| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-151 |
Sentence |
denotes |
Identification of a novel family of snake venom proteins Veficolins from Cerberus rynchops using a venom gland transcriptomics and proteomics approach. |
| T2 |
152-254 |
Sentence |
denotes |
Cerberus rynchops (dog-faced water snake) belongs to Homalopsidae of Colubroidea (rear-fanged snakes). |
| T3 |
255-333 |
Sentence |
denotes |
So far, venom compositions of snakes of the Homalopsidae family are not known. |
| T4 |
334-445 |
Sentence |
denotes |
To determine the venom composition of C. rynchops, we have used both transcriptomics and proteomics approaches. |
| T5 |
446-600 |
Sentence |
denotes |
The venom gland transcriptome revealed 104 ESTs and the presence of three known snake protein families, namely, metalloprotease, CRISP, and C-type lectin. |
| T6 |
601-750 |
Sentence |
denotes |
In addition, we identified two proteins that showed sequence homology to ficolin, a mammalian protein with collagen-like and fibrinogen-like domains. |
| T7 |
751-888 |
Sentence |
denotes |
We named them as ryncolin 1 and ryncolin 2 (rynchops ficolin) and this new family of snake venom proteins as veficolins (venom ficolins). |
| T8 |
889-1041 |
Sentence |
denotes |
On the basis of its structural similarity to ficolin, we speculate that ryncolins may induce platelet aggregation and/or initiate complement activation. |
| T9 |
1042-1209 |
Sentence |
denotes |
To determine the proteome, the whole C. rynchops venom was trypsinized and fractionated by reverse phase HPLC followed by MALDI-MS/MS analysis of the tryptic peptides. |
| T10 |
1210-1344 |
Sentence |
denotes |
Analysis of the tandem mass spectrometric data indicated the presence of all protein families compared to the translated cDNA library. |
| T11 |
1345-1564 |
Sentence |
denotes |
Overall, our combined approach of transcriptomics and proteomics revealed that C. rynchops venom is among the least complex snake venom characterized to date despite the presence of a new family of snake venom proteins. |
| T1 |
0-151 |
Sentence |
denotes |
Identification of a novel family of snake venom proteins Veficolins from Cerberus rynchops using a venom gland transcriptomics and proteomics approach. |
| T2 |
152-254 |
Sentence |
denotes |
Cerberus rynchops (dog-faced water snake) belongs to Homalopsidae of Colubroidea (rear-fanged snakes). |
| T3 |
255-333 |
Sentence |
denotes |
So far, venom compositions of snakes of the Homalopsidae family are not known. |
| T4 |
334-445 |
Sentence |
denotes |
To determine the venom composition of C. rynchops, we have used both transcriptomics and proteomics approaches. |
| T5 |
446-600 |
Sentence |
denotes |
The venom gland transcriptome revealed 104 ESTs and the presence of three known snake protein families, namely, metalloprotease, CRISP, and C-type lectin. |
| T6 |
601-750 |
Sentence |
denotes |
In addition, we identified two proteins that showed sequence homology to ficolin, a mammalian protein with collagen-like and fibrinogen-like domains. |
| T7 |
751-888 |
Sentence |
denotes |
We named them as ryncolin 1 and ryncolin 2 (rynchops ficolin) and this new family of snake venom proteins as veficolins (venom ficolins). |
| T8 |
889-1041 |
Sentence |
denotes |
On the basis of its structural similarity to ficolin, we speculate that ryncolins may induce platelet aggregation and/or initiate complement activation. |
| T9 |
1042-1209 |
Sentence |
denotes |
To determine the proteome, the whole C. rynchops venom was trypsinized and fractionated by reverse phase HPLC followed by MALDI-MS/MS analysis of the tryptic peptides. |
| T10 |
1210-1344 |
Sentence |
denotes |
Analysis of the tandem mass spectrometric data indicated the presence of all protein families compared to the translated cDNA library. |
| T11 |
1345-1564 |
Sentence |
denotes |
Overall, our combined approach of transcriptomics and proteomics revealed that C. rynchops venom is among the least complex snake venom characterized to date despite the presence of a new family of snake venom proteins. |
