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PubMed:19996135 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.
T2 105-116 Sentence denotes BACKGROUND:
T3 117-306 Sentence denotes In 2 separate centers, we observed a notable increase in the incidence of postoperative convulsive seizures from 1.3% to 3.8% in patients having undergone major cardiac surgical procedures.
T14 1407-1512 Sentence denotes No evidence of brain ischemic, metabolic, or hyperthermia-induced causes for their seizures was apparent.
T4 307-469 Sentence denotes These events were temporally coincident with the initial use of high-dose tranexamic acid (TXA) therapy after withdrawal of aprotinin from general clinical usage.
T5 470-630 Sentence denotes The purpose of this review was to perform a retrospective analysis to examine whether there was a relation between TXA usage and seizures after cardiac surgery.
T6 631-639 Sentence denotes METHODS:
T7 640-736 Sentence denotes An in-depth chart review was undertaken in all 24 patients who developed perioperative seizures.
T8 737-888 Sentence denotes Electroencephalographic activity was recorded in 11 of these patients, and all patients had a formal neurological evaluation and brain imaging studies.
T9 889-897 Sentence denotes RESULTS:
T10 898-1051 Sentence denotes Twenty-one of the 24 patients did not have evidence of new cerebral ischemic injury, but seizures were likely due to ischemic brain injury in 3 patients.
T11 1052-1129 Sentence denotes All patients with seizures did not have permanent neurological abnormalities.
T12 1130-1343 Sentence denotes All 24 patients with seizures received high doses of TXA intraoperatively ranging from 61 to 259 mg/kg, had a mean age of 69.9 years, and 21 of 24 had undergone open chamber rather than coronary bypass procedures.
T13 1344-1406 Sentence denotes All but one patient were managed using cardiopulmonary bypass.
T15 1513-1524 Sentence denotes CONCLUSION:
T16 1525-1726 Sentence denotes Our results suggest that use of high-dose TXA in older patients in conjunction with cardiopulmonary bypass and open-chamber cardiac surgery is associated with clinical seizures in susceptible patients.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6827 10-25 ChemicalEntity denotes tranexamic Acid MESH:D014148
6828 66-74 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6829 95-103 OrganismTaxon denotes patients NCBITaxon:9606
6830 205-224 DiseaseOrPhenotypicFeature denotes convulsive seizures MESH:D012640
6831 246-254 OrganismTaxon denotes patients NCBITaxon:9606
6832 381-396 ChemicalEntity denotes tranexamic acid MESH:D014148
6833 398-401 ChemicalEntity denotes TXA MESH:D014148
6834 585-588 ChemicalEntity denotes TXA MESH:D014148
6835 599-607 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6836 690-698 OrganismTaxon denotes patients NCBITaxon:9606
6837 727-735 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6838 798-806 OrganismTaxon denotes patients NCBITaxon:9606
6839 816-824 OrganismTaxon denotes patients NCBITaxon:9606
6840 919-927 OrganismTaxon denotes patients NCBITaxon:9606
6841 957-981 DiseaseOrPhenotypicFeature denotes cerebral ischemic injury MESH:D001930
6842 987-995 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6843 1015-1036 DiseaseOrPhenotypicFeature denotes ischemic brain injury MESH:D001930
6844 1042-1050 OrganismTaxon denotes patients NCBITaxon:9606
6845 1056-1064 OrganismTaxon denotes patients NCBITaxon:9606
6846 1070-1078 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6847 1102-1128 DiseaseOrPhenotypicFeature denotes neurological abnormalities MESH:D009422
6848 1137-1145 OrganismTaxon denotes patients NCBITaxon:9606
6849 1151-1159 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6850 1183-1186 ChemicalEntity denotes TXA MESH:D014148
6851 1356-1363 OrganismTaxon denotes patient NCBITaxon:9606
6852 1422-1436 DiseaseOrPhenotypicFeature denotes brain ischemic MESH:D002546
6853 1452-1464 DiseaseOrPhenotypicFeature denotes hyperthermia MESH:D005334
6854 1490-1498 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6855 1567-1570 ChemicalEntity denotes TXA MESH:D014148
6856 1580-1588 OrganismTaxon denotes patients NCBITaxon:9606
6857 1693-1701 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6858 1717-1725 OrganismTaxon denotes patients NCBITaxon:9606

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 957-965 DiseaseOrPhenotypicFeature denotes cerebral 0002645
T2 975-981 DiseaseOrPhenotypicFeature denotes injury 0021178
T3 1024-1036 DiseaseOrPhenotypicFeature denotes brain injury 0043510
T4 1030-1036 DiseaseOrPhenotypicFeature denotes injury 0021178
T5 1592-1603 DiseaseOrPhenotypicFeature denotes conjunction 0003799

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-4 GeneOrGeneProduct denotes High
T2 21-25 GeneOrGeneProduct denotes Acid
T3 66-74 GeneOrGeneProduct denotes seizures
T4 117-121 GeneOrGeneProduct denotes In 2
T5 122-130 GeneOrGeneProduct denotes separate
T6 216-224 GeneOrGeneProduct denotes seizures
T7 272-277 GeneOrGeneProduct denotes major
T8 356-363 GeneOrGeneProduct denotes initial
T9 371-375 GeneOrGeneProduct denotes high
T10 392-396 GeneOrGeneProduct denotes acid
T11 431-440 GeneOrGeneProduct denotes aprotinin
T12 599-607 GeneOrGeneProduct denotes seizures
T13 631-638 GeneOrGeneProduct denotes METHODS
T14 683-686 GeneOrGeneProduct denotes all
T15 727-735 GeneOrGeneProduct denotes seizures
T16 761-769 GeneOrGeneProduct denotes activity
T17 783-788 GeneOrGeneProduct denotes in 11
T18 812-815 GeneOrGeneProduct denotes all
T19 825-830 GeneOrGeneProduct denotes had a
T20 866-871 GeneOrGeneProduct denotes brain
T21 987-995 GeneOrGeneProduct denotes seizures
T22 1001-1007 GeneOrGeneProduct denotes likely
T23 1024-1029 GeneOrGeneProduct denotes brain
T24 1037-1041 GeneOrGeneProduct denotes in 3
T25 1052-1055 GeneOrGeneProduct denotes All
T26 1070-1078 GeneOrGeneProduct denotes seizures
T27 1130-1133 GeneOrGeneProduct denotes All
T28 1151-1159 GeneOrGeneProduct denotes seizures
T29 1169-1173 GeneOrGeneProduct denotes high
T30 1204-1211 GeneOrGeneProduct denotes ranging
T31 1227-1229 GeneOrGeneProduct denotes mg
T32 1234-1239 GeneOrGeneProduct denotes had a
T33 1257-1262 GeneOrGeneProduct denotes years
T34 1291-1295 GeneOrGeneProduct denotes open
T35 1325-1331 GeneOrGeneProduct denotes bypass
T36 1344-1347 GeneOrGeneProduct denotes All
T37 1399-1405 GeneOrGeneProduct denotes bypass
T38 1422-1427 GeneOrGeneProduct denotes brain
T39 1465-1472 GeneOrGeneProduct denotes induced
T40 1490-1498 GeneOrGeneProduct denotes seizures
T41 1557-1561 GeneOrGeneProduct denotes high
T42 1625-1631 GeneOrGeneProduct denotes bypass
T43 1636-1640 GeneOrGeneProduct denotes open
T44 1693-1701 GeneOrGeneProduct denotes seizures

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 66-74 GeneOrGeneProduct denotes seizures
T2 216-224 GeneOrGeneProduct denotes seizures
T3 272-277 GeneOrGeneProduct denotes major
T4 371-375 GeneOrGeneProduct denotes high
T5 392-396 GeneOrGeneProduct denotes acid
T6 431-440 GeneOrGeneProduct denotes aprotinin
T7 599-607 GeneOrGeneProduct denotes seizures
T8 727-735 GeneOrGeneProduct denotes seizures
T9 866-871 GeneOrGeneProduct denotes brain
T10 987-995 GeneOrGeneProduct denotes seizures
T11 1024-1029 GeneOrGeneProduct denotes brain
T12 1070-1078 GeneOrGeneProduct denotes seizures
T13 1151-1159 GeneOrGeneProduct denotes seizures
T14 1169-1173 GeneOrGeneProduct denotes high
T15 1325-1331 GeneOrGeneProduct denotes bypass
T16 1399-1405 GeneOrGeneProduct denotes bypass
T17 1422-1427 GeneOrGeneProduct denotes brain
T18 1490-1498 GeneOrGeneProduct denotes seizures
T19 1557-1561 GeneOrGeneProduct denotes high
T20 1625-1631 GeneOrGeneProduct denotes bypass
T21 1693-1701 GeneOrGeneProduct denotes seizures

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 66-74 DiseaseOrPhenotypicFeature denotes seizures D012640
T2 205-224 DiseaseOrPhenotypicFeature denotes convulsive seizures D012640
T3 599-607 DiseaseOrPhenotypicFeature denotes seizures D012640
T4 727-735 DiseaseOrPhenotypicFeature denotes seizures D012640
T5 966-974 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T6 975-981 DiseaseOrPhenotypicFeature denotes injury D014947
T7 987-995 DiseaseOrPhenotypicFeature denotes seizures D012640
T8 1015-1023 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T9 1024-1036 DiseaseOrPhenotypicFeature denotes brain injury D001930
T10 1070-1078 DiseaseOrPhenotypicFeature denotes seizures D012640
T11 1151-1159 DiseaseOrPhenotypicFeature denotes seizures D012640
T12 1428-1436 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T13 1452-1464 DiseaseOrPhenotypicFeature denotes hyperthermia D000084462
T14 1490-1498 DiseaseOrPhenotypicFeature denotes seizures D012640
T15 1693-1701 DiseaseOrPhenotypicFeature denotes seizures D012640

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 431-440 GeneOrGeneProduct denotes aprotinin

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 975-981 DiseaseOrPhenotypicFeature denotes injury 0021178
T2 1024-1036 DiseaseOrPhenotypicFeature denotes brain injury 0043510

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 66-74 DiseaseOrPhenotypicFeature denotes seizures D012640
T2 205-224 DiseaseOrPhenotypicFeature denotes convulsive seizures D012640
T3 599-607 DiseaseOrPhenotypicFeature denotes seizures D012640
T4 727-735 DiseaseOrPhenotypicFeature denotes seizures D012640
T5 957-974 DiseaseOrPhenotypicFeature denotes cerebral ischemic DISEASE
T6 975-981 DiseaseOrPhenotypicFeature denotes injury D014947
T7 987-995 DiseaseOrPhenotypicFeature denotes seizures D012640
T8 1015-1023 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T9 1024-1036 DiseaseOrPhenotypicFeature denotes brain injury D001930
T10 1070-1078 DiseaseOrPhenotypicFeature denotes seizures D012640
T11 1102-1128 DiseaseOrPhenotypicFeature denotes neurological abnormalities DISEASE
T12 1151-1159 DiseaseOrPhenotypicFeature denotes seizures D012640
T13 1422-1436 DiseaseOrPhenotypicFeature denotes brain ischemic DISEASE
T14 1452-1464 DiseaseOrPhenotypicFeature denotes hyperthermia D000084462
T15 1490-1498 DiseaseOrPhenotypicFeature denotes seizures D012640
T16 1693-1701 DiseaseOrPhenotypicFeature denotes seizures D012640

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 66-74 DiseaseOrPhenotypicFeature denotes seizures D012640
T2 205-224 DiseaseOrPhenotypicFeature denotes convulsive seizures D012640
T3 599-607 DiseaseOrPhenotypicFeature denotes seizures D012640
T4 727-735 DiseaseOrPhenotypicFeature denotes seizures D012640
T5 957-974 DiseaseOrPhenotypicFeature denotes cerebral ischemic DISEASE
T6 987-995 DiseaseOrPhenotypicFeature denotes seizures D012640
T7 1015-1023 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T8 1024-1036 DiseaseOrPhenotypicFeature denotes brain injury D001930
T9 1070-1078 DiseaseOrPhenotypicFeature denotes seizures D012640
T10 1102-1128 DiseaseOrPhenotypicFeature denotes neurological abnormalities DISEASE
T11 1151-1159 DiseaseOrPhenotypicFeature denotes seizures D012640
T12 1422-1436 DiseaseOrPhenotypicFeature denotes brain ischemic DISEASE
T13 1452-1464 DiseaseOrPhenotypicFeature denotes hyperthermia D000084462
T14 1490-1498 DiseaseOrPhenotypicFeature denotes seizures D012640
T15 1693-1701 DiseaseOrPhenotypicFeature denotes seizures D012640

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 10-25 ChemicalEntity denotes tranexamic Acid D014148|http://purl.obolibrary.org/obo/CHEBI_48669
T3 381-396 ChemicalEntity denotes tranexamic acid D014148|http://purl.obolibrary.org/obo/CHEBI_48669
T5 398-401 ChemicalEntity denotes TXA http://purl.obolibrary.org/obo/CHEBI_36088|D014148
T7 585-588 ChemicalEntity denotes TXA http://purl.obolibrary.org/obo/CHEBI_36088|D014148
T9 831-837 ChemicalEntity denotes formal http://purl.obolibrary.org/obo/CHEBI_48341
T10 1183-1186 ChemicalEntity denotes TXA http://purl.obolibrary.org/obo/CHEBI_36088|D014148
T12 1567-1570 ChemicalEntity denotes TXA http://purl.obolibrary.org/obo/CHEBI_36088|D014148

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 95-103 OrganismTaxon denotes patients
T2 246-254 OrganismTaxon denotes patients
T3 690-698 OrganismTaxon denotes patients
T4 798-806 OrganismTaxon denotes patients
T5 816-824 OrganismTaxon denotes patients
T6 919-927 OrganismTaxon denotes patients
T7 1042-1050 OrganismTaxon denotes patients
T8 1056-1064 OrganismTaxon denotes patients
T9 1137-1145 OrganismTaxon denotes patients
T10 1356-1363 OrganismTaxon denotes patient
T11 1580-1588 OrganismTaxon denotes patients
T12 1717-1725 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T12 1567-1570 ChemicalEntity denotes TXA D014148|http://purl.obolibrary.org/obo/CHEBI_36088
T10 1183-1186 ChemicalEntity denotes TXA D014148|http://purl.obolibrary.org/obo/CHEBI_36088
T9 831-837 ChemicalEntity denotes formal http://purl.obolibrary.org/obo/CHEBI_48341
T7 585-588 ChemicalEntity denotes TXA D014148|http://purl.obolibrary.org/obo/CHEBI_36088
T5 398-401 ChemicalEntity denotes TXA D014148|http://purl.obolibrary.org/obo/CHEBI_36088
T3 381-396 ChemicalEntity denotes tranexamic acid http://purl.obolibrary.org/obo/CHEBI_48669|D014148
T1 10-25 ChemicalEntity denotes tranexamic Acid http://purl.obolibrary.org/obo/CHEBI_48669|D014148
T97703 431-440 GeneOrGeneProduct denotes aprotinin
T15 1693-1701 DiseaseOrPhenotypicFeature denotes seizures D012640
T14 1490-1498 DiseaseOrPhenotypicFeature denotes seizures D012640
T13 1452-1464 DiseaseOrPhenotypicFeature denotes hyperthermia D000084462
T9063 1422-1436 DiseaseOrPhenotypicFeature denotes brain ischemic DISEASE
T11 1151-1159 DiseaseOrPhenotypicFeature denotes seizures D012640
T43799 1102-1128 DiseaseOrPhenotypicFeature denotes neurological abnormalities DISEASE
T96369 1070-1078 DiseaseOrPhenotypicFeature denotes seizures D012640
T8 1024-1036 DiseaseOrPhenotypicFeature denotes brain injury D001930
T92755 1015-1023 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T6 987-995 DiseaseOrPhenotypicFeature denotes seizures D012640
T45166 957-974 DiseaseOrPhenotypicFeature denotes cerebral ischemic DISEASE
T4 727-735 DiseaseOrPhenotypicFeature denotes seizures D012640
T58910 599-607 DiseaseOrPhenotypicFeature denotes seizures D012640
T2 205-224 DiseaseOrPhenotypicFeature denotes convulsive seizures D012640
T5256 66-74 DiseaseOrPhenotypicFeature denotes seizures D012640
T94116 1717-1725 OrganismTaxon denotes patients
T39441 1580-1588 OrganismTaxon denotes patients
T89505 1356-1363 OrganismTaxon denotes patient
T30911 1137-1145 OrganismTaxon denotes patients
T14212 1056-1064 OrganismTaxon denotes patients
T45700 1042-1050 OrganismTaxon denotes patients
T18168 919-927 OrganismTaxon denotes patients
T33671 816-824 OrganismTaxon denotes patients
T25345 798-806 OrganismTaxon denotes patients
T56750 690-698 OrganismTaxon denotes patients
T77030 246-254 OrganismTaxon denotes patients
T93868 95-103 OrganismTaxon denotes patients

Allie

Id Subject Object Predicate Lexical cue
SS1_19996135_3_0 381-396 expanded denotes tranexamic acid
SS2_19996135_3_0 398-401 abbr denotes TXA
AE1_19996135_3_0 SS1_19996135_3_0 SS2_19996135_3_0 abbreviatedTo tranexamic acid,TXA

bc5cdr-valid-experiment

Id Subject Object Predicate Lexical cue
T1 10-25 Chemical denotes tranexamic Acid
T2 66-74 Disease denotes seizures
T3 205-215 Disease denotes convulsive
T4 216-224 Disease denotes seizures
T5 381-396 Chemical denotes tranexamic acid
T6 398-401 Chemical denotes TXA
T7 585-588 Chemical denotes TXA
T8 599-607 Disease denotes seizures
T9 727-735 Disease denotes seizures
T10 957-981 Disease denotes cerebral ischemic injury
T11 987-995 Disease denotes seizures
T12 1015-1036 Disease denotes ischemic brain injury
T13 1070-1078 Disease denotes seizures
T14 1102-1128 Disease denotes neurological abnormalities
T15 1151-1159 Disease denotes seizures
T16 1183-1186 Chemical denotes TXA
T17 1422-1436 Disease denotes brain ischemic
T18 1452-1464 Disease denotes hyperthermia
T19 1490-1498 Disease denotes seizures
T20 1567-1570 Chemical denotes TXA
T21 1693-1701 Disease denotes seizures