PubMed:20022960
Annnotations
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 0-15 | GlycoEpitope | denotes | Heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 247-262 | GlycoEpitope | denotes | Heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-79 | Sentence | denotes | Heparan sulfate is required for embryonic stem cells to exit from self-renewal. |
| T2 | 80-246 | Sentence | denotes | Pluripotent embryonic stem cells (ESCs) must select between alternative fates of self-renewal and lineage commitment at each division during continuous proliferation. |
| T3 | 247-349 | Sentence | denotes | Heparan sulfate (HS) is a highly sulfated polysaccharide and is present abundantly on the ESC surface. |
| T4 | 350-469 | Sentence | denotes | In this study, we investigated the role of HS in ESC self-renewal by examining Ext1(-/-) ESCs that are deficient in HS. |
| T5 | 470-639 | Sentence | denotes | We found that Ext1(-/-) ESCs retained their self-renewal potential but failed to transit from self-renewal to differentiation upon removal of leukemia inhibitory factor. |
| T6 | 640-850 | Sentence | denotes | Furthermore, we found that the aberrant cell fate commitment is caused by defects in fibroblast growth factor signaling, which directly retained high expression of the pluripotency gene Nanog in Ext1(-/-) ESCs. |
| T7 | 851-1114 | Sentence | denotes | Therefore, our studies identified and defined HS as a novel factor that controls ESC fate commitment and also delineates that HS facilitates fibroblast growth factor signaling, which, in turn, inhibits Nanog expression and commits ESCs to lineage differentiation. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 42-52 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T2 | 42-46 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T3 | 102-112 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T4 | 102-106 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 612-620 | HP_0001909 | denotes | leukemia |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20022960_1_0 | 92-112 | expanded | denotes | embryonic stem cells |
| SS2_20022960_1_0 | 114-118 | abbr | denotes | ESCs |
| SS1_20022960_2_0 | 247-262 | expanded | denotes | Heparan sulfate |
| SS2_20022960_2_0 | 264-266 | abbr | denotes | HS |
| AE1_20022960_1_0 | SS1_20022960_1_0 | SS2_20022960_1_0 | abbreviatedTo | embryonic stem cells,ESCs |
| AE1_20022960_2_0 | SS1_20022960_2_0 | SS2_20022960_2_0 | abbreviatedTo | Heparan sulfate,HS |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 114-118 | Disease | denotes | ESCs | http://purl.obolibrary.org/obo/MONDO_0009989 |
| T2 | 337-340 | Disease | denotes | ESC | http://purl.obolibrary.org/obo/MONDO_0007579 |
| T3 | 399-402 | Disease | denotes | ESC | http://purl.obolibrary.org/obo/MONDO_0007579 |
| T4 | 439-443 | Disease | denotes | ESCs | http://purl.obolibrary.org/obo/MONDO_0009989 |
| T5 | 494-498 | Disease | denotes | ESCs | http://purl.obolibrary.org/obo/MONDO_0009989 |
| T6 | 612-620 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T7 | 845-849 | Disease | denotes | ESCs | http://purl.obolibrary.org/obo/MONDO_0009989 |
| T8 | 932-935 | Disease | denotes | ESC | http://purl.obolibrary.org/obo/MONDO_0007579 |
| T9 | 1082-1086 | Disease | denotes | ESCs | http://purl.obolibrary.org/obo/MONDO_0009989 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 42-52 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T2 | 102-112 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 612-620 | Phenotype | denotes | leukemia | HP:0001909 |
Glycosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 0-15 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 247-262 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 264-266 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 393-395 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T5 | 466-468 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T6 | 897-899 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T7 | 977-979 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 42-52 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T2 | 102-112 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T3 | 725-735 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
| T4 | 992-1002 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 32-52 | Cell | denotes | embryonic stem cells | http://purl.obolibrary.org/obo/CL:0002322 |
| T2 | 92-112 | Cell | denotes | embryonic stem cells | http://purl.obolibrary.org/obo/CL:0002322 |
| T3 | 114-118 | Cell | denotes | ESCs | http://purl.obolibrary.org/obo/CL:0002322 |
| T4 | 439-443 | Cell | denotes | ESCs | http://purl.obolibrary.org/obo/CL:0002322 |
| T5 | 494-498 | Cell | denotes | ESCs | http://purl.obolibrary.org/obo/CL:0002322 |
| T6 | 725-735 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
| T7 | 845-849 | Cell | denotes | ESCs | http://purl.obolibrary.org/obo/CL:0002322 |
| T8 | 992-1002 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
| T9 | 1082-1086 | Cell | denotes | ESCs | http://purl.obolibrary.org/obo/CL:0002322 |