PubMed:20139089
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 226-237 | Cell | denotes | Tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-139 | Sentence | denotes | Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. |
| T2 | 140-225 | Sentence | denotes | Glioblastoma multiforme is the most common and lethal primary brain cancer in adults. |
| T3 | 226-327 | Sentence | denotes | Tumor cells diffusely infiltrate the brain making focal surgical and radiation treatment challenging. |
| T4 | 328-463 | Sentence | denotes | The invasion of glioma cells into normal brain is facilitated by the activity of ion channels aiding dynamic regulation of cell volume. |
| T5 | 464-565 | Sentence | denotes | Recent studies have specifically implicated ClC-3, a voltage-gated chloride channel, in this process. |
| T6 | 566-653 | Sentence | denotes | However, the interaction between ClC-3 activity and cell movement is poorly understood. |
| T7 | 654-866 | Sentence | denotes | Here, we demonstrate that ClC-3 is highly expressed on the plasma membrane of human glioma cells where its activity is regulated through phosphorylation via Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). |
| T8 | 867-1074 | Sentence | denotes | Intracellular infusion of autoactivated CaMKII via patch pipette enhanced chloride currents 3-fold, and this regulation was inhibited by autocamtide-2 related inhibitory peptide, a CaMKII-specific inhibitor. |
| T9 | 1075-1240 | Sentence | denotes | CaMKII modulation of chloride currents was also lost upon stable small hairpin RNA knockdown of ClC-3 channels indicating a specific interaction of ClC-3 and CaMKII. |
| T10 | 1241-1362 | Sentence | denotes | In ClC-3-expressing cells, inhibition of CaMKII reduced glioma invasion to the same extent as direct inhibition of ClC-3. |
| T11 | 1363-1525 | Sentence | denotes | The importance of the molecular interaction of ClC-3 and CaMKII is further supported by our finding that CaMKII co-localizes and co-immunoprecipitates with ClC-3. |
| T12 | 1526-1639 | Sentence | denotes | ClC-3 and CaMKII also co-immunoprecipitate in tissue biopsies from patients diagnosed with grade IV glioblastoma. |
| T13 | 1640-1729 | Sentence | denotes | These tumor samples show 10-fold higher ClC-3 protein expression than nonmalignant brain. |
| T14 | 1730-1941 | Sentence | denotes | These data suggest that CaMKII is a molecular link translating intracellular calcium changes, which are intrinsically associated with glioma migration, to changes in ClC-3 conductance required for cell movement. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 202-207 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T2 | 263-268 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T3 | 369-374 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T4 | 1723-1728 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 140-152 | HP_0100843 | denotes | Glioblastoma |
| T2 | 140-163 | HP_0012174 | denotes | Glioblastoma multiforme |
| T3 | 208-214 | HP_0002664 | denotes | cancer |
| T4 | 226-231 | HP_0002664 | denotes | Tumor |
| T5 | 344-350 | HP_0009733 | denotes | glioma |
| T6 | 738-744 | HP_0009733 | denotes | glioma |
| T7 | 1297-1303 | HP_0009733 | denotes | glioma |
| T8 | 1626-1638 | HP_0100843 | denotes | glioblastoma |
| T9 | 1646-1651 | HP_0002664 | denotes | tumor |
| T10 | 1864-1870 | HP_0009733 | denotes | glioma |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20139089_0_0 | 65-103 | expanded | denotes | calmodulin-dependent protein kinase II |
| SS2_20139089_0_0 | 105-111 | abbr | denotes | CaMKII |
| SS1_20139089_6_0 | 818-856 | expanded | denotes | calmodulin-dependent protein kinase II |
| SS2_20139089_6_0 | 858-864 | abbr | denotes | CaMKII |
| AE1_20139089_0_0 | SS1_20139089_0_0 | SS2_20139089_0_0 | abbreviatedTo | calmodulin-dependent protein kinase II,CaMKII |
| AE1_20139089_6_0 | SS1_20139089_6_0 | SS2_20139089_6_0 | abbreviatedTo | calmodulin-dependent protein kinase II,CaMKII |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 122-138 | Disease | denotes | malignant glioma | http://purl.obolibrary.org/obo/MONDO_0015917 |
| T2 | 140-163 | Disease | denotes | Glioblastoma multiforme | http://purl.obolibrary.org/obo/MONDO_0018177 |
| T3 | 202-214 | Disease | denotes | brain cancer | http://purl.obolibrary.org/obo/MONDO_0001657 |
| T4 | 226-231 | Disease | denotes | Tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 344-350 | Disease | denotes | glioma | http://purl.obolibrary.org/obo/MONDO_0021042 |
| T6 | 738-744 | Disease | denotes | glioma | http://purl.obolibrary.org/obo/MONDO_0021042 |
| T7 | 1297-1303 | Disease | denotes | glioma | http://purl.obolibrary.org/obo/MONDO_0021042 |
| T8 | 1626-1638 | Disease | denotes | glioblastoma | http://purl.obolibrary.org/obo/MONDO_0018177|http://purl.obolibrary.org/obo/MONDO_0020690 |
| T10 | 1646-1651 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T11 | 1864-1870 | Disease | denotes | glioma | http://purl.obolibrary.org/obo/MONDO_0021042 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 132-138 | Phenotype | denotes | glioma | HP:0009733 |
| T2 | 140-163 | Phenotype | denotes | Glioblastoma multiforme | HP:0012174 |
| T3 | 208-214 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 226-231 | Phenotype | denotes | Tumor | HP:0002664 |
| T5 | 344-350 | Phenotype | denotes | glioma | HP:0009733 |
| T6 | 738-744 | Phenotype | denotes | glioma | HP:0009733 |
| T7 | 1297-1303 | Phenotype | denotes | glioma | HP:0009733 |
| T8 | 1626-1638 | Phenotype | denotes | glioblastoma | HP:0012174 |
| T9 | 1646-1651 | Phenotype | denotes | tumor | HP:0002664 |
| T10 | 1864-1870 | Phenotype | denotes | glioma | HP:0009733 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 116-121 | OrganismTaxon | denotes | human | 9606 |
| T2 | 732-737 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 202-207 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T3 | 263-268 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 369-374 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 713-728 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T8 | 867-880 | Body_part | denotes | Intracellular | http://purl.obolibrary.org/obo/GO_0005622 |
| T9 | 1572-1578 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T10 | 1723-1728 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T12 | 1793-1806 | Body_part | denotes | intracellular | http://purl.obolibrary.org/obo/GO_0005622 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 202-207 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 263-268 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 369-374 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 1723-1728 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |