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PubMed:2011512 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 9-22 protein denotes Oct2 isoforms
T2 85-110 protein denotes Oct2 transcription factor
T3 120-141 DNA denotes cognate octamer motif
T4 216-236 DNA denotes immunoglobulin genes
T5 260-276 DNA denotes cloned Oct2 cDNA
T6 364-382 cell_type denotes non-lymphoid cells
T7 434-448 DNA denotes multiple cDNAs
T8 458-468 protein denotes mouse Oct2
T9 476-494 cell_line denotes mature B-cell line
T10 542-562 protein denotes transcription factor
T11 641-649 protein denotes isoforms
T12 735-748 DNA denotes octamer motif
T13 783-791 protein denotes isoforms
T14 820-826 cell_type denotes B-cell
T15 868-874 cell_type denotes B-cell
T16 916-924 protein denotes isoforms
T17 1016-1024 protein denotes isoforms
T18 1049-1056 DNA denotes octamer
T19 1068-1084 DNA denotes promoter element
T20 1180-1188 protein denotes isoforms
T21 1222-1253 protein denotes lymphoid-specific Oct2B protein
T22 1317-1330 DNA denotes octamer motif
T23 1353-1394 DNA denotes immunoglobulin heavy-chain (IgH) enhancer

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-61 Sentence denotes Multiple Oct2 isoforms are generated by alternative splicing.
S2 62-237 Sentence denotes The interaction of the Oct2 transcription factor with the cognate octamer motif ATGCAAAT is a critical determinant of the lymphoid-specific expression of immunoglobulin genes.
S3 238-383 Sentence denotes Ectopic expression of cloned Oct2 cDNA was shown to be sufficient to reconstitute at least some aspects of this regulation in non-lymphoid cells.
S4 384-632 Sentence denotes We describe the isolation and characterization of multiple cDNAs encoding mouse Oct2 from a mature B-cell line and we show that a variety of isoforms of this transcription factor is generated from a single gene by an alternative splicing mechanism.
S5 633-749 Sentence denotes All the isoforms retain the previously characterized POU-domain and are therefore able to bind to the octamer motif.
S6 750-964 Sentence denotes Different amounts of the various isoforms are present within the same B-cell regardless of the developmental stage of B-cell differentiation and at least some of the isoforms are conserved between mouse and humans.
S7 965-1146 Sentence denotes In cotransfection experiments we show that all the isoforms are able to activate an octamer containing promoter element in fibroblasts revealing an unexpected functional redundancy.
S8 1147-1395 Sentence denotes Finally, we show that one of the isoforms encodes the previously described lymphoid-specific Oct2B protein which has been suggested to be involved in the function of the octamer motif in the context of the immunoglobulin heavy-chain (IgH) enhancer.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-22 NP denotes Multiple Oct2 isoforms
C2 116-150 NP denotes the cognate octamer motif ATGCAAAT
C3 458-468 NP denotes mouse Oct2
C5 537-562 NP denotes this transcription factor
C4 512-562 NP denotes a variety of isoforms of this transcription factor
C6 633-649 NP denotes All the isoforms
C7 731-748 NP denotes the octamer motif
C8 771-791 NP denotes the various isoforms
C9 912-924 NP denotes the isoforms
C10 1008-1024 NP denotes all the isoforms
C11 1176-1188 NP denotes the isoforms
C12 1197-1253 NP denotes the previously described lymphoid-specific Oct2B protein
C13 1254-1259 NP denotes which
C14 1313-1330 NP denotes the octamer motif
R1 C5 C3 coref-ident this transcription factor,mouse Oct2
R2 C4 C1 coref-other a variety of isoforms of this transcription factor,Multiple Oct2 isoforms
R3 C6 C4 coref-ident All the isoforms,a variety of isoforms of this transcription factor
R4 C7 C2 coref-ident the octamer motif,the cognate octamer motif ATGCAAAT
R5 C8 C6 coref-other the various isoforms,All the isoforms
R6 C9 C8 coref-other the isoforms,the various isoforms
R7 C10 C6 coref-ident all the isoforms,All the isoforms
R8 C11 C9 coref-ident the isoforms,the isoforms
R9 C13 C12 coref-relat which,the previously described lymphoid-specific Oct2B protein
R10 C14 C7 coref-ident the octamer motif,the octamer motif

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 9-22 protein_family_or_group denotes Oct2 isoforms
T2 40-60 other_name denotes alternative splicing
T3 85-110 protein_molecule denotes Oct2 transcription factor
T4 120-141 DNA_domain_or_region denotes cognate octamer motif
T5 142-150 polynucleotide denotes ATGCAAAT
T6 184-212 other_name denotes lymphoid-specific expression
T7 216-236 DNA_family_or_group denotes immunoglobulin genes
T8 238-256 other_name denotes Ectopic expression
T9 260-276 DNA_molecule denotes cloned Oct2 cDNA
T10 364-382 cell_type denotes non-lymphoid cells
T11 434-448 DNA_family_or_group denotes multiple cDNAs
T12 458-468 protein_molecule denotes mouse Oct2
T13 476-494 cell_line denotes mature B-cell line
T14 542-562 protein_family_or_group denotes transcription factor
T15 601-631 other_name denotes alternative splicing mechanism
T16 641-649 protein_family_or_group denotes isoforms
T17 735-748 DNA_domain_or_region denotes octamer motif
T18 783-791 protein_family_or_group denotes isoforms
T19 820-826 cell_type denotes B-cell
T20 868-874 cell_type denotes B-cell
T21 916-924 protein_family_or_group denotes isoforms
T22 947-952 multi_cell denotes mouse
T23 957-963 multi_cell denotes humans
T24 1016-1024 protein_family_or_group denotes isoforms
T25 1049-1056 DNA_domain_or_region denotes octamer
T26 1068-1084 DNA_domain_or_region denotes promoter element
T27 1180-1188 protein_family_or_group denotes isoforms
T28 1222-1253 protein_molecule denotes lymphoid-specific Oct2B protein
T29 1317-1330 DNA_domain_or_region denotes octamer motif
T30 1353-1379 protein_subunit denotes immunoglobulin heavy-chain
T31 1381-1384 protein_subunit denotes IgH