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PubMed:19933495 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-221 Sentence denotes Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: functional roles of two CCAAT/enhancer-binding protein beta sites in activation and interferon beta-mediated suppression.
T2 222-487 Sentence denotes CCAAT/enhancer-binding protein (C/EBP) beta and C/EBP sites in the HIV-1 long terminal repeat (LTR) are crucial for HIV-1 replication in monocyte/macrophages and for the ability of interferon beta (IFN beta) to inhibit ongoing active HIV replication in these cells.
T3 488-675 Sentence denotes This IFN beta-mediated down-regulation involves induction of the truncated, dominant-negative isoform of C/EBP beta referred to as liver-enriched transcriptional inhibitory protein (LIP).
T4 676-1023 Sentence denotes Although binding of the C/EBP beta isoform to C/EBP sites in the simian immunodeficiency virus (SIV) LTR has previously been examined, the importance of these sites in core promoter-mediated transcription, virus replication, IFN beta-mediated regulation, and the relative binding of the two isoforms (C/EBP beta and LIP) has not been investigated.
T5 1024-1241 Sentence denotes Here, we specifically examine two C/EBP sites, JC1 (-100 bp) and DS1 (+134 bp), located within the minimal region of the SIV LTR, required for core promoter-mediated transcription and virus replication in macrophages.
T6 1242-1440 Sentence denotes Our studies revealed that the JC1 but not DS1 C/EBP site is important for basal level transcription, whereas the DS1 C/EBP site is imperative for productive virus replication in primary macrophages.
T7 1441-1598 Sentence denotes In contrast, either JC1 or DS1 C/EBP site is sufficient to mediate IFN beta-induced down-regulation of SIV LTR activity and virus replication in these cells.
T8 1599-1704 Sentence denotes We also characterized the differential binding properties of C/EBP beta and LIP to the JC1 and DS1 sites.
T9 1705-1940 Sentence denotes In conjunction with previous studies from our laboratory, we demonstrate the importance of these sites in virus gene expression, and we propose a model for their role in establishing latency and persistence in macrophages in the brain.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 619-624 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1934-1939 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

DisGeNET

Id Subject Object Predicate Lexical cue
T0 272-275 gene:10682 denotes EBP
T1 289-292 disease:C0019693 denotes HIV
T2 272-275 gene:152503 denotes EBP
T3 289-292 disease:C0019693 denotes HIV
T4 272-275 gene:2720 denotes EBP
T5 289-292 disease:C0019693 denotes HIV
T6 272-275 gene:10682 denotes EBP
T7 338-341 disease:C0019693 denotes HIV
T8 272-275 gene:152503 denotes EBP
T9 338-341 disease:C0019693 denotes HIV
T10 272-275 gene:2720 denotes EBP
T11 338-341 disease:C0019693 denotes HIV
T12 272-275 gene:10682 denotes EBP
T13 456-459 disease:C0019693 denotes HIV
T14 272-275 gene:152503 denotes EBP
T15 456-459 disease:C0019693 denotes HIV
T16 272-275 gene:2720 denotes EBP
T17 456-459 disease:C0019693 denotes HIV
T18 403-418 gene:3456 denotes interferon beta
T19 289-292 disease:C0019693 denotes HIV
T20 403-418 gene:3456 denotes interferon beta
T21 338-341 disease:C0019693 denotes HIV
T22 403-418 gene:3456 denotes interferon beta
T23 456-459 disease:C0019693 denotes HIV
R1 T0 T1 associated_with EBP,HIV
R2 T2 T3 associated_with EBP,HIV
R3 T4 T5 associated_with EBP,HIV
R4 T6 T7 associated_with EBP,HIV
R5 T8 T9 associated_with EBP,HIV
R6 T10 T11 associated_with EBP,HIV
R7 T12 T13 associated_with EBP,HIV
R8 T14 T15 associated_with EBP,HIV
R9 T16 T17 associated_with EBP,HIV
R10 T18 T19 associated_with interferon beta,HIV
R11 T20 T21 associated_with interferon beta,HIV
R12 T22 T23 associated_with interferon beta,HIV

Allie

Id Subject Object Predicate Lexical cue
SS1_19933495_1_0 295-315 expanded denotes long terminal repeat
SS2_19933495_1_0 317-320 abbr denotes LTR
SS1_19933495_1_1 403-418 expanded denotes interferon beta
SS2_19933495_1_1 420-428 abbr denotes IFN beta
SS1_19933495_1_2 222-252 expanded denotes CCAAT/enhancer-binding protein
SS2_19933495_1_2 254-259 abbr denotes C/EBP
SS1_19933495_2_0 619-668 expanded denotes liver-enriched transcriptional inhibitory protein
SS2_19933495_2_0 670-673 abbr denotes LIP
SS1_19933495_3_0 741-770 expanded denotes simian immunodeficiency virus
SS2_19933495_3_0 772-775 abbr denotes SIV
AE1_19933495_1_0 SS1_19933495_1_0 SS2_19933495_1_0 abbreviatedTo long terminal repeat,LTR
AE1_19933495_1_1 SS1_19933495_1_1 SS2_19933495_1_1 abbreviatedTo interferon beta,IFN beta
AE1_19933495_1_2 SS1_19933495_1_2 SS2_19933495_1_2 abbreviatedTo CCAAT/enhancer-binding protein,C/EBP
AE1_19933495_2_0 SS1_19933495_2_0 SS2_19933495_2_0 abbreviatedTo liver-enriched transcriptional inhibitory protein,LIP
AE1_19933495_3_0 SS1_19933495_3_0 SS2_19933495_3_0 abbreviatedTo simian immunodeficiency virus,SIV

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 14-17 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T2 670-673 Disease denotes LIP http://purl.obolibrary.org/obo/MONDO_0009537
T3 748-764 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T4 772-775 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T5 992-995 Disease denotes LIP http://purl.obolibrary.org/obo/MONDO_0009537
T6 1145-1148 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T7 1544-1547 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T8 1675-1678 Disease denotes LIP http://purl.obolibrary.org/obo/MONDO_0009537

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 748-764 Phenotype denotes immunodeficiency HP:0002721

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 14-17 OrganismTaxon denotes SIV 11723
T2 741-770 OrganismTaxon denotes simian immunodeficiency virus 11723
T3 772-775 OrganismTaxon denotes SIV 11723
T4 1145-1148 OrganismTaxon denotes SIV 11723
T5 1544-1547 OrganismTaxon denotes SIV 11723

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 87-98 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T2 359-367 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T4 368-379 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T5 619-624 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T6 1229-1240 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 1428-1439 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T8 1915-1926 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T9 1934-1939 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 619-624 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 1934-1939 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 26-31 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T2 87-98 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T4 359-367 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T6 368-379 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T8 1229-1240 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T10 1316-1321 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T11 1428-1439 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T13 1915-1926 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394