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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 152-163 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 152-163 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 152-163 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937.
TextSentencer_T2 140-318 Sentence denotes Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
TextSentencer_T3 319-409 Sentence denotes Here, we report that clustering of Siglec-7 with a specific F(ab')(2) elicited cell death.
TextSentencer_T4 410-578 Sentence denotes Interestingly, a truncated Siglec-7 lacking the cytosolic ITIM domain still induced the cell death, suggesting that the ITIMs are not essential for the death signaling.
TextSentencer_T5 579-757 Sentence denotes Further analyses of the death signaling revealed that an oxygen radical scavenger, N-acetyl cysteine, completely inhibited the cell death, whereas a pancaspase inhibitor did not.
TextSentencer_T6 758-931 Sentence denotes In addition, caspase-3 activation, DNA ladder formation, and nuclear condensation were not detected during the death process, suggesting that the cell death is nonapoptotic.
TextSentencer_T7 932-1116 Sentence denotes To identify the critical region for the death signaling, we prepared a series of shuffling chimeras between Siglec-7 and Siglec-9, the latter of which did not transduce a death signal.
TextSentencer_T8 1117-1280 Sentence denotes The critical region was mapped to the middle of the membrane-proximal C2-set domain, which contained only six amino acid differences between Siglec-7 and Siglec-9.
TextSentencer_T9 1281-1415 Sentence denotes Point mutation analyses of each of these six amino acids revealed that four of the six amino acids were critical for the death signal.
TextSentencer_T10 1416-1545 Sentence denotes A computer-assisted 3D modeling revealed that these four amino acids were proximally located on the surface of the C2-set domain.
TextSentencer_T11 1546-1672 Sentence denotes In conclusion, Siglec-7 induces nonapoptotic cell death, the signal for which is transduced by an extracellular C2-set domain.
T1 0-139 Sentence denotes Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937.
T2 140-318 Sentence denotes Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
T3 319-409 Sentence denotes Here, we report that clustering of Siglec-7 with a specific F(ab')(2) elicited cell death.
T4 410-578 Sentence denotes Interestingly, a truncated Siglec-7 lacking the cytosolic ITIM domain still induced the cell death, suggesting that the ITIMs are not essential for the death signaling.
T5 579-757 Sentence denotes Further analyses of the death signaling revealed that an oxygen radical scavenger, N-acetyl cysteine, completely inhibited the cell death, whereas a pancaspase inhibitor did not.
T6 758-931 Sentence denotes In addition, caspase-3 activation, DNA ladder formation, and nuclear condensation were not detected during the death process, suggesting that the cell death is nonapoptotic.
T7 932-1116 Sentence denotes To identify the critical region for the death signaling, we prepared a series of shuffling chimeras between Siglec-7 and Siglec-9, the latter of which did not transduce a death signal.
T8 1117-1280 Sentence denotes The critical region was mapped to the middle of the membrane-proximal C2-set domain, which contained only six amino acid differences between Siglec-7 and Siglec-9.
T9 1281-1415 Sentence denotes Point mutation analyses of each of these six amino acids revealed that four of the six amino acids were critical for the death signal.
T10 1416-1545 Sentence denotes A computer-assisted 3D modeling revealed that these four amino acids were proximally located on the surface of the C2-set domain.
T11 1546-1672 Sentence denotes In conclusion, Siglec-7 induces nonapoptotic cell death, the signal for which is transduced by an extracellular C2-set domain.
T1 0-139 Sentence denotes Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937.
T2 140-318 Sentence denotes Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
T3 319-409 Sentence denotes Here, we report that clustering of Siglec-7 with a specific F(ab')(2) elicited cell death.
T4 410-578 Sentence denotes Interestingly, a truncated Siglec-7 lacking the cytosolic ITIM domain still induced the cell death, suggesting that the ITIMs are not essential for the death signaling.
T5 579-757 Sentence denotes Further analyses of the death signaling revealed that an oxygen radical scavenger, N-acetyl cysteine, completely inhibited the cell death, whereas a pancaspase inhibitor did not.
T6 758-931 Sentence denotes In addition, caspase-3 activation, DNA ladder formation, and nuclear condensation were not detected during the death process, suggesting that the cell death is nonapoptotic.
T7 932-1116 Sentence denotes To identify the critical region for the death signaling, we prepared a series of shuffling chimeras between Siglec-7 and Siglec-9, the latter of which did not transduce a death signal.
T8 1117-1280 Sentence denotes The critical region was mapped to the middle of the membrane-proximal C2-set domain, which contained only six amino acid differences between Siglec-7 and Siglec-9.
T9 1281-1415 Sentence denotes Point mutation analyses of each of these six amino acids revealed that four of the six amino acids were critical for the death signal.
T10 1416-1545 Sentence denotes A computer-assisted 3D modeling revealed that these four amino acids were proximally located on the surface of the C2-set domain.
T11 1546-1672 Sentence denotes In conclusion, Siglec-7 induces nonapoptotic cell death, the signal for which is transduced by an extracellular C2-set domain.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1178-1186 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T2 1490-1500 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximally

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 78-86 FMAID:196757 denotes tyrosine
_T2 78-86 FMAID:82768 denotes tyrosine
_T3 114-123 FMAID:62864 denotes monocytic
_T4 114-123 FMAID:167164 denotes monocytic
_T5 172-186 FMAID:167181 denotes immunoglobulin
_T6 172-186 FMAID:62871 denotes immunoglobulin
_T7 172-186 FMAID:167177 denotes immunoglobulin
_T8 172-186 FMAID:62873 denotes immunoglobulin
_T9 172-186 FMAID:62874 denotes immunoglobulin
_T10 172-186 FMAID:167178 denotes immunoglobulin
_T11 172-186 FMAID:167185 denotes immunoglobulin
_T12 172-186 FMAID:62875 denotes immunoglobulin
_T13 172-186 FMAID:167187 denotes immunoglobulin
_T14 172-186 FMAID:62876 denotes immunoglobulin
_T15 172-186 FMAID:167183 denotes immunoglobulin
_T16 172-186 FMAID:62872 denotes immunoglobulin
_T17 277-285 FMAID:82768 denotes tyrosine
_T18 277-285 FMAID:196757 denotes tyrosine
_T19 671-679 FMAID:82751 denotes cysteine
_T20 671-679 FMAID:196740 denotes cysteine
_T21 1067-1073 FMAID:30332 denotes latter
_T22 1067-1073 FMAID:171168 denotes latter
_T23 1141-1147 FMAID:90078 denotes mapped
_T24 1155-1161 FMAID:74544 denotes middle
_T25 1155-1161 FMAID:179281 denotes middle
_T26 1178-1186 FMAID:30326 denotes proximal
_T27 1178-1186 FMAID:171415 denotes proximal
_T28 1187-1189 FMAID:63494 denotes C2
_T29 1187-1189 FMAID:167719 denotes C2
_T30 1227-1237 FMAID:196728 denotes amino acid
_T31 1227-1237 FMAID:82739 denotes amino acid
_T32 1281-1286 FMAID:146304 denotes Point
_T33 1281-1286 FMAID:50596 denotes Point
_T34 1326-1337 FMAID:82739 denotes amino acids
_T35 1326-1337 FMAID:196728 denotes amino acids
_T36 1368-1379 FMAID:196728 denotes amino acids
_T37 1368-1379 FMAID:82739 denotes amino acids
_T38 1473-1484 FMAID:82739 denotes amino acids
_T39 1473-1484 FMAID:196728 denotes amino acids
_T40 1490-1500 FMAID:30326 denotes proximally
_T41 1490-1500 FMAID:171415 denotes proximally
_T42 1516-1523 FMAID:146300 denotes surface
_T43 1516-1523 FMAID:50594 denotes surface
_T44 1516-1530 FMAID:63163 denotes surface of the
_T45 1516-1530 FMAID:25241 denotes surface of the
_T46 1516-1530 FMAID:25320 denotes surface of the
_T47 1516-1530 FMAID:117967 denotes surface of the
_T48 1516-1530 FMAID:117867 denotes surface of the
_T49 1516-1530 FMAID:167552 denotes surface of the
_T50 1516-1530 FMAID:25456 denotes surface of the
_T51 1516-1530 FMAID:118168 denotes surface of the
_T52 1531-1533 FMAID:63494 denotes C2
_T53 1531-1533 FMAID:167719 denotes C2
_T54 1658-1660 FMAID:63494 denotes C2
_T55 1658-1660 FMAID:167719 denotes C2

uniprot-human

Id Subject Object Predicate Lexical cue
T1 0-8 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T2 140-148 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T3 354-362 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T4 437-445 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T5 1040-1048 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T6 1258-1266 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T7 1561-1569 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T8 771-780 http://www.uniprot.org/uniprot/P42574 denotes caspase-3
T9 1053-1061 http://www.uniprot.org/uniprot/Q9Y336 denotes Siglec-9
T10 1271-1279 http://www.uniprot.org/uniprot/Q9Y336 denotes Siglec-9
T11 1187-1189 http://www.uniprot.org/uniprot/P06681 denotes C2
T12 1531-1533 http://www.uniprot.org/uniprot/P06681 denotes C2
T13 1658-1660 http://www.uniprot.org/uniprot/P06681 denotes C2

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 771-780 http://www.uniprot.org/uniprot/P70677 denotes caspase-3
T2 1187-1189 http://www.uniprot.org/uniprot/P21180 denotes C2
T3 1531-1533 http://www.uniprot.org/uniprot/P21180 denotes C2
T4 1658-1660 http://www.uniprot.org/uniprot/P21180 denotes C2

GO-BP

Id Subject Object Predicate Lexical cue
T1 31-41 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T2 398-408 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3 498-508 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T4 706-716 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T5 904-914 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T6 1591-1601 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T7 31-55 http://purl.obolibrary.org/obo/GO_0012501 denotes cell death independently
T8 36-41 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T9 403-408 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T10 503-508 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11 562-567 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T12 603-608 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13 711-716 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T14 869-874 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T15 909-914 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T16 972-977 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T17 1103-1108 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18 1402-1407 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T19 1596-1601 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T20 236-243 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T21 568-577 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T22 609-618 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T23 978-987 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T24 1109-1115 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T25 1408-1414 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T26 1607-1613 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T27 486-508 http://purl.obolibrary.org/obo/GO_0071888 denotes induced the cell death
T28 486-508 http://purl.obolibrary.org/obo/GO_0043276 denotes induced the cell death
T29 692-716 http://purl.obolibrary.org/obo/GO_1901215 denotes inhibited the cell death
T30 692-716 http://purl.obolibrary.org/obo/GO_1904093 denotes inhibited the cell death
T31 692-716 http://purl.obolibrary.org/obo/GO_0043069 denotes inhibited the cell death
T32 779-796 http://purl.obolibrary.org/obo/GO_0046403 denotes 3 activation, DNA
T33 804-813 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T34 904-930 http://purl.obolibrary.org/obo/GO_0012501 denotes cell death is nonapoptotic

GO-MF

Id Subject Object Predicate Lexical cue
T1 164-171 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 164-171 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T3 164-171 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T4 164-171 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T5 164-186 http://purl.obolibrary.org/obo/GO_0019865 denotes binding immunoglobulin
T6 172-186 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin

GO-CC

Id Subject Object Predicate Lexical cue
T1 31-35 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 124-128 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 398-402 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 498-502 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 706-710 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 904-908 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7 1591-1595 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 252-261 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosolic
T9 458-467 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosolic
T10 1169-1177 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T11 1644-1657 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular

Allie

Id Subject Object Predicate Lexical cue
SS1_20032046_1_0 262-309 expanded denotes immunoreceptor tyrosine-based inhibitory motifs
SS2_20032046_1_0 311-316 abbr denotes ITIMs
AE1_20032046_1_0 SS1_20032046_1_0 SS2_20032046_1_0 abbreviatedTo immunoreceptor tyrosine-based inhibitory motifs,ITIMs

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1067-1073 http://purl.obolibrary.org/obo/MAT_0000488 denotes latter
T2 1178-1186 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T3 1490-1500 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximally

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1178-1186 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491
T2 1490-1500 Body_part denotes proximally http://purl.obolibrary.org/obo/MAT_0000491

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937.
T2 140-318 Sentence denotes Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
T3 319-409 Sentence denotes Here, we report that clustering of Siglec-7 with a specific F(ab')(2) elicited cell death.
T4 410-578 Sentence denotes Interestingly, a truncated Siglec-7 lacking the cytosolic ITIM domain still induced the cell death, suggesting that the ITIMs are not essential for the death signaling.
T5 579-757 Sentence denotes Further analyses of the death signaling revealed that an oxygen radical scavenger, N-acetyl cysteine, completely inhibited the cell death, whereas a pancaspase inhibitor did not.
T6 758-931 Sentence denotes In addition, caspase-3 activation, DNA ladder formation, and nuclear condensation were not detected during the death process, suggesting that the cell death is nonapoptotic.
T7 932-1116 Sentence denotes To identify the critical region for the death signaling, we prepared a series of shuffling chimeras between Siglec-7 and Siglec-9, the latter of which did not transduce a death signal.
T8 1117-1280 Sentence denotes The critical region was mapped to the middle of the membrane-proximal C2-set domain, which contained only six amino acid differences between Siglec-7 and Siglec-9.
T9 1281-1415 Sentence denotes Point mutation analyses of each of these six amino acids revealed that four of the six amino acids were critical for the death signal.
T10 1416-1545 Sentence denotes A computer-assisted 3D modeling revealed that these four amino acids were proximally located on the surface of the C2-set domain.
T11 1546-1672 Sentence denotes In conclusion, Siglec-7 induces nonapoptotic cell death, the signal for which is transduced by an extracellular C2-set domain.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 651-660 OrganismTaxon denotes scavenger 30848

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1169-1177 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1644-1657 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 114-123 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054