> top > docs > PubMed:19949854 > annotations

PubMed:19949854 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 38-43 D009369 denotes tumor
T2 38-43 D009369 denotes tumor
T5 64-88 D002285 denotes ductal carcinoma in situ
T6 64-88 D002285 denotes ductal carcinoma in situ
T11 126-131 D009369 denotes tumor
T12 126-131 D009369 denotes tumor
T13 195-200 D009369 denotes tumor
T14 195-200 D009369 denotes tumor
T15 229-235 UBERON:0003891 denotes stroma
T16 331-341 CL:0000235 denotes macrophage
T29 343-346 UBERON:0001359 denotes CSF
T30 343-347 PR:Q12150 denotes CSF1
T32 343-347 P09603 denotes CSF1
T35 343-347 PR:P07141 denotes CSF1
T36 343-347 PR:P09603 denotes CSF1
T37 343-347 PR:Q8JZQ0 denotes CSF1
T38 343-347 PR:000005930 denotes CSF1
T39 343-347 P07141 denotes CSF1
T40 343-347 Q8JZQ0 denotes CSF1
T31 343-347 D016173 denotes CSF1
T33 343-347 D016173 denotes CSF1
T34 343-347 GO:0005011 denotes CSF1
T41 432-438 UBERON:0000310 denotes breast
T42 439-446 D009369 denotes cancers
T43 439-446 D009369 denotes cancers
T44 568-574 UBERON:0003891 denotes stroma
T47 578-602 D002285 denotes ductal carcinoma in situ
T48 578-602 D002285 denotes ductal carcinoma in situ
T54 604-608 CVCL_5552 denotes DCIS
T53 604-608 D002285 denotes DCIS
T55 604-608 D002285 denotes DCIS
T56 645-649 SO:0000704 denotes gene
T57 645-660 GO:0010467 denotes gene expression
T59 716-720 CVCL_5552 denotes DCIS
T58 716-720 D002285 denotes DCIS
T60 716-720 D002285 denotes DCIS
T61 760-766 UBERON:0000479 denotes tissue
T63 781-785 CVCL_5552 denotes DCIS
T62 781-785 D002285 denotes DCIS
T64 781-785 D002285 denotes DCIS
T65 799-805 UBERON:0000310 denotes breast
T66 799-812 D001943 denotes breast cancer
T67 799-812 D001943 denotes breast cancer
T68 829-833 SO:0000704 denotes gene
T69 829-844 GO:0010467 denotes gene expression
T70 888-898 CL:0000235 denotes macrophage
T71 912-922 CL:0000057 denotes fibroblast
T72 964-970 UBERON:0003891 denotes stroma
T74 985-989 CVCL_5552 denotes DCIS
T73 985-989 D002285 denotes DCIS
T75 985-989 D002285 denotes DCIS
T77 1040-1044 CVCL_5552 denotes DCIS
T76 1040-1044 D002285 denotes DCIS
T78 1040-1044 D002285 denotes DCIS
T79 1085-1091 UBERON:0000310 denotes breast
T80 1085-1098 D001943 denotes breast cancer
T81 1085-1098 D001943 denotes breast cancer
T82 1155-1165 CL:0000235 denotes macrophage
T83 1175-1184 SO:0001978 denotes signature
T85 1217-1221 CVCL_5552 denotes DCIS
T84 1217-1221 D002285 denotes DCIS
T86 1217-1221 D002285 denotes DCIS
T87 1274-1284 CL:0000057 denotes fibroblast
T88 1285-1294 SO:0001978 denotes signature
T90 1353-1357 CVCL_5552 denotes DCIS
T89 1353-1357 D002285 denotes DCIS
T91 1353-1357 D002285 denotes DCIS
T93 1396-1400 CVCL_5552 denotes DCIS
T92 1396-1400 D002285 denotes DCIS
T94 1396-1400 D002285 denotes DCIS
T95 1414-1420 UBERON:0000310 denotes breast
T96 1414-1427 D001943 denotes breast cancer
T97 1414-1427 D001943 denotes breast cancer
T99 1488-1492 CVCL_5552 denotes DCIS
T98 1488-1492 D002285 denotes DCIS
T100 1488-1492 D002285 denotes DCIS
T101 1506-1522 D044584 denotes ductal carcinoma
T102 1506-1522 D044584 denotes ductal carcinoma
T105 1566-1576 CL:0000235 denotes macrophage
T106 1594-1604 CL:0000057 denotes fibroblast
T108 1721-1725 CVCL_5552 denotes DCIS
T107 1721-1725 D002285 denotes DCIS
T109 1721-1725 D002285 denotes DCIS
T110 1807-1816 SO:0000856 denotes conserved
T111 1824-1829 D009369 denotes tumor
T112 1824-1829 D009369 denotes tumor
T114 1846-1850 CVCL_5552 denotes DCIS
T113 1846-1850 D002285 denotes DCIS
T115 1846-1850 D002285 denotes DCIS
T116 1863-1869 UBERON:0000310 denotes breast
T117 1863-1876 D001943 denotes breast cancer
T118 1863-1876 D001943 denotes breast cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 343-347 gene:1435 denotes CSF1
T1 432-446 disease:C0006142 denotes breast cancers
R1 T0 T1 associated_with CSF1,breast cancers

Allie

Id Subject Object Predicate Lexical cue
SS1_19949854_3_0 578-602 expanded denotes ductal carcinoma in situ
SS2_19949854_3_0 604-608 abbr denotes DCIS
SS1_19949854_4_0 728-748 expanded denotes immunohistochemistry
SS2_19949854_4_0 750-753 abbr denotes IHC
SS1_19949854_8_0 1497-1522 expanded denotes invasive ductal carcinoma
SS2_19949854_8_0 1524-1527 abbr denotes IDC
AE1_19949854_3_0 SS1_19949854_3_0 SS2_19949854_3_0 abbreviatedTo ductal carcinoma in situ,DCIS
AE1_19949854_4_0 SS1_19949854_4_0 SS2_19949854_4_0 abbreviatedTo immunohistochemistry,IHC
AE1_19949854_8_0 SS1_19949854_8_0 SS2_19949854_8_0 abbreviatedTo invasive ductal carcinoma,IDC

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-89 DRI_Background denotes Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ.
T2 90-253 DRI_Background denotes Recent advances in the study of the tumor microenvironment have revealed significant interaction between tumor cells and their surrounding stroma in model systems.
T3 254-492 DRI_Outcome denotes We have previously shown that two distinct stromal signatures derived from a macrophage (CSF1) response and a fibroblastic (DTF-like) response are present in subsets of invasive breast cancers and show a correlation with clinical outcome.
T4 493-610 DRI_Background denotes In the present study we explore whether these signatures also exist in the stroma of ductal carcinoma in situ (DCIS).
T5 611-819 DRI_Outcome denotes We studied the signatures by both gene expression profile analysis of a publically available data set of DCIS and by immunohistochemistry (IHC) on a tissue microarray of DCIS and invasive breast cancer cases.
T6 820-996 DRI_Outcome denotes Both the gene expression and immunohistochemical data show that the macrophage response and fibroblast expression signatures are present in the stroma of subsets of DCIS cases.
T7 997-1132 DRI_Approach denotes The incidence of the stromal signatures in DCIS is similar to the incidence in invasive breast cancer that we have previously reported.
T8 1133-1358 DRI_Outcome denotes We also find that the macrophage response signature is associated with higher grade DCIS and cases which are ER and PR negative, whereas the fibroblast signature was not associated with any clinicopathologic features in DCIS.
T9 1359-1658 DRI_Outcome denotes A comparison of 115 matched cases of DCIS and invasive breast cancer found a correlation between the type of stromal response in DCIS and invasive ductal carcinoma (IDC) within the same patient for both the macrophage response and the fibroblast stromal signatures (P = 0.03 and 0.08, respectively).
T10 1659-1726 DRI_Background denotes This study is a first characterization of these signatures in DCIS.
T11 1727-1877 DRI_Background denotes These signatures have significant clinicopathologic associations and tend to be conserved as the tumor progresses from DCIS to invasive breast cancer.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 90-253 DRI_Background denotes Recent advances in the study of the tumor microenvironment have revealed significant interaction between tumor cells and their surrounding stroma in model systems.
T2 254-492 DRI_Outcome denotes We have previously shown that two distinct stromal signatures derived from a macrophage (CSF1) response and a fibroblastic (DTF-like) response are present in subsets of invasive breast cancers and show a correlation with clinical outcome.
T3 493-610 DRI_Background denotes In the present study we explore whether these signatures also exist in the stroma of ductal carcinoma in situ (DCIS).
T4 611-819 DRI_Outcome denotes We studied the signatures by both gene expression profile analysis of a publically available data set of DCIS and by immunohistochemistry (IHC) on a tissue microarray of DCIS and invasive breast cancer cases.
T5 820-996 DRI_Outcome denotes Both the gene expression and immunohistochemical data show that the macrophage response and fibroblast expression signatures are present in the stroma of subsets of DCIS cases.
T6 997-1132 DRI_Approach denotes The incidence of the stromal signatures in DCIS is similar to the incidence in invasive breast cancer that we have previously reported.
T7 1133-1358 DRI_Outcome denotes We also find that the macrophage response signature is associated with higher grade DCIS and cases which are ER and PR negative, whereas the fibroblast signature was not associated with any clinicopathologic features in DCIS.
T8 1359-1658 DRI_Outcome denotes A comparison of 115 matched cases of DCIS and invasive breast cancer found a correlation between the type of stromal response in DCIS and invasive ductal carcinoma (IDC) within the same patient for both the macrophage response and the fibroblast stromal signatures (P = 0.03 and 0.08, respectively).
T9 1659-1726 DRI_Background denotes This study is a first characterization of these signatures in DCIS.
T10 1727-1877 DRI_Background denotes These signatures have significant clinicopathologic associations and tend to be conserved as the tumor progresses from DCIS to invasive breast cancer.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19949854-2#89#93#gene1435 343-347 gene1435 denotes CSF1
19949854-2#178#192#diseaseC0006142 432-446 diseaseC0006142 denotes breast cancers
89#93#gene1435178#192#diseaseC0006142 19949854-2#89#93#gene1435 19949854-2#178#192#diseaseC0006142 associated_with CSF1,breast cancers