0002664 denotes tumor
T2 377-382 HP_0002664 denotes tumor
T3 719-743 HP_0001402 denotes hepatocellular carcinoma
T4 822-846 HP_0001402 denotes hepatocellular carcinoma
T5 1087-1092 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_20164180_1_0 92-117 expanded denotes alternative reading frame
SS2_20164180_1_0 119-122 abbr denotes ARF
AE1_20164180_1_0 SS1_20164180_1_0 SS2_20164180_1_0 abbreviatedTo alternative reading frame,ARF

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20164180-6#0#4#gene23376 683-687 gene23376 denotes NLBP
20164180-6#36#60#diseaseC2239176 719-743 diseaseC2239176 denotes hepatocellular carcinoma
20164180-6#139#163#diseaseC2239176 822-846 diseaseC2239176 denotes hepatocellular carcinoma
0#4#gene2337636#60#diseaseC2239176 20164180-6#0#4#gene23376 20164180-6#36#60#diseaseC2239176 associated_with NLBP,hepatocellular carcinoma
0#4#gene23376139#163#diseaseC2239176 20164180-6#0#4#gene23376 20164180-6#139#163#diseaseC2239176 associated_with NLBP,hepatocellular carcinoma

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 183-188 Phenotype denotes tumor HP:0002664
T2 377-382 Phenotype denotes tumor HP:0002664
T3 719-743 Phenotype denotes hepatocellular carcinoma HP:0001402
T4 822-846 Phenotype denotes hepatocellular carcinoma HP:0001402
T5 1087-1092 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 183-188 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 377-382 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 719-743 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T4 822-846 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T5 1087-1092 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070