PubMed:19944736 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/19944736","sourcedb":"PubMed","sourceid":"19944736","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/19944736","text":"A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB.\nThe purpose of this investigation was to explore the potentiality of a novel animal model to be used for the in vivo evaluation of the ability of a drug delivery system to promote the passage through the blood-brain barrier (BBB) and/or to improve the brain localization of a bioactive compound. A Tween 80-coated poly-L-lactid acid nanoparticles was used as a model of colloidal drug delivery system, able to trespass the BBB. Tacrine, administered in LiCl pre-treated rats, induces electrocorticographic seizures and delayed hippocampal damage. The toxic effects of tacrine-loaded poly-L-lactid acid nanoparticles (5mg/kg), a saline solution of tacrine (5mg/kg) and an empty colloidal nanoparticle suspension were compared following i.p. administration in LiCl-pre-treated Wistar rats. All the animals treated with tacrine-loaded nanoparticles showed an earlier outcome of CNS adverse symptoms, i.e. epileptic onset, with respect to those animals treated with the free compound (10 min vs. 22 min respectively). In addition, tacrine-loaded nanoparticles administration induced damage of neuronal cells in CA1 field of the hippocampus in all treated animals, while the saline solution of tacrine only in 60% of animals. Empty nanoparticles provided similar results to control (saline-treated) group of animals. In conclusion, the evaluation of time-to-onset of symptoms and the severity of neurodegenerative processes induced by the tacrine-lithium model of epilepsy in the rat, could be used to evaluate preliminarily the capability of a drug delivery system to trespass (or not) the BBB in vivo.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_19944736_1_0","span":{"begin":315,"end":334},"obj":"expanded"},{"id":"SS2_19944736_1_0","span":{"begin":336,"end":339},"obj":"abbr"}],"relations":[{"id":"AE1_19944736_1_0","pred":"abbreviatedTo","subj":"SS1_19944736_1_0","obj":"SS2_19944736_1_0"}],"attributes":[{"subj":"SS1_19944736_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_19944736_1_0","pred":"source","obj":"Allie"}]},{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T2","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T3","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T4","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T5","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T6","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T11","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T12","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T13","span":{"begin":1190,"end":1214},"obj":"Disease"},{"id":"T14","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T15","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T16","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T17","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-experiment"}]},{"project":"bc5cdr-valid-gpt-nr-ng","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T11","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T13","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T14","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T15","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-nr-ng"}]},{"project":"bc5cdr-valid-gpt-nr-g","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":662,"end":675},"obj":"Disease"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T11","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T12","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T13","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T14","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-nr-g"}]},{"project":"bc5cdr-valid-gpt-r-ng","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":595,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T11","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T13","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T14","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T15","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-ng"}]},{"project":"bc5cdr-valid-gpt-r-g","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T7","span":{"begin":662,"end":675},"obj":"Disease"},{"id":"T8","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T9","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T10","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T11","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T12","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T13","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T14","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T15","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T16","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T17","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T18","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gpt-r-g"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gpt-r-g"}]},{"project":"bc5cdr-valid-gpt-r-m2","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T11","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T12","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T13","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T14","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T15","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T16","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gpt-r-m2"}]},{"project":"bc5cdr-valid-gemini-nr-ng","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T7","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T8","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T9","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T10","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T11","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T12","span":{"begin":1013,"end":1028},"obj":"Disease"},{"id":"T13","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T14","span":{"begin":1190,"end":1214},"obj":"Disease"},{"id":"T15","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T16","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gemini-nr-ng"}]},{"project":"bc5cdr-valid-gemini-nr-g","denotations":[{"id":"T1","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T2","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T3","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T4","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T5","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T6","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T7","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T8","span":{"begin":986,"end":989},"obj":"Disease"},{"id":"T9","span":{"begin":990,"end":1006},"obj":"Disease"},{"id":"T10","span":{"begin":1013,"end":1028},"obj":"Disease"},{"id":"T11","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T12","span":{"begin":1502,"end":1519},"obj":"Disease"},{"id":"T13","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T14","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gemini-nr-g"}]},{"project":"bc5cdr-valid-gemini-r-ng","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T7","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T8","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T9","span":{"begin":739,"end":754},"obj":"Chemical"},{"id":"T10","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T11","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T12","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T13","span":{"begin":986,"end":1006},"obj":"Disease"},{"id":"T14","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T15","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T16","span":{"begin":1190,"end":1214},"obj":"Disease"},{"id":"T17","span":{"begin":1281,"end":1296},"obj":"Chemical"},{"id":"T18","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T19","span":{"begin":1502,"end":1529},"obj":"Disease"},{"id":"T20","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T21","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-gemini-r-ng"}]},{"project":"bc5cdr-valid-gemini-r-g","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T7","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T8","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T9","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T10","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T11","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T12","span":{"begin":986,"end":1006},"obj":"Disease"},{"id":"T13","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T14","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T15","span":{"begin":1190,"end":1214},"obj":"Disease"},{"id":"T16","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T17","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T18","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gemini-r-g"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gemini-r-g"}]},{"project":"bc5cdr-valid-gemini-r-m","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T7","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T8","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T9","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T10","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T11","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T12","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T13","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T14","span":{"begin":1190,"end":1214},"obj":"Disease"},{"id":"T15","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T16","span":{"begin":1502,"end":1529},"obj":"Disease"},{"id":"T17","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T18","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gemini-r-m"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gemini-r-m"}]},{"project":"bc5cdr-valid-deepseek-nr-ng","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":595,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":630,"end":656},"obj":"Disease"},{"id":"T7","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T8","span":{"begin":846,"end":850},"obj":"Chemical"},{"id":"T9","span":{"begin":1013,"end":1028},"obj":"Disease"},{"id":"T10","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T11","span":{"begin":1561,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng"}]},{"project":"bc5cdr-valid-deepseek-r-ng","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T6","span":{"begin":739,"end":745},"obj":"Chemical"},{"id":"T7","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-deepseek-r-ng"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-deepseek-r-ng"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-deepseek-r-ng"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-deepseek-r-ng"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-deepseek-r-ng"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-deepseek-r-ng"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-deepseek-r-ng"}]},{"project":"bc5cdr-valid-deepseek-r-g","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T11","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T12","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T13","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-deepseek-r-g"}]},{"project":"bc5cdr-valid","denotations":[{"id":"T1","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T2","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T3","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T4","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T5","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T6","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T11","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T12","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T13","span":{"begin":1190,"end":1214},"obj":"Disease"},{"id":"T14","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T15","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T16","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T17","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid"}]},{"project":"bc5cdr-valid-deepseek-nr-g","denotations":[{"id":"T1","span":{"begin":8,"end":14},"obj":"Disease"},{"id":"T2","span":{"begin":50,"end":54},"obj":"Chemical"},{"id":"T3","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T4","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T5","span":{"begin":444,"end":457},"obj":"Chemical"},{"id":"T6","span":{"begin":491,"end":495},"obj":"Chemical"},{"id":"T7","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T8","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T9","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T10","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T11","span":{"begin":662,"end":667},"obj":"Disease"},{"id":"T12","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T13","span":{"begin":713,"end":726},"obj":"Chemical"},{"id":"T14","span":{"begin":739,"end":745},"obj":"Chemical"},{"id":"T15","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T16","span":{"begin":893,"end":896},"obj":"Disease"},{"id":"T17","span":{"begin":907,"end":914},"obj":"Disease"},{"id":"T18","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T19","span":{"begin":998,"end":1006},"obj":"Disease"},{"id":"T20","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T21","span":{"begin":1200,"end":1208},"obj":"Disease"},{"id":"T22","span":{"begin":1502,"end":1519},"obj":"Disease"},{"id":"T23","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T24","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g"}]},{"project":"bc5cdr-valid-deepseek-r-m","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":638,"end":656},"obj":"Disease"},{"id":"T7","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T10","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T11","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-deepseek-r-m"}]},{"project":"bc5cdr-valid-gpt-r-m","denotations":[{"id":"T1","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T2","span":{"begin":425,"end":443},"obj":"Chemical"},{"id":"T3","span":{"begin":539,"end":546},"obj":"Chemical"},{"id":"T4","span":{"begin":564,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":617,"end":625},"obj":"Disease"},{"id":"T6","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T7","span":{"begin":694,"end":712},"obj":"Chemical"},{"id":"T8","span":{"begin":758,"end":765},"obj":"Chemical"},{"id":"T9","span":{"begin":869,"end":873},"obj":"Chemical"},{"id":"T10","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T11","span":{"begin":1013,"end":1022},"obj":"Disease"},{"id":"T12","span":{"begin":1138,"end":1145},"obj":"Chemical"},{"id":"T13","span":{"begin":1300,"end":1307},"obj":"Chemical"},{"id":"T14","span":{"begin":1545,"end":1552},"obj":"Chemical"},{"id":"T15","span":{"begin":1553,"end":1560},"obj":"Chemical"},{"id":"T16","span":{"begin":1570,"end":1578},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-m"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gpt-r-m"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ec93b0","default":true},{"id":"bc5cdr-valid-experiment","color":"#93caec"},{"id":"bc5cdr-valid-gpt-nr-ng","color":"#e4ec93"},{"id":"bc5cdr-valid-gpt-nr-g","color":"#da93ec"},{"id":"bc5cdr-valid-gpt-r-ng","color":"#93ecc0"},{"id":"bc5cdr-valid-gpt-r-g","color":"#eca693"},{"id":"bc5cdr-valid-gpt-r-m2","color":"#9399ec"},{"id":"bc5cdr-valid-gemini-nr-ng","color":"#b3ec93"},{"id":"bc5cdr-valid-gemini-nr-g","color":"#ec93cd"},{"id":"bc5cdr-valid-gemini-r-ng","color":"#93e7ec"},{"id":"bc5cdr-valid-gemini-r-g","color":"#ecd693"},{"id":"bc5cdr-valid-gemini-r-m","color":"#bc93ec"},{"id":"bc5cdr-valid-deepseek-nr-ng","color":"#93eca2"},{"id":"bc5cdr-valid-deepseek-r-ng","color":"#ec939d"},{"id":"bc5cdr-valid-deepseek-r-g","color":"#93b7ec"},{"id":"bc5cdr-valid","color":"#d1ec93"},{"id":"bc5cdr-valid-deepseek-nr-g","color":"#ec93eb"},{"id":"bc5cdr-valid-deepseek-r-m","color":"#93ecd3"},{"id":"bc5cdr-valid-gpt-r-m","color":"#ecb893"}]}]}}