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GlyCosmos6-Glycan-Motif-Image

Id	Subject	Object	Predicate	Lexical cue	image
T1	780-789	Glycan_Motif	denotes	galactose	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T3	829-844	Glycan_Motif	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW
T4	885-892	Glycan_Motif	denotes	mannose	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T5	1205-1220	Glycan_Motif	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW

Glycosmos6-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glyco_epitope_db_id
T1	829-844	GlycoEpitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085
T2	1205-1220	GlycoEpitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-118	Sentence	denotes	Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain.
T2	119-299	Sentence	denotes	Langerin is categorized as a C-type lectin selectively expressed in Langerhans cells, playing roles in the first line of defense against pathogens and in Birbeck granule formation.
T3	300-538	Sentence	denotes	Although these functions are thought to be exerted through glycan-binding activity of the C-type carbohydrate recognition domain, sugar-binding properties of Langerin have not been fully elucidated in relation to its biological functions.
T4	539-739	Sentence	denotes	Here, we investigated the glycan-binding specificity of Langerin using comprehensive glycoconjugate microarray, quantitative frontal affinity chromatography, and conventional cell biological analyses.
T5	740-954	Sentence	denotes	Langerin showed outstanding affinity to galactose-6-sulfated oligosaccharides, including keratan sulfate, while it preserved binding activity to mannose, as a common feature of the C-type lectins with an EPN motif.
T6	955-1062	Sentence	denotes	By a mutagenesis study, Lys-299 and Lys-313 were found to form extended binding sites for sulfated glycans.
T7	1063-1255	Sentence	denotes	Consistent with the former observation, the sulfated Langerin ligands were found to be expressed in brain and spleen, where the transcript of keratan sulfate 6-O-sulfotransferase is expressed.
T8	1256-1428	Sentence	denotes	Moreover, such sulfated ligands were up-regulated in glioblastoma relative to normal brain tissues, and Langerin-expressing cells were localized in malignant brain tissues.
T9	1429-1544	Sentence	denotes	Langerin also recognized pathogenic fungi, such as Candida and Malassezia, expressing heavily mannosylated glycans.
T10	1545-1781	Sentence	denotes	These observations provide strong evidence that Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain.

GlyCosmos6-Glycan-Motif-Structure

Id	Subject	Object	Predicate	Lexical cue
T1	780-789	https://glytoucan.org/Structures/Glycans/G65889KE	denotes	galactose
T2	780-789	https://glytoucan.org/Structures/Glycans/G68158BT	denotes	galactose
T3	829-844	https://glytoucan.org/Structures/Glycans/G82109MW	denotes	keratan sulfate
T4	885-892	https://glytoucan.org/Structures/Glycans/G70323CJ	denotes	mannose
T5	1205-1220	https://glytoucan.org/Structures/Glycans/G82109MW	denotes	keratan sulfate

Glycosmos6-MAT

Id	Subject	Object	Predicate	Lexical cue
T1	1163-1168	http://purl.obolibrary.org/obo/MAT_0000098	denotes	brain
T2	1173-1179	http://purl.obolibrary.org/obo/MAT_0000085	denotes	spleen
T3	1341-1346	http://purl.obolibrary.org/obo/MAT_0000098	denotes	brain
T4	1414-1419	http://purl.obolibrary.org/obo/MAT_0000098	denotes	brain

PubmedHPO

Id	Subject	Object	Predicate	Lexical cue
T1	1309-1321	HP_0100843	denotes	glioblastoma

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	1309-1321	Phenotype	denotes	glioblastoma	HP:0012174

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	1309-1321	Disease	denotes	glioblastoma	http://purl.obolibrary.org/obo/MONDO_0018177\|http://purl.obolibrary.org/obo/MONDO_0020690

GlyCosmos-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glycoepitope_id
T1	829-844	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085
T2	1205-1220	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085

GlyCosmos15-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	1309-1321	Phenotype	denotes	glioblastoma	HP:0012174

GlyCosmos15-NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	1465-1470	OrganismTaxon	denotes	fungi	4751
T2	1480-1487	OrganismTaxon	denotes	Candida	5475
T3	1492-1502	OrganismTaxon	denotes	Malassezia	55193

GlyCosmos15-CL

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	187-203	Cell	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL:0000453
T2	1632-1648	Cell	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL:0000453

GlyCosmos15-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	187-203	Body_part	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL_0000453
T2	664-671	Body_part	denotes	frontal	http://purl.obolibrary.org/obo/UBERON_0000209
T3	1163-1168	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636
T5	1173-1179	Body_part	denotes	spleen	http://purl.obolibrary.org/obo/UBERON_0002106
T6	1341-1346	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636
T8	1414-1419	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636
T10	1632-1648	Body_part	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL_0000453

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-118	Sentence	denotes	Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain.
T2	119-299	Sentence	denotes	Langerin is categorized as a C-type lectin selectively expressed in Langerhans cells, playing roles in the first line of defense against pathogens and in Birbeck granule formation.
T3	300-538	Sentence	denotes	Although these functions are thought to be exerted through glycan-binding activity of the C-type carbohydrate recognition domain, sugar-binding properties of Langerin have not been fully elucidated in relation to its biological functions.
T4	539-739	Sentence	denotes	Here, we investigated the glycan-binding specificity of Langerin using comprehensive glycoconjugate microarray, quantitative frontal affinity chromatography, and conventional cell biological analyses.
T5	740-954	Sentence	denotes	Langerin showed outstanding affinity to galactose-6-sulfated oligosaccharides, including keratan sulfate, while it preserved binding activity to mannose, as a common feature of the C-type lectins with an EPN motif.
T6	955-1062	Sentence	denotes	By a mutagenesis study, Lys-299 and Lys-313 were found to form extended binding sites for sulfated glycans.
T7	1063-1255	Sentence	denotes	Consistent with the former observation, the sulfated Langerin ligands were found to be expressed in brain and spleen, where the transcript of keratan sulfate 6-O-sulfotransferase is expressed.
T8	1256-1428	Sentence	denotes	Moreover, such sulfated ligands were up-regulated in glioblastoma relative to normal brain tissues, and Langerin-expressing cells were localized in malignant brain tissues.
T9	1429-1544	Sentence	denotes	Langerin also recognized pathogenic fungi, such as Candida and Malassezia, expressing heavily mannosylated glycans.
T10	1545-1781	Sentence	denotes	These observations provide strong evidence that Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain.

GlyCosmos15-Sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-118	Sentence	denotes	Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain.
T2	119-299	Sentence	denotes	Langerin is categorized as a C-type lectin selectively expressed in Langerhans cells, playing roles in the first line of defense against pathogens and in Birbeck granule formation.
T3	300-538	Sentence	denotes	Although these functions are thought to be exerted through glycan-binding activity of the C-type carbohydrate recognition domain, sugar-binding properties of Langerin have not been fully elucidated in relation to its biological functions.
T4	539-739	Sentence	denotes	Here, we investigated the glycan-binding specificity of Langerin using comprehensive glycoconjugate microarray, quantitative frontal affinity chromatography, and conventional cell biological analyses.
T5	740-954	Sentence	denotes	Langerin showed outstanding affinity to galactose-6-sulfated oligosaccharides, including keratan sulfate, while it preserved binding activity to mannose, as a common feature of the C-type lectins with an EPN motif.
T6	955-1062	Sentence	denotes	By a mutagenesis study, Lys-299 and Lys-313 were found to form extended binding sites for sulfated glycans.
T7	1063-1255	Sentence	denotes	Consistent with the former observation, the sulfated Langerin ligands were found to be expressed in brain and spleen, where the transcript of keratan sulfate 6-O-sulfotransferase is expressed.
T8	1256-1428	Sentence	denotes	Moreover, such sulfated ligands were up-regulated in glioblastoma relative to normal brain tissues, and Langerin-expressing cells were localized in malignant brain tissues.
T9	1429-1544	Sentence	denotes	Langerin also recognized pathogenic fungi, such as Candida and Malassezia, expressing heavily mannosylated glycans.
T10	1545-1781	Sentence	denotes	These observations provide strong evidence that Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain.

Glycan-GlyCosmos

Id	Subject	Object	Predicate	Lexical cue	image
T1	829-844	Glycan	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW
T2	1205-1220	Glycan	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW

GlyCosmos15-GlycoEpitope

Id	Subject	Object	Predicate	Lexical cue	glycoepitope_id
T1	829-844	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085
T2	1205-1220	http://purl.jp/bio/12/glyco/glycan#Glycan_epitope	denotes	keratan sulfate	http://www.glycoepitope.jp/epitopes/EP0085

Lectin-Jamboree-Sentence

Id	Subject	Object	Predicate	Lexical cue
T1	0-118	Sentence	denotes	Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain.
T2	119-299	Sentence	denotes	Langerin is categorized as a C-type lectin selectively expressed in Langerhans cells, playing roles in the first line of defense against pathogens and in Birbeck granule formation.
T3	300-538	Sentence	denotes	Although these functions are thought to be exerted through glycan-binding activity of the C-type carbohydrate recognition domain, sugar-binding properties of Langerin have not been fully elucidated in relation to its biological functions.
T4	539-739	Sentence	denotes	Here, we investigated the glycan-binding specificity of Langerin using comprehensive glycoconjugate microarray, quantitative frontal affinity chromatography, and conventional cell biological analyses.
T5	740-954	Sentence	denotes	Langerin showed outstanding affinity to galactose-6-sulfated oligosaccharides, including keratan sulfate, while it preserved binding activity to mannose, as a common feature of the C-type lectins with an EPN motif.
T6	955-1062	Sentence	denotes	By a mutagenesis study, Lys-299 and Lys-313 were found to form extended binding sites for sulfated glycans.
T7	1063-1255	Sentence	denotes	Consistent with the former observation, the sulfated Langerin ligands were found to be expressed in brain and spleen, where the transcript of keratan sulfate 6-O-sulfotransferase is expressed.
T8	1256-1428	Sentence	denotes	Moreover, such sulfated ligands were up-regulated in glioblastoma relative to normal brain tissues, and Langerin-expressing cells were localized in malignant brain tissues.
T9	1429-1544	Sentence	denotes	Langerin also recognized pathogenic fungi, such as Candida and Malassezia, expressing heavily mannosylated glycans.
T10	1545-1781	Sentence	denotes	These observations provide strong evidence that Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain.

GlyCosmos15-Glycan

Id	Subject	Object	Predicate	Lexical cue	image
T1	829-844	Glycan	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW
T2	1205-1220	Glycan	denotes	keratan sulfate	https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW

GlyCosmos15-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	1309-1321	Disease	denotes	glioblastoma	MONDO:0018177\|MONDO:0020690

GlyCosmos15-FMA

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	187-203	Body_part	denotes	Langerhans cells	FMA:63072
T2	273-288	Body_part	denotes	Birbeck granule	FMA:70575
T3	1163-1168	Body_part	denotes	brain	FMA:50801
T4	1173-1179	Body_part	denotes	spleen	FMA:7196
T5	1341-1346	Body_part	denotes	brain	FMA:50801
T6	1347-1354	Body_part	denotes	tissues	FMA:9637
T7	1414-1419	Body_part	denotes	brain	FMA:50801
T8	1420-1427	Body_part	denotes	tissues	FMA:9637
T9	1632-1648	Body_part	denotes	Langerhans cells	FMA:63072

GlyCosmos15-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	1163-1168	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098
T2	1173-1179	Body_part	denotes	spleen	http://purl.obolibrary.org/obo/MAT_0000085
T3	1341-1346	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098
T4	1414-1419	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	1465-1470	OrganismTaxon	denotes	fungi	4751
T2	1480-1487	OrganismTaxon	denotes	Candida	5475
T3	1492-1502	OrganismTaxon	denotes	Malassezia	55193

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	187-203	Body_part	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL_0000453
T2	664-671	Body_part	denotes	frontal	http://purl.obolibrary.org/obo/UBERON_0000209
T3	1163-1168	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636
T5	1173-1179	Body_part	denotes	spleen	http://purl.obolibrary.org/obo/UBERON_0002106
T6	1341-1346	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636
T8	1414-1419	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955\|http://purl.obolibrary.org/obo/UBERON_6110636
T10	1632-1648	Body_part	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL_0000453

Anatomy-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	1163-1168	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098
T2	1173-1179	Body_part	denotes	spleen	http://purl.obolibrary.org/obo/MAT_0000085
T3	1341-1346	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098
T4	1414-1419	Body_part	denotes	brain	http://purl.obolibrary.org/obo/MAT_0000098

CL-cell

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	187-203	Cell	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL:0000453
T2	1632-1648	Cell	denotes	Langerhans cells	http://purl.obolibrary.org/obo/CL:0000453