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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-50 Sentence denotes Defensin-immunology in inflammatory bowel disease.
T2 51-203 Sentence denotes Defensins are endogenous antibiotics with microbicidal activity against Gram-negative and Gram-positive bacteria, fungi, enveloped viruses and protozoa.
T3 204-380 Sentence denotes A disturbed antimicrobial defense, as provided by Paneth- and other epithelial cell defensins, seems to be a critical factor in the pathogenesis of inflammatory bowel diseases.
T4 381-602 Sentence denotes Conspicuously, there is a relative lack of Paneth cell beta-defensins HD-5 and HD-6 in ileal Crohn's disease, both in the absence of a pattern recognition receptor NOD2 mutation and, even more pronounced, in its presence.
T5 603-729 Sentence denotes This deficit is independent of concurrent active inflammation and results in a diminished antibacterial killing by the mucosa.
T6 730-927 Sentence denotes The Crohn's disease mucosa has not only a significant lack in killing different Escherichia coli but also an impaired ability in clearing Staphylococcus aureus as well as anaerobic micro-organisms.
T7 928-1045 Sentence denotes Thus, this dysfunction in antibacterial barrier seems to be broad and is not restricted to a single bacterial strain.
T8 1046-1181 Sentence denotes In addition to directly controlling barrier function, Paneth cell defensins also regulate the composition of the bacterial stool flora.
T9 1182-1348 Sentence denotes In the majority of patients, the Paneth cell deficiency is mediated by WNT signalling which suggests a disturbed Paneth cell differentiation in ileal Crohn's disease.
T10 1349-1521 Sentence denotes In contrast, colonic Crohn's disease is characterised by an impaired induction of mucosal beta-defensins, partly due to a low copy number of the beta-defensin gene cluster.
T11 1522-1621 Sentence denotes Therefore it seems plausible that bacteria take advantage of a niche formed by defensin deficiency.
T12 1622-1749 Sentence denotes This would represent a paradigm shift in understanding Crohn's disease and provides a target for future therapeutic strategies.
T1 0-50 Sentence denotes Defensin-immunology in inflammatory bowel disease.
T2 51-203 Sentence denotes Defensins are endogenous antibiotics with microbicidal activity against Gram-negative and Gram-positive bacteria, fungi, enveloped viruses and protozoa.
T3 204-380 Sentence denotes A disturbed antimicrobial defense, as provided by Paneth- and other epithelial cell defensins, seems to be a critical factor in the pathogenesis of inflammatory bowel diseases.
T4 381-602 Sentence denotes Conspicuously, there is a relative lack of Paneth cell beta-defensins HD-5 and HD-6 in ileal Crohn's disease, both in the absence of a pattern recognition receptor NOD2 mutation and, even more pronounced, in its presence.
T5 603-729 Sentence denotes This deficit is independent of concurrent active inflammation and results in a diminished antibacterial killing by the mucosa.
T6 730-927 Sentence denotes The Crohn's disease mucosa has not only a significant lack in killing different Escherichia coli but also an impaired ability in clearing Staphylococcus aureus as well as anaerobic micro-organisms.
T7 928-1045 Sentence denotes Thus, this dysfunction in antibacterial barrier seems to be broad and is not restricted to a single bacterial strain.
T8 1046-1181 Sentence denotes In addition to directly controlling barrier function, Paneth cell defensins also regulate the composition of the bacterial stool flora.
T9 1182-1348 Sentence denotes In the majority of patients, the Paneth cell deficiency is mediated by WNT signalling which suggests a disturbed Paneth cell differentiation in ileal Crohn's disease.
T10 1349-1521 Sentence denotes In contrast, colonic Crohn's disease is characterised by an impaired induction of mucosal beta-defensins, partly due to a low copy number of the beta-defensin gene cluster.
T11 1522-1621 Sentence denotes Therefore it seems plausible that bacteria take advantage of a niche formed by defensin deficiency.
T12 1622-1749 Sentence denotes This would represent a paradigm shift in understanding Crohn's disease and provides a target for future therapeutic strategies.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 545-549 gene:64127 denotes NOD2
T1 474-479 disease:C0010346 denotes Crohn
R1 T0 T1 associated_with NOD2,Crohn

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 474-489 HP_0100280 denotes Crohn's disease
T2 734-749 HP_0100280 denotes Crohn's disease
T3 1332-1347 HP_0100280 denotes Crohn's disease
T4 1370-1385 HP_0100280 denotes Crohn's disease
T5 1677-1692 HP_0100280 denotes Crohn's disease

disease_gene_microbe_small

Id Subject Object Predicate Lexical cue
T0 23-49 DOID:0050589 denotes inflammatory bowel disease
T1 475-490 DOID:8778 denotes rohn's disease,
T2 546-550 stringdb:9606.ENSP00000300589 denotes OD2
T3 735-750 DOID:8778 denotes rohn's disease
T4 1333-1348 DOID:8778 denotes rohn's disease.
T5 1371-1386 DOID:8778 denotes rohn's disease
T6 1678-1693 DOID:8778 denotes rohn's disease
T7 156-164 taxonomy:2 denotes acteria,
T8 166-171 taxonomy:4751 denotes ungi,
T9 183-190 taxonomy:10239 denotes iruses
T10 811-827 taxonomy:562 denotes scherichia coli
T11 869-890 taxonomy:1280 denotes taphylococcus aureus
T12 1557-1565 taxonomy:2 denotes acteria