PubMed:20157255
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 127-287 | DRI_Background | denotes | Accumulation of amyloid-beta (Abeta) peptide and deposition of hyperphosphorylated tau protein are two major pathological hallmarks of Alzheimer's disease (AD). |
| T2 | 288-429 | DRI_Outcome | denotes | We have shown that cholesterol-enriched diets and its metabolite 27-hydroxycholesterol (27-OHC) increase Abeta and phosphorylated tau levels. |
| T3 | 430-551 | DRI_Background | denotes | However, the mechanisms by which cholesterol and 27-OHC regulate Abeta production and tau phosphorylation remain unclear. |
| T4 | 552-726 | DRI_Background | denotes | Leptin, an adipocytokine involved in cell survival and in learning, has been demonstrated to regulate Abeta production and tau hyperphosphorylation in transgenic mice for AD. |
| T5 | 727-802 | DRI_Challenge | denotes | However, the involvement of leptin signaling in cholesterol and cholesterol |
| T6 | 829-894 | DRI_Challenge | denotes | accumulation and tau hyperphosphorylation are yet to be examined. |
| T7 | 895-1047 | DRI_Approach | denotes | In this study, we determined the effect of high cholesterol diet and 27-OHC on leptin expression levels and the extent to which leptin treatment affects |
| T8 | 1071-1081 | DRI_Approach | denotes | pathology. |
| T9 | 1082-1333 | DRI_Outcome | denotes | Our results show that feeding rabbits a 2% cholesterol-enriched diet for 12 weeks reduces the levels of leptin by approximately 80% and incubating organotypic slices from adult rabbit hippocampus with 27-OHC reduced leptin levels by approximately 30%. |
| T10 | 1334-1445 | DRI_Approach | denotes | 27-OHC induces a 1.5-fold increase in Abeta (40) and a 3-fold increase in Abeta (42) and in phosphorylated tau. |
| T11 | 1446-1599 | DRI_Background | denotes | Treatment with leptin reversed the 27-OHC-induced increase in Abeta and phosphorylated tau by decreasing the levels of BACE-1 and GSK-3beta respectively. |
| T12 | 1600-1734 | DRI_Outcome | denotes | Our results suggest that cholesterol-enriched diets and cholesterol metabolites induce AD-like pathology by altering leptin signaling. |
| T13 | 1735-1910 | DRI_Outcome | denotes | We propose that leptin administration may prevent the progression of sporadic forms of AD that are related to increased cholesterol and oxidized cholesterol metabolite levels. |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 75-77 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T2 | 151-155 | CVCL_R799|Transformed_cell_line|Gorilla gorilla gorilla | denotes | beta |
| T3 | 283-285 | CVCL_M606|Cancer_cell_line|Homo sapiens | denotes | AD |
| T4 | 288-290 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
| T5 | 353-355 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T6 | 376-378 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T7 | 479-481 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T8 | 560-562 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
| T9 | 560-562 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
| T10 | 620-623 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
| T11 | 620-623 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
| T12 | 723-725 | CVCL_M606|Cancer_cell_line|Homo sapiens | denotes | AD |
| T13 | 910-912 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T14 | 964-966 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T15 | 1048-1050 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T16 | 1063-1065 | CVCL_M606|Cancer_cell_line|Homo sapiens | denotes | AD |
| T17 | 1120-1123 | CVCL_1939|Spontaneously_immortalized_cell_line|Xiphophorus xiphidium | denotes | a 2 |
| T18 | 1120-1123 | CVCL_4099|Spontaneously_immortalized_cell_line|Cricetulus griseus | denotes | a 2 |
| T19 | 1120-1123 | CVCL_RG54|Induced_pluripotent_stem_cell|Homo sapiens | denotes | a 2 |
| T20 | 1120-1123 | CVCL_ZU42|Transformed_cell_line|Homo sapiens | denotes | a 2 |
| T21 | 1120-1121 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T22 | 1283-1285 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T23 | 1329-1331 | CVCL_J925|Hybridoma|Mus musculus | denotes | 30 |
| T24 | 1334-1336 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T25 | 1349-1350 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T26 | 1379-1381 | CVCL_IW90|Cancer_cell_line|Mus musculus | denotes | 40 |
| T27 | 1387-1390 | CVCL_1061|Cancer_cell_line|Homo sapiens | denotes | a 3 |
| T28 | 1387-1390 | CVCL_1Q37|Spontaneously_immortalized_cell_line|Cricetulus griseus | denotes | a 3 |
| T29 | 1387-1390 | CVCL_5A61|Spontaneously_immortalized_cell_line|Cricetulus griseus | denotes | a 3 |
| T30 | 1387-1390 | CVCL_G649|Hybridoma|Mus musculus | denotes | a 3 |
| T31 | 1387-1390 | CVCL_JH29|Cancer_cell_line|Homo sapiens | denotes | a 3 |
| T32 | 1387-1390 | CVCL_LN35|Cancer_cell_line|Homo sapiens | denotes | a 3 |
| T33 | 1387-1390 | CVCL_ZU43|Transformed_cell_line|Homo sapiens | denotes | a 3 |
| T34 | 1387-1388 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T35 | 1415-1417 | CVCL_2561|Transformed_cell_line|Homo sapiens | denotes | 42 |
| T36 | 1481-1483 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
| T37 | 1687-1689 | CVCL_M606|Cancer_cell_line|Homo sapiens | denotes | AD |
| T38 | 1735-1737 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
| T39 | 1773-1776 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
| T40 | 1822-1824 | CVCL_M606|Cancer_cell_line|Homo sapiens | denotes | AD |
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-6 | Q9TU09 | denotes | Leptin |
| T2 | 0-6 | P50595 | denotes | Leptin |
| T3 | 0-6 | Q29406 | denotes | Leptin |
| T4 | 0-6 | Q706D1 | denotes | Leptin |
| T5 | 0-6 | P41160 | denotes | Leptin |
| T6 | 0-6 | Q257X2 | denotes | Leptin |
| T7 | 0-6 | Q28603 | denotes | Leptin |
| T8 | 0-6 | P41159 | denotes | Leptin |
| T10 | 0-6 | Q5J732 | denotes | Leptin |
| T11 | 0-6 | Q28504 | denotes | Leptin |
| T14 | 0-6 | Q95234 | denotes | Leptin |
| T15 | 0-6 | O93416 | denotes | Leptin |
| T16 | 0-6 | Q588F8 | denotes | Leptin |
| T17 | 0-6 | O02720 | denotes | Leptin |
| T18 | 0-6 | O42164 | denotes | Leptin |
| T19 | 0-6 | O02750 | denotes | Leptin |
| T20 | 0-6 | PR:000009758 | denotes | Leptin |
| T21 | 0-6 | Q9XSW9 | denotes | Leptin |
| T22 | 0-6 | Q9N2C1 | denotes | Leptin |
| T23 | 0-6 | Q95189 | denotes | Leptin |
| T24 | 0-6 | Q706D0 | denotes | Leptin |
| T25 | 0-6 | P50596 | denotes | Leptin |
| T26 | 0-6 | Q1XG29 | denotes | Leptin |
| T27 | 0-6 | Q588G0 | denotes | Leptin |
| T9 | 0-6 | D020738 | denotes | Leptin |
| T12 | 0-6 | D020738 | denotes | Leptin |
| T13 | 0-6 | CHEBI:81571 | denotes | Leptin |
| T28 | 35-40 | PR:000036193 | denotes | Abeta |
| T29 | 60-63 | PR:P16525 | denotes | tau |
| T30 | 60-63 | PR:000024142 | denotes | tau |
| T31 | 60-63 | PR:P10636 | denotes | tau |
| T32 | 60-63 | PR:000010173 | denotes | tau |
| T33 | 60-63 | PR:P19332 | denotes | tau |
| T35 | 60-63 | PR:P10637 | denotes | tau |
| T34 | 60-63 | CHEBI:36355 | denotes | tau |
| T36 | 75-96 | CHEBI:76591 | denotes | 27-hydroxycholesterol |
| T37 | 75-96 | CHEBI:17703 | denotes | 27-hydroxycholesterol |
| T38 | 75-96 | C076996 | denotes | 27-hydroxycholesterol |
| T39 | 75-96 | C076996 | denotes | 27-hydroxycholesterol |
| T41 | 100-106 | 813859 | denotes | rabbit |
| T40 | 100-106 | D011817 | denotes | rabbit |
| T42 | 100-106 | 9986 | denotes | rabbit |
| T44 | 143-155 | CHEBI:64645 | denotes | amyloid-beta |
| T47 | 157-162 | PR:000036193 | denotes | Abeta |
| T48 | 164-171 | SO:0001064 | denotes | peptide |
| T49 | 164-171 | PR:000018264 | denotes | peptide |
| T51 | 164-171 | PR:000018263 | denotes | peptide |
| T50 | 164-171 | CHEBI:16670 | denotes | peptide |
| T52 | 210-213 | PR:P16525 | denotes | tau |
| T53 | 210-213 | PR:000024142 | denotes | tau |
| T54 | 210-213 | PR:P10636 | denotes | tau |
| T55 | 210-213 | PR:000010173 | denotes | tau |
| T56 | 210-213 | PR:P19332 | denotes | tau |
| T58 | 210-213 | PR:P10637 | denotes | tau |
| T59 | 210-221 | D016875 | denotes | tau protein |
| T60 | 210-221 | CHEBI:17916 | denotes | tau protein |
| T65 | 214-221 | SO:0000104 | denotes | protein |
| T64 | 214-221 | PR:000000001 | denotes | protein |
| T61 | 214-221 | GO:0003675 | denotes | protein |
| T70 | 262-281 | D000544 | denotes | Alzheimer's disease |
| T71 | 262-281 | D000544 | denotes | Alzheimer's disease |
| T76 | 307-318 | 2438 | denotes | cholesterol |
| T74 | 307-318 | D002784 | denotes | cholesterol |
| T75 | 307-318 | CHEBI:16113 | denotes | cholesterol |
| T77 | 307-318 | D002784 | denotes | cholesterol |
| T78 | 342-352 | CHEBI:25212 | denotes | metabolite |
| T79 | 353-374 | CHEBI:76591 | denotes | 27-hydroxycholesterol |
| T80 | 353-374 | CHEBI:17703 | denotes | 27-hydroxycholesterol |
| T81 | 353-374 | C076996 | denotes | 27-hydroxycholesterol |
| T82 | 353-374 | C076996 | denotes | 27-hydroxycholesterol |
| T83 | 393-398 | PR:000036193 | denotes | Abeta |
| T84 | 418-421 | PR:P16525 | denotes | tau |
| T85 | 418-421 | PR:000024142 | denotes | tau |
| T86 | 418-421 | PR:P10636 | denotes | tau |
| T87 | 418-421 | PR:000010173 | denotes | tau |
| T88 | 418-421 | PR:P19332 | denotes | tau |
| T90 | 418-421 | PR:P10637 | denotes | tau |
| T89 | 418-421 | CHEBI:36355 | denotes | tau |
| T93 | 463-474 | 2438 | denotes | cholesterol |
| T91 | 463-474 | D002784 | denotes | cholesterol |
| T92 | 463-474 | CHEBI:16113 | denotes | cholesterol |
| T94 | 463-474 | D002784 | denotes | cholesterol |
| T95 | 495-500 | PR:000036193 | denotes | Abeta |
| T96 | 516-519 | PR:P16525 | denotes | tau |
| T97 | 516-519 | PR:000024142 | denotes | tau |
| T98 | 516-519 | PR:P10636 | denotes | tau |
| T99 | 516-519 | PR:000010173 | denotes | tau |
| T100 | 516-519 | PR:P19332 | denotes | tau |
| T102 | 516-519 | PR:P10637 | denotes | tau |
| T101 | 516-519 | CHEBI:36355 | denotes | tau |
| T103 | 520-535 | GO:0016310 | denotes | phosphorylation |
| T104 | 552-558 | Q9TU09 | denotes | Leptin |
| T105 | 552-558 | P50595 | denotes | Leptin |
| T106 | 552-558 | Q29406 | denotes | Leptin |
| T107 | 552-558 | Q706D1 | denotes | Leptin |
| T108 | 552-558 | P41160 | denotes | Leptin |
| T109 | 552-558 | Q257X2 | denotes | Leptin |
| T110 | 552-558 | Q28603 | denotes | Leptin |
| T111 | 552-558 | P41159 | denotes | Leptin |
| T113 | 552-558 | Q5J732 | denotes | Leptin |
| T114 | 552-558 | Q28504 | denotes | Leptin |
| T117 | 552-558 | Q95234 | denotes | Leptin |
| T118 | 552-558 | O93416 | denotes | Leptin |
| T119 | 552-558 | Q588F8 | denotes | Leptin |
| T120 | 552-558 | O02720 | denotes | Leptin |
| T121 | 552-558 | O42164 | denotes | Leptin |
| T122 | 552-558 | O02750 | denotes | Leptin |
| T123 | 552-558 | PR:000009758 | denotes | Leptin |
| T124 | 552-558 | Q9XSW9 | denotes | Leptin |
| T125 | 552-558 | Q9N2C1 | denotes | Leptin |
| T126 | 552-558 | Q95189 | denotes | Leptin |
| T127 | 552-558 | Q706D0 | denotes | Leptin |
| T128 | 552-558 | P50596 | denotes | Leptin |
| T129 | 552-558 | Q1XG29 | denotes | Leptin |
| T130 | 552-558 | Q588G0 | denotes | Leptin |
| T112 | 552-558 | D020738 | denotes | Leptin |
| T115 | 552-558 | D020738 | denotes | Leptin |
| T116 | 552-558 | CHEBI:81571 | denotes | Leptin |
| T131 | 654-659 | PR:000036193 | denotes | Abeta |
| T132 | 675-678 | PR:P16525 | denotes | tau |
| T133 | 675-678 | PR:000024142 | denotes | tau |
| T134 | 675-678 | PR:P10636 | denotes | tau |
| T135 | 675-678 | PR:000010173 | denotes | tau |
| T136 | 675-678 | PR:P19332 | denotes | tau |
| T138 | 675-678 | PR:P10637 | denotes | tau |
| T137 | 675-678 | CHEBI:36355 | denotes | tau |
| T139 | 679-699 | GO:0048151 | denotes | hyperphosphorylation |
| T140 | 703-713 | SO:0000781 | denotes | transgenic |
| T141 | 703-718 | 10090 | denotes | transgenic mice |
| T142 | 703-718 | D008822 | denotes | transgenic mice |
| T143 | 714-718 | PR:000005054 | denotes | mice |
| T145 | 714-718 | O89094 | denotes | mice |
| T147 | 755-761 | Q9TU09 | denotes | leptin |
| T148 | 755-761 | P50595 | denotes | leptin |
| T149 | 755-761 | Q29406 | denotes | leptin |
| T150 | 755-761 | Q706D1 | denotes | leptin |
| T151 | 755-761 | P41160 | denotes | leptin |
| T152 | 755-761 | Q257X2 | denotes | leptin |
| T153 | 755-761 | Q28603 | denotes | leptin |
| T154 | 755-761 | P41159 | denotes | leptin |
| T156 | 755-761 | Q5J732 | denotes | leptin |
| T157 | 755-761 | Q28504 | denotes | leptin |
| T160 | 755-761 | Q95234 | denotes | leptin |
| T161 | 755-761 | O93416 | denotes | leptin |
| T162 | 755-761 | Q588F8 | denotes | leptin |
| T163 | 755-761 | O02720 | denotes | leptin |
| T164 | 755-761 | O42164 | denotes | leptin |
| T165 | 755-761 | O02750 | denotes | leptin |
| T166 | 755-761 | PR:000009758 | denotes | leptin |
| T167 | 755-761 | Q9XSW9 | denotes | leptin |
| T168 | 755-761 | Q9N2C1 | denotes | leptin |
| T169 | 755-761 | Q95189 | denotes | leptin |
| T170 | 755-761 | Q706D0 | denotes | leptin |
| T171 | 755-761 | P50596 | denotes | leptin |
| T172 | 755-761 | Q1XG29 | denotes | leptin |
| T173 | 755-761 | Q588G0 | denotes | leptin |
| T155 | 755-761 | D020738 | denotes | leptin |
| T158 | 755-761 | D020738 | denotes | leptin |
| T159 | 755-761 | CHEBI:81571 | denotes | leptin |
| T174 | 762-771 | GO:0023052 | denotes | signaling |
| T177 | 775-786 | 2438 | denotes | cholesterol |
| T175 | 775-786 | D002784 | denotes | cholesterol |
| T176 | 775-786 | CHEBI:16113 | denotes | cholesterol |
| T178 | 775-786 | D002784 | denotes | cholesterol |
| T181 | 791-802 | 2438 | denotes | cholesterol |
| T179 | 791-802 | D002784 | denotes | cholesterol |
| T180 | 791-802 | CHEBI:16113 | denotes | cholesterol |
| T182 | 791-802 | D002784 | denotes | cholesterol |
| T183 | 803-814 | CHEBI:25212 | denotes | metabolites |
| T184 | 823-828 | PR:000036193 | denotes | Abeta |
| T185 | 846-849 | PR:P16525 | denotes | tau |
| T186 | 846-849 | PR:000024142 | denotes | tau |
| T187 | 846-849 | PR:P10636 | denotes | tau |
| T188 | 846-849 | PR:000010173 | denotes | tau |
| T189 | 846-849 | PR:P19332 | denotes | tau |
| T191 | 846-849 | PR:P10637 | denotes | tau |
| T190 | 846-849 | CHEBI:36355 | denotes | tau |
| T192 | 850-870 | GO:0048151 | denotes | hyperphosphorylation |
| T195 | 943-954 | 2438 | denotes | cholesterol |
| T193 | 943-954 | D002784 | denotes | cholesterol |
| T194 | 943-954 | CHEBI:16113 | denotes | cholesterol |
| T196 | 943-954 | D002784 | denotes | cholesterol |
| T197 | 974-980 | Q9TU09 | denotes | leptin |
| T198 | 974-980 | P50595 | denotes | leptin |
| T199 | 974-980 | Q29406 | denotes | leptin |
| T200 | 974-980 | Q706D1 | denotes | leptin |
| T201 | 974-980 | P41160 | denotes | leptin |
| T202 | 974-980 | Q257X2 | denotes | leptin |
| T203 | 974-980 | Q28603 | denotes | leptin |
| T204 | 974-980 | P41159 | denotes | leptin |
| T206 | 974-980 | Q5J732 | denotes | leptin |
| T207 | 974-980 | Q28504 | denotes | leptin |
| T210 | 974-980 | Q95234 | denotes | leptin |
| T211 | 974-980 | O93416 | denotes | leptin |
| T212 | 974-980 | Q588F8 | denotes | leptin |
| T213 | 974-980 | O02720 | denotes | leptin |
| T214 | 974-980 | O42164 | denotes | leptin |
| T215 | 974-980 | O02750 | denotes | leptin |
| T216 | 974-980 | PR:000009758 | denotes | leptin |
| T217 | 974-980 | Q9XSW9 | denotes | leptin |
| T218 | 974-980 | Q9N2C1 | denotes | leptin |
| T219 | 974-980 | Q95189 | denotes | leptin |
| T220 | 974-980 | Q706D0 | denotes | leptin |
| T221 | 974-980 | P50596 | denotes | leptin |
| T222 | 974-980 | Q1XG29 | denotes | leptin |
| T223 | 974-980 | Q588G0 | denotes | leptin |
| T205 | 974-980 | D020738 | denotes | leptin |
| T208 | 974-980 | D020738 | denotes | leptin |
| T209 | 974-980 | CHEBI:81571 | denotes | leptin |
| T224 | 1023-1029 | Q9TU09 | denotes | leptin |
| T225 | 1023-1029 | P50595 | denotes | leptin |
| T226 | 1023-1029 | Q29406 | denotes | leptin |
| T227 | 1023-1029 | Q706D1 | denotes | leptin |
| T228 | 1023-1029 | P41160 | denotes | leptin |
| T229 | 1023-1029 | Q257X2 | denotes | leptin |
| T230 | 1023-1029 | Q28603 | denotes | leptin |
| T231 | 1023-1029 | P41159 | denotes | leptin |
| T233 | 1023-1029 | Q5J732 | denotes | leptin |
| T234 | 1023-1029 | Q28504 | denotes | leptin |
| T237 | 1023-1029 | Q95234 | denotes | leptin |
| T238 | 1023-1029 | O93416 | denotes | leptin |
| T239 | 1023-1029 | Q588F8 | denotes | leptin |
| T240 | 1023-1029 | O02720 | denotes | leptin |
| T241 | 1023-1029 | O42164 | denotes | leptin |
| T242 | 1023-1029 | O02750 | denotes | leptin |
| T243 | 1023-1029 | PR:000009758 | denotes | leptin |
| T244 | 1023-1029 | Q9XSW9 | denotes | leptin |
| T245 | 1023-1029 | Q9N2C1 | denotes | leptin |
| T246 | 1023-1029 | Q95189 | denotes | leptin |
| T247 | 1023-1029 | Q706D0 | denotes | leptin |
| T248 | 1023-1029 | P50596 | denotes | leptin |
| T249 | 1023-1029 | Q1XG29 | denotes | leptin |
| T250 | 1023-1029 | Q588G0 | denotes | leptin |
| T232 | 1023-1029 | D020738 | denotes | leptin |
| T235 | 1023-1029 | D020738 | denotes | leptin |
| T236 | 1023-1029 | CHEBI:81571 | denotes | leptin |
| T251 | 1112-1119 | D011817 | denotes | rabbits |
| T252 | 1112-1119 | 9986 | denotes | rabbits |
| T255 | 1125-1136 | 2438 | denotes | cholesterol |
| T253 | 1125-1136 | D002784 | denotes | cholesterol |
| T254 | 1125-1136 | CHEBI:16113 | denotes | cholesterol |
| T256 | 1125-1136 | D002784 | denotes | cholesterol |
| T257 | 1186-1192 | Q9TU09 | denotes | leptin |
| T258 | 1186-1192 | P50595 | denotes | leptin |
| T259 | 1186-1192 | Q29406 | denotes | leptin |
| T260 | 1186-1192 | Q706D1 | denotes | leptin |
| T261 | 1186-1192 | P41160 | denotes | leptin |
| T262 | 1186-1192 | Q257X2 | denotes | leptin |
| T263 | 1186-1192 | Q28603 | denotes | leptin |
| T264 | 1186-1192 | P41159 | denotes | leptin |
| T266 | 1186-1192 | Q5J732 | denotes | leptin |
| T267 | 1186-1192 | Q28504 | denotes | leptin |
| T270 | 1186-1192 | Q95234 | denotes | leptin |
| T271 | 1186-1192 | O93416 | denotes | leptin |
| T272 | 1186-1192 | Q588F8 | denotes | leptin |
| T273 | 1186-1192 | O02720 | denotes | leptin |
| T274 | 1186-1192 | O42164 | denotes | leptin |
| T275 | 1186-1192 | O02750 | denotes | leptin |
| T276 | 1186-1192 | PR:000009758 | denotes | leptin |
| T277 | 1186-1192 | Q9XSW9 | denotes | leptin |
| T278 | 1186-1192 | Q9N2C1 | denotes | leptin |
| T279 | 1186-1192 | Q95189 | denotes | leptin |
| T280 | 1186-1192 | Q706D0 | denotes | leptin |
| T281 | 1186-1192 | P50596 | denotes | leptin |
| T282 | 1186-1192 | Q1XG29 | denotes | leptin |
| T283 | 1186-1192 | Q588G0 | denotes | leptin |
| T265 | 1186-1192 | D020738 | denotes | leptin |
| T268 | 1186-1192 | D020738 | denotes | leptin |
| T269 | 1186-1192 | CHEBI:81571 | denotes | leptin |
| T284 | 1253-1258 | UBERON:0007023 | denotes | adult |
| T286 | 1259-1265 | 813859 | denotes | rabbit |
| T285 | 1259-1265 | D011817 | denotes | rabbit |
| T287 | 1259-1265 | 9986 | denotes | rabbit |
| T288 | 1266-1277 | UBERON:0002421 | denotes | hippocampus |
| T289 | 1266-1277 | UBERON:0001954 | denotes | hippocampus |
| T290 | 1266-1277 | UBERON:0002961 | denotes | hippocampus |
| T291 | 1298-1304 | Q9TU09 | denotes | leptin |
| T292 | 1298-1304 | P50595 | denotes | leptin |
| T293 | 1298-1304 | Q29406 | denotes | leptin |
| T294 | 1298-1304 | Q706D1 | denotes | leptin |
| T295 | 1298-1304 | P41160 | denotes | leptin |
| T296 | 1298-1304 | Q257X2 | denotes | leptin |
| T297 | 1298-1304 | Q28603 | denotes | leptin |
| T298 | 1298-1304 | P41159 | denotes | leptin |
| T300 | 1298-1304 | Q5J732 | denotes | leptin |
| T301 | 1298-1304 | Q28504 | denotes | leptin |
| T304 | 1298-1304 | Q95234 | denotes | leptin |
| T305 | 1298-1304 | O93416 | denotes | leptin |
| T306 | 1298-1304 | Q588F8 | denotes | leptin |
| T307 | 1298-1304 | O02720 | denotes | leptin |
| T308 | 1298-1304 | O42164 | denotes | leptin |
| T309 | 1298-1304 | O02750 | denotes | leptin |
| T310 | 1298-1304 | PR:000009758 | denotes | leptin |
| T311 | 1298-1304 | Q9XSW9 | denotes | leptin |
| T312 | 1298-1304 | Q9N2C1 | denotes | leptin |
| T313 | 1298-1304 | Q95189 | denotes | leptin |
| T314 | 1298-1304 | Q706D0 | denotes | leptin |
| T315 | 1298-1304 | P50596 | denotes | leptin |
| T316 | 1298-1304 | Q1XG29 | denotes | leptin |
| T317 | 1298-1304 | Q588G0 | denotes | leptin |
| T299 | 1298-1304 | D020738 | denotes | leptin |
| T302 | 1298-1304 | D020738 | denotes | leptin |
| T303 | 1298-1304 | CHEBI:81571 | denotes | leptin |
| T318 | 1355-1359 | PR:000022679 | denotes | fold |
| T319 | 1355-1359 | PR:Q2FZJ6 | denotes | fold |
| T320 | 1355-1359 | PR:A5I112 | denotes | fold |
| T321 | 1355-1359 | PR:P24186 | denotes | fold |
| T323 | 1372-1381 | PR:000025584 | denotes | Abeta (40 |
| T324 | 1391-1395 | PR:000022679 | denotes | fold |
| T325 | 1391-1395 | PR:Q2FZJ6 | denotes | fold |
| T326 | 1391-1395 | PR:A5I112 | denotes | fold |
| T327 | 1391-1395 | PR:P24186 | denotes | fold |
| T329 | 1408-1417 | PR:000025583 | denotes | Abeta (42 |
| T330 | 1441-1444 | PR:P16525 | denotes | tau |
| T331 | 1441-1444 | PR:000024142 | denotes | tau |
| T332 | 1441-1444 | PR:P10636 | denotes | tau |
| T333 | 1441-1444 | PR:000010173 | denotes | tau |
| T334 | 1441-1444 | PR:P19332 | denotes | tau |
| T336 | 1441-1444 | PR:P10637 | denotes | tau |
| T335 | 1441-1444 | CHEBI:36355 | denotes | tau |
| T337 | 1461-1467 | Q9TU09 | denotes | leptin |
| T338 | 1461-1467 | P50595 | denotes | leptin |
| T339 | 1461-1467 | Q29406 | denotes | leptin |
| T340 | 1461-1467 | Q706D1 | denotes | leptin |
| T341 | 1461-1467 | P41160 | denotes | leptin |
| T342 | 1461-1467 | Q257X2 | denotes | leptin |
| T343 | 1461-1467 | Q28603 | denotes | leptin |
| T344 | 1461-1467 | P41159 | denotes | leptin |
| T346 | 1461-1467 | Q5J732 | denotes | leptin |
| T347 | 1461-1467 | Q28504 | denotes | leptin |
| T350 | 1461-1467 | Q95234 | denotes | leptin |
| T351 | 1461-1467 | O93416 | denotes | leptin |
| T352 | 1461-1467 | Q588F8 | denotes | leptin |
| T353 | 1461-1467 | O02720 | denotes | leptin |
| T354 | 1461-1467 | O42164 | denotes | leptin |
| T355 | 1461-1467 | O02750 | denotes | leptin |
| T356 | 1461-1467 | PR:000009758 | denotes | leptin |
| T357 | 1461-1467 | Q9XSW9 | denotes | leptin |
| T358 | 1461-1467 | Q9N2C1 | denotes | leptin |
| T359 | 1461-1467 | Q95189 | denotes | leptin |
| T360 | 1461-1467 | Q706D0 | denotes | leptin |
| T361 | 1461-1467 | P50596 | denotes | leptin |
| T362 | 1461-1467 | Q1XG29 | denotes | leptin |
| T363 | 1461-1467 | Q588G0 | denotes | leptin |
| T345 | 1461-1467 | D020738 | denotes | leptin |
| T348 | 1461-1467 | D020738 | denotes | leptin |
| T349 | 1461-1467 | CHEBI:81571 | denotes | leptin |
| T364 | 1508-1513 | PR:000036193 | denotes | Abeta |
| T365 | 1533-1536 | PR:P16525 | denotes | tau |
| T366 | 1533-1536 | PR:000024142 | denotes | tau |
| T367 | 1533-1536 | PR:P10636 | denotes | tau |
| T368 | 1533-1536 | PR:000010173 | denotes | tau |
| T369 | 1533-1536 | PR:P19332 | denotes | tau |
| T371 | 1533-1536 | PR:P10637 | denotes | tau |
| T370 | 1533-1536 | CHEBI:36355 | denotes | tau |
| T376 | 1565-1571 | PR:P56819 | denotes | BACE-1 |
| T377 | 1565-1571 | PR:P56817 | denotes | BACE-1 |
| T378 | 1565-1571 | PR:000004615 | denotes | BACE-1 |
| T379 | 1565-1571 | PR:P56818 | denotes | BACE-1 |
| T381 | 1576-1579 | GO:0050321 | denotes | GSK |
| T392 | 1576-1585 | Q9WV60 | denotes | GSK-3beta |
| T393 | 1576-1585 | P18266 | denotes | GSK-3beta |
| T394 | 1576-1585 | Q5YJC2 | denotes | GSK-3beta |
| T395 | 1576-1585 | P49841 | denotes | GSK-3beta |
| T396 | 1576-1585 | PR:000008288 | denotes | GSK-3beta |
| T397 | 1576-1585 | Q91757 | denotes | GSK-3beta |
| T391 | 1576-1585 | D000071679 | denotes | GSK-3beta |
| T402 | 1625-1636 | 2438 | denotes | cholesterol |
| T400 | 1625-1636 | D002784 | denotes | cholesterol |
| T401 | 1625-1636 | CHEBI:16113 | denotes | cholesterol |
| T403 | 1625-1636 | D002784 | denotes | cholesterol |
| T406 | 1656-1667 | 2438 | denotes | cholesterol |
| T404 | 1656-1667 | D002784 | denotes | cholesterol |
| T405 | 1656-1667 | CHEBI:16113 | denotes | cholesterol |
| T407 | 1656-1667 | D002784 | denotes | cholesterol |
| T408 | 1668-1679 | CHEBI:25212 | denotes | metabolites |
| T409 | 1717-1723 | Q9TU09 | denotes | leptin |
| T410 | 1717-1723 | P50595 | denotes | leptin |
| T411 | 1717-1723 | Q29406 | denotes | leptin |
| T412 | 1717-1723 | Q706D1 | denotes | leptin |
| T413 | 1717-1723 | P41160 | denotes | leptin |
| T414 | 1717-1723 | Q257X2 | denotes | leptin |
| T415 | 1717-1723 | Q28603 | denotes | leptin |
| T416 | 1717-1723 | P41159 | denotes | leptin |
| T418 | 1717-1723 | Q5J732 | denotes | leptin |
| T419 | 1717-1723 | Q28504 | denotes | leptin |
| T422 | 1717-1723 | Q95234 | denotes | leptin |
| T423 | 1717-1723 | O93416 | denotes | leptin |
| T424 | 1717-1723 | Q588F8 | denotes | leptin |
| T425 | 1717-1723 | O02720 | denotes | leptin |
| T426 | 1717-1723 | O42164 | denotes | leptin |
| T427 | 1717-1723 | O02750 | denotes | leptin |
| T428 | 1717-1723 | PR:000009758 | denotes | leptin |
| T429 | 1717-1723 | Q9XSW9 | denotes | leptin |
| T430 | 1717-1723 | Q9N2C1 | denotes | leptin |
| T431 | 1717-1723 | Q95189 | denotes | leptin |
| T432 | 1717-1723 | Q706D0 | denotes | leptin |
| T433 | 1717-1723 | P50596 | denotes | leptin |
| T434 | 1717-1723 | Q1XG29 | denotes | leptin |
| T435 | 1717-1723 | Q588G0 | denotes | leptin |
| T417 | 1717-1723 | D020738 | denotes | leptin |
| T420 | 1717-1723 | D020738 | denotes | leptin |
| T421 | 1717-1723 | CHEBI:81571 | denotes | leptin |
| T436 | 1724-1733 | GO:0023052 | denotes | signaling |
| T437 | 1751-1757 | Q9TU09 | denotes | leptin |
| T438 | 1751-1757 | P50595 | denotes | leptin |
| T439 | 1751-1757 | Q29406 | denotes | leptin |
| T440 | 1751-1757 | Q706D1 | denotes | leptin |
| T441 | 1751-1757 | P41160 | denotes | leptin |
| T442 | 1751-1757 | Q257X2 | denotes | leptin |
| T443 | 1751-1757 | Q28603 | denotes | leptin |
| T444 | 1751-1757 | P41159 | denotes | leptin |
| T446 | 1751-1757 | Q5J732 | denotes | leptin |
| T447 | 1751-1757 | Q28504 | denotes | leptin |
| T450 | 1751-1757 | Q95234 | denotes | leptin |
| T451 | 1751-1757 | O93416 | denotes | leptin |
| T452 | 1751-1757 | Q588F8 | denotes | leptin |
| T453 | 1751-1757 | O02720 | denotes | leptin |
| T454 | 1751-1757 | O42164 | denotes | leptin |
| T455 | 1751-1757 | O02750 | denotes | leptin |
| T456 | 1751-1757 | PR:000009758 | denotes | leptin |
| T457 | 1751-1757 | Q9XSW9 | denotes | leptin |
| T458 | 1751-1757 | Q9N2C1 | denotes | leptin |
| T459 | 1751-1757 | Q95189 | denotes | leptin |
| T460 | 1751-1757 | Q706D0 | denotes | leptin |
| T461 | 1751-1757 | P50596 | denotes | leptin |
| T462 | 1751-1757 | Q1XG29 | denotes | leptin |
| T463 | 1751-1757 | Q588G0 | denotes | leptin |
| T445 | 1751-1757 | D020738 | denotes | leptin |
| T448 | 1751-1757 | D020738 | denotes | leptin |
| T449 | 1751-1757 | CHEBI:81571 | denotes | leptin |
| T466 | 1855-1866 | 2438 | denotes | cholesterol |
| T464 | 1855-1866 | D002784 | denotes | cholesterol |
| T465 | 1855-1866 | CHEBI:16113 | denotes | cholesterol |
| T467 | 1855-1866 | D002784 | denotes | cholesterol |
| T468 | 1871-1891 | CHEBI:63906 | denotes | oxidized cholesterol |
| T471 | 1880-1891 | 2438 | denotes | cholesterol |
| T473 | 1892-1902 | CHEBI:25212 | denotes | metabolite |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 143-150 | HP_0011034 | denotes | amyloid |
| T2 | 262-281 | HP_0002511 | denotes | Alzheimer's disease |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20157255_1_0 | 262-281 | expanded | denotes | Alzheimer's disease |
| SS2_20157255_1_0 | 283-285 | abbr | denotes | AD |
| AE1_20157255_1_0 | SS1_20157255_1_0 | SS2_20157255_1_0 | abbreviatedTo | Alzheimer's disease,AD |