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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 878-885 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 878-885 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 878-885 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 878-885 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 878-885 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-71 Sentence denotes Heparan sulfate mediates amyloid-beta internalization and cytotoxicity.
TextSentencer_T2 72-284 Sentence denotes Heparan sulfate (HS) has been found associated with amyloid deposits, including the toxic amyloid-beta (Abeta) peptide aggregates in cerebral vasculature and neuronal tissues in patients with Alzheimer's disease.
TextSentencer_T3 285-379 Sentence denotes However, the pathophysiological significance of the HS-Abeta interaction has remained unclear.
TextSentencer_T4 380-492 Sentence denotes In the present study, we applied cell models to gain insight into the roles of HS in relation to Abeta toxicity.
TextSentencer_T5 493-668 Sentence denotes Wild-type Chinese hamster ovary (CHO-WT) cells showed loss of viability following exposure to Abeta40, whereas the HS-deficient cell line, pgsD-677, was essentially resistant.
TextSentencer_T6 669-760 Sentence denotes Immunocytochemical analysis showed Abeta internalization by CHO-WT, but not pgsD-677 cells.
TextSentencer_T7 761-856 Sentence denotes Abeta40 toxicity was also attenuated in human embryonic kidney cells overexpressing heparanase.
TextSentencer_T8 857-1008 Sentence denotes Finally, addition of heparin to human umbilical vein endothelial cells prevented internalization of added Abeta40 and protected against Abeta toxicity.
TextSentencer_T9 1009-1113 Sentence denotes Taken together, these findings suggest that cell-surface HS mediates Abeta internalization and toxicity.
T1 0-71 Sentence denotes Heparan sulfate mediates amyloid-beta internalization and cytotoxicity.
T2 72-284 Sentence denotes Heparan sulfate (HS) has been found associated with amyloid deposits, including the toxic amyloid-beta (Abeta) peptide aggregates in cerebral vasculature and neuronal tissues in patients with Alzheimer's disease.
T3 285-379 Sentence denotes However, the pathophysiological significance of the HS-Abeta interaction has remained unclear.
T4 380-492 Sentence denotes In the present study, we applied cell models to gain insight into the roles of HS in relation to Abeta toxicity.
T5 493-668 Sentence denotes Wild-type Chinese hamster ovary (CHO-WT) cells showed loss of viability following exposure to Abeta40, whereas the HS-deficient cell line, pgsD-677, was essentially resistant.
T6 669-760 Sentence denotes Immunocytochemical analysis showed Abeta internalization by CHO-WT, but not pgsD-677 cells.
T7 761-856 Sentence denotes Abeta40 toxicity was also attenuated in human embryonic kidney cells overexpressing heparanase.
T8 857-1008 Sentence denotes Finally, addition of heparin to human umbilical vein endothelial cells prevented internalization of added Abeta40 and protected against Abeta toxicity.
T9 1009-1113 Sentence denotes Taken together, these findings suggest that cell-surface HS mediates Abeta internalization and toxicity.
T1 0-71 Sentence denotes Heparan sulfate mediates amyloid-beta internalization and cytotoxicity.
T2 72-284 Sentence denotes Heparan sulfate (HS) has been found associated with amyloid deposits, including the toxic amyloid-beta (Abeta) peptide aggregates in cerebral vasculature and neuronal tissues in patients with Alzheimer's disease.
T3 285-379 Sentence denotes However, the pathophysiological significance of the HS-Abeta interaction has remained unclear.
T4 380-492 Sentence denotes In the present study, we applied cell models to gain insight into the roles of HS in relation to Abeta toxicity.
T5 493-668 Sentence denotes Wild-type Chinese hamster ovary (CHO-WT) cells showed loss of viability following exposure to Abeta40, whereas the HS-deficient cell line, pgsD-677, was essentially resistant.
T6 669-760 Sentence denotes Immunocytochemical analysis showed Abeta internalization by CHO-WT, but not pgsD-677 cells.
T7 761-856 Sentence denotes Abeta40 toxicity was also attenuated in human embryonic kidney cells overexpressing heparanase.
T8 857-1008 Sentence denotes Finally, addition of heparin to human umbilical vein endothelial cells prevented internalization of added Abeta40 and protected against Abeta toxicity.
T9 1009-1113 Sentence denotes Taken together, these findings suggest that cell-surface HS mediates Abeta internalization and toxicity.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 0-15 http://www.glycoepitope.jp/epitopes/EP0086 denotes Heparan sulfate
T2 72-87 http://www.glycoepitope.jp/epitopes/EP0086 denotes Heparan sulfate
T3 89-91 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T4 337-339 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T5 459-461 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T6 608-610 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T7 1066-1068 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 214-225 http://purl.obolibrary.org/obo/MAT_0000393 denotes vasculature
T2 817-823 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T3 905-909 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein

ICD10

Id Subject Object Predicate Lexical cue
T1 264-283 http://purl.bioontology.org/ontology/ICD10/G30.9 denotes Alzheimer's disease
T2 264-283 http://purl.bioontology.org/ontology/ICD10/G30 denotes Alzheimer's disease

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 0-7 FMAID:165191 denotes Heparan
_T2 0-7 FMAID:67110 denotes Heparan
_T3 0-15 FMAID:167405 denotes Heparan sulfate
_T4 0-15 FMAID:63023 denotes Heparan sulfate
_T5 38-53 FMAID:214710 denotes internalization
_T6 72-79 FMAID:165191 denotes Heparan
_T7 72-79 FMAID:67110 denotes Heparan
_T8 72-87 FMAID:63023 denotes Heparan sulfate
_T9 72-87 FMAID:167405 denotes Heparan sulfate
_T10 214-225 FMAID:169597 denotes vasculature
_T11 214-225 FMAID:69050 denotes vasculature
_T12 214-229 FMAID:85577 denotes vasculature and
_T13 214-229 FMAID:200195 denotes vasculature and
_T14 230-238 FMAID:150783 denotes neuronal
_T15 230-238 FMAID:54527 denotes neuronal
_T16 230-238 FMAID:166033 denotes neuronal
_T17 239-246 FMAID:256050 denotes tissues
_T18 428-432 FMAID:216818 denotes gain
_T19 519-524 FMAID:93687 denotes ovary
_T20 519-524 FMAID:7209 denotes ovary
_T21 534-539 FMAID:169002 denotes cells
_T22 534-539 FMAID:68646 denotes cells
_T23 710-725 FMAID:214710 denotes internalization
_T24 754-759 FMAID:68646 denotes cells
_T25 754-759 FMAID:169002 denotes cells
_T26 817-823 FMAID:7203 denotes kidney
_T27 817-823 FMAID:93681 denotes kidney
_T28 824-829 FMAID:68646 denotes cells
_T29 824-829 FMAID:169002 denotes cells
_T30 878-885 FMAID:167420 denotes heparin
_T31 878-885 FMAID:82839 denotes heparin
_T32 895-909 FMAID:70317 denotes umbilical vein
_T33 895-909 FMAID:171155 denotes umbilical vein
_T34 905-909 FMAID:217490 denotes vein
_T35 905-909 FMAID:217063 denotes vein
_T36 905-909 FMAID:185470 denotes vein
_T37 905-909 FMAID:171667 denotes vein
_T38 905-909 FMAID:50723 denotes vein
_T39 910-921 FMAID:63916 denotes endothelial
_T40 910-921 FMAID:162384 denotes endothelial
_T41 910-927 FMAID:164926 denotes endothelial cells
_T42 910-927 FMAID:169653 denotes endothelial cells
_T43 910-927 FMAID:69075 denotes endothelial cells
_T44 910-927 FMAID:66772 denotes endothelial cells
_T45 922-927 FMAID:169002 denotes cells
_T46 922-927 FMAID:68646 denotes cells
_T47 938-953 FMAID:214710 denotes internalization
_T48 957-962 FMAID:177242 denotes added
_T49 1053-1065 FMAID:200942 denotes cell-surface
_T50 1053-1065 FMAID:212684 denotes cell-surface
_T51 1058-1065 FMAID:146300 denotes surface
_T52 1058-1065 FMAID:50594 denotes surface
_T53 1084-1099 FMAID:214710 denotes internalization

uniprot-human

Id Subject Object Predicate Lexical cue
T1 845-855 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 845-855 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 33-37 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes beta
T2 33-37 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes beta
T3 170-174 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes beta
T4 170-174 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes beta
T5 239-246 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T6 465-473 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes relation
T7 534-539 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 754-759 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 824-829 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 922-927 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T11 1031-1039 http://purl.bioontology.org/ontology/STY/T033 denotes findings

GO-BP

Id Subject Object Predicate Lexical cue
T1 8-15 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T2 80-87 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T3 526-529 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO
T4 729-732 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO

GO-CC

Id Subject Object Predicate Lexical cue
T1 413-417 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 621-625 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 534-539 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 754-759 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 824-829 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 922-927 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1053-1065 http://purl.obolibrary.org/obo/GO_0009986 denotes cell-surface

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 214-225 http://purl.obolibrary.org/obo/UBERON_0002049 denotes vasculature
T2 239-246 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T3 817-823 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T4 895-909 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
T5 895-921 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
T6 905-909 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein

Allie

Id Subject Object Predicate Lexical cue
SS1_20053627_1_0 72-87 expanded denotes Heparan sulfate
SS2_20053627_1_0 89-91 abbr denotes HS
AE1_20053627_1_0 SS1_20053627_1_0 SS2_20053627_1_0 abbreviatedTo Heparan sulfate,HS

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 183-190 http://edamontology.org/topic_0154 denotes peptide
T2 276-283 http://edamontology.org/topic_0634 denotes disease
T3 346-357 http://edamontology.org/topic_0602 denotes interaction
T4 395-400 http://edamontology.org/topic_3678 denotes study
T5 801-806 http://edamontology.org/topic_2815 denotes human
T6 889-894 http://edamontology.org/topic_2815 denotes human

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 132-140 http://edamontology.org/operation_3431 denotes deposits
T2 183-190 http://edamontology.org/data_2906 denotes peptide
T3 688-696 http://edamontology.org/operation_2945 denotes analysis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 124-131 HP_0011034 denotes amyloid
T2 162-169 HP_0011034 denotes amyloid
T3 264-283 HP_0002511 denotes Alzheimer's disease

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 214-225 http://purl.obolibrary.org/obo/MAT_0000393 denotes vasculature
T2 817-823 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T3 905-909 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 878-885 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 0-15 http://www.glycoepitope.jp/epitopes/EP0086 denotes Heparan sulfate
PD-GlycoEpitope-B_T2 72-87 http://www.glycoepitope.jp/epitopes/EP0086 denotes Heparan sulfate

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 239-246 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 817-823 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T3 214-225 http://purl.obolibrary.org/obo/UBERON_0002049 denotes vasculature
PD-UBERON-AE-B_T4 230-238 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T5 895-909 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
PD-UBERON-AE-B_T6 895-921 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
PD-UBERON-AE-B_T7 905-909 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 25-32 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 124-131 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T3 162-169 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T4 264-283 Disease denotes Alzheimer's disease http://purl.obolibrary.org/obo/MONDO_0004975

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 264-283 Phenotype denotes Alzheimer's disease HP:0002511

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes Heparan sulfate mediates amyloid-beta internalization and cytotoxicity.
T2 72-284 Sentence denotes Heparan sulfate (HS) has been found associated with amyloid deposits, including the toxic amyloid-beta (Abeta) peptide aggregates in cerebral vasculature and neuronal tissues in patients with Alzheimer's disease.
T3 285-379 Sentence denotes However, the pathophysiological significance of the HS-Abeta interaction has remained unclear.
T4 380-492 Sentence denotes In the present study, we applied cell models to gain insight into the roles of HS in relation to Abeta toxicity.
T5 493-668 Sentence denotes Wild-type Chinese hamster ovary (CHO-WT) cells showed loss of viability following exposure to Abeta40, whereas the HS-deficient cell line, pgsD-677, was essentially resistant.
T6 669-760 Sentence denotes Immunocytochemical analysis showed Abeta internalization by CHO-WT, but not pgsD-677 cells.
T7 761-856 Sentence denotes Abeta40 toxicity was also attenuated in human embryonic kidney cells overexpressing heparanase.
T8 857-1008 Sentence denotes Finally, addition of heparin to human umbilical vein endothelial cells prevented internalization of added Abeta40 and protected against Abeta toxicity.
T9 1009-1113 Sentence denotes Taken together, these findings suggest that cell-surface HS mediates Abeta internalization and toxicity.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 25-32 Disease denotes amyloid MONDO:0019065
T2 124-131 Disease denotes amyloid MONDO:0019065
T3 162-169 Disease denotes amyloid MONDO:0019065
T4 264-283 Disease denotes Alzheimer's disease MONDO:0004975

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 250-258 Organism denotes patients 9606
T2 503-518 Organism denotes Chinese hamster 10029
T3 801-806 Organism denotes human 9606
T4 889-894 Organism denotes human 9606

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 0-15 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 72-87 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T3 89-91 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T4 337-339 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T5 459-461 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T6 608-610 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T7 1066-1068 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 214-225 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T2 519-524 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T3 807-823 Body_part denotes embryonic kidney http://purl.obolibrary.org/obo/UBERON_0002120
T4 895-909 Body_part denotes umbilical vein http://purl.obolibrary.org/obo/UBERON_0002066
T5 910-927 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 214-225 Body_part denotes vasculature FMA:69050
T2 239-246 Body_part denotes tissues FMA:9637
T3 519-524 Body_part denotes ovary FMA:7209
T4 817-823 Body_part denotes kidney FMA:7203
T5 895-909 Body_part denotes umbilical vein FMA:70317
T6 910-927 Body_part denotes endothelial cells FMA:66772
T7 1053-1065 Body_part denotes cell-surface FMA:67653

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 214-225 Body_part denotes vasculature http://purl.obolibrary.org/obo/MAT_0000393
T2 817-823 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T3 905-909 Body_part denotes vein http://purl.obolibrary.org/obo/MAT_0000037

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 503-518 OrganismTaxon denotes Chinese hamster 10029
T2 801-806 OrganismTaxon denotes human 9606
T3 889-894 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 214-225 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T2 519-524 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T3 807-823 Body_part denotes embryonic kidney http://purl.obolibrary.org/obo/UBERON_0002120
T4 895-909 Body_part denotes umbilical vein http://purl.obolibrary.org/obo/UBERON_0002066
T5 910-927 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 214-225 Body_part denotes vasculature http://purl.obolibrary.org/obo/MAT_0000393
T2 817-823 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T3 905-909 Body_part denotes vein http://purl.obolibrary.org/obo/MAT_0000037

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 264-283 Phenotype denotes Alzheimer's disease HP:0002511

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 230-238 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 817-829 Cell denotes kidney cells http://purl.obolibrary.org/obo/CL:1000497
T3 905-927 Cell denotes vein endothelial cells http://purl.obolibrary.org/obo/CL:0002543